Background:Esophageal cancer poses a significant global burden,while its patterns and trends remain to be clarified.The aim of this study is to provide an update on the incidence and mortality rates of esophageal canc...Background:Esophageal cancer poses a significant global burden,while its patterns and trends remain to be clarified.The aim of this study is to provide an update on the incidence and mortality rates of esophageal cancer and their trends in China based on data from the National Cancer Registry.Methods:We extracted data from the National Central Cancer Registry(NCCR)of China from 2000 to 2016 and performed comprehensive quality control.We calculated age-standardized rates of China(ASR China)and world(ASR world)using the Chinese population in 2000 and the Segi’s world standard population,and performed a joinpoint regression analysis to examine the trend in incidence and mortality of esophageal cancer.The annual percent change(APC)and weighted average APC(AAPC)over the entire study period were estimated to measure the changing trend.Subgroup analyses were conducted by sex,region and pathological type.Results:A total of 487 eligible cancer registries were included in the data analysis and 22 registries with unin-terrupted registration data were used for trend analysis.In 2016,there were an estimated of 184,500 incident cases of esophageal cancer and 142,300 deaths in China.The crude incidence,ASR China and ASR world were 25.25/100,000,11.00/100,000 and 11.13/100,000,respectively.And the crude mortality,ASR China and ASR world were 19.38/100,000,8.25/100,000 and 8.28/100,000,respectively.Esophageal squamous cell carcinoma(ESCC)was the most common histological type,accounting for 85.79%of all cases,followed by esophageal ade-nocarcinoma(EAC)(11.00%)and others(3.21%).There was a decreasing trend of ASR world in incidence and mortality during 2000-2016 with the AAPC of-4.6%(95%CI:-5.7%,-3.4%)and-4.6%(95%CI:-5.2%,-3.9%).The pattern and trend of esophageal cancer differ in sex,region and pathological type.Conclusions:The burden of esophageal cancer in China remains high with sex,regional and subtype differences.The incidence and mortality of esophageal cancer have continued to decline over the past decade,which was due in part to the reductions in risk factor exposure and the implementation of screening.展开更多
Background： Hebei province is located in North of China with of approximately 6% of whole national population. It is known as a high-risk area for esophageal cancer in China and worldwide. The aim of our study was to...Background： Hebei province is located in North of China with of approximately 6% of whole national population. It is known as a high-risk area for esophageal cancer in China and worldwide. The aim of our study was to estimate the esophageal cancer burden and trend in Hebei Province. Methods： Eight cancer registries in Hebei Province submitted cancer registry data to the Hebei Provincial Cancer Registry Center. All data were qualified and compiled for cancer statistics in 2011. The pooled data were stratified by gender and age group （0, 1-4, 5-9, 10-14...80＋）. Incidence and mortality rates were age-standardized to World Segi＇s population standard and expressed per 100,000 persons. In addition, proportions and cumulative incidence/mortality rates for esophageal cancer were calculated. Esophageal cancer mortality data during the periods 1973-1975, 1990-1992, and 2004-2005 were extracted from the national death surveys. Mortality and incidence rate data from Cixian and Shexian were obtained from population-based cancer registries in each county. Results： The estimated number of newly diagnosed esophageal cancer cases and deaths in 2011 in Hebei Province was 24,318 and 18,226, respectively. The crude incidence rate of esophageal cancer was 33.37/100,000 （males, 42.18/100,000 and females, 24.31/100,000）. The age-standardized rate by world standard population （ASRW） was 28.09/100,000, ranking third among all cancers. The esophageal cancer mortality rate was 25.01/100,000 （males, 31.40/100,000 and females, 18.45/100,000）, ranking third in deaths among all cancers. The mortality rates of esophageal cancer displayed a significant decreasing trend in Hebei Province from 1973-1975 （ASRW =48.69/100,000） to 2004-2005 （ASRW =28.02/100,000）, with a decreased rate of 42.45%. In Cixian, the incidence of esophageal cancer decreased from 250.76/100,000 to 106.74/100,000 in males and from 153.86/100,000 to 75.41/100,000 in females, with annual percentage changes （APC） of 2.13 and 2.16, while the mortality rates declined with an APC of 2.46 for males and 3.10 for females from 1988 to 2011. In Shexian, the incidence rate decreased from 116.90/100,000 to 74.12/100,000 in males and from 46.98/100,000 to 40.64/100,000 in females, while the mortality rates declined, with an APC of 4.89 in males from 2003 to 2011. Conclusions： Although the incidence and mortality rates of esophageal cancer remain high, an obvious decreasing trend has been observed in Hebei Province, as well as in high-risk regions, such as Cixian and Shexian, over the past 40 years.展开更多
