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Equivalent linear model for seismic damage evaluation of single-degree-of-freedom systems representing reinforced concrete structures considering cyclic degradation behavior
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作者 Lulu Yan Ding-Hao Yu 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第3期637-648,共12页
In this study,a novel equivalent damping ratio model that is suitable for reinforced concrete(RC)structures considering cyclic degradation behavior is developed,and a new equivalent linearization analysis method for i... In this study,a novel equivalent damping ratio model that is suitable for reinforced concrete(RC)structures considering cyclic degradation behavior is developed,and a new equivalent linearization analysis method for implementing the proposed equivalent damping ratio model for use in seismic damage evaluation is presented.To this end,Ibarra’s peak-oriented model,which incorporates an energy-based degradation rule,is selected for representing hysteretic behavior of RC structure,and the optimized equivalent damping for predicting the maximum displacement response is presented by using the empirical method,in which the effect of cyclic degradation is considered.Moreover,the relationship between the hysteretic energy dissipation of the inelastic system and the elastic strain energy of the equivalent linear system is established so that the proposed equivalent linear system can be directly integrated with the Park-Ang seismic model to implement seismic damage evaluation.Due to the simplicity of the equivalent linearization method,the proposed method provides an efficient and reliable way of obtaining comprehensive insight into the seismic performance of RC structures.The verification demonstrates the validity of the proposed method. 展开更多
关键词 degrading system equivalent linear system equivalent damping seismic damage RC structures
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Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?
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作者 Changming Hong Yujian Huang +6 位作者 Shuting Cao Li Wang Xuefen Yang Shenglan Hu Kaiguo Gao Zongyong Jiang Hao Xiao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第2期519-534,共16页
Oxidative stress has been associated with a number of physiological problems in swine,including reduced production efficiency.Recently,although there has been increased research into regulatory mechanisms and antioxid... Oxidative stress has been associated with a number of physiological problems in swine,including reduced production efficiency.Recently,although there has been increased research into regulatory mechanisms and antioxidant strategies in relation to oxidative stress-induced pig production,it remains so far largely unsuccessful to develop accurate models and nutritional strategies for specific oxidative stress factors.Here,we discuss the dose and dose intensity of the causes of oxidative stress involving physiological,environmental and dietary factors,recent research models and the antioxidant strategies to provide theoretical guidance for future oxidative stress research in swine. 展开更多
关键词 Accurate models dose Nutritional strategies Oxidative stress SWINE
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Determination of Timer Error and Evaluation of Its Effect on Dose for OB6, GammaBeam X200 and X-Ray Irradiators at the Secondary Standard Dosimetry Laboratory in Nigeria
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作者 Olumide Olaife Akerele Samuel Mofolorunsho Oyeyemi +3 位作者 David Olakanmi Olaniyi Francis Adole Agada Bamidele Musbau Adeniran Latifat Ronke Owoade 《World Journal of Nuclear Science and Technology》 CAS 2024年第2期118-130,共13页
Timer error as well as its convention is very important for dose accuracy during irradiation. This paper determines the timer error of irradiators at Secondary Standard Dosimetry Laboratory (SSDL) in Nigeria. The irra... Timer error as well as its convention is very important for dose accuracy during irradiation. This paper determines the timer error of irradiators at Secondary Standard Dosimetry Laboratory (SSDL) in Nigeria. The irradiators are Cs-137 OB6 irradiator and X-ray irradiators at the Protection level SSDL;and Co-60 irradiator at the Therapy Level SSDL. PTW UNIDOS electrometer and LS01 Ionization chamber were used at the Protection Level to obtain doses for both Cs-137 OB6 and X-ray irradiators while an IBA farmer type ionization chamber and an IBA DOSE 1 electrometer were used at the Protection Level SSDL. Single/multiple exposure method and graphical method were used in the determination of the timer error for the three irradiators. The timer error obtained for Cs-137 OB6 irradiator was 0.48 ± 0.01 s, the timer error for the X-ray irradiator was 0.09 ± 0.01 s while the timer error obtained for GammaBeam X200 was 1.21 ± 0.04 s. It was observed that the timer error is not affected by source to detector distance. It was also observed that the timer error of Co-60 Gamma X200 irradiator is increasing with the age of the machine. Source to detector distance and field size do not contribute towards the timer error of the irradiators. The timer error of the Co-60 Gamma X200 irradiator (the only irradiator among the irradiators with a pneumatic system) increases with the age of the irradiator. 展开更多
