Objective: To explore the effect of postoperative early enteral nutrition support on anti-tumor immune response and inflammatory response process in the elderly patients with esophageal cancer. Methods: A total of 110...Objective: To explore the effect of postoperative early enteral nutrition support on anti-tumor immune response and inflammatory response process in the elderly patients with esophageal cancer. Methods: A total of 110 cases of elderly patients with esophageal cancer who underwent radical operation in this hospital between January 2015 and December 2017 were divided into the parenteral nutrition group (n=57) who received parenteral nutrition support and the enteral nutrition group (n=53) who received enteral nutrition support according to the postoperative nutrition intervention methods. The differences in anti-tumor immune response and inflammatory response degree were compared between the two groups of patients immediately after the patients returned to the ward (T0), 48h after nutritional support (T1) and 72h after nutritional support (T2). Results: At T0, there was no statistically significant difference in the contents of Th1/Th2 immune response and Th17/Treg immune response indexes as well as inflammatory mediators in serum between the two groups of patients. At T1 and T2, serum Th1 cytokines IFN-γ and IL-12 contents of enteral nutrition group were higher than those of parenteral nutrition group whereas Th2 cytokines IL-4 and IL-13 contents were lower than those of parenteral nutrition group;serum contents of Th17 cytokines IL-6 and IL-17 as well as Treg cytokines TGF-β and IL-10 were lower than those of parenteral nutrition group;serum inflammatory mediators hs-CRP, PGE and HMGB1 contents were lower than those of parenteral nutrition group. Conclusion: Postoperative early enteral nutrition support can effectively regulate the Th1/Th2 and Th17/Treg immune response balance and inhibit the systemic inflammatory response in elderly patients with esophageal cancer.展开更多
Objectives: Aim of our work is to study the effect of early enteral feeding through either nasoentral or feeding jejunostomy tube post esophagectomy on patients recovery and hospital stay. Background: Postoperative nu...Objectives: Aim of our work is to study the effect of early enteral feeding through either nasoentral or feeding jejunostomy tube post esophagectomy on patients recovery and hospital stay. Background: Postoperative nutrition is a well known aspect of care in recent years and has been shown to decrease the incidence of complications and hospital stay. Enteral nutrition has been shown to be superior to parenteral nutrition as it is more physiological, safer, cheaper and early enteral nutrition has been clearly confirmed to reduce postoperative morbidity. Methods: This is randomized combined retrospective and prospective study that is conducted in surgical oncology department, South Egypt cancer institute, Assiut University;from October 2012 to October 2016. Patients in this study were divided into two groups: group 1 includes patients with feeding jejunostomy and group 2 is patients with nasoenteral tube. Results: 25 Patients included in this study (19 males & 6 females). All cases were primarily diagnosed as esophageal cancer, middle and lower 1/3 esophagus or proximal gastric carcinoma infiltrating cardia by clinical data associated with abdominal sonar and/or C.T scan and upper endoscopy with biopsy. There was no significant difference in catheter related complications (P value 0.238). There was no operative mortality. Conclusion: Early postoperative enteral nutrition was feasible and safe for patients undergoing esophagectomy. There is no significant difference between NE and FJ. Enteral nutrition either through nasoenteral or feeding jejunostomy is an effective method for postoperative nutritional support in this type of major surgery.展开更多
Objective: To study the effects of enteral nutrition intervention on immune nutritional status and radiation damage in patients with esophageal cancer radiotherapy. Methods: Patients with esophageal cancer who underwe...Objective: To study the effects of enteral nutrition intervention on immune nutritional status and radiation damage in patients with esophageal cancer radiotherapy. Methods: Patients with esophageal cancer who underwent radiotherapy in West China Hospital, Sichuan University between January and October 2017 were chosen as the research subjects and divided into the experimental group who received enteral nutrition intervention and the control group who received routine intervention. The contents of nutrition indicators and radiation damage markers in serum as well as the contents of immune cells in peripheral blood were determined before radiotherapy and after radiotherapy ended. Results: Compared with those before radiotherapy, serum ALB, PA, TRF and RBP contents as well as peripheral blood Th cell, NK cell, Breg cell and Treg cell contents of experimental group did not change significantly while serum PDGF-BB, TGF-β1, CTGF, TNF-α and SAA contents were significantly higher after radiotherapy;serum ALB, PA, TRF and RBP contents as well as peripheral blood Th cell and NK cell contents of control group were significantly lower while serum PDGF-BB, TGF-β1, CTGF, TNF-α and SAA contents as well as peripheral blood Breg cell and Treg cell contents were significantly higher after radiotherapy;serum ALB, PA, TRF and RBP contents as well as peripheral blood Th cell and NK cell contents of experimental group after radiotherapy were higher than those of control group while serum PDGF-BB, TGF-β1, CTGF, TNF-α and SAA contents as well as peripheral blood Breg cell and Treg cell contents were lower than those of control group. Conclusion: enteral nutrition intervention can improve immune nutritional status and reduce radiation damage in patients with esophageal cancer radiotherapy.展开更多
基金Natural Science Foundation of China,No:NSFC82049351.