Objective:This study aimed to provide a comprehensive overview of the global burden of esophageal cancer(EC)and determine the temporal trends and factors influencing changes in the global burden.Methods:The latest inc...Objective:This study aimed to provide a comprehensive overview of the global burden of esophageal cancer(EC)and determine the temporal trends and factors influencing changes in the global burden.Methods:The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN 2022.The mortality and disability-adjusted life years(DALYs)rates for EC from 1990±2019 were sourced from the 2019 Global Burden of Diseases.Trends in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression model.The trends in age-related EC burden were assessed using a decomposition approach.Results:An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths worldwide.Approximately 75%of cases and deaths occurred in Asia.Nearly 50%of global EC deaths and DALYs were attributed to tobacco use in men in 2019,while 20%were attributed to high body mass index(BMI)in women.From 1990±2019,EC deaths and DALYs attributable to almost all risk factors had declining trends,while EC deaths and DALYs attributed to high BMI in men had upward trends.The age-related EC burden exhibited an upward trend driven by population growth and aging,which contributed to 307.4 thousand deaths and 7.2 million DALYs due to EC.Conclusions:The EC burden remains substantial worldwide.Effective tobacco and obesity control measures are critical for addressing the risk-attributable burden of EC.Population growth and aging pose challenges for EC prevention and control efforts.展开更多
Objective: The aim of our study was to investigate the epidemiological characteristics of esophageal cancer from 2009 to 2011 in Huai'an area, China. Methods: The data about the incidence and mortality of esophage...Objective: The aim of our study was to investigate the epidemiological characteristics of esophageal cancer from 2009 to 2011 in Huai'an area, China. Methods: The data about the incidence and mortality of esophageal cancer were provid- ed by Huai'an Cancer Registry, and the epidemiological characteristics of the disease were analyzed. Results: Esophageal cancer was not only the first most common cancer, but also the leading cause of cancer death in Huai'an area. The crude and standardized incidence rates were 62.91/10 5 and 49.92/10 5 , and the crude and standardized mortality rates were 46.75/10 5 and 36.87/10 5 , respectively. The sex ratio (male-female) was 1.69:1 in incidence, and the incidence increased in people aged 40 years and over, reaching the peak at the ages of 70-75 years. The mortality rate was at low level under the age of 50 years, but increased after the age of 50 years, reaching the peak at the age of 75-85 years. Incidence and mortality rates varied regionally with the highest rate found in Chuzhou district (90.76/10 5 and 67.17/10 5 ) and lowest rate observed in Qinghe district (32.41/10 5 and 8.75/10 5 ). Conclusion: Esophageal cancer is the major burden of cancer in Huai'an area, and has marked geographic distribution difference. The key period of age for screening and prevention of the disease is 55-85 years old.展开更多
[目的]分析2015—2019年四川省肿瘤登记地区食管癌的发病率、死亡率以及潜在寿命损失年的变化趋势。[方法]基于四川省各肿瘤登记处上报的2015—2019年间食管癌发病/死亡数据,以性别和年龄为分层依据,分别计算粗发病/死亡率和标化发病/...[目的]分析2015—2019年四川省肿瘤登记地区食管癌的发病率、死亡率以及潜在寿命损失年的变化趋势。[方法]基于四川省各肿瘤登记处上报的2015—2019年间食管癌发病/死亡数据,以性别和年龄为分层依据,分别计算粗发病/死亡率和标化发病/死亡率。使用潜在减寿年数(potential years of life lost,PYLL)、平均潜在减寿年数(potential years of life lost,APYLL)和潜在减寿率(prospective life lost rate,PYLLR)等指标评估食管癌对人群生存与预期寿命的影响。利用Joinpoint软件计算年度变化百分比(percentage change,APC),分析2015—2019年变化趋势。[结果]2015—2019年四川省肿瘤登记地区食管癌的粗发病率为26.85/10万,其中男性的粗发病率(41.26/10万)高于女性(11.78/10万);粗死亡率为20.74/10万,男性粗死亡率(32.09/10万)高于女性(8.86/10万);无论男性、女性还是总体人群,标化发病率和死亡率均呈明显下降趋势(P均<0.05),标化发病率APC分别为-6.45%、-15.25%、-8.52%,标化死亡率APC分别为-5.63%、-11.77%、-6.94%。因食管癌死亡导致的总PYLL、APYLL和PYLLR分别为267048人年、5.77人年和1.20‰。其中,APYLL和PYLLR均呈下降趋势(APC分别为-5.47%、-7.29%,P均<0.05),男性食管癌PYLL、APYLL和PYLLR均高于女性。[结论]2015—2019年四川省食管癌发病、死亡均呈下降趋势,男性和老年人是食管癌重点防治人群。展开更多
基金supported by the National Natural Science Foundation of China(grant numbers:81903403,81974493)Beijing Natural Science Foundation(grant number:7204294)+1 种基金National Science&Technology Fundamental Resources Investigation Program of China(grant number:2019FY101101)the Chinese Academic of Medical Sciences Innovation Fund for Medical Sciences(grant numbers:2021-I2M-1-010,2021-I2M-1-013).