关键词 Timer Error Irradiation SSDL Irradiators dose Accuracy
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A Bioequivalence Study of Empagliflozin/Metformin Fixed-Dose Combination in Healthy Subjects under Fasting Conditions
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作者 Evelyn Pena Alfredo Inatti +2 位作者 Anyoly Taly José Chacón Xenon Serrano-Martin 《Journal of Biosciences and Medicines》 2024年第9期235-250,共16页
Background: This study evaluated the bioequivalence of empagliflozin 12.5 mg/metformin 1000 mg tablets compared to Synjardy® (Empagliflozin 12.5 mg/metformin 1000 mg) tablets in healthy male subjects under fastin... Background: This study evaluated the bioequivalence of empagliflozin 12.5 mg/metformin 1000 mg tablets compared to Synjardy® (Empagliflozin 12.5 mg/metformin 1000 mg) tablets in healthy male subjects under fasting conditions. Methods: This was a phase I, randomized, single-dose, two-period, two-sequence, crossover study to evaluate the bioequivalence (BE) profiles of two fixed-dose combinations (FDCs) of empagliflozin/metformin. Cmax, AUC0-t and AUC0-∞ from test and reference formulations were evaluated to access BE. The plasma concentrations were measured using a validated liquid chromatography-mass spectrometry (LC-MS/MS) method. Of the 24 subjects enrolled, 23 completed both periods of the study. The two formulations test and reference were considered bioequivalent if 90% confidence interval (CI) fell within 80.00% - 125.00% for Cmax, AUC0-t and AUC0-∞. Tolerability and safety were assessed throughout the study. Results: The pharmacokinetic (PK) parameters were similar between the test product (T) and reference product (R) Synjardy®. The 90% CI of the test/reference ratios of log-transformed PK parameters point estimates was Cmax: 89.87% (85.68% - 94.27%), AUC0-t: 87.91% (83.65% - 92.39%) and AUC0-∞: 87.16% (82.80% - 91.75%) to empagliflozin and Cmax: 92.19% (87.95% - 96.65%), AUC0-t: 91.38% (84.42% - 98.91%) and AUC0-∞: 93.78% (83.82% - 104.93%) to metformin respectively (90% CI for all PK parameters fell within 80.00% - 125.00%). Conclusion: Our results demonstrated BE between the test and reference formulations of oral tablets of empagliflozin 12.5 mg/metformin 1000 mg (FDC) in healthy male subjects under fasting conditions. 展开更多
关键词 BIOEQUIVALENCE Fix dose Combinations PHARMACOKINETIC Empagliflozin
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Validation of the TOPAS Monte-Carlo Code of the Off-Field Dose of a 6 MV Synergy Linac
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作者 Kodjo Joel Fabrice N’Guessan Ibrahima Sakho Bogbé D. L. H. Gogon 《Journal of Biosciences and Medicines》 2024年第7期38-54,共17页
The risk of radiation-induced second cancer and the late tissue loss due to Off-field doses in radiotherapy remain a serious concern. Monte Carlo (MC) simulation is currently one of the most accurate methods for calcu... The risk of radiation-induced second cancer and the late tissue loss due to Off-field doses in radiotherapy remain a serious concern. Monte Carlo (MC) simulation is currently one of the most accurate methods for calculating these doses. MC simulation model based on the Particle Simulation Tool (TOPAS) has been developed to simulate the off-field dose of an Elekta Synergy linear accelerator (Linac) emitting 6 MV photons. Measurements were taken in a water phantom using an ionization chamber to validate this model. The Percentage Depth Dose (PDD) at the depth of 0.0, 5.0, 10.0 and 15.0 cm from the beam axis for a 10 × 10 cm2 field size was measured and simulated. Off-field dose profiles at the depth of 1.5 (dmax), 5.0 and 10.0 cm for field sizes of 5 × 5, 10 × 10, 15 × 15, and 20 × 20 cm2 respectively were measured and simulated. Comparison of measured and simulated off-field dose values showed a good agreement. The average gamma passing rate of the PDDs and profiles curves for off-field doses were 87.5% and 98.11% respectively. The local dose difference based on the PDD curve between the measured and simulated was less than 6.0 % for all locations. For all field size considered in this study, the average difference between profile curves for off-field dose measured and simulated was 9.1%. PDDs and Profiles curves for off-field dose simulation uncertainties were less than 2.0% and 1.0% respectively. TOPAS-MC simulation model developed is a good representation of our 6 MV Linac Elekta Synergy for assessing off-field dose, which would be the primary cause of some secondary cancers. 展开更多
