Efficacy evaluation and survival analysis of the combination of oxaliplatin plus Teysuno (SOX) with immune checkpoint inhibitors in the conversion therapy of locally advanced gastric cancer

Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been explored.However,limited research exists on its effectiveness in conversion therapy,and its superiority over standalone chemotherapy remains to be elucidated.This study aims to investigate the efficacy and survival outcomes of patients treated with ICIs in combination with conversion therapy for locally advanced gastric cancer.Methods:Retrospective data from patients with locally advanced gastric cancer treated with either oxaliplatin+S-1(SOX)alone or in combination with ICIs in conversion therapywere collected.Clinical andpathological characteristics,disease-free survival,andefficacy assessments in nonoperable patients were compared between the 2 treatment groups.Efficacy was further evaluated through dynamic changes in serum markers,and patients’quality of life was assessed using the QLQ-STO22(Gastric Cancer–Specific Quality of Life Questionnaire)quality-of-life measurement scale.Results:A total of 140 patients underwent conversion therapy:80 in the SOX alone group and 60 in the SOX combined with the ICIs group.There were no significant differences in baseline characteristics between the 2 groups.Compared with the SOX alone group,the SOX combined with ICIs group exhibited a higher conversion rate(83.3%vs 75%,P=0.23),R0 resection rate(90.0%vs 83.3%,P=0.31),pathological complete response(pCR)rate(18%vs 5%,P=0.02),median disease-free survival(21.4 vs 16.9 months,P=0.007),the objective response rate in nonoperable patients(60%vs 40%,P=0.301),and median progression-free survival time(7.9 vs 5.7 months,P=0.009).The QLQ-STO22 quality-of-life assessment revealed statistically significant improvements in pain,swallowing difficulties,and dietary restrictions in the combination therapy group compared with those in the monotherapy group.The enhanced efficacy of immune combination with SOX is evident,as demonstrated by the significantly prolonged surgical duration in operated patients(206.6±26.6 min vs 197.8±19.8 min,P=0.35)and intraoperative blood loss(158.9±21.2 mL vs 148.9±25.1 mL,P=0.59).No significant differences were observed in postoperative complications.Conclusions:Compared with the SOX conversion therapy regimen,SOX combined with ICIs demonstrated higher conversion rates,R0 resection rates,pathological response rates,and disease-free survival without increasing surgical difficulty or complications.Nonoperable patients also experienced longer progression-free survival and objective response rates.

Contribution of the MERISE-Type Conceptual Data Model to the Construction of Monitoring and Evaluation Indicators of the Effectiveness of Training in Relation to the Needs of the Labor Market in the Republic of Congo

This study proposes the use of the MERISE conceptual data model to create indicators for monitoring and evaluating the effectiveness of vocational training in the Republic of Congo. The importance of MERISE for structuring and analyzing data is underlined, as it enables the measurement of the adequacy between training and the needs of the labor market. The innovation of the study lies in the adaptation of the MERISE model to the local context, the development of innovative indicators, and the integration of a participatory approach including all relevant stakeholders. Contextual adaptation and local innovation: The study suggests adapting MERISE to the specific context of the Republic of Congo, considering the local particularities of the labor market. Development of innovative indicators and new measurement tools: It proposes creating indicators to assess skills matching and employer satisfaction, which are crucial for evaluating the effectiveness of vocational training. Participatory approach and inclusion of stakeholders: The study emphasizes actively involving training centers, employers, and recruitment agencies in the evaluation process. This participatory approach ensures that the perspectives of all stakeholders are considered, leading to more relevant and practical outcomes. Using the MERISE model allows for: • Rigorous data structuring, organization, and standardization: Clearly defining entities and relationships facilitates data organization and standardization, crucial for effective data analysis. • Facilitation of monitoring, analysis, and relevant indicators: Developing both quantitative and qualitative indicators helps measure the effectiveness of training in relation to the labor market, allowing for a comprehensive evaluation. • Improved communication and common language: By providing a common language for different stakeholders, MERISE enhances communication and collaboration, ensuring that all parties have a shared understanding. The study’s approach and contribution to existing research lie in: • Structured theoretical and practical framework and holistic approach: The study offers a structured framework for data collection and analysis, covering both quantitative and qualitative aspects, thus providing a comprehensive view of the training system. • Reproducible methodology and international comparison: The proposed methodology can be replicated in other contexts, facilitating international comparison and the adoption of best practices. • Extension of knowledge and new perspective: By integrating a participatory approach and developing indicators adapted to local needs, the study extends existing research and offers new perspectives on vocational training evaluation.

