According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by th... According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by the method of reinforcing the kidney to strengthen the bone, with satisfactory therapeutic results reported as follows.……展开更多
Postmenopausal osteoporosis （PMO） is considered a polygenic disease. The estrogen receptor β （ESR2） gene is a candidate mediating the genetic influence on bone mass and the risk of osteoporosis. The aim of this s...Postmenopausal osteoporosis （PMO） is considered a polygenic disease. The estrogen receptor β （ESR2） gene is a candidate mediating the genetic influence on bone mass and the risk of osteoporosis. The aim of this study is to investigate the association of a cytosine-adenine （CA） repeat polymorphism in the fifth intron of the ESR2 gene with PMO in Chinese Han population. The CA repeat polymorphism was genotyped in a case-control study, involving 78 femoral neck PMO patients vs. 122 controls and 108 lumbar spine （L2-4） PMO patients vs. 92 controls. The （CA）n〈22 and （CA）n≥22 alleles were designated short （S） and long （L）, respectively. ESR2 genotype was categorically defined as SS （2 S alleles）, SL （having the mixed S and L alleles）, and LL （2 L alleles）. At both the femoral neck and the L2-4 region, LL genotype and L allele frequencies of the PMO group were significantly higher than those of the control group （P〈0.01）. The subjects with the SL, the LL, and the combined SL and LL genotype had a significant increased risk of PMO when compared with those with the SS genotype （P〈0.05）. After adjustments for age, years since menopause, menopausal age, and body mass index, logistic regression analysis showed that the subjects with the combined SL and LL genotype had increased risk of PMO when compared with those with the SS genotype both at the femoral neck （adjusted OR 4.923, 95% CI 1.986-12.203 , P=0.001） and the L2-4 （adjusted OR 2.267, 95% CI 1.121-4.598, P=0.023）. This extensive association study has identified the ESR2 CA repeat polymorphism to be independently associated with PMO at the femoral neck and the L2-4 in Chinese Han population. The data also suggested that the presence of the L allele may dominantly increase the risk of PMO at the two regions.展开更多
Objective： To observe the effect of Gengnianchun Recipe （更年春方, GNC） on bone mineral density （BMD）, bone biomechanical parameters and serum lipid level in the bilaterally ovariectomized （OVX） rats and to exp...Objective： To observe the effect of Gengnianchun Recipe （更年春方, GNC） on bone mineral density （BMD）, bone biomechanical parameters and serum lipid level in the bilaterally ovariectomized （OVX） rats and to explore the prophylactic and therapeutic action of GNC on ovariectomy induced osteoporosis and hyperlipidemia. Methods： OVX SD rats, 10- 12 months old, were divided into different groups and fed with GNC 2 g/d, GNC 1 g/d and Nilestriol 0. 125 mg/week, respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae, and the serum levels of total cholesterol （TO）, triglyceride（TG）, high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）, and to compare the effect of the two drugs on the morphology of the uterus. Results： There was marked reduction in BMD and biomechanical parameters in lumbar vertebrae （ P〈0. 01 ） and increase of serum TO and LDL-C levels （ P〈0. 01 ） in rats after OVX. GNC or Nilestriol significantly improved the decreased BMD and biomechanical parameters of the lumbar vertebrae （ P〈0.05 or P〈0. 01 ）, and reduced the serum TO and LDL-C levels （ P〈0. 01 ）. In the Nilestriol group, the wet weight of uterus got increased obviously （ P〈0.01 ）, the number of uterine glands increased, uterine columnar epithelium thickened, and the mitotic figures in the epithelial stroma and myointimal cells augmented. But no such effect in wet weight and morphology of uterus was found in the GNC group. Conclusion： GNC could increase the BMD and biomechanical parameters of the lumbar vertebrae, reduce the serum TO and LDL-C levels, yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus.展开更多