文摘Background:Esophageal cancer poses a significant global burden,while its patterns and trends remain to be clarified.The aim of this study is to provide an update on the incidence and mortality rates of esophageal cancer and their trends in China based on data from the National Cancer Registry.Methods:We extracted data from the National Central Cancer Registry(NCCR)of China from 2000 to 2016 and performed comprehensive quality control.We calculated age-standardized rates of China(ASR China)and world(ASR world)using the Chinese population in 2000 and the Segi’s world standard population,and performed a joinpoint regression analysis to examine the trend in incidence and mortality of esophageal cancer.The annual percent change(APC)and weighted average APC(AAPC)over the entire study period were estimated to measure the changing trend.Subgroup analyses were conducted by sex,region and pathological type.Results:A total of 487 eligible cancer registries were included in the data analysis and 22 registries with unin-terrupted registration data were used for trend analysis.In 2016,there were an estimated of 184,500 incident cases of esophageal cancer and 142,300 deaths in China.The crude incidence,ASR China and ASR world were 25.25/100,000,11.00/100,000 and 11.13/100,000,respectively.And the crude mortality,ASR China and ASR world were 19.38/100,000,8.25/100,000 and 8.28/100,000,respectively.Esophageal squamous cell carcinoma(ESCC)was the most common histological type,accounting for 85.79%of all cases,followed by esophageal ade-nocarcinoma(EAC)(11.00%)and others(3.21%).There was a decreasing trend of ASR world in incidence and mortality during 2000-2016 with the AAPC of-4.6%(95%CI:-5.7%,-3.4%)and-4.6%(95%CI:-5.2%,-3.9%).The pattern and trend of esophageal cancer differ in sex,region and pathological type.Conclusions:The burden of esophageal cancer in China remains high with sex,regional and subtype differences.The incidence and mortality of esophageal cancer have continued to decline over the past decade,which was due in part to the reductions in risk factor exposure and the implementation of screening.
基金supported by grants from the National Natural Scientific Foundation of China(81272682)the National Natural Scientific Foundation of Hebei Province(C2011206058)financial department of Hebei Province[No.(2012)2056]
文摘Background： Hebei province is located in North of China with of approximately 6% of whole national population. It is known as a high-risk area for esophageal cancer in China and worldwide. The aim of our study was to estimate the esophageal cancer burden and trend in Hebei Province. Methods： Eight cancer registries in Hebei Province submitted cancer registry data to the Hebei Provincial Cancer Registry Center. All data were qualified and compiled for cancer statistics in 2011. The pooled data were stratified by gender and age group （0, 1-4, 5-9, 10-14...80＋）. Incidence and mortality rates were age-standardized to World Segi＇s population standard and expressed per 100,000 persons. In addition, proportions and cumulative incidence/mortality rates for esophageal cancer were calculated. Esophageal cancer mortality data during the periods 1973-1975, 1990-1992, and 2004-2005 were extracted from the national death surveys. Mortality and incidence rate data from Cixian and Shexian were obtained from population-based cancer registries in each county. Results： The estimated number of newly diagnosed esophageal cancer cases and deaths in 2011 in Hebei Province was 24,318 and 18,226, respectively. The crude incidence rate of esophageal cancer was 33.37/100,000 （males, 42.18/100,000 and females, 24.31/100,000）. The age-standardized rate by world standard population （ASRW） was 28.09/100,000, ranking third among all cancers. The esophageal cancer mortality rate was 25.01/100,000 （males, 31.40/100,000 and females, 18.45/100,000）, ranking third in deaths among all cancers. The mortality rates of esophageal cancer displayed a significant decreasing trend in Hebei Province from 1973-1975 （ASRW =48.69/100,000） to 2004-2005 （ASRW =28.02/100,000）, with a decreased rate of 42.45%. In Cixian, the incidence of esophageal cancer decreased from 250.76/100,000 to 106.74/100,000 in males and from 153.86/100,000 to 75.41/100,000 in females, with annual percentage changes （APC） of 2.13 and 2.16, while the mortality rates declined with an APC of 2.46 for males and 3.10 for females from 1988 to 2011. In Shexian, the incidence rate decreased from 116.90/100,000 to 74.12/100,000 in males and from 46.98/100,000 to 40.64/100,000 in females, while the mortality rates declined, with an APC of 4.89 in males from 2003 to 2011. Conclusions： Although the incidence and mortality rates of esophageal cancer remain high, an obvious decreasing trend has been observed in Hebei Province, as well as in high-risk regions, such as Cixian and Shexian, over the past 40 years.