The Application and Effect Evaluation of Corpus Linguistics in English Teaching

This paper explores the application and effect evaluation of corpus linguistics in English teaching.It first introduces the basic concepts and development history of corpus linguistics,then analyzes its connection with language teaching theories,discussing the advantages and challenges of using corpora in language teaching.Next,it delves into the methods and technologies for building and utilizing corpora,as well as their role in developing teaching resources.Lastly,within the framework and methods of teaching effect evaluation,specific application cases of corpus linguistics in teaching design are analyzed,and their effects are assessed.Recommendations for teaching improvement and future development directions are also proposed.

Study on effectiveness evaluation of weapon systems based on grey relational analysis and TOPSIS

To evaluate the effectiveness of weapon systems, the advantages and disadvantages of grey relational analysis and TOPSIS for multiattribute decision-making is pointed out, and an effectiveness evaluation model of weapon systems by combining grey relational analysis and TOPSIS is proposed. The model aggregates the grey relational grade and the distance to a new integrated closeness and reflects not only the trend but also the situation of the alternative. The example illuminates that the model is effective for the effectiveness evaluation of weapon systems.

Comprehensive evaluation weight-variable identification model of top coal caving effect and its application

Based on the theory of attribute identification, a weight-variable identification model was put forward on top coal caving effect in fully mechanized top coal caving face. Contribution value of all kinds of evaluation factor of the caving coal and waste were used to determine weight coefficient. And then comprehensively estimated it by the given credible degree value. This kind of method can not only classify for attribute identification, but also can classify it into sub-classification according to comprehensive score compositor that of the same attribute. The comprehensive estimate result of plane and solid caving experiments shows that the result is true, credible, simple and that is not only one of the effective method of theory study, but also can be regarded as a quantitative examine method of the top coal caving effect in scene.

Research on Tourism Resources Development Pattern Effect Evaluation based on Regression Analysis and Neural Network

In this paper, we conduct research on the tourism resources development pattern effect evaluation based on regression analysis andneural network. Tourism resources development and the protection of all sorts of the contradictions, in the fi nal analysis is the confl ict betweenthe interests of stakeholders. Real life in China, and tourism resources development and protection of the interests of the relevant party basicallyhas the following six parties the local government, investment and the business practice, the original residents, tourists, tourism practitioners, thesocial organization. The survival and the development of general tourism industry is based on the premise of environmental protection, tourismlandscape are carefully protected, let the natural landscape and human landscape form a virtuous cycle, to attract more tourists, promote thesustainable development of scenic spots. Under this basis, this paper proposes the new idea on the issues that is meaningful.

System failure analysis based on DEMATEL–ISM and FMECA

A new method of system failure analysis was proposed. First, considering the relationships between the failure subsystems,the decision making trial and evaluation laboratory(DEMATEL) method was used to calculate the degree of correlation between the failure subsystems, analyze the combined effect of related failures, and obtain the degree of correlation by using the directed graph and matrix operations. Then, the interpretative structural modeling(ISM) method was combined to intuitively show the logical relationship of many failure subsystems and their influences on each other by using multilevel hierarchical structure model and obtaining the critical subsystems. Finally, failure mode effects and criticality analysis(FMECA) was used to perform a qualitative hazard analysis of critical subsystems, determine the critical failure mode, and clarify the direction of reliability improvement.Through an example, the result demonstrates that the proposed method can be efficiently applied to system failure analysis problems.

The Influence Evaluation of Tourism on Chinese Rural People Living in Minority Areas

In this paper, through understanding the basic situation of three villages at different stages of life cycle development about tourism, using the method of grey correlation analysis from the quantitative aspects, the results show that impact assessment on rural tourism in different stages is different [1]. The impact on tourism stable stage is the most;tourism decline stage is relatively weak;tourism development stage is the weakest.