Summary： To evaluate the efficacy and safety of risedronate sodium in treatment of postmenopausal osteoporosis, one-year randomized, double blind clinical trial was performed among 54 women with postmenopausal osteop...Summary： To evaluate the efficacy and safety of risedronate sodium in treatment of postmenopausal osteoporosis, one-year randomized, double blind clinical trial was performed among 54 women with postmenopausal osteoporosis. The changes were compared in bone mineral density （BMD）, bone metabolism markers and adverse events after 12 months oral administration of risedronate sodium. BMD was measured by dual energy X-ray absorptionmetry （DEXA） and bone turnover marker was detected. The results showed that there was a significant increase in BMD of the lumbar spine （3.29 %±41.18 %, 4.51%±1.64 % respectively） after 6 and 12 months in the risedronate treatment group versus placebo control group （-0.62 %±0.24 %, 0.48 %±0. 18 % respectively）. Bone turnover was decreased to a stable nadir over 6 and 12 months for resorption markers [N-Telopeptide （NTx）, P〈0.05] and over 12 months for formation marker （ALP, P〈0.05; BGP, P〈0. 05）. The safety profile of risedronate sodium was similar to that of placebo. There were no trends toward increased frequency of any adverse experience except for gastrointestinal symptoms （7.1%）, rash （7.1%） and hematuria （3.6 %）, which were usually mild, transient, and resolved with continued treatment. It was concluded that risedronate was an efficacious and safe drug in treatment of postmenopausal osteoporosis.展开更多
目的:本研究旨在对比腰骶椎椎体松质骨的CT值与双能X线骨密度仪(dual energy X ray absorptiometry,DXA)的骨密度值,评估腰骶椎椎体CT值诊断绝经后女性骨质疏松症的应用价值。方法:收集95例临床均确诊为绝经后女性患者,年龄≥59,且≤96...目的:本研究旨在对比腰骶椎椎体松质骨的CT值与双能X线骨密度仪(dual energy X ray absorptiometry,DXA)的骨密度值,评估腰骶椎椎体CT值诊断绝经后女性骨质疏松症的应用价值。方法:收集95例临床均确诊为绝经后女性患者,年龄≥59,且≤96岁,平均(76.45±10.88)岁,均在入院2周内进行腰椎CT和DXA检查。本研究测量腰椎CT检查中的L2至S1椎体CT值,与测量DXA检查的总T-score值进行分析。结果:骨量减少组与骨质疏松组L2至S1椎体的CT值均低于骨质正常组椎体的CT值(P<0.01)。L2至S1椎体CT值和总T-score值为显著正相关(P<0.01)。ROC曲线分析显示,L2和L5椎体CT值的曲线下面积最大,且L2椎体CT值的相关系数最大。因此,本研究选择L2椎体CT值低于72.25HU,作为提示发生骨质疏松症的阈值。结论:通过测量绝经后女性腰椎CT检查中的L2至S1椎体CT值,或将成为提前筛查骨质疏松症、降低患者开支和不良预后风险的有力方式。展开更多
绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是女性绝经后由于雌激素分泌不足引起的代谢性骨病。诊断骨质疏松症的金标准是骨密度(Bone Mineral Density BMD)。双膦酸盐、降钙素、雌激素等药物是现代临床治疗PMOP的主力军,但...绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是女性绝经后由于雌激素分泌不足引起的代谢性骨病。诊断骨质疏松症的金标准是骨密度(Bone Mineral Density BMD)。双膦酸盐、降钙素、雌激素等药物是现代临床治疗PMOP的主力军,但不良反应和药物服用周期存在争议。甘肃省天水市中医医院马小军主任医师认为,肾虚是PMOP发生的重要内在基础,肝肾阴虚是发病的关键。中医将肾奉为“先天之本”,元阴元阳贮藏于肾,肾之阴阳为人体阴阳之本,能够濡养和温煦全身脏腑,且肾主骨生髓。女子以肝为先天,肝肾阴虚导致女子“天癸”亏虚,肝肾同源,久病及肾,肾虚则导致骨失濡养,日久则导致骨质疏松。肝肾阴虚作为本病发病的关键,滋补肝肾应贯穿本病发展始终。基于以上理论,马小军主任医师自拟枸地健骨汤滋补肝肾,益精填髓;在对PMOP症状的缓解和减少复发方面均有较好的临床疗效。本文以案例的形式介绍马小军主任医师临诊PMOP的经验,希望为临床提供依据。展开更多
文摘 According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by the method of reinforcing the kidney to strengthen the bone, with satisfactory therapeutic results reported as follows.……
文摘Postmenopausal osteoporosis （PMO） is considered a polygenic disease. The estrogen receptor β （ESR2） gene is a candidate mediating the genetic influence on bone mass and the risk of osteoporosis. The aim of this study is to investigate the association of a cytosine-adenine （CA） repeat polymorphism in the fifth intron of the ESR2 gene with PMO in Chinese Han population. The CA repeat polymorphism was genotyped in a case-control study, involving 78 femoral neck PMO patients vs. 122 controls and 108 lumbar spine （L2-4） PMO patients vs. 92 controls. The （CA）n〈22 and （CA）n≥22 alleles were designated short （S） and long （L）, respectively. ESR2 genotype was categorically defined as SS （2 S alleles）, SL （having the mixed S and L alleles）, and LL （2 L alleles）. At both the femoral neck and the L2-4 region, LL