基金funded by the National Natural Science Foundation of China (Grant No. 82273721)Capital’s Funds for Health Improvement and Research (Grant No. 2024-1G-4023)。
文摘Objective:This study aimed to provide a comprehensive overview of the global burden of esophageal cancer(EC)and determine the temporal trends and factors influencing changes in the global burden.Methods:The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN 2022.The mortality and disability-adjusted life years(DALYs)rates for EC from 1990±2019 were sourced from the 2019 Global Burden of Diseases.Trends in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression model.The trends in age-related EC burden were assessed using a decomposition approach.Results:An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths worldwide.Approximately 75%of cases and deaths occurred in Asia.Nearly 50%of global EC deaths and DALYs were attributed to tobacco use in men in 2019,while 20%were attributed to high body mass index(BMI)in women.From 1990±2019,EC deaths and DALYs attributable to almost all risk factors had declining trends,while EC deaths and DALYs attributed to high BMI in men had upward trends.The age-related EC burden exhibited an upward trend driven by population growth and aging,which contributed to 307.4 thousand deaths and 7.2 million DALYs due to EC.Conclusions:The EC burden remains substantial worldwide.Effective tobacco and obesity control measures are critical for addressing the risk-attributable burden of EC.Population growth and aging pose challenges for EC prevention and control efforts.
基金Supported by grants from the Medical Science and Technology Innovation Foundation of Nanjing Military Command of Chinese People’s Liberation Army (No. 08MA036)Jiangsu Province Preventive Medicine Foundation (No. YZ201008)
文摘Objective: The aim of our study was to investigate the epidemiological characteristics of esophageal cancer from 2009 to 2011 in Huai'an area, China. Methods: The data about the incidence and mortality of esophageal cancer were provid- ed by Huai'an Cancer Registry, and the epidemiological characteristics of the disease were analyzed. Results: Esophageal cancer was not only the first most common cancer, but also the leading cause of cancer death in Huai'an area. The crude and standardized incidence rates were 62.91/10 5 and 49.92/10 5 , and the crude and standardized mortality rates were 46.75/10 5 and 36.87/10 5 , respectively. The sex ratio (male-female) was 1.69:1 in incidence, and the incidence increased in people aged 40 years and over, reaching the peak at the ages of 70-75 years. The mortality rate was at low level under the age of 50 years, but increased after the age of 50 years, reaching the peak at the age of 75-85 years. Incidence and mortality rates varied regionally with the highest rate found in Chuzhou district (90.76/10 5 and 67.17/10 5 ) and lowest rate observed in Qinghe district (32.41/10 5 and 8.75/10 5 ). Conclusion: Esophageal cancer is the major burden of cancer in Huai'an area, and has marked geographic distribution difference. The key period of age for screening and prevention of the disease is 55-85 years old.
文摘[目的]分析2015—2019年四川省肿瘤登记地区食管癌的发病率、死亡率以及潜在寿命损失年的变化趋势。[方法]基于四川省各肿瘤登记处上报的2015—2019年间食管癌发病/死亡数据,以性别和年龄为分层依据,分别计算粗发病/死亡率和标化发病/死亡率。使用潜在减寿年数(potential years of life lost,PYLL)、平均潜在减寿年数(potential years of life lost,APYLL)和潜在减寿率(prospective life lost rate,PYLLR)等指标评估食管癌对人群生存与预期寿命的影响。利用Joinpoint软件计算年度变化百分比(percentage change,APC),分析2015—2019年变化趋势。[结果]2015—2019年四川省肿瘤登记地区食管癌的粗发病率为26.85/10万,其中男性的粗发病率(41.26/10万)高于女性(11.78/10万);粗死亡率为20.74/10万,男性粗死亡率(32.09/10万)高于女性(8.86/10万);无论男性、女性还是总体人群,标化发病率和死亡率均呈明显下降趋势(P均<0.05),标化发病率APC分别为-6.45%、-15.25%、-8.52%,标化死亡率APC分别为-5.63%、-11.77%、-6.94%。因食管癌死亡导致的总PYLL、APYLL和PYLLR分别为267048人年、5.77人年和1.20‰。其中,APYLL和PYLLR均呈下降趋势(APC分别为-5.47%、-7.29%,P均<0.05),男性食管癌PYLL、APYLL和PYLLR均高于女性。[结论]2015—2019年四川省食管癌发病、死亡均呈下降趋势,男性和老年人是食管癌重点防治人群。