关键词 Radiotherapy Off-Field dose Secondary Cancer TOPAS-MC Simulation DOSIMETRY
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An equivalent target plate damage probability calculation mathematics model and damage evaluation method
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作者 Hanshan Li Xiaoqian Zhang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第11期82-103,共22页
Aiming at the requirement of damage testing and evaluation of equivalent target plate based on the explosion of intelligent ammunition, this paper proposes a novel method for damage testing and evaluation method of ci... Aiming at the requirement of damage testing and evaluation of equivalent target plate based on the explosion of intelligent ammunition, this paper proposes a novel method for damage testing and evaluation method of circumferential equivalent target plate. Leveraging the dispersion characteristics parameters of fragment, we establish a calculation model of the fragment power situation and the damage calculation model under the condition of fragment ultimate penetration equivalent target plate. The damage model of equivalent target plate involves the fragment dispersion density, the local perforation damage criterion, the tearing damage model, and the damage probability. We use the camera to obtain the image of the equivalent target plate with fragment perforation, and research the algorithm of fragment distribution position recognition and fragment perforation area calculation method on the equivalent target plate by image processing technology. Based on the obtained parameters of the breakdown position and perforation area of fragments on equivalent target plate, we apply to damage calculation model of equivalent target plate, and calculate the damage probability of each equivalent target plate, and use the combined probabilistic damage calculation method to obtain the damage evaluation results of the circumferential equivalent target plate in an intelligent ammunition explosion experiment. Through an experimental testing, we verify the feasibility and rationality of the proposed damage evaluation method by comparison, the calculation results can reflect the actual damage effect of the equivalent target plate. 展开更多
关键词 Target damage evaluation Damage probability FRAGMENTS equivalent target plate Image processing
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Total ionizing dose effect modeling method for CMOS digital-integrated circuit
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作者 Bo Liang Jin-Hui Liu +3 位作者 Xiao-Peng Zhang Gang Liu Wen-Dan Tan Xin-Dan Zhang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第2期32-46,共15页
Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID eff... Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was proposed.The digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional area.Each of these three parts was separately modeled.Using the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using VHDL-AMS.In the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area models.Furthermore,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital IC.TID experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose point.This confirms the practicality and accuracy of the proposed modeling method.The TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs. 展开更多
关键词 CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters
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Normalized glandular dose coefficients for digital breast tomosynthesis using detailed Chinese breast models
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作者 Jia-Hao Wang Rui Qiu +4 位作者 An-Kang Hu Ye-Qi Liu Zhen Wu Hui Zhang Jun-Li Li 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第5期42-59,共18页