genotype and L allele frequencies of the PMO group were significantly higher than those of the control group （P〈0.01）. The subjects with the SL, the LL, and the combined SL and LL genotype had a significant increased risk of PMO when compared with those with the SS genotype （P〈0.05）. After adjustments for age, years since menopause, menopausal age, and body mass index, logistic regression analysis showed that the subjects with the combined SL and LL genotype had increased risk of PMO when compared with those with the SS genotype both at the femoral neck （adjusted OR 4.923, 95% CI 1.986-12.203 , P=0.001） and the L2-4 （adjusted OR 2.267, 95% CI 1.121-4.598, P=0.023）. This extensive association study has identified the ESR2 CA repeat polymorphism to be independently associated with PMO at the femoral neck and the L2-4 in Chinese Han population. The data also suggested that the presence of the L allele may dominantly increase the risk of PMO at the two regions.
文摘Objective： To observe the effect of Gengnianchun Recipe （更年春方, GNC） on bone mineral density （BMD）, bone biomechanical parameters and serum lipid level in the bilaterally ovariectomized （OVX） rats and to explore the prophylactic and therapeutic action of GNC on ovariectomy induced osteoporosis and hyperlipidemia. Methods： OVX SD rats, 10- 12 months old, were divided into different groups and fed with GNC 2 g/d, GNC 1 g/d and Nilestriol 0. 125 mg/week, respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae, and the serum levels of total cholesterol （TO）, triglyceride（TG）, high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）, and to compare the effect of the two drugs on the morphology of the uterus. Results： There was marked reduction in BMD and biomechanical parameters in lumbar vertebrae （ P〈0. 01 ） and increase of serum TO and LDL-C levels （ P〈0. 01 ） in rats after OVX. GNC or Nilestriol significantly improved the decreased BMD and biomechanical parameters of the lumbar vertebrae （ P〈0.05 or P〈0. 01 ）, and reduced the serum TO and LDL-C levels （ P〈0. 01 ）. In the Nilestriol group, the wet weight of uterus got increased obviously （ P〈0.01 ）, the number of uterine glands increased, uterine columnar epithelium thickened, and the mitotic figures in the epithelial stroma and myointimal cells augmented. But no such effect in wet weight and morphology of uterus was found in the GNC group. Conclusion： GNC could increase the BMD and biomechanical parameters of the lumbar vertebrae, reduce the serum TO and LDL-C levels, yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus.
文摘Summary： To evaluate the efficacy and safety of risedronate sodium in treatment of postmenopausal osteoporosis, one-year randomized, double blind clinical trial was performed among 54 women with postmenopausal osteoporosis. The changes were compared in bone mineral density （BMD）, bone metabolism markers and adverse events after 12 months oral administration of risedronate sodium. BMD was measured by dual energy X-ray absorptionmetry （DEXA） and bone turnover marker was detected. The results showed that there was a significant increase in BMD of the lumbar spine （3.29 %±41.18 %, 4.51%±1.64 % respectively） after 6 and 12 months in the risedronate treatment group versus placebo control group （-0.62 %±0.24 %, 0.48 %±0. 18 % respectively）. Bone turnover was decreased to a stable nadir over 6 and 12 months for resorption markers [N-Telopeptide （NTx）, P〈0.05] and over 12 months for formation marker （ALP, P〈0.05; BGP, P〈0. 05）. The safety profile of risedronate sodium was similar to that of placebo. There were no trends toward increased frequency of any adverse experience except for gastrointestinal symptoms （7.1%）, rash （7.1%） and hematuria （3.6 %）, which were usually mild, transient, and resolved with continued treatment. It was concluded that risedronate was an efficacious and safe drug in treatment of postmenopausal osteoporosis.