Advanced Methods of Evaluating Benefits from Improved Flood Immunity in Queensland

The regular occurrence and the high costs of flooding to both road agencies and communities is a strong impetus to investigate the methodologies applied to evaluating flood immunity road projects. Very little literature exists on methods of evaluating the benefits of improving flood immunity through better road infrastructure. This paper attempts to address some of the numerous issues hindering the accurate evaluation of flood immunity road projects. The methodologies presented in this paper are designed to evaluate benefits that are not normally included or not fully considered in evaluations; such benefits include reduced flood related road accidents, costs of not travelling during the closure period and additional costs from unanticipated flood events. A key focus of the paper is the consideration of the evaluation of improved flood immunity from a network perspective rather than the typical approach of evaluating flood immunity projects in isolation to each other. The application of the proposed methodologies is demonstrated with a hypothetical example of a typical rural network subjected to regular flooding. The results of the analysis, conducted using the proposed methodologies, reveals that the currently applied methodologies account for less than half the likely value of benefits of a package of projects that will prevent the complete isolation of communities during serious flood events.

降雨作用下考虑结构面劣化的边坡块体稳定性评价

降雨是诱发边坡失稳,发生崩塌、落石、滑坡的一个主要诱因,降雨作用下结构面强度会发生劣化,导致边坡块体失稳塌落,引起地质灾害,对人民生命财产构成严重威胁。基于离散元数值分析方法,考虑降雨作用对结构面抗剪强度的影响,分析结构面强度参数劣化及孔隙水压力变化规律,建立抗剪强度劣化模型;结合坐标投影原理提出考虑降雨作用下结构面强度劣化效应的块体稳定性系数计算方法;基于有限元分析方法研究降雨强度与降雨历时对岩质边坡块体稳定性的影响,并进一步分析稳定性系数与降雨强度及降雨历时的关系,提出降雨作用下考虑结构面劣化的边坡块体稳定性评价方法。研究表明,不同含水率作用下结构面的抗剪强度劣化不仅受黏聚力和内摩擦角影响,还与孔隙水压力有关,针对单滑面和双滑面型块体构建了考虑结构面降雨劣化的稳定性分析数学模型,提出的以降雨时长、降雨强度和块体稳定性关系曲线的共同评价体系可为边坡块体稳定性评价提供科学依据,并推动边坡地质灾害防治和工程建设发展。

医疗失效模式与效应分析在新生儿医院感染防控中的应用

目的研究医疗失效模式与效应分析(healthcare failure mode and effect analysis,HFMEA)在新生儿医院感染防控中的应用效果。方法选取揭阳市人民医院新生儿中心2020年7月—2021年6月住院患儿1150例为对照组,2021年7月—2022年6月住院患儿1353例为观察组。对照组应用常规感染防控管理模式,观察组应用HFMEA管理模式进行医院感染防控干预。比较2组新生儿医院感染例次发病率、工作人员(医护、保洁)医院感染知识知晓率、手卫生依从率和正确率。结果观察组新生儿医院感染例次发病率为3.92%,低于对照组的5.65%,差异有统计学意义(P<0.05)。观察组医护人员医院感染知识知晓率、手卫生依从率、手卫生正确率为93.25%、90.25%、88.98%,高于对照组的51.84%、80.64%、79.94%,差异有统计学意义(P<0.05)。观察组保洁人员医院感染知识知晓率、手卫生依从率、手卫生正确率为91.15%、76.71%、75.71%,高于对照组的65.31%、60.65%、62.50%,差异有统计学意义(P<0.05)。结论应用HFMEA对新生儿中心进行科学管理,可有效指导新生儿医院感染防控,提升医院感染管理水平。