The rise in breast cancer diagnoses among Chinese women has necessitated the use of X-ray breast screening,which carries a radiation risk.This study aimed to provide a dosimetry protocol for the Chinese female populat... The rise in breast cancer diagnoses among Chinese women has necessitated the use of X-ray breast screening,which carries a radiation risk.This study aimed to provide a dosimetry protocol for the Chinese female population to replace the traditional standard that utilizes simplified breast models,for the accurate estimation of the mean glandular dose of a patient undergoing digital breast tomosynthesis(DBT).The first set of detailed Chinese female breast models and representative breast parameters was constructed.Considering backscatter radiation and computational efficiency,we improved the combination of these models and the Chinese reference adult female whole-body voxel phantom.Image acquisition for four commercial DBT systems that are widely employed in China was simulated using the Monte Carlo method to obtain the normalized glandular dose coefficients of DBT(D_(gN)^(DBT))and the glandular depth dose(D_(g)^(dep)(z))for different breast characteristics and X-ray spectra.We calculated a series of D_(gN)^(DBT) values for breasts with different percentage mass glandularities(5%,25%,50%,75%,and 100%)and compressed breast thicknesses(2,3,4,5,6,and 7 cm)at various tube potentials(25,28,30,32,35,and 49 kV)and target/filter combinations(W/Rh,W/Al,Mo/Mo,Rh/Rh,and Rh/Ag).The parameter dependence of the breast characteristics and beam conditions on D_(gN)^(DBT) in detailed breast models was investigated.The D_(gN)^(DBT) results were 14.6-51.0%lower than those of the traditional dosimetry standard in China.The difference in D_(gN)^(DBT) was mainly due to a decrease in the depth of the main energy deposition area caused by the glandular distribution along the depth direction.The results obtained in this study may be used to improve breast dosimetry in China and provide more detailed information on risk assessment during DBT. 展开更多
关键词 Digital breast tomosynthesis Normalized glandular dose coefficients detailed breast model Monte Carlo simulation
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An efficient approach for the equivalent linearization of frame structures with plastic hinges under nonstationary seismic excitations
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作者 Huang Huan Li Yingxiong Li Yuyu 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第3期677-690,共14页
An efficient approach is proposed for the equivalent linearization of frame structures with plastic hinges under nonstationary seismic excitations.The concentrated plastic hinges,described by the Bouc-Wen model,are as... An efficient approach is proposed for the equivalent linearization of frame structures with plastic hinges under nonstationary seismic excitations.The concentrated plastic hinges,described by the Bouc-Wen model,are assumed to occur at the two ends of a linear-elastic beam element.The auxiliary differential equations governing the plastic rotational displacements and their corresponding hysteretic displacements are replaced with linearized differential equations.Then,the two sets of equations of motion for the original nonlinear system can be reduced to an expanded-order equivalent linearized equation of motion for equivalent linear systems.To solve the equation of motion for equivalent linear systems,the nonstationary random vibration analysis is carried out based on the explicit time-domain method with high efficiency.Finally,the proposed treatment method for initial values of equivalent parameters is investigated in conjunction with parallel computing technology,which provides a new way of obtaining the equivalent linear systems at different time instants.Based on the explicit time-domain method,the key responses of interest of the converged equivalent linear system can be calculated through dimension reduction analysis with high efficiency.Numerical examples indicate that the proposed approach has high computational efficiency,and shows good applicability to weak nonlinear and medium-intensity nonlinear systems. 展开更多
关键词 nonstationary random vibration plastic hinge equivalent linearization method explicit time-domain method parallel computation
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An improved algorithm based on equivalent sound velocity profile method at large incident angle
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作者 Qianqian Li Qian Tong +3 位作者 Fanlin Yang Qi Li Zhihao Juan Yu Luo 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第2期161-167,共7页
