THE CIRCADIAN ALTERATIONS OF BLOOD PRESSURE IN PATIENTS WITH SECONDARY HYPERTENSION

Objective To study the pattern of circadian blood pressure changes in patients with se-condary hypertension. Methods The 24h ambulatory blood pressure monitoring was performed in 80 patients with secondary hypertension (SH) including primary aldosteronism in 44, pheochromocytoma in 11, renovas-cular hypertension in 10, renoparenchymal hypertension in 15 and compared with 80 patients with essential hy-pertension (EH) matched by age and sex. Results The diurnal rhythm in patients with SH was different from that of patients with EU. The diurnal curves in SU and EU was overlapped in daytime and separated from each other at nighttime. The nocturnal blood pressure fall was less and average blood pressure at nighttime was higher in patients with SH than those in patients with Eli (P <0. 01). The nighttime blood pressure loading and non-dipper phenomenon were much more frequently seen in patients with SH than those in patients with Eli (P <0. 01). The nighttime blood pressure/daytime blood pressure ratio was significantly higher in patients with SH than that in patients with Eli (P <0. 01). Conclusion The non-invasive 24h ambulatory blood pressure monitoring may be a useful method in screening for

清热利湿活血法联合易善复治疗非酒精性脂肪性肝病的临床研究

目的:观察清热利湿、活血行气的中药联合易善复治疗非酒精性脂肪性肝病患者的临床疗效。方法:将120例符合诊断标准的非酒精性脂肪性肝病患者随机分为两组,每组60例,两组患者无显著差异,具有可比性。对照组给予易善复,治疗组给予口服清热利湿、活血行气的中药联合易善复进行治疗。治疗3个疗程,观察治疗前后两组患者的B超评分,肝功能酶(ALT、AST、GGT),血脂(TC、TG、HDL-C),超氧化物歧化酶,瘦素及临床疗效。结果:治疗组和对照组患者的B超评分、ALT、AST、GGT、TC、TG、瘦素显著降低,HDL-C、超氧化物歧化酶显著升高,而治疗组的各项指标改善的更显著;治疗组患者显效率显著高于对照组。结论:口服清热利湿、活血行气的中药联合易善复治疗非酒精性脂肪性肝病患者可以取得较好的疗效。

刺络泻血对非酒精性脂肪肝模型大鼠瘦素及脂联素的影响

目的:观察刺络泻血干预对非酒精性脂肪肝模型大鼠血清中瘦素及脂联素的影响。方法:选取清洁级雄性SD大鼠40只,随机分为正常组(10只),模型组(10只),易善复组(10只),刺血干预组(10只)。选用高脂饮食饲料喂养法建立非酒精性脂肪肝模型。造模8周后,各造模组仍给予高脂饲料饲养,易善复组给予易善复0.159 g/(kg·d)灌胃,刺血干预组予"丰隆""太冲"穴三棱针刺血,治疗4周后取材,观察4组大鼠肝指数及肝脏病理变化,用酶联免疫吸附试验(ELISA)检测血清瘦素、脂联素的水平。结果:与正常组比较,模型组血清瘦素水平显著升高,脂联素水平显著降低,差异有统计学意义(P<0.05);与模型组比较,易善复组及刺血干预组瘦素水平明显下降,血清脂联素水平明显升高,差异有统计学意义(P<0.05);与易善复组比较,刺血干预组瘦素水平稍高,血清脂联素水平则稍低,差异无统计学意义(P>0.05)。结论:刺血干预可显著减轻非酒精性脂肪肝大鼠模型肝损伤,其机制可能与降低血清中瘦素水平,上调脂联素水平有关。

东宝肝泰片联合易善复治疗非酒精性脂肪肝65例

目的研究东宝肝泰片联合易善复治疗非酒精性脂肪肝患者的临床效果。方法使用随机数字表法将收治的126例患者分为对照组61例和观察组65例。对照组给予易善复2粒/次,3次/日;观察组在此基础上给予东宝肝泰片3片/次,3次/日。90 d后检测患者的肝功能和血脂水平,并记录不良反应发生情况。结果与治疗前相比,治疗后两组患者的丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)、总胆固醇(TC)和三酰甘油(TG)均有明显下降(P<0.05),观察组降低更明显,其中TC和TG与对照组比较差异有统计学意义(P<0.05)。治疗后观察组症状体征、肝功能和血脂的复常率均明显高于对照组(P<0.05)。观察组不良反应发生率低于对照组,组间差异无统计学意义(P>0.05),停药后均可自行缓解。结论东宝肝泰片联合易善复治疗非酒精性脂肪肝的临床效果确切,能明显改善患者肝功能和血脂,安全性较好,值得推广。

易善复胶囊对脂肪肝大鼠血脂及血流变影响的实验研究

目的:探讨易善复对脂肪肝大鼠血脂和血液流变学的影响。方法:采用复合方式建立大鼠脂肪肝模型,36只wastar大鼠随机分为3组,每组12只。治疗组经灌胃予易善复乳剂、空白组予等量的生理盐水、模型组未予药物。治疗结束后,通过组织病理学及生化学检测不同组别的肝组织脂肪变性及血脂;同时检测全血高、中、低切黏度、血浆黏度。结果:易善复可显著降低肝组织损伤和脂肪变性程度,降低肝组织及血浆中甘油三酯、胆固醇含量,显著降低全血黏度、血浆黏度。结论:易善复具有显著的抗肝组织损伤和脂肪变性作用,可改变脂肪肝大鼠血脂及血液流变学的作用,对脂肪肝起到治疗作用。

健胃消胀片治疗非酒精性脂肪性肝病临床研究

目的:观察健胃消胀片治疗非酒精性脂肪性肝病(NAFLD)的临床效果。方法:纳入60例NAFLD患者,随机分为治疗组和对照组各30例,治疗组服用健胃消胀片治疗,对照组服用易善复胶囊治疗,2组患者均治疗12周,观察2组患者的临床主要症状积分、肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)]、血脂指标[甘油三酯(TG)、总胆固醇(TC)]及肝脏超声等的变化。结果:治疗后,治疗组总有效率为90.00%,对照组总有效率为83.33%。2组疗效比较,差异无统计学意义(P>0.05)。2组ALT、AST水平均较治疗前下降(P<0.05),治疗组2项指标水平均低于对照组(P<0.05)。2组TC、TG水平与主症积分、肝脏超声积分均较治疗前下降(P<0.05),2组TC、TG、肝脏超声积分比较,差异均无统计学意义(P>0.05),治疗组主症积分低于对照组(P<0.05)。结论:健胃消胀片治疗NAFLD在临床疗效及改善血脂代谢方面与易善复胶囊相当,而在改善临床症状及肝功能等方面有明确优势。

Acupuncture method of“Huoxue Sanfeng,Shugan Jianpi ” for morning blood pressure in patients with cerebral infarction combined with essential hypertension: a randomized controlled trial

Objective To observe the clinical effects of acupuncture method of'Huoxue Sanfeng,Shugan Jianpi'(activating blood and eliminating wind,soothing liver and strengthening spleen)on morning blood pressure in patients with cerebral infarction combined with essential hypertension.Methods Sixty-eight patients were randomly divided into an observation group and a control group,34 cases in each one.The patients in the