Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attack...Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attackers to obtain complete network information in realistic network scenarios,Reinforcement Learning(RL)is a promising solution to discover the optimal penetration path under incomplete information about the target network.Existing RL-based methods are challenged by the sizeable discrete action space,which leads to difficulties in the convergence.Moreover,most methods still rely on experts’knowledge.To address these issues,this paper proposes a penetration path planning method based on reinforcement learning with episodic memory.First,the penetration testing problem is formally described in terms of reinforcement learning.To speed up the training process without specific prior knowledge,the proposed algorithm introduces episodic memory to store experienced advantageous strategies for the first time.Furthermore,the method offers an exploration strategy based on episodic memory to guide the agents in learning.The design makes full use of historical experience to achieve the purpose of reducing blind exploration and improving planning efficiency.Ultimately,comparison experiments are carried out with the existing RL-based methods.The results reveal that the proposed method has better convergence performance.The running time is reduced by more than 20%.展开更多
The sequence stratigraphy framework of Paleogene of Qikou Sag has been built in this paper. The evolution law of episodic subsidence in Qikou Sag has been expounded, with the analysis of the characteristic of sequence...The sequence stratigraphy framework of Paleogene of Qikou Sag has been built in this paper. The evolution law of episodic subsidence in Qikou Sag has been expounded, with the analysis of the characteristic of sequence thickness, as well as the study of consedimental tectonic activity, subsidence history, paleogeomorphology and the coupling relationship among them. The faults controlling action was the dominant mechanism during rifting stage I , as the depression was the dominant mechanism during rifting stage III, which embodies a process from intense disparity fault depression to integral subsidence. Meanwhile, under the control of regional faulting and later stage depression, subsidence rate centers and paleogeomorphic concave centers are always corresponding to the sequence thickness centers, and the changes of subsidence centers and paleogeomorphology concave centers are consistent with the migration of thickness centers, which presents the restriction, coupling and response among them and clarifies the law that tectonic activity controls the basin fill by means of controlling the subsidence rate and paleogeomorphology from contributing factor angle. On this basis, the dynamic evolution of the composite pattern of structure-subsidence-deposition in the fault controlling actic region during the three rifting stages and their petroleum geological significance has been discussed.展开更多
Multi-stage uplift of the Tibetan Plateau during the Cenozoic implies a complex geodynamic process.In this paper,we review main geodynamic models for the uplift of the plateau,and,in particular,analyze the spatio-temp...Multi-stage uplift of the Tibetan Plateau during the Cenozoic implies a complex geodynamic process.In this paper,we review main geodynamic models for the uplift of the plateau,and,in particular,analyze the spatio-temporal framework of the Cenozoic deformation structures,which are closely related to the deep geodynamic mechanism for the plateau uplift.From this perspective,significant change of the deformation regime over the Tibetan Plateau occurred by the middle-late Miocene,while thrust and thrust-folding system under NS compression was succeded by extension or stress-relaxation.Meanwhile,a series of large-scale strike-slip faults commenced or was kinemtically reversed.Based on a systematic synthesis of the structure deformation,magmatism,geomorphological process and geophysical exploration,we propose a periodical model of alternating crustal compression and extension for episodic uplift of the Tibetan Plateau.展开更多
Abstract Episodic carbonate deposits on the Triassic continental slope in southern China are mainly composed of gravity-flow limestones and contourite limestones. Gravity-flow limestones were well developed in the low...Abstract Episodic carbonate deposits on the Triassic continental slope in southern China are mainly composed of gravity-flow limestones and contourite limestones. Gravity-flow limestones were well developed in the lower and middle Yangtze area in the Early Triassic and in the Yunnan-Guizhou-Guangxi area in the Early and Middle Triassic. Five fundamental types of gravity-flow limestones are recognized: slide limestone, debris-flow limestone, grain-flow limestone, turbidite limestone and rockfall limestone. They form six types of assemblage beds: slide-debris-flow limestones, slide-debris-flow-turbidite limestone, slide-debris-flow-grain-flow-turbidite limestone, rockfall-debris-flow limestone, debris-flow-turbidite limestone, and debris-flow-grain-flow-turbidite limestone. The first two were formed mainly in the Early Triassic slopes. The Middle Triassic slopes were characterized by widespread rockfall limestone. Growth faults, storms, earthquakes and oversteepened slopes are considered to be the probable triggers of the gravity flows.展开更多