With the development of ultra-wide coverage technology,multibeam echo-sounder(MBES)system has put forward higher requirements for localization accuracy and computational efficiency of ray tracing method.The classical ... With the development of ultra-wide coverage technology,multibeam echo-sounder(MBES)system has put forward higher requirements for localization accuracy and computational efficiency of ray tracing method.The classical equivalent sound speed profile(ESSP)method replaces the measured sound velocity profile(SVP)with a simple constant gradient SVP,reducing the computational workload of beam positioning.However,in deep-sea environment,the depth measurement error of this method rapidly increases from the central beam to the edge beam.By analyzing the positioning error of the ESSP method at edge beam,it is discovered that the positioning error increases monotonically with the incident angle,and the relationship between them could be expressed by polynomial function.Therefore,an error correction algorithm based on polynomial fitting is obtained.The simulation experiment conducted on an inclined seafloor shows that the proposed algorithm exhibits comparable efficiency to the original ESSP method,while significantly improving bathymetry accuracy by nearly eight times in the edge beam. 展开更多
关键词 equivalent sound speed profile ray tracing method large incident angle edge beam deep sea error correction multibeam echo-sounder system
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Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning
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作者 Do Nang Toan Lam Thanh Hien +2 位作者 Ha Manh Toan Nguyen Trong Vinh Pham Trung Hieu 《Intelligent Automation & Soft Computing》 2024年第2期319-335,共17页
Cancer is one of the most dangerous diseaseswith highmortality.One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill ... Cancer is one of the most dangerous diseaseswith highmortality.One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and technicians.In our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer patients.Medical image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction problem.We proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and augmentation.In strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the architecture.The output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation doses.Our experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation therapy.The results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is 1.78.In addition,we also conducted a comparison with the results of another study in the same context of using the loss function. 展开更多
关键词 CT image 3D dose prediction data preprocessing augmentation
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基于高维PDE投影恢复的低剂量CT重建方法
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作者 牛善洲 唐诗洲 +3 位作者 黄舒彦 梁礼境 李硕 刘汉明 《南方医科大学学报》 CAS CSCD 北大核心 2024年第4期682-688,共7页
目的提出一种基于高维偏微分方程(PDE)投影恢复的低剂量CT重建方法。方法先将原始的投影数据映射到高维空间中,构造投影数据的高维表示,通过移动高维空间中的点来对高维表示进行更新,再使用偏微分方程对投影数据进行滤波,最后将恢复后... 目的提出一种基于高维偏微分方程(PDE)投影恢复的低剂量CT重建方法。方法先将原始的投影数据映射到高维空间中,构造投影数据的高维表示,通过移动高维空间中的点来对高维表示进行更新,再使用偏微分方程对投影数据进行滤波,最后将恢复后的数据使用FBP算法重建出最终CT图像。结果在Shepp-Logan体模实验中,与FBP,PWLS-QM和TGV-WLS方法相比,新方法在相对均方根误差指标上分别降低了68.87%、50.15%和27.36%,结构相似性上分别提高了23.50%,8.83%和1.62%,特征相似性上分别提高了17.30%、2.71%和2.82%。在腹部临床数据实验中,与FBP,PWLS-QM和TGV-WLS方法相比,新方法在相对均方根误差中分别降低了42.09%、31.04%和21.93%,结构相似性上分别提高了18.33%、13.45%和4.63%,特征相似性上分别提高了3.13%、1.46%和1.10%。结论本研究提出的新方法在有效去除低剂量CT图像中的条形伪影和噪声的同时,可以保持图像的空间分辨率。 展开更多
关键词 低剂量CT 偏微分方程 投影数据恢复 图像重建
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Dem与轴率比预测3-14岁儿童屈光状态效率的比较
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作者 王丽娜 闫春妮 +2 位作者 梁甜 吕文超 宋金鑫 《国际眼科杂志》 CAS 2024年第12期1975-1981,共7页
目的:研究Dem、轴率比与3-14岁儿童屈光状态的关系,比较Dem、轴率比预测近视的效率,探寻定量预测儿童屈光状态更为有效的方法。方法:横断面研究。收集2021-03/2022-12就诊于西安市第一医院眼科门诊的3-14岁儿童共519例519眼(均取右眼数... 目的:研究Dem、轴率比与3-14岁儿童屈光状态的关系,比较Dem、轴率比预测近视的效率,探寻定量预测儿童屈光状态更为有效的方法。方法:横断面研究。收集2021-03/2022-12就诊于西安市第一医院眼科门诊的3-14岁儿童共519例519眼(均取右眼数据)。于睫状肌麻痹验光前采集眼球生物测量数据,记录眼轴长度(AL)、角膜曲率(K值)、Dem、睫状肌麻痹后等效球镜度数(SER)等,SER≤-0.50 D判断为近视。结果:3-14岁儿童SER与Dem呈正相关(r=0.88,P<0.01),与AL/CR比值呈负相关(r=-0.87,P<0.01)。Dem、AL/CR截点分别为20.40 D、3.02,当Dem≤20.40 D或AL/CR≥3.02时可判断为近视。Dem每减小1 D,SER减小0.57 D,AL/CR每增加0.06,SER减小1.00 D。ROC曲线下面积(AUC)Dem(0.958)>AL/CR(0.940)。结论:3-14岁儿童SER与Dem呈正相关,与AL/CR呈负相关,预判近视的效率Dem优于AL/CR。眼球生物测量仪可直接提供Dem,且Dem与SER量效关系更便于计算,用于预测儿童SER更为便捷。 展开更多
关键词 等效球镜度数 眼轴长度 轴率比 deM
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Effect of low dose laser cycloplasty on deepening anterior chamber in chronic angle-closure glaucoma 被引量:2
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作者 Xuan-Li Zheng Hai-Shuang Lin +4 位作者 Xiao-Jie Wang Jia-Qian Li Yan-Qian Xie Shao-Dan Zhang Yuan-Bo Liang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第12期2011-2017,共7页