文摘Objective: To explore the effect of postoperative early enteral nutrition support on anti-tumor immune response and inflammatory response process in the elderly patients with esophageal cancer. Methods: A total of 110 cases of elderly patients with esophageal cancer who underwent radical operation in this hospital between January 2015 and December 2017 were divided into the parenteral nutrition group (n=57) who received parenteral nutrition support and the enteral nutrition group (n=53) who received enteral nutrition support according to the postoperative nutrition intervention methods. The differences in anti-tumor immune response and inflammatory response degree were compared between the two groups of patients immediately after the patients returned to the ward (T0), 48h after nutritional support (T1) and 72h after nutritional support (T2). Results: At T0, there was no statistically significant difference in the contents of Th1/Th2 immune response and Th17/Treg immune response indexes as well as inflammatory mediators in serum between the two groups of patients. At T1 and T2, serum Th1 cytokines IFN-γ and IL-12 contents of enteral nutrition group were higher than those of parenteral nutrition group whereas Th2 cytokines IL-4 and IL-13 contents were lower than those of parenteral nutrition group;serum contents of Th17 cytokines IL-6 and IL-17 as well as Treg cytokines TGF-β and IL-10 were lower than those of parenteral nutrition group;serum inflammatory mediators hs-CRP, PGE and HMGB1 contents were lower than those of parenteral nutrition group. Conclusion: Postoperative early enteral nutrition support can effectively regulate the Th1/Th2 and Th17/Treg immune response balance and inhibit the systemic inflammatory response in elderly patients with esophageal cancer.
文摘Objectives: Aim of our work is to study the effect of early enteral feeding through either nasoentral or feeding jejunostomy tube post esophagectomy on patients recovery and hospital stay. Background: Postoperative nutrition is a well known aspect of care in recent years and has been shown to decrease the incidence of complications and hospital stay. Enteral nutrition has been shown to be superior to parenteral nutrition as it is more physiological, safer, cheaper and early enteral nutrition has been clearly confirmed to reduce postoperative morbidity. Methods: This is randomized combined retrospective and prospective study that is conducted in surgical oncology department, South Egypt cancer institute, Assiut University;from October 2012 to October 2016. Patients in this study were divided into two groups: group 1 includes patients with feeding jejunostomy and group 2 is patients with nasoenteral tube. Results: 25 Patients included in this study (19 males & 6 females). All cases were primarily diagnosed as esophageal cancer, middle and lower 1/3 esophagus or proximal gastric carcinoma infiltrating cardia by clinical data associated with abdominal sonar and/or C.T scan and upper endoscopy with biopsy. There was no significant difference in catheter related complications (P value 0.238). There was no operative mortality. Conclusion: Early postoperative enteral nutrition was feasible and safe for patients undergoing esophagectomy. There is no significant difference between NE and FJ. Enteral nutrition either through nasoenteral or feeding jejunostomy is an effective method for postoperative nutritional support in this type of major surgery.
文摘Objective: To study the effects of enteral nutrition intervention on immune nutritional status and radiation damage in patients with esophageal cancer radiotherapy. Methods: Patients with esophageal cancer who underwent radiotherapy in West China Hospital, Sichuan University between January and October 2017 were chosen as the research subjects and divided into the experimental group who received enteral nutrition intervention and the control group who received routine intervention. The contents of nutrition indicators and radiation damage markers in serum as well as the contents of immune cells in peripheral blood were determined before radiotherapy and after radiotherapy ended. Results: Compared with those before radiotherapy, serum ALB, PA, TRF and RBP contents as well as peripheral blood Th cell, NK cell, Breg cell and Treg cell contents of experimental group did not change significantly while serum PDGF-BB, TGF-β1, CTGF, TNF-α and SAA contents were significantly higher after radiotherapy;serum ALB, PA, TRF and RBP contents as well as peripheral blood Th cell and NK cell contents of control group were significantly lower while serum PDGF-BB, TGF-β1, CTGF, TNF-α and SAA contents as well as peripheral blood Breg cell and Treg cell contents were significantly higher after radiotherapy;serum ALB, PA, TRF and RBP contents as well as peripheral blood Th cell and NK cell contents of experimental group after radiotherapy were higher than those of control group while serum PDGF-BB, TGF-β1, CTGF, TNF-α and SAA contents as well as peripheral blood Breg cell and Treg cell contents were lower than those of control group. Conclusion: enteral nutrition intervention can improve immune nutritional status and reduce radiation damage in patients with esophageal cancer radiotherapy.