AIM:To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of Oddi dysfunction(SOD).METHODS:Although several treatments have bee...AIM:To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of Oddi dysfunction(SOD).METHODS:Although several treatments have been utilized to reduce pain and associated disability,measurement tools have not been developed to reliably track outcomes.Two pilot studies were conducted to assess test-retest reliability of a newly developed instrument,the recurrent abdominal pain intensity and disability(RAPID) instrument.The RAPID score is a 90-d summation of days where productivity for various daily activities is reduced as a result of abdominal pain episodes,and is modeled after the migraine disability assessment instrument used to measure headache-related disability.RAPID was administered by telephone on 2 consecutive occasions in 2 consenting populations with suspected SOD:a pre-sphincterotomy population(Pilot Ⅰ,n = 55) and a post-sphincterotomy population(Pilot Ⅱ,n = 70).RESULTS:The average RAPID scores for Pilots Ⅰ and Ⅱ were:82 d(median:81.5 d,SD:64 d) and 48 d(median:0 d,SD:91 d),respectively.The concordance between the 2 assessments for both populations was very good:0.81 for the pre-sphincterotomy population and 0.95 for the post-sphincterotomy population.CONCLUSION:The described pilot studies suggest that RAPID is a reliable instrument for measuring disability resulting from abdominal pain in suspected SOD patients.展开更多
The fracturing of the pressure compartments in sedimentary basins may not be caused completely by natural hydraulic fracturing. On the bases of fracture mechanics and numerical simulation, we consider that there are t...The fracturing of the pressure compartments in sedimentary basins may not be caused completely by natural hydraulic fracturing. On the bases of fracture mechanics and numerical simulation, we consider that there are two mechanisms concerning the fracturing of pressure compartments, which are as follows: (1) natural hydraulic fracturing of the sediments within pressure compartments, and (2) tensile fracturing due to tangential traction. When the fracture, formed in the sediments within pressure compartments due to hydraulic fracturing, arrives at the base of the seal, the intensely tangential tensile stresses are created and lead to the fracturing of the seal. After the seal fractured, the fluid escaped from the pressure compartments. In a shallow pressure compartment, the duration of fracture opening and fluid expulsion is about 10-20 years in a cycle.展开更多
The advantage of high-resolution sequence stratigraphy, which takes base-levels as reference, is that it can be applied to continental depositional basins controlled by multiple factors and can effectively improve the...The advantage of high-resolution sequence stratigraphy, which takes base-levels as reference, is that it can be applied to continental depositional basins controlled by multiple factors and can effectively improve the accuracy and resolution of sequential stratigraphic analysis. Moreover, the principles of base-level cycles are also suitable for analyzing sequential stratigraphy in continental coal-bearing basins because of their accuracy in forecasting distribution of coal measures. By taking the Dongsheng coalfield in the Ordos basin as an example, the extensive application of base-level cycles in exploration and exploitation of coal is analyzed. The result shows that the Yan’an formation in the Dongsheng area is a long-term base-level cycle which is bordered by nonconformities and made up of five mid-term cycles and 13 short-term cycles. The long-term cycle and the mid-term cycles are obvious in comparison with a transverse profile. The episodic coal accumulation in the Mesozoic Ordos basin means that the deposition of primary matter (peat bogs) of coalification is discontinuous, periodical and cyclical in the evolution of the basin. The episodic accumulation of coal measures in the Yan’an stage is controlled by ascending-descending changes of a long-term cycle and middle-term cycles. Coal measures formed during the early and late periods of the long-term cycle are characterized by multiple layers, big cumulative thickness and poor continuity. Coal measures formed in the mid-term of the long cycle are dominated by good continuity, fewer layers and a small additive thickness, which is favorable for the accumulation of thick and continuous coal measures in the transition stage of mid term base-level cycles.展开更多
Episodic deposition has been recognized as a major factor affecting the decomposition rate of detrital material in salt marshes. In this paper, three one-off burial treatments, no burial treatment(0 cm, NBT), current ...Episodic deposition has been recognized as a major factor affecting the decomposition rate of detrital material in salt marshes. In this paper, three one-off burial treatments, no burial treatment(0 cm, NBT), current burial treatment(10 cm, CBT) and strong burial treatment(20 cm, SBT), were designed in intertidal zone of the Yellow River Estuary to determine the potential influences of episodic deposition on nutrient(C, N) and heavy metal(Pb, Cr, Cu, Zn, Ni, Mn, Cd, V and Co) variations in decomposing litters of Suaeda glauca. Results showed that although various burial treatments showed no statistical difference in decomposition rate of S. glauca, the values generally followed the sequence of CBT(0.002 403/d) > SBT(0.002 195/d) > NBT(0.002 060/d). The nutrients and heavy metals in decomposing litters of the three burial treatments exhibited different variations except for N, Cu, Cr, Ni and Co. Except for Mn, no significant differences in C, N, Pb, Cr, Cu, Zn, Ni, V and Co concentrations occurred among the three treatments(P > 0.05). With increasing burial depth, Cr and Cd levels generally increased while Cu, Ni and Mn concentrations decreased. Although episodic deposition was generally favorable for C and N release from S. glauca, its influence on release was insignificant. In the three burial treatments, Pb, Cr, Zn, Ni, Mn, V and Co stocks in S. glauca generally evidenced the export of metals from litter to environment, and, with increasing burial depth, the export amounts increased greatly. The S. glauca were particular efficient in binding Cd and releasing Pb, Cr, Zn, Ni, Mn, V and Co, and, with increasing burial depth, stocks of Cu in decomposing litters generally shifted from release to accumulation. The experiment indicated that the potential eco-toxic risk of Pb, Cr, Zn, Ni, Mn, V and Co exposure would be serious as the strong burial episodes occurred in S. glauca marsh.展开更多