AIM:To describe the outcome of using low-dose laser cycloplasty(LCP)in chronic angle-closure glaucoma(CACG).METHODS:A retrospective case series.Medical charts of CACG patients who underwent LCP in the Eye Hospital of ... AIM:To describe the outcome of using low-dose laser cycloplasty(LCP)in chronic angle-closure glaucoma(CACG).METHODS:A retrospective case series.Medical charts of CACG patients who underwent LCP in the Eye Hospital of Wenzhou Medical University were reviewed.The main outcomes included intraocular pressure(IOP),the number of glaucoma medication,anterior segment parameters and surgery-related complications.RESULTS:A total of 7 eyes of 7 CACG patients(age 38.9±11.0y)underwent LCP with a mean follow-up of 27.1±13.7mo(range 16-48mo).Following LCP,mean IOP and glaucoma medications decreased from 26.1±6.1 mm Hg with 3.1±1.1 glaucoma medications pre-treatment to 14.9±3.1 mm Hg(P=0.027)with 0.4±1.1 glaucoma medications(P=0.001)at final follow-up.The anterior chamber depth(ACD),angle opening distance500 and trabecular-iris angle increased from 1.65±0.33 mm,0.05 mm(range 0-0.30 mm)and 5.1°(range,0-31.97°)at baseline to 1.98±0.43 mm(P=0.073),0.53 mm(range 0.42-0.91 mm,P=0.015),45.9°(range,40.2°-59.4°),(P=0.015)in the long-term follow-up,respectively.The deepening of ACD and reopening of anterior chamber angle(ACA)was observed in 6 eyes(85.7%).CONCLUSION:LCP is a promising treatment option for patients with CACG via reducing IOP and glaucoma medication without serious complications.In addition,LCP can bring a significant deepening in ACD and reopening of ACA. 展开更多
关键词 chronic angle-closure glaucoma low dose laser cycloplasty anterior chamber depth intraocular pressure
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Force Analysis of the Overconstrained Mechanisms Based on Equivalent Stiffness Considering Limb Axial Deformation 被引量:1
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作者 Jinwei Guo Yongsheng Zhao +3 位作者 Bo Chen Guoxing Zhang Yundou Xu Jiantao Yao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第1期292-304,共13页
Overconstrained mechanism has the advantages of large bearing capacity and high motion reliability,but its force analysis is complex and difficult because the mechanism system contains overconstraints.Considering the ... Overconstrained mechanism has the advantages of large bearing capacity and high motion reliability,but its force analysis is complex and difficult because the mechanism system contains overconstraints.Considering the limb axial deformation,taking typical 2SS+P and 7-SS passive overconstrained mechanisms,2SPS+P and 7-SPS active overconstrained mechanisms,and 2SPS+P and 7-SPS passive-input overconstrained mechanisms as examples,a new force analysis method based on the idea of equivalent stiffness is proposed.The equivalent stiffness matrix of passive overconstrained mechanism is derived by combining the force balance and deformation compatibility equations with consideration of axial elastic limb deformations.The relationship between the constraint wrench magnitudes and the external force,limb stiffness is established.The equivalent stiffness matrix of active overconstrained mechanism is derived by combining the force balance and displacement compatibility equations.Here,the relationship between the magnitudes of the actuated wrenches and the external force,limb stiffness is investigated.Combining with the equivalent stiffness of the passive overconstrained mechanism,an analytical relationship between the actuated forces of passive-input overconstrained mechanism and the output displacement,limb stiffness is explored.Finally,adaptability of the equivalent stiffness to overconstrained mechanisms is discussed,and the effect of the limb stiffness on overconstrained mechanisms force distribution is revealed.The research results provide a theoretical reference for the design,research and practical application of overconstrained mechanism. 展开更多
关键词 Active overconstrained Passive overconstrained Passive-input overconstrained equivalent stiffness Force distribution
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Generalized-Extended-State-Observer and Equivalent-Input-Disturbance Methods for Active Disturbance Rejection: Deep Observation and Comparison 被引量:3
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作者 Jinhua She Kou Miyamoto +3 位作者 Qing-Long Han Min Wu Hiroshi Hashimoto Qing-Guo Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第4期957-968,共12页
Active disturbance-rejection methods are effective in estimating and rejecting disturbances in both transient and steady-state responses.This paper presents a deep observation on and a comparison between two of those ... Active disturbance-rejection methods are effective in estimating and rejecting disturbances in both transient and steady-state responses.This paper presents a deep observation on and a comparison between two of those methods:the generalized extended-state observer(GESO)and the equivalent input disturbance(EID)from assumptions,system configurations,stability conditions,system design,disturbance-rejection performance,and extensibility.A time-domain index is introduced to assess the disturbance-rejection performance.A detailed observation of disturbance-suppression mechanisms reveals the superiority of the EID approach over the GESO method.A comparison between these two methods shows that assumptions on disturbances are more practical and the adjustment of disturbance-rejection performance is easier for the EID approach than for the GESO method. 展开更多