文摘目的比较新型北京友谊医院绝经后妇女骨质疏松筛查工具(Beijing Friendship Hospital osteoporosis self-assessment tool,BFH-OST)和亚洲人骨质疏松自我筛查工具(osteoporosis self-assessment tool for Asians,OSTA)对绝经后妇女骨质疏松风险的预测作用。方法随机选取2021年1月至2022年11月就诊于民航总医院的115例绝经后妇女,以双能X射线吸收法(dual energy X-ray absorptiometry,DXA)为诊断标准,通过受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析BFH-OST、OSTA的诊断效能。结果BFH-OST和OSTA均与DXA诊断骨质疏松存在明显相关性(P<0.01),BFH-OST的曲线下面积(area under the curve,AUC)为0.819,截断值≤12.2,敏感度为81.25%,特异性为75.90%;OSTA的AUC为0.809,截断值≤–1.2,敏感度为81.25%,特异性72.29%。BFH-OST和OSTA的ROC曲线比较,差异有统计学意义(P<0.05)。结论BFH-OST和OSTA对绝经后妇女骨质疏松风险均有预测作用,BFH-OST的诊断效能优于OSTA。
文摘目的:本研究旨在对比腰骶椎椎体松质骨的CT值与双能X线骨密度仪(dual energy X ray absorptiometry,DXA)的骨密度值,评估腰骶椎椎体CT值诊断绝经后女性骨质疏松症的应用价值。方法:收集95例临床均确诊为绝经后女性患者,年龄≥59,且≤96岁,平均(76.45±10.88)岁,均在入院2周内进行腰椎CT和DXA检查。本研究测量腰椎CT检查中的L2至S1椎体CT值,与测量DXA检查的总T-score值进行分析。结果:骨量减少组与骨质疏松组L2至S1椎体的CT值均低于骨质正常组椎体的CT值(P<0.01)。L2至S1椎体CT值和总T-score值为显著正相关(P<0.01)。ROC曲线分析显示,L2和L5椎体CT值的曲线下面积最大,且L2椎体CT值的相关系数最大。因此,本研究选择L2椎体CT值低于72.25HU,作为提示发生骨质疏松症的阈值。结论:通过测量绝经后女性腰椎CT检查中的L2至S1椎体CT值,或将成为提前筛查骨质疏松症、降低患者开支和不良预后风险的有力方式。
文摘绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是女性绝经后由于雌激素分泌不足引起的代谢性骨病。诊断骨质疏松症的金标准是骨密度(Bone Mineral Density BMD)。双膦酸盐、降钙素、雌激素等药物是现代临床治疗PMOP的主力军,但不良反应和药物服用周期存在争议。甘肃省天水市中医医院马小军主任医师认为,肾虚是PMOP发生的重要内在基础,肝肾阴虚是发病的关键。中医将肾奉为“先天之本”,元阴元阳贮藏于肾,肾之阴阳为人体阴阳之本,能够濡养和温煦全身脏腑,且肾主骨生髓。女子以肝为先天,肝肾阴虚导致女子“天癸”亏虚,肝肾同源,久病及肾,肾虚则导致骨失濡养,日久则导致骨质疏松。肝肾阴虚作为本病发病的关键,滋补肝肾应贯穿本病发展始终。基于以上理论,马小军主任医师自拟枸地健骨汤滋补肝肾,益精填髓;在对PMOP症状的缓解和减少复发方面均有较好的临床疗效。本文以案例的形式介绍马小军主任医师临诊PMOP的经验,希望为临床提供依据。