An 82-year-old male suffered from prostatic cancer five years ago. Since then, he has taken flutamide and was bothered with episodic vertigo (EV) every morning. In order to treat prostatic cancer, flutamide was not di...An 82-year-old male suffered from prostatic cancer five years ago. Since then, he has taken flutamide and was bothered with episodic vertigo (EV) every morning. In order to treat prostatic cancer, flutamide was not discontinued, but conservative treatment and life-style change were recommended. Finally, EV actually subsided. Herein, we report the rare case, in which EV was an unexpected side effect of flutamide. Herein we review his whole history, physical examination, vestibular function test, electronystagmogram, caloric test, awake encephalogram, blood examinations, color-coded duplex ultrasonogram and magnetic resonance imaging/angiogram to suggest a mechanism of flutamide responsible for EV.展开更多
1 Introduction Mafic rocks are widespread throughout the Liaodong Peninsula and vicinity,northeastern North China Craton,providing important constraints on their mantle source characteristics of individual episodes,as...1 Introduction Mafic rocks are widespread throughout the Liaodong Peninsula and vicinity,northeastern North China Craton,providing important constraints on their mantle source characteristics of individual episodes,as they have展开更多
This paper focuses on developing a system that allows presentation authors to effectively retrieve presentation slides for reuse from a large volume of existing presentation materials. We assume episodic memories of t...This paper focuses on developing a system that allows presentation authors to effectively retrieve presentation slides for reuse from a large volume of existing presentation materials. We assume episodic memories of the authors can be used as contextual keywords in query expressions to efficiently dig out the expected slides for reuse rather than using only the part-of-slide-descriptions-based keyword queries. As a system, a new slide repository is proposed, composed of slide material collections, slide content data and pieces of information from authors' episodic memories related to each slide and presentation together with a slide retrieval application enabling authors to use the episodic memories as part of queries. The result of our experiment shows that the episodic memory-used queries can give more discoverability than the keyword-based queries. Additionally, an improvement model is discussed on the slide retrieval for further slide-finding efficiency by expanding the episodic memories model in the repository taking in the links with the author-and-slide-related data and events having been post on the private and social media sites.展开更多
The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlat...The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlation between terrestrial environmental changes and Wrangellia volcanism in the Ordos Basin during the CPE remains poorly understood.Records of negative carbon isotopic excursions(NCIEs),mercury(Hg),Hg/TOC,and Hg enrichment factor(HgEF)from oil shales in a large-scale terrestrial Ordos Basin in the Eastern Tethys were correlated with marine and other terrestrial successions.The three significant NCIEs in the study section were consistently correlated with those in the CPE successions of Europe,the UK,and South and North China.The U-Pb geochronology indicates a Ladinian-Carnian age for the Chang 7 Member.A comprehensive overview of the geochronology,NCIE correlation,and previous bio-and chronostratigraphic frameworks shows that the Ladinian-Carnian boundary is located in the lower part of Chang 7 in the Yishicun section.HgEF may be a more reliable proxy for tracing volcanic eruptions than the Hg/TOC ratio because the accumulation rates of TOC content largely vary in terrestrial and marine successions.The records of Hg,Hg/TOC,HgEF,and NCIEs in the Ordos Basin aligned with Carnian successions worldwide and were marked by similar anomalies,indicating a global response to the Wrangellia LIP during the CPE.Anoxia,a warm-humid climate,enhancement of detrital input,and NCIEs are synchronous with the CPE interval in the Ordos Basin,which suggests that the CPE combined with the regional Qinling Orogeny should dominate the enhanced rate of terrigenous input and paleoenvironmental evolution in the Ordos Basin.展开更多
