The Deformed Hartree-Fock States of A≈70 Even-even Nuclei

The calculation for ten even-even nuclei of transitional nuclei Zn,Ge,Se andKr is performed by using KB-Ⅱ matrix elements and deformed Hartree-Fock method,and ensuing solutions of the prolate,oblate and particle-hole excited configurations ofthese nuclei are obtained.The results show that there are shape transitions and shapecoexistence in A≈70 nucleus region,the single-particle energy levels are different notonly for different mass numbers of the nuclei but also for different configurations.

The breaking of spin symmetry in the single-particle resonances in deformed nuclei

The exploration of spin symmetry (SS) in nuclear physics has been instrumental in identifying atomic nucleus structures.In this study,we solve the Dirac equation from the relativistic mean field (RMF) in complex momentum representation.We investigated SS and its breaking in single-particle resonant states within deformed nuclei,with a focus on the illustrative nucleus168Er.This was the initial discovery of a resonant spin doublet in a deformed nucleus,with the expectation of the SS approaching the continuum threshold.With increasing single-particle energy,the splitting of the resonant spin doublets widened significantly.This escalating splitting implies diminishing adherence to the SS,indicating a departure from the expected behavior as the energy levels increase.We also analyzed the width of the resonant states,showing that lower orbital angular momentum resonances possess shorter decay times and that SS is preserved within broad resonant doublets,as opposed to narrow resonant doublets.Comparing the radial density of the upper components for the bound-state and resonant-state doublets,it becomes evident that while SS is well-preserved in the bound states,it deteriorates in the resonant states.The impact of nuclear deformation (β_(2)) on SS was examined,demonstrating that an increase in β_(2) resulted in higher energy and width splitting in the resonant spin doublets,which is attributed to increased component mixing.Furthermore,the sensitivity of spin doublets to various potential parameters such as surface diffuseness (a),radius (R),and depth (Σ0) is discussed,emphasizing the role of these parameters in SS.This study provides valuable insights into the behavior of spin doublets in deformed nuclei and their interplay with the nuclear structure,thereby advancing our understanding of SS in the resonance state.

Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics research.The upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution power.This provides an opportunity to study the production and properties of neutron-rich nuclei around N=126.In this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through simulations.The results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high statistics.Using the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously identified.Moreover,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity technique.This indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

RETRACTED: Nuclear Structure Study of Odd-Odd Yttrium Nuclei within Interacting-Boson Fermi-Fermion Model (IBFFM)

Short Retraction NoticeThe paper does not meet the standards of "Journal of Applied Mathematics and Physics". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.Editor guiding this retraction: Prof. Wen-Xiu Ma (EiC of JAMP)The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".

α Decay Properties of Even-Even Nuclei296-308120 Within the Two-Potential Approach

In the present work,we predict the α decay half-lives of unknown even-even nuclei 296-308120 within the two-potential approach,whose α decay energy Qa is calculated using WS3+mass model.To reduce the deviations between the predictions and experimental data due to nuclear shell effect,the analytic formula of α decay hindrance factor is introduced to the two-potential approach,whose parameters had been extracted from even-even nuclei in the region of 82 <Z <126 and 152 <N ≤184 in our previous work [Deng et al.,Chin.Phys.C 42(2018) 044102].In addition,for comparing,we use a type of α decay general formula Universal Decay Law(UDL) and a semi-empirical formula in the superheavy nucleus(SEMFLS) to calculate the half-lives of even-even nuclei 296-308120.The results indicate that our predicted values and the calculated values of the above two empirical formulas are mutually confirmed.Meanwhile,we systematically study α decay chains of 296-308120 and predict the decay modes for superheavy nuclei to help to identify new superheavy isotopes.