关键词 Active disturbance-rejection control(ADRC) disturbance observer(DOB) equivalent input disturbance(EID) extendedstate observer(ESO) generalized extended-state observer(GESO)
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Retrieving chlorophyll content and equivalent water thickness of Moso bamboo(Phyllostachys pubescens) forests under Pantana phyllostachysae Chao-induced stress from Sentinel-2A/B images in a multiple LUTs-based PROSAIL framework 被引量:1
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作者 Zhanghua Xu Anqi He +10 位作者 Yiwei Zhang Zhenbang Hao Yifan Li Songyang Xiang Bin Li Lingyan Chen Hui Yu Wanling Shen Xuying Huang Xiaoyu Guo Zenglu Li 《Forest Ecosystems》 SCIE CSCD 2023年第2期252-267,共16页
Biochemical components of Moso bamboo(Phyllostachys pubescens)are critical to physiological and ecological processes and play an important role in the material and energy cycles of the ecosystem.The coupled PROSPECT w... Biochemical components of Moso bamboo(Phyllostachys pubescens)are critical to physiological and ecological processes and play an important role in the material and energy cycles of the ecosystem.The coupled PROSPECT with SAIL(PROSAIL)radiative transfer model is widely used for vegetation biochemical component content inversion.However,the presence of leaf-eating pests,such as Pantana phyllostachysae Chao(PPC),weakens the performance of the model for estimating biochemical components of Moso bamboo and thus must be considered.Therefore,this study considered pest-induced stress signals associated with Sentinel-2A/B images and field data and established multiple sets of biochemical canopy reflectance look-up tables(LUTs)based on the PROSAIL framework by setting different parameter ranges according to infestation levels.Quantitative inversions of leaf area index(LAI),leaf chlorophyll content(LCC),and leaf equivalent water thickness(LEWT)were derived.The scale conversions from LCC to canopy chlorophyll content(CCC)and LEWT to canopy equivalent water thickness(CEWT)were calculated.The results showed that LAI,CCC,and CEWT were inversely related with PPC-induced stress.When applying multiple LUTs,the p-values were<0.01;the R2 values for LAI,CCC,and CEWT were 0.71,0.68,and 0.65 with root mean square error(RMSE)(normalized RMSE,NRMSE)values of 0.38(0.16),17.56μg cm-2(0.20),and 0.02 cm(0.51),respectively.Compared to the values obtained for the traditional PROSAIL model,for October,R2 values increased by 0.05 and 0.10 and NRMSE decreased by 0.09 and 0.02 for CCC and CEWT,respectively and RMSE decreased by 0.35μg cm-2 for CCC.The feasibility of the inverse strategy for integrating pest-induced stress factors into the PROSAIL model,while establishing multiple LUTs under different pest-induced damage levels,was successfully demonstrated and can potentially enhance future vegetation parameter inversion and monitoring of bamboo forest health and ecosystems. 展开更多
关键词 Moso bamboo Chlorophyll content equivalent water thickness PROSAIL model Multiple LUTs Pantana phyllostachysae Chao Sentinel-2A/B images
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Effects of different doses of long-acting growth hormone in treating children with growth hormone deficiency 被引量:1
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作者 Wei Xia Ting Wang Jia-Yan Pan 《World Journal of Clinical Cases》 SCIE 2023年第28期6715-6724,共10页
BACKGROUND With the improvement of economy and living standards,the attention paid to short stature in children has been increasingly highlighted.Numerous causes can lead to short stature in children,among which growt... BACKGROUND With the improvement of economy and living standards,the attention paid to short stature in children has been increasingly highlighted.Numerous causes can lead to short stature in children,among which growth hormone deficiency(GHD)is a significant factor.AIM To investigate the long-term efficacy and safety of different doses of long-acting polyethylene glycol recombinant human growth hormone(PEG-rhGH)in the treatment of GHD in children.METHODS We selected 44 pediatric patients diagnosed with GHD who were treated at Wuhu First People's Hospital from 2014 to 2018.Total 23 patients were administered a high dose of long-acting PEG-rhGH at 0.2 mg/kg subcutaneously each week,forming the high-dose group.Meanwhile,21 patients were given a lower dose of long-acting PEG-rhGH at 0.14 mg/kg subcutaneously each week,establishing the low-dose Group.The total treatment period was 2 years,during which we monitored the patients’height,annual growth velocity(GV),height standard deviation score(HtSDS),chronological age(CA),bone age(BA),and serum levels of insulin-like growth factor-1(IGF-1)and insulin-like growth factor-binding protein-3(IGFBP-3)before treatment and at 6 mo,1 year,and 2 years after treatment initiation.We also monitored thyroid function,fasting plasma glucose,fasting insulin,and other side effects.Furthermore,we calculated the homeostatic model assessment for insulin resistance.RESULTS After 1 year of treatment,the GV,HtSDS,IGF-1,BA,and IGFBP-3 in both groups significantly improved compared to the pre-treatment levels(P<0.05).Moreover,when comparing GV,HtSDS,IGF-1,BA,and IGFBP-3 between the two groups,there were no statistically significant differences either before or after the treatment(P>0.05).During the treatment intervals of 0-1.0 years and 1.0-2.0 years,both patient groups experienced a slowdown in GV and a decline in HtSDS improvement(P<0.05).CONCLUSION The use of PEG-rhGH in treating GHD patients was confirmed to be effective,with similar outcomes observed in both the high-dose group and low-dose groups,and no significant differences in the main side effects. 展开更多
关键词 CHILDREN Growth hormone deficiency Polyethylene glycol recombinant human growth hormone Different doses Bone age
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Photon energy response optimization using few-channel spectroscopy dose method for Si-PIN photodetector applied in personal dose equivalent measurements 被引量:1
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作者 Ping Huang Shu-Qiong Li +3 位作者 Run-Dong Yang Yun-Tian Sun Yong Yang Wu Gao 《Nuclear Science and Techniques》 SCIE CAS CSCD 2020年第4期37-46,共10页
Si-PIN photodetectors having features such as low cost,small size,low weight,low voltage,and low power consumption are widely used as radiation detectors in electronic personal dosimeters(EPDs).The technical parameter... Si-PIN photodetectors having features such as low cost,small size,low weight,low voltage,and low power consumption are widely used as radiation detectors in electronic personal dosimeters(EPDs).The technical parameters of EPDs based on the Si-PIN photodetectors include photon energy response(PER),angular response,inherent error,and dose rate linearity.Among them,PER is a key parameter for evaluation of EPD measurement accuracy.At present,owing to the limitations of volume,power consumption,and EPD cost,the PER is usually corrected by a combination of single-channel counting techniques and filtering material methods.However,the above-mentioned methods have problems such as poor PER and low measurement accuracy.To solve such problems,in this study,a 1024-channel spectrometry system using a Si-PIN photodetector was developed and fullspectrum measurement in the reference radiation fields was conducted for radiation protection.The measurement results using the few-channel spectroscopy dose method showed that the PER could be controlled within±14%and±2%under the conditions of two and three energy intervals,respectively,with different channel numbers.The PER measured at 0°angle of radiation incidence meets the-29%to+67%requirements of IEC 61526:2010.Meanwhile,the channel number and counts-to-dose conversion factors formed in the experiment can be integrated into an EPD. 展开更多
关键词 Electronic PERSONAL dosimeter Si-PIN PHOTOdeTECTOR PERSONAL dose equivalent Photon energy response Few-channel SPECTROSCOPY dose method
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基于L-SHADE算法的AUV载体磁干扰参数辨识的数值模拟
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作者 周国华 李林锋 +2 位作者 吴轲娜 刘月林 夏帅 《兵工学报》 EI CAS CSCD 北大核心 2024年第8期2678-2687,共10页
采用自主水下航行器(Autonomous Underwater Vehicle,AUV)磁测平台可开展海洋地磁场测量、水下磁性目标探测和识别等工作,AUV磁测平台具有广阔的应用前景,但目前AUV载体磁干扰补偿技术研究尚不成熟,制约着水下航行器测磁精度。基于磁测... 采用自主水下航行器(Autonomous Underwater Vehicle,AUV)磁测平台可开展海洋地磁场测量、水下磁性目标探测和识别等工作,AUV磁测平台具有广阔的应用前景,但目前AUV载体磁干扰补偿技术研究尚不成熟,制约着水下航行器测磁精度。基于磁测平台抗磁干扰基本原理,提出一种基于线性种群规模缩减和成功历史的参数自适应差分进化(Success History-based Adaptive Differential Evolution with Linear Population Size Reduction,L-SHADE)算法的AUV载体磁干扰参数辨识的数值模拟方法。用磁偶极子和旋转椭球壳混合模型来等效模拟AUV载体磁干扰,通过模拟航行获得多组磁测数据,据此建立磁干扰参数辨识模型,并采用L-SHADE算法求解。通过数值模拟实验定量分析研究磁测平台测磁精度随磁传感器、平台姿态及航向等误差的传播规律。研究结果表明:当磁传感器测量精度为10 nT、姿态测量精度为0.01°、航向测量精度为0.1°时,测磁误差可小于100 nT。设计的AUV磁测平台抗干扰试验表明,地磁场总量最大相对误差为1.07%。 展开更多
关键词 自主水下航行器 磁干扰补偿 参数辨识 磁等效数学模型 L-SHAde算法
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