BACKGROUND Diagnosing laryngopharyngeal reflux(LPR)is challenging due to overlapping symptoms.While proton pump inhibitors(PPIs)are commonly prescribed,reliable predictors of their responsiveness are unclear.Reflux mo...BACKGROUND Diagnosing laryngopharyngeal reflux(LPR)is challenging due to overlapping symptoms.While proton pump inhibitors(PPIs)are commonly prescribed,reliable predictors of their responsiveness are unclear.Reflux monitoring techno-server reliability.We hypothesized that PAR episodes alone might also predict PPI responsiveness.AIM To investigate whether PAR episodes alone predict a positive response to PPI therapy.METHODS Patients suspected of having LPR were prospectively recruited from otolaryngologic clinics in three Taiwan residents tertiary centers.They underwent a 24-hour esophagopharyngeal pH test using either 3-pH-sensor or hypopha-ryngeal MII-pH catheters while off medication,followed by a 12-week esomeprazole course(40 mg twice daily).Participants were categorized into four groups based on pH results:PAR alone,EAR alone,both pH(+),and both pH(-).The primary outcome was a≥50%reduction in primary laryngeal symptoms,with observers blinded to group assignments.RESULTS A total of 522 patients(mean age 52.3±12.8 years,54%male)were recruited.Of these,190(mean age 51.5±12.4 years,61%male)completed the treatment,and 89(47%)responded to PPI therapy.Response rates were highest in the PAR alone group(73%,n=11),followed by EAR alone(59%,n=68),both pH(+)(56%,n=18),and both pH(-)(33%,n=93).Multivariate analysis adjusting for age,sex,body mass index,and endoscopic esophagitis showed that participants with PAR alone,EAR alone,and both pH(+)were 7.4-fold(P=0.008),4.2-fold(P=0.0002),and 3.4-fold(P=0.03)more likely to respond to PPI therapy,respectively,compared to the both pH(-)group.Secondary analyses using the definition of≥1 PAR episode were less robust.CONCLUSION In the absence of proven hypopharyngeal predictors,this post-hoc analysis found that baseline≥2 PAR episodes alone are linked to PPI responsiveness,suggesting the importance of hypopharyngeal reflux monitoring.展开更多
This study investigated episodic memory in prodromal HD. Three groups were compared (N = 70): mutation carriers with less than 12.5 years to disease onset (n = 16), mutation carriers with 12.5 or more years to disease...This study investigated episodic memory in prodromal HD. Three groups were compared (N = 70): mutation carriers with less than 12.5 years to disease onset (n = 16), mutation carriers with 12.5 or more years to disease onset (n = 16), and noncarriers (n = 38). Episodic memory was assessed using the Fuld Object Memory Evaluation, which included multimodal presentation and selective reminding, and the Claeson-Dahl Learning Test which included verbal repeated presentation and recall trials. Both carrier groups demonstrated deficient episodic memory compared to noncarriers. The results suggest deficient episodic memory in prodromal HD, and that inconsistent retrieval contributes to these deficits. Multimodal presentation attenuates the deficits.展开更多
The chemical characteristics(water-soluble ions and carbonaceous species) of PM2.5 in Guangzhou were measured during a typical haze episode.Most of the chemical species in PM2.5 showed significant difference between...The chemical characteristics(water-soluble ions and carbonaceous species) of PM2.5 in Guangzhou were measured during a typical haze episode.Most of the chemical species in PM2.5 showed significant difference between normal and haze days.The highest contributors to PM2.5 were organic carbon(OC),nitrate,and sulfate in haze days and were OC,sulfate,and elemental carbon(EC) in normal days.The concentrations of secondary species such as,NO3^-,SO4^2-,and NH4^+ in haze days were 6.5,3.9,and 5.3 times higher than those in normal days,respectively,while primary species(EC,Ca^2+,K^+) show similar increase from normal to haze days by a factor about 2.2-2.4.OC/EC ratio ranged from 2.8 to 6.2 with an average of 4.7 and the estimation on a minimum OC/EC ratio showed that SOC(secondary organic carbon) accounted more than 36.6% for the total organic carbon in haze days.The significantly increase in the secondary species(SOC,NO3^-,SO4^2-,and NH4^+),especially in NO3^-,caused the worst air quality in this region.Simultaneously,the result illustrated that the serious air pollution in haze episodes was strongly correlated with the meteorological conditions.During the sampling periods,air pollution and visibility had a good relationship with the air mass transport distance;the shorter air masses transport distance,the worse air quality and visibility in Guangzhou,indicating the strong domination of local sources contributing to haze formation.High concentration of the secondary aerosol in haze episodes was likely due to the higher oxidation rates of sulfur and nitrogen species.展开更多
文摘Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attackers to obtain complete network information in realistic network scenarios,Reinforcement Learning(RL)is a promising solution to discover the optimal penetration path under incomplete information about the target network.Existing RL-based methods are challenged by the sizeable discrete action space,which leads to difficulties in the convergence.Moreover,most methods still rely on experts’knowledge.To address these issues,this paper proposes a penetration path planning method based on reinforcement learning with episodic memory.First,the penetration testing problem is formally described in terms of reinforcement learning.To speed up the training process without specific prior knowledge,the proposed algorithm introduces episodic memory to store experienced advantageous strategies for the first time.Furthermore,the method offers an exploration strategy based on episodic memory to guide the agents in learning.The design makes full use of historical experience to achieve the purpose of reducing blind exploration and improving planning efficiency.Ultimately,comparison experiments are carried out with the existing RL-based methods.The results reveal that the proposed method has better convergence performance.The running time is reduced by more than 20%.