Constraining nuclear symmetry energy with the charge radii of mirror-pair nuclei

The nuclear charge radius plays a vital role in determining the equation of state of isospin asymmetric nuclear matter.Based on the correlation between the differences in charge radii of mirror-partner nuclei and the slope parameter(L)of symmetry energy at the nuclear saturation density,an analysis of the calibrated slope parameter L was performed in finite nuclei.In this study,relativistic and nonrelativistic energy density functionals were employed to constrain the nuclear symmetry energy through the available databases of the mirror-pair nuclei^(36)Ca–^(36)S,^(38)Ca–^(38)Ar,and ^(54)Ni–^(54)Fe.The deduced nuclear symmetry energy was located in the range 29.89–31.85 MeV,and L of the symmetry energy essentially covered the range 22.50–51.55 MeV at the saturation density.Moreover,the extracted L_(s) at the sensitivity density p_(s)=0.10 fm^(-3) was located in the interval range 30.52–39.76 MeV.

Stability of Nuclei Based on the New Proton and Neutron Model

According to the new proton and neutron nuclear picture described earlier, the structure of the nucleus will also be given a new interpretation. The role of the delocalized electrons detached from the outer shell of neutrons is shown in the binding energy value of the nucleus. It is pointed out that the spatial arrangement of nucleons is also very important for the stability of nuclei according to the analyzation of the magic numbers from a geometric point of view.

Nuclei Segmentation in Histopathology Images Using Structure-Preserving Color Normalization Based Ensemble Deep Learning Frameworks

This paper presents a novel computerized technique for the segmentation of nuclei in hematoxylin and eosin(H&E)stained histopathology images.The purpose of this study is to overcome the challenges faced in automated nuclei segmentation due to the diversity of nuclei structures that arise from differences in tissue types and staining protocols,as well as the segmentation of variable-sized and overlapping nuclei.To this extent,the approach proposed in this study uses an ensemble of the UNet architecture with various Convolutional Neural Networks(CNN)architectures as encoder backbones,along with stain normalization and test time augmentation,to improve segmentation accuracy.Additionally,this paper employs a Structure-Preserving Color Normalization(SPCN)technique as a preprocessing step for stain normalization.The proposed model was trained and tested on both single-organ and multi-organ datasets,yielding an F1 score of 84.11%,mean Intersection over Union(IoU)of 81.67%,dice score of 84.11%,accuracy of 92.58%and precision of 83.78%on the multi-organ dataset,and an F1 score of 87.04%,mean IoU of 86.66%,dice score of 87.04%,accuracy of 96.69%and precision of 87.57%on the single-organ dataset.These findings demonstrate that the proposed model ensemble coupled with the right pre-processing and post-processing techniques enhances nuclei segmentation capabilities.

Cyclic feeding regime may delay aging in animals by enhancing the hepatocytes nuclei structure

Background:The liver is fundamental for keeping up the entire body’s homeostasis.The liver hepatocytes have been shown to undergo genomic instability with aging.The stability of the hepatocytes depends on its nuclear architecture.Calorie restriction has been shown to extend life-span favorably and this may be through the reorganization of the nuclear structure.Objective:To study the effect of cyclic feeding regime on the chromatin assembly anchored to the nuclear membrane scaffold of rat models hepatocytes nuclei.Method:Rats models underwent cyclic feeding regime,after which nuclei were isolated;then,we investigated the chromatin decondensation and nuclear membrane disintegration of the hepatocytes using fluorescence imaging methods.Results:In 60 seconds,protease decondensed the chromatin and disintegrated the nuclear membrane structure of controls.After the first fasting,the time increased to 145 seconds in 3-month-old rats.The first refeeding increased the time to 156 seconds with a further rise to 340 seconds following the second fasting,then dropped to 116 seconds by the second refeeding.20 months old rats showed 186 seconds increase in the time of chromatin decondensation and nuclear membrane disintegration after the first fasting,with a decrease to 140 seconds observed after first refeeding.The second fasting increased the time to 165 seconds,which then slightly decreased to 163 seconds after the second refeeding.Conclusion:These results show that intermittent fasting may have acted on chromatin histone interactions and the structural lamin networks of the nuclear membranes in bringing about nuclear stability,which is essential for normal cellular function.

