Wound healing activity of Abroma augusta in Wistar rats

Objective:The study was undertaken to evaluate the wound healing profile of alcoholic extract of Abroma augusta and its effect on dexamethasone suppressed wound healing in Wistar rats.Methods:An alcoholic extract of Abroma augusta was prepared.Three models were used - incision,excision and dead space wound models. Four groups of animals were used for each model.They were administered 2%gum acacia(orally),alcoholic extract of Abroma augusta(orally),dexamethasone(intramuscularly) and combination of Abroma augusta(orally) with dexamethasone(intramuscularly) respectively.The parameters studied included breaking strength of incision wound,period of epithelization and wound contraction rate in the excision wound,breaking strength,dry weight and hydroxyproline content of granulation tissue in dead space wound.Results:The breaking strength of incision wound of Abroma augusta treated group was significantly increased(P <0.001 ) while that of dexamethasone treated animals was significantly decreased(P<0.001) as compared to control. Coadministration of dexamethasone and Abroma augusta significantly reversed the dexamethasone suppressed wound healing in incision wound model(P< 0.001 ).Animals treated with both dexamethasone and Abroma augusta also showed significant(P <0.004) increase in the breaking strength of granulation tissue in the dead space wound and a significant(P <0.011) reduction in the period of epithelization in the excision wound as compared to rats treated with dexamethasone alone.The rate of wound contraction was not significantly altered in any of the groups.Conclusion:The alcoholic extract of Abroma augusta was found to reverse dexamethasone suppressed wound healing.

Antioxidant,Antimicrobial and Wound Healing Potential of Helicteres isora Linn.Leaf Extracts

Objective To investigate the antioxidant,antimicrobial and wound healing potential of Helicteres isora Linn.leaf extracts.Methods The petroleum ether,chloroform,acetone,ethanol and hydroalcoholic extracts of leaves were screened for phytochemicals.The 1,1-diphenyl-2-picrylhydrazyl(DPPH),nitric oxide(NO)radical scavenging tests and reducing power assays were performed to measure antioxidant activity;disc diffusion methods were used to evaluate antimicrobial potential.Wound healing activity was evaluated by incision and excision wound rat models.Results The extracts contained mainly sterols and flavonoids.The hydroalcoholic extract showed remarkable antioxidant and antimicrobial potential and significant(P<0.05)wound healing activity.Conclusions The identified activities of the hydroalcoholic extract may be attributable to its constituent phytochemicals.

Soft Tissue Myoepithelioma in Children:A Rare Case Report of the Mediastinum and a Review of the Literature

Myoepithelioma(ME)is a rare tumor composed of myoepithelial cells that usually surround glandular tissue.MEs differ from mixed tumors as they present minimal or no ductal differentiation^([1]).MEs can originate from soft tissue and bones,but histogenesis remains uncertain.

UNSCHEDULED DNA REPAIR SYNTHESIS IN HUMAN FETAL RESPIRATORY CELLS

In order to study and copare the diffe-rence of DNA repair synthesis induced bychemical carcinogens in human respiratoryepithelial cells and fibroblast cells,the nasopharyngeal and

THE MORPHOLOGICAL ALTERATION IN EARLY STAGE OF CARCINOGENESIS OF HUMAN RESPIRATORY TRACT

The carcinogenic effect of BaP on the re-spiratory system have been extensively inves-tigated.It has not been reported that thehuman respiratory tract(HRT)would undergopreneoplastic lesions experimentally afterexposure to BaP,because of being in diffi-culty to obtain the studying materials ofnormal HRT.