基金support from the National Natural Science Foundation of China (Grant No.40872077)National Major Science and Technology Project of China (Grant No. 2011ZX05009-002)Open Project Foundation of Ministry of Education Key Laboratory of Tectonics and Petroleum Resources (Grant No. TPR-2011-09)
文摘The sequence stratigraphy framework of Paleogene of Qikou Sag has been built in this paper. The evolution law of episodic subsidence in Qikou Sag has been expounded, with the analysis of the characteristic of sequence thickness, as well as the study of consedimental tectonic activity, subsidence history, paleogeomorphology and the coupling relationship among them. The faults controlling action was the dominant mechanism during rifting stage I , as the depression was the dominant mechanism during rifting stage III, which embodies a process from intense disparity fault depression to integral subsidence. Meanwhile, under the control of regional faulting and later stage depression, subsidence rate centers and paleogeomorphic concave centers are always corresponding to the sequence thickness centers, and the changes of subsidence centers and paleogeomorphology concave centers are consistent with the migration of thickness centers, which presents the restriction, coupling and response among them and clarifies the law that tectonic activity controls the basin fill by means of controlling the subsidence rate and paleogeomorphology from contributing factor angle. On this basis, the dynamic evolution of the composite pattern of structure-subsidence-deposition in the fault controlling actic region during the three rifting stages and their petroleum geological significance has been discussed.
基金supported by the National Special Project on the Tibetan Plateau of the China Geological Survey (1212011121261, 1212010610103)the National Natural Science Foundation of China (Nos. 41202144, 40902060)
文摘Multi-stage uplift of the Tibetan Plateau during the Cenozoic implies a complex geodynamic process.In this paper,we review main geodynamic models for the uplift of the plateau,and,in particular,analyze the spatio-temporal framework of the Cenozoic deformation structures,which are closely related to the deep geodynamic mechanism for the plateau uplift.From this perspective,significant change of the deformation regime over the Tibetan Plateau occurred by the middle-late Miocene,while thrust and thrust-folding system under NS compression was succeded by extension or stress-relaxation.Meanwhile,a series of large-scale strike-slip faults commenced or was kinemtically reversed.Based on a systematic synthesis of the structure deformation,magmatism,geomorphological process and geophysical exploration,we propose a periodical model of alternating crustal compression and extension for episodic uplift of the Tibetan Plateau.
文摘Abstract Episodic carbonate deposits on the Triassic continental slope in southern China are mainly composed of gravity-flow limestones and contourite limestones. Gravity-flow limestones were well developed in the lower and middle Yangtze area in the Early Triassic and in the Yunnan-Guizhou-Guangxi area in the Early and Middle Triassic. Five fundamental types of gravity-flow limestones are recognized: slide limestone, debris-flow limestone, grain-flow limestone, turbidite limestone and rockfall limestone. They form six types of assemblage beds: slide-debris-flow limestones, slide-debris-flow-turbidite limestone, slide-debris-flow-grain-flow-turbidite limestone, rockfall-debris-flow limestone, debris-flow-turbidite limestone, and debris-flow-grain-flow-turbidite limestone. The first two were formed mainly in the Early Triassic slopes. The Middle Triassic slopes were characterized by widespread rockfall limestone. Growth faults, storms, earthquakes and oversteepened slopes are considered to be the probable triggers of the gravity flows.
基金Supported by The development of the RAPID instrument was supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases, No R03 DK069328-01
文摘AIM:To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of Oddi dysfunction(SOD).METHODS:Although several treatments have been utilized to reduce pain and associated disability,measurement tools have not been developed to reliably track outcomes.Two pilot studies were conducted to assess test-retest reliability of a newly developed instrument,the recurrent abdominal pain intensity and disability(RAPID) instrument.The RAPID score is a 90-d summation of days where productivity for various daily activities is reduced as a result of abdominal pain episodes,and is modeled after the migraine disability assessment instrument used to measure headache-related disability.RAPID was administered by telephone on 2 consecutive occasions in 2 consenting populations with suspected SOD:a pre-sphincterotomy population(Pilot Ⅰ,n = 55) and a post-sphincterotomy population(Pilot Ⅱ,n = 70).RESULTS:The average RAPID scores for Pilots Ⅰ and Ⅱ were:82 d(median:81.5 d,SD:64 d) and 48 d(median:0 d,SD:91 d),respectively.The concordance between the 2 assessments for both populations was very good:0.81 for the pre-sphincterotomy population and 0.95 for the post-sphincterotomy population.CONCLUSION:The described pilot studies suggest that RAPID is a reliable instrument for measuring disability resulting from abdominal pain in suspected SOD patients.
文摘The fracturing of the pressure compartments in sedimentary basins may not be caused completely by natural hydraulic fracturing. On the bases of fracture mechanics and numerical simulation, we consider that there are two mechanisms concerning the fracturing of pressure compartments, which are as follows: (1) natural hydraulic fracturing of the sediments within pressure compartments, and (2) tensile fracturing due to tangential traction. When the fracture, formed in the sediments within pressure compartments due to hydraulic fracturing, arrives at the base of the seal, the intensely tangential tensile stresses are created and lead to the fracturing of the seal. After the seal fractured, the fluid escaped from the pressure compartments. In a shallow pressure compartment, the duration of fracture opening and fluid expulsion is about 10-20 years in a cycle.
基金Project2003CB214603 supported by Development Plan of the State Key Fundamental Research, China
文摘The advantage of high-resolution sequence stratigraphy, which takes base-levels as reference, is that it can be applied to continental depositional basins controlled by multiple factors and can effectively improve the accuracy and resolution of sequential stratigraphic analysis. Moreover, the principles of base-level cycles are also suitable for analyzing sequential stratigraphy in continental coal-bearing basins because of their accuracy in forecasting distribution of coal measures. By taking the Dongsheng coalfield in the Ordos basin as an example, the extensive application of base-level cycles in exploration and exploitation of coal is analyzed. The result shows that the Yan’an formation in the Dongsheng area is a long-term base-level cycle which is bordered by nonconformities and made up of five mid-term cycles and 13 short-term cycles. The long-term cycle and the mid-term cycles are obvious in comparison with a transverse profile. The episodic coal accumulation in the Mesozoic Ordos basin means that the deposition of primary matter (peat bogs) of coalification is discontinuous, periodical and cyclical in the evolution of the basin. The episodic accumulation of coal measures in the Yan’an stage is controlled by ascending-descending changes of a long-term cycle and middle-term cycles. Coal measures formed during the early and late periods of the long-term cycle are characterized by multiple layers, big cumulative thickness and poor continuity. Coal measures formed in the mid-term of the long cycle are dominated by good continuity, fewer layers and a small additive thickness, which is favorable for the accumulation of thick and continuous coal measures in the transition stage of mid term base-level cycles.
基金Under the auspices of National Natural Science Foundation of China(No.41971128,41371104)Key Foundation of Science and Technology Department of Fujian Province(No.2016R1032-1)the Award Program for Min River Scholar in Fujian Province(No.Min 201531)。
文摘Episodic deposition has been recognized as a major factor affecting the decomposition rate of detrital material in salt marshes. In this paper, three one-off burial treatments, no burial treatment(0 cm, NBT), current burial treatment(10 cm, CBT) and strong burial treatment(20 cm, SBT), were designed in intertidal zone of the Yellow River Estuary to determine the potential influences of episodic deposition on nutrient(C, N) and heavy metal(Pb, Cr, Cu, Zn, Ni, Mn, Cd, V and Co) variations in decomposing litters of Suaeda glauca. Results showed that although various burial treatments showed no statistical difference in decomposition rate of S. glauca, the values generally followed the sequence of CBT(0.002 403/d) > SBT(0.002 195/d) > NBT(0.002 060/d). The nutrients and heavy metals in decomposing litters of the three burial treatments exhibited different variations except for N, Cu, Cr, Ni and Co. Except for Mn, no significant differences in C, N, Pb, Cr, Cu, Zn, Ni, V and Co concentrations occurred among the three treatments(P > 0.05). With increasing burial depth, Cr and Cd levels generally increased while Cu, Ni and Mn concentrations decreased. Although episodic deposition was generally favorable for C and N release from S. glauca, its influence on release was insignificant. In the three burial treatments, Pb, Cr, Zn, Ni, Mn, V and Co stocks in S. glauca generally evidenced the export of metals from litter to environment, and, with increasing burial depth, the export amounts increased greatly. The S. glauca were particular efficient in binding Cd and releasing Pb, Cr, Zn, Ni, Mn, V and Co, and, with increasing burial depth, stocks of Cu in decomposing litters generally shifted from release to accumulation. The experiment indicated that the potential eco-toxic risk of Pb, Cr, Zn, Ni, Mn, V and Co exposure would be serious as the strong burial episodes occurred in S. glauca marsh.
文摘An 82-year-old male suffered from prostatic cancer five years ago. Since then, he has taken flutamide and was bothered with episodic vertigo (EV) every morning. In order to treat prostatic cancer, flutamide was not discontinued, but conservative treatment and life-style change were recommended. Finally, EV actually subsided. Herein, we report the rare case, in which EV was an unexpected side effect of flutamide. Herein we review his whole history, physical examination, vestibular function test, electronystagmogram, caloric test, awake encephalogram, blood examinations, color-coded duplex ultrasonogram and magnetic resonance imaging/angiogram to suggest a mechanism of flutamide responsible for EV.
基金financially supported by the National Natural Science Foundation of China (Grant No. 41430207 and 90914001)National Key Basic Research Program of China (Grant No. 2012CB416603)+1 种基金the Opening Foundation of the Peking University (Grant No. 0000010541)the Undergraduates Innovating Experimentation Project of Jilin University (Grant No. 2010C61164)
文摘1 Introduction Mafic rocks are widespread throughout the Liaodong Peninsula and vicinity,northeastern North China Craton,providing important constraints on their mantle source characteristics of individual episodes,as they have
文摘This paper focuses on developing a system that allows presentation authors to effectively retrieve presentation slides for reuse from a large volume of existing presentation materials. We assume episodic memories of the authors can be used as contextual keywords in query expressions to efficiently dig out the expected slides for reuse rather than using only the part-of-slide-descriptions-based keyword queries. As a system, a new slide repository is proposed, composed of slide material collections, slide content data and pieces of information from authors' episodic memories related to each slide and presentation together with a slide retrieval application enabling authors to use the episodic memories as part of queries. The result of our experiment shows that the episodic memory-used queries can give more discoverability than the keyword-based queries. Additionally, an improvement model is discussed on the slide retrieval for further slide-finding efficiency by expanding the episodic memories model in the repository taking in the links with the author-and-slide-related data and events having been post on the private and social media sites.
基金supported by the National Natural Science Foundation of China(Grant Nos.42172109,41872113,42172108)China National Petroleum Corporation-China University of Petroleum(Beijing)Strategic Cooperation Science and Technology Project(Grant No.ZLZX2020-02)+1 种基金State's Key Project of Research and Development Plan(Grant No.2018YFA0702405)Science Foundation of China University of Petroleum(Beijing)(Grant Nos.2462020BJRC002,2462020YXZZ020)。
文摘The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlation between terrestrial environmental changes and Wrangellia volcanism in the Ordos Basin during the CPE remains poorly understood.Records of negative carbon isotopic excursions(NCIEs),mercury(Hg),Hg/TOC,and Hg enrichment factor(HgEF)from oil shales in a large-scale terrestrial Ordos Basin in the Eastern Tethys were correlated with marine and other terrestrial successions.The three significant NCIEs in the study section were consistently correlated with those in the CPE successions of Europe,the UK,and South and North China.The U-Pb geochronology indicates a Ladinian-Carnian age for the Chang 7 Member.A comprehensive overview of the geochronology,NCIE correlation,and previous bio-and chronostratigraphic frameworks shows that the Ladinian-Carnian boundary is located in the lower part of Chang 7 in the Yishicun section.HgEF may be a more reliable proxy for tracing volcanic eruptions than the Hg/TOC ratio because the accumulation rates of TOC content largely vary in terrestrial and marine successions.The records of Hg,Hg/TOC,HgEF,and NCIEs in the Ordos Basin aligned with Carnian successions worldwide and were marked by similar anomalies,indicating a global response to the Wrangellia LIP during the CPE.Anoxia,a warm-humid climate,enhancement of detrital input,and NCIEs are synchronous with the CPE interval in the Ordos Basin,which suggests that the CPE combined with the regional Qinling Orogeny should dominate the enhanced rate of terrigenous input and paleoenvironmental evolution in the Ordos Basin.
文摘BACKGROUND Diagnosing laryngopharyngeal reflux(LPR)is challenging due to overlapping symptoms.While proton pump inhibitors(PPIs)are commonly prescribed,reliable predictors of their responsiveness are unclear.Reflux monitoring techno-server reliability.We hypothesized that PAR episodes alone might also predict PPI responsiveness.AIM To investigate whether PAR episodes alone predict a positive response to PPI therapy.METHODS Patients suspected of having LPR were prospectively recruited from otolaryngologic clinics in three Taiwan residents tertiary centers.They underwent a 24-hour esophagopharyngeal pH test using either 3-pH-sensor or hypopha-ryngeal MII-pH catheters while off medication,followed by a 12-week esomeprazole course(40 mg twice daily).Participants were categorized into four groups based on pH results:PAR alone,EAR alone,both pH(+),and both pH(-).The primary outcome was a≥50%reduction in primary laryngeal symptoms,with observers blinded to group assignments.RESULTS A total of 522 patients(mean age 52.3±12.8 years,54%male)were recruited.Of these,190(mean age 51.5±12.4 years,61%male)completed the treatment,and 89(47%)responded to PPI therapy.Response rates were highest in the PAR alone group(73%,n=11),followed by EAR alone(59%,n=68),both pH(+)(56%,n=18),and both pH(-)(33%,n=93).Multivariate analysis adjusting for age,sex,body mass index,and endoscopic esophagitis showed that participants with PAR alone,EAR alone,and both pH(+)were 7.4-fold(P=0.008),4.2-fold(P=0.0002),and 3.4-fold(P=0.03)more likely to respond to PPI therapy,respectively,compared to the both pH(-)group.Secondary analyses using the definition of≥1 PAR episode were less robust.CONCLUSION In the absence of proven hypopharyngeal predictors,this post-hoc analysis found that baseline≥2 PAR episodes alone are linked to PPI responsiveness,suggesting the importance of hypopharyngeal reflux monitoring.
基金Department of Clinical Genetics, Karolinska University Hospital
文摘This study investigated episodic memory in prodromal HD. Three groups were compared (N = 70): mutation carriers with less than 12.5 years to disease onset (n = 16), mutation carriers with 12.5 or more years to disease onset (n = 16), and noncarriers (n = 38). Episodic memory was assessed using the Fuld Object Memory Evaluation, which included multimodal presentation and selective reminding, and the Claeson-Dahl Learning Test which included verbal repeated presentation and recall trials. Both carrier groups demonstrated deficient episodic memory compared to noncarriers. The results suggest deficient episodic memory in prodromal HD, and that inconsistent retrieval contributes to these deficits. Multimodal presentation attenuates the deficits.
基金supported by the National Excellent Youth Foundation of China (No. 20625722)the China Postdoctoral Science Foundation (No. 20080430396)
文摘The chemical characteristics(water-soluble ions and carbonaceous species) of PM2.5 in Guangzhou were measured during a typical haze episode.Most of the chemical species in PM2.5 showed significant difference between normal and haze days.The highest contributors to PM2.5 were organic carbon(OC),nitrate,and sulfate in haze days and were OC,sulfate,and elemental carbon(EC) in normal days.The concentrations of secondary species such as,NO3^-,SO4^2-,and NH4^+ in haze days were 6.5,3.9,and 5.3 times higher than those in normal days,respectively,while primary species(EC,Ca^2+,K^+) show similar increase from normal to haze days by a factor about 2.2-2.4.OC/EC ratio ranged from 2.8 to 6.2 with an average of 4.7 and the estimation on a minimum OC/EC ratio showed that SOC(secondary organic carbon) accounted more than 36.6% for the total organic carbon in haze days.The significantly increase in the secondary species(SOC,NO3^-,SO4^2-,and NH4^+),especially in NO3^-,caused the worst air quality in this region.Simultaneously,the result illustrated that the serious air pollution in haze episodes was strongly correlated with the meteorological conditions.During the sampling periods,air pollution and visibility had a good relationship with the air mass transport distance;the shorter air masses transport distance,the worse air quality and visibility in Guangzhou,indicating the strong domination of local sources contributing to haze formation.High concentration of the secondary aerosol in haze episodes was likely due to the higher oxidation rates of sulfur and nitrogen species.