氨基质子转移成像对帕金森患者小脑微结构代谢变化的初步探究

目的 探讨利用MR氨基质子转移成像(amide proton transfer,APT)和弥散张量成像(diffusion tensor image,DTI)对帕金森病(parkinson’s disease,PD)患者小脑微结构变化的临床应用价值。方法 选取我院46例PD患者为PD组进行APT和DTI检查,并选取48例健康者作为对照组。根据APT和DTI分别对感兴趣区测出MTR值和FA值,并分析组间差异。以t检验评估其参数对PD是否有一定诊断价值。结果 PD组小脑髓质的FA值和ADC值与对照组相比FA值减低,ADC值增高,差异有统计学意义(P<0.001);PD组齿状核FA值低于对照组,MTR值低于对照组,差异有统计学意义(P<0.001)。PD组黑质FA值低于对照组,MTR值低于对照组,差异有统计学意义(P<0.001)。在ROC分析中齿状核与黑质在MTR值对PD具有一定的诊断准确性(P<0.05),小脑髓质、齿状核与黑质FA值对PD具有一定的诊断准确性(P<0.05)。结论 APT可以反映PD患者小脑微结构代谢的变化,其参考值可以作为PD患者评估指标。

首发抑郁症伴自杀意念患者中缝核功能连接的改变

目的观察首发抑郁症伴自杀意念(SI)患者中缝核功能连接(FC)改变。方法前瞻性纳入98例首发抑郁症患者,根据伴SI与否将其分为伴SI组(n=56)与不伴SI组(n=42);另以47名健康志愿者为对照组。以静息态功能MRI观察背侧中缝核(DRN)、中缝中央核(MRN)与全脑间的FC;比较3组及两两组间FC,分析伴SI组差异脑区FC与临床资料的相关性。结果相比对照组,伴与不伴SI组DRN与左侧小脑及左侧壳核的FC均降低(P均<0.05),MRN与右侧颞下回的FC均升高而与左侧额下回、右侧枕上回、左侧顶下小叶及左侧壳核的FC均降低(P均<0.05);其中,伴SI组DRN与左侧壳核的FC高于不伴SI组(P<0.05);相比不伴SI组及对照组,伴SI组MRN与右侧中央后回的FC升高(P均<0.05)。伴SI组MRN与左侧壳核的FC与24项汉密尔顿抑郁量表(HAMD-24)体质量得分呈正相关(r_(s)=0.297,P=0.026)。结论首发抑郁症伴SI患者中缝核与皮层和皮层下区的FC存在异常改变,且其MRN与左侧壳核的FC与HAMD-24体质量得分呈正相关。

延胡索酸水合酶与2琥珀酸半胱氨酸在初筛延胡索酸水合酶缺陷型子宫平滑肌瘤的应用价值

目的探讨延胡索酸水合酶(fumarate hydratase,FH)和2琥珀酸半胱氨酸(2-succinocysteine,2SC)在具有奇异核特征平滑肌瘤中的表达,分析2种蛋白在初筛延胡索酸水合酶缺陷型(fumarate hydratase-deficient,FH-d)平滑肌瘤中的诊断价值。方法收集67例具有奇异核特征平滑肌瘤的临床资料,采用免疫组化EnVision两步法染色,分析FH、2SC表达与FH-d型平滑肌瘤形态学特征的相关性,并复习相关文献。结果67例患者有27例为FH-d型平滑肌瘤,FH在FH-d型平滑肌瘤中的阳性率为(2/27,7.41%),低于无FH-d形态平滑肌瘤(31/40,77.50%);2SC在FH-d型平滑肌瘤中的阳性率为(26/27,96.30%),高于无FH-d形态平滑肌瘤(11/40,27.50%)。统计学显示FH和2SC的表达存在相关性(P<0.05),且FH、2SC阳性与显著嗜酸性核仁、核仁周围空晕、嗜酸性包涵体和鹿角形血管均有关(P<0.05)。FH免疫组化染色显示FH-d型平滑肌瘤的敏感度为92.59%,特异度77.50%。2SC免疫组化染色显示FH-d型平滑肌瘤的敏感度为96.30%,特异度为72.50%。结论多数FH-d形态的平滑肌瘤中FH阴性和2SC阳性,对两者行联合检测可显著提高FH-d型平滑肌瘤的诊断准确性。

基于单细胞核转录组测序的多发性大动脉炎外周血单个核细胞图谱分析

目的基于单细胞核转录组测序(snRNA-seq)技术描绘多发性大动脉炎(TAK)外周血单个核细胞(PBMC)基因和功能的异质性改变,阐述TAK可能的免疫机制。方法收集确诊为TAK患者的PBMC共6例为疾病组(TAK组),同期就诊的健康人群6例PBMC为正常组(NC组)。基于snRNA-seq工作流程建库测序,下机数据采用R 3.6.2软件进行主成分分析(PCA)及t-分布随机邻域嵌入(tSNE)分析等手段对两组PBMC样本池的单个核细胞的基因表达进行检测。结果TAK患者PBMC的免疫细胞的相对比例和含量都发生了改变;高克隆TCR可高度同源性匹配整合素beta-3的氨基酸序列;T细胞介导的干扰素γ和TNFα通路显著上调;TNFRSF13B+记忆B细胞比例明显升高;所有细胞类型中单核细胞所形成的的配体受体相互作用始终最多。结论TAK的发生发展过程中PBMC参与了复杂的调节,多种免疫炎症因子异常表达,其中单核细胞在PBMC的相互作用中占据了重要地位。

基于Transformer与距离图谱的泛癌细胞核图像分割

肿瘤细胞的密度、核质比和平均尺寸等指标对癌症的分级和预后有重要的意义.在计算病理学中,细胞核分割是肿瘤微环境分析的基础.通过对分割结果进行统计分析,对新的肿瘤标记物的探索有重大的意义.病理图像背景下的细胞核形态不规则,细胞核染色不均匀,且细胞核边缘之间存在黏连的问题,而现有的深度学习算法在细胞核主体分割正确的情况下,边缘的分割错误不会对总体的损失造成太大的影响,黏连的细胞核很容易被当作同一个分割目标.为了解决细胞核重叠问题,本文提出一种基于Transformer与距离图谱的分割模型,将Transformer中的核心多头自注意力机制与距离图谱引导算法相结合,重视细胞核内部,弱化细胞核边界,提升对图像局部和全局上下文信息的学习能力.本文方法在两个公开数据集上的平均Dice系数为0.7979、精度为0.7561、AJI系数为0.6672、Hausdorff距离为10.11.实验结果表明,相较其他分割算法,本文方法的性能更好,能够有效提高细胞核的分割精度,同时较好地解决了细胞核之间的黏连问题.

运动疲劳通过基底神经节输出核团损伤大鼠工作记忆能力

目的:探讨基底神经节输出核团[脚内核(EPN)和黑质网状部(SNr)]内小清蛋白(PV)阳性神经元参与运动疲劳损害工作记忆能力的神经调控机制。方法:采用随机数字法将雄性SD大鼠分为对照组(Control)和疲劳组(Fatigue),选用三级递增负荷跑台训练方案,建立慢性力竭运动疲劳模型。利用Y迷宫自主交替实验评估大鼠的工作记忆能力。免疫组织化学染色观察大鼠EPN和SNr内PV和caspase-3的表达。结果:Y迷宫自主交替实验表明,疲劳组大鼠自主交替正确率较对照组大鼠呈显著性降低(P<0.05)。免疫组织化学染色结果显示,疲劳组大鼠EPN和SNr内PV阳性细胞密度和阳性纤维染色程度与对照组相比均大幅降低(P<0.05,P<0.01)。同时,疲劳组大鼠EPN和SNr内caspase-3阳性细胞密度明显升高(P<0.05,P<0.01)。结论:运动疲劳导致大鼠工作记忆能力受损,其机制可能与EPN和SNr内PV阳性神经元凋亡有关。

中微子事件IC220624A候选射电对应体J1458+4121的VLBI观测研究

收集并分析了中微子发射事件IC-220624A的候选体J1458+4121仅有的几次甚大天线阵(VLA)的历史数据;在此基础上,利用甚长基线阵列(VLBA)对其进行首次VLBI观测,观测波段为L和C波段。通过数据处理和分析研究,得到J1458+4121 VLBA的射电辐射形态。此外,利用相位参考技术,还获得J1458+4121更精确的坐标(α=14:58:20.772, δ=41:21:01.911)。VLA观测的射电总流量强度在1.4~8.4 GHz范围内呈下降趋势,说明J1458+4121的射电能谱可能是幂律谱;而VLBA观测的射电总流量强度在1.5~5 GHz范围内呈上升趋势,意味着其射电能谱在GHz波段是反转谱。因此,J1458+4121极有可能是一个年轻射电源,其中微子产生可能是由于新喷流成分的出现。该结果有助于J1458+4121的后续研究,并将中微子起源的关注对象从明亮的耀变体扩展至其他类型的活动星系核。

α-synuclein C端截短体的胞内分布

目的研究α-synuclein的4种C端截短体胞内的表达分布情况。方法PCR法获得α-synuclein的4个C端截短体基因片段,分别克隆入pEGFP-N1载体,并转染MN9D细胞、PC12细胞及SH-SY5Y细胞,于Confocal荧光显微镜下观察α-synuclein 4个C端截短体胞内的表达分布情况。结果α-synuclein的不同C端截短体胞内分布明显不一致,表现为随着C端部分的增长,α-synuclein截短体向核分布的趋势增强。结论α-synuclein的胞内定位与其C端密切相关,并且整个C端序列都可能在其核分布中发挥重要作用。

掺C-S-H纳米晶核混凝土的早期强度与收缩性能

C-S-H纳米晶核可促进水泥水化,提升混凝土早期强度发展,有利于预应力混凝土结构提前进行预应力张拉。采用C-S-H纳米晶核早强剂制备早强低收缩混凝土,探究了C-S-H纳米晶核对混凝土早期强度、收缩变形性能及其发展规律的影响。结果表明:养护温度的提升有利于纳米晶核早强性能的发挥;混凝土早期强度随纳米晶核掺量增加呈先增加后稳定的趋势,当掺量为4%时混凝土的早强效果最佳,且不影响后期强度发展。纳米晶核的早强效果优于其他传统早强剂,传统早强剂6 h强度提升幅度为10%~20%,纳米晶核强度提升幅度可达105.2%,早强效果明显。同时,掺纳米晶核混凝土的体积变形与强度发展同步,主要集中在早期,前3 d收缩率占28 d龄期时收缩率的67%,且掺入纳米晶核试件的28 d收缩率为空白组的75%,体积稳定性好,可实现预应力提前张拉。

Improved nuclear mass formula with an additional term from the Fermi gas model

Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear astrophysics.Owing to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding energies.In this study,the mass formula was improved by considering an additional term from the Fermi gas model.All nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear region.The RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6.

Isotopic dependence of the yield ratios of light fragments from different projectiles and their unified neutron skin thicknesses

The yield ratios of neutron-proton(R(n/p))and^(3)H-^(3)He(R(^(3)H∕^(3)He))with reduced rapidity from 0 to 0.5 were simulated at 50 MeV/u even-even ^(36−56)Ca+^(40)Ca,even-even ^(48−78)Ni+^(58)Ni,and ^(100−139)Sn(every third isotopes)+112 Sn for full reduced impact parameters using the isospin-dependent quantum molecular dynamics(IQMD)model.The neutron and proton density distributions and root-mean-square radii of the reaction systems were obtained using the Skyrme-Hartree-Fock model,which was used for the phase space initialization of the projectile and target in IQMD.We defined the unified neutron skin thickness asΔRnp=<r^(2)>^(1∕2) n−<r^(2)>^(1∕2)p,which was negative for neutron-deficient nuclei.The unifiedΔRnp values for nuclei with the same relative neutron excess from different isotopic chains were nearly equal,except for extreme neutron-rich isotopes,which is a type of scaling behavior.The yield ratios of the three isotopic chain-induced reactions,which depended on the reduced impact parameter and unified neutron skin thickness,were studied.The results showed that both R(n/p)and R(^(3)H∕^(3)He)decreased with a reduced impact parameter for extreme neutron-deficient isotopes;however,they increased with reduced impact parameters for extreme neutron-rich isotopes,and increased with theΔRnp of the projectiles for all reduced impact parameters.In addition,a scaling phenomenon was observed betweenΔR np and the yield ratios in peripheral colli-sions from different isotopic chain projectiles(except for extreme neutron-rich isotopes).Thