Of 2487 cases of esophageal carcinoma pathologically confirmed after resection in 1978-1988 in Shantou,adenocarcinoma accounted for 1.93% (48 cases).These were divided into 6 types;Ordinary well-differentiated adenoc...Of 2487 cases of esophageal carcinoma pathologically confirmed after resection in 1978-1988 in Shantou,adenocarcinoma accounted for 1.93% (48 cases).These were divided into 6 types;Ordinary well-differentiated adenocarcinoma, 10 cases;Ordinary poorly-differentiated adenocarcinoma,11 cases;Adeno-squamous carcinoma,18 cases;Muco-epidermoid carcinoma, 4 cases;“Basal Cell-Like Carcinoma”, 4 cases;Cylindroma-Like carcinoma, 1 case.Mucohistochemistry and immunohistochemistry studies revealed some differences among these types;And their prognosis also varied. The tissue origin of these tumors were discussed.展开更多
Objective To explore the biological features of basaloid squamous cell carcinoma (BSC) of the esophagus.Methods Cytokeratins (CK4, CK18 and CK19), epithelial membrane antigen (EMA), carcino embryoantigen (CEA), α-s...Objective To explore the biological features of basaloid squamous cell carcinoma (BSC) of the esophagus.Methods Cytokeratins (CK4, CK18 and CK19), epithelial membrane antigen (EMA), carcino embryoantigen (CEA), α-smooth muscle antigen (α-SMA), S-100, laminin (LN), collagen Ⅳ (Col-Ⅳ), neuralspecific enolase (NSE), proliferating cell nuclear antigen (PCNA) and p53 antibodies were used to detect the corresponding antigen expression in 8 cases of BSC with ABC immunohistochemical methods.Results Two kinds of BSC cell components have different responses to the above antibodies. For basaloid cells (BCs), 7 cases were positive for CK19, and were negative for the other 4 epithelial antibodies CK4, CK18, CEA and EMA. BCs of 4 cases were positive to the muscular antibodies α-SMA and S-100, and the hyaline degeneration in the tumor nests was positive for LN and Col-Ⅳ. BCs had a high index of PCNA, with an average level of 54%. For squamous cells (SCs), 7 cases were positive for the epithelial antigen CK4, CEA and EMA, but were negative for CK19, α-SMA and S-100. The index of PCNA of SC was low, with an average level of 25%.Conclusion BSC of the esophagus is a high-malignancy tumor which is of multi-oriented differentiation.BCs represent basal cells which have the tendency of myoepithelial differentiation and have strong proliferation ability, whereas SCs represent typical squamous cell differentiation.展开更多
文摘Of 2487 cases of esophageal carcinoma pathologically confirmed after resection in 1978-1988 in Shantou,adenocarcinoma accounted for 1.93% (48 cases).These were divided into 6 types;Ordinary well-differentiated adenocarcinoma, 10 cases;Ordinary poorly-differentiated adenocarcinoma,11 cases;Adeno-squamous carcinoma,18 cases;Muco-epidermoid carcinoma, 4 cases;“Basal Cell-Like Carcinoma”, 4 cases;Cylindroma-Like carcinoma, 1 case.Mucohistochemistry and immunohistochemistry studies revealed some differences among these types;And their prognosis also varied. The tissue origin of these tumors were discussed.
文摘Objective To explore the biological features of basaloid squamous cell carcinoma (BSC) of the esophagus.Methods Cytokeratins (CK4, CK18 and CK19), epithelial membrane antigen (EMA), carcino embryoantigen (CEA), α-smooth muscle antigen (α-SMA), S-100, laminin (LN), collagen Ⅳ (Col-Ⅳ), neuralspecific enolase (NSE), proliferating cell nuclear antigen (PCNA) and p53 antibodies were used to detect the corresponding antigen expression in 8 cases of BSC with ABC immunohistochemical methods.Results Two kinds of BSC cell components have different responses to the above antibodies. For basaloid cells (BCs), 7 cases were positive for CK19, and were negative for the other 4 epithelial antibodies CK4, CK18, CEA and EMA. BCs of 4 cases were positive to the muscular antibodies α-SMA and S-100, and the hyaline degeneration in the tumor nests was positive for LN and Col-Ⅳ. BCs had a high index of PCNA, with an average level of 54%. For squamous cells (SCs), 7 cases were positive for the epithelial antigen CK4, CEA and EMA, but were negative for CK19, α-SMA and S-100. The index of PCNA of SC was low, with an average level of 25%.Conclusion BSC of the esophagus is a high-malignancy tumor which is of multi-oriented differentiation.BCs represent basal cells which have the tendency of myoepithelial differentiation and have strong proliferation ability, whereas SCs represent typical squamous cell differentiation.