2020-2022年湖南省小反刍兽疫春、秋季免疫效果评估

为掌握湖南省小反刍兽疫集中免疫效果,科学评估各市州免疫质量,2020~2022年在全省开展小反刍兽疫春、秋季免疫效果评估。结果显示:2020~2022年小反刍兽疫集中免疫的群体合格率为65.3%,个体合格率为71.0%。全省各地区小反刍兽疫免疫不平衡,个体免疫率最高的可达94.4%,最低的仅为47.5%。规模场免疫效果好于散养户。调查显示,一些散养户免疫意识较弱,存在免疫操作不规范情况。需要进一步加强对散养户的宣传和指导。

基于FAST和Sobol指数法的雷达系统效能敏感性分析

为了以较小的代价快速提升对空探测雷达系统的综合效能,首先搭建了对空探测雷达系统综合效能的评估指标体系,在此基础上完成了综合效能评估模型的建立。选择两种基于方差原理的全局敏感性分析方法,即傅里叶幅度敏感性测试(Fourier amplitudes sensitivity test,FAST)和Sobol指数法,分别从频域和时域对建立的评估模型进行敏感性分析。在基于FAST进行敏感性分析时,提出了21维输入指标所对应的特征频率集的选取方法;在基于Sobol指数法进行敏感性分析时,考虑了二阶及高阶敏感性指数的影响。对比FAST和Sobol指数法的分析结果,两种方法获得的敏感性分析结果具有较好的一致性。其中,功率和频率为对空探测雷达系统的主要影响指标,为雷达系统的研发和升级提供了可靠性依据。

基于柯氏模式的药物分析在线学习效果评估

基于柯氏模式构建反应层、学习层、行为层、结果层4个层级在线学习效果评估模式,在药物分析在线课程教学中进行实践。通过对4个层级的数据进行分析,给予药物分析在线课程建设和提升学生在线学习效果的反馈性意见,为进一步改进职业人才培养模式、调整教学策略提供建议,达到以评促建、以评促学的目的。

可持续生计视角下水库移民后期帮扶效果评估研究

基于广西岩滩水电移民的调研数据,运用组合赋权法、Topsis模型对由3种能力构成的可持续生计进行量化,并采用方差分析探讨后期帮扶及其具体措施对移民户整体和3种类型移民户可持续生计的影响,以此来评价帮扶效果。结果表明:移民户可持续生计整体处于中等偏下的水平,且非贫困户、一般脱贫户和低保脱贫户可持续生计水平依次降低;综合帮扶对整体移民户可持续生计的提升显著,具体措施是否参与对不同移民户可持续生计的作用不同,其中教育培训对3种类型移民户提升可持续生计均显著;参与帮扶措施多寡对非贫困户和低保脱贫户可持续生计的影响显著,但对一般脱贫户影响不显著。拓展了移民后期帮扶效果评估领域的研究方法,可以为精准高效推进移民扶持提供依据。

基于网状Meta分析对8个经典名方治疗不稳定型心绞痛的临床疗效评价

目的:运用网状Meta分析方法系统评价8种经典名方联合西医常规治疗不稳定型心绞痛(UAP)的临床疗效,并分别进一步比较不同经典名方治疗实证和虚证(包括虚实夹杂)2大证型的疗效。方法:检索并筛选中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)、中国国家知识基础设施数据库(CNKI)与中国学术期刊数据库(CSPD)等数据库中关于8个经典名方(血府逐瘀汤、补阳还五汤、四妙勇安汤、丹参饮、炙甘草汤、枳实薤白桂枝汤、瓜蒌薤白半夏汤、化痰祛瘀通脉汤)联合西医常规治疗UAP的随机对照试验(RCT),检索时限从各数据库建库至2022年1月14日,采用Stata 16.0软件进行网状Meta分析。结果:共纳入60个RCT,总计5088例UAP患者,涉及9种干预措施。其中,UAP属实证的有41个RCT,UAP患者共3432例,涉及5种干预措施;虚证或虚实夹杂共13个,共1130例患者,涉及4种干预措施。网状Meta分析结果提示,枳实薤白桂枝汤+西医常规治疗总有效率最优,UAP属实证者,四妙勇安汤+西医常规治疗最佳;虚证或虚实夹杂者,补阳还五汤+西医常规治疗最佳;心电图改善方面,四妙勇安汤疗效最佳;枳实薤白桂枝汤+西医常规在降低超敏C反应蛋白(hs-CRP)改善炎症反应方面更优。结论:与西医常规治疗UAP比较,枳实薤白桂枝汤联合西药常规治疗疗效较显著。但仍需要纳入更多高质量的RCT证实。

海战场环境下反舰导弹效能评估方法研究

对海打击是海上编队最为重要的作战样式之一,开展武器装备作战效能评估方法研究,科学评估其作战能力,是装备列装定型的必要条件。基于作战能力评估的复杂性,在系统分析以往效能评估方法和步骤基础上,建立了武器装备不同类型指标的归一化模型和关键作战能力评估模型,可为靶场开展作战效能评估提供重要理论参考,为部队作战使用提供支撑和帮助。

课程思政教学效果评价体系的思考与构建——以生物化学下册课程为例

课程思政教学评价是对思政教学改革的总结与反馈,更是不断提升教学效果的重要基础。由于课程思政是通过挖掘和隐性化嵌入思想道德和精神塑造元素而构建的复合式协同育人教育模式,因而对其教学效果的评估也具有特殊性。课程思政教学评价应在注重评价指标全面性的同时兼顾思政教学针对性,强调思政元素融入的协调性、合理性,同时应力求反映出课程思政教学对课程教学促进的协同性及达成度。该文以烟台大学生物科学专业的生物化学下册专业教学改革为案例,尝试建立适合自身需求的课程全过程评价和达成度评价双重评价体系。实践检验结果为今后进一步完善和优化课程教学提供了重要依据。

FMEA模型和6S管理方法在降低儿童专科医院PIVAS调剂差错中的应用

目的降低儿童专科医院静脉药物配置中心(PIVAS)的调剂差错。方法采用失效模式和效应分析(FMEA)模型,对我院PIVAS调剂流程进行风险识别,找出各环节中可能导致调剂差错的潜在失效模式,分析其失效原因,并对潜在失效模式的严重度、发生率和检测度进行量化评分,计算其风险优先指数,从而筛选需要优先改善的失效模式;应用6S管理方法,从整理(seiri)、整顿(seiton)、清扫(seiso)、清洁(seiketsu)、素养(shitsuke)和安全(safety)6个方面制定相应的改善措施,并对实施前后的干预效果进行评价。结果根据风险优先指数评估筛选出32个潜在失效模式,其中需要优先改善的关键失效模式共18个。根据6S管理方法采取相应措施后,18个关键失效模式的风险优先指数均有所下降,风险优先指数值由497降至142,降幅达71.43%;其中15个关键失效模式的差错率均较实施前显著降低(P<0.05)。结论应用FMEA模式和6S管理方法对PIVAS工作流程的各环节进行风险管控的预测和改进,能有效降低PIVAS调剂差错风险,保障儿童静脉用药安全。

基于能值的海岸带生态修复成效评估——以鹦鹉洲湿地为例

鹦鹉洲湿地自建成以来已开展了连续5年以上的实地调查和监测,结合长期监测数据构建科学系统的修复成效评价体系对海岸带生态修复工程的评估具有重要的参考价值.采用能值分析方法,通过实地调研、科学监测和查阅文献,搜集所需相关数据,构建了湿地生态系统能量分析结构图和能值指标体系,对自然资产、生态服务等主要能值指标进行了分析,并比较了不同修复时期湿地的功能表现.研究结果表明:2021年,鹦鹉洲湿地自然资产总能值为8.92×1016 sej,相当于能值–货币价值22.47万元,湿地生态服务总能值为8.88×1017 sej·a^(-1);实施生态修复后,鹦鹉洲生态质量明显改善,其自然资产和生态服务能值分别是修复前的5.01倍和5.73倍;鹦鹉洲湿地生态系统的能值自给率(emergy self-support ratio,ESR)为0.47,能值产出率(emergy yield ratio,EYR)和能值可持续指数(emergy sustainable index,ESI)分别为28.29和25.03,表明湿地产出效率高且可持续发展空间较大.研究显示:基于长期监测数据,采用能值分析方法可较好地反映海岸带生态修复工程成效,所构建的评估体系及方法可为类似海岸带修复工程提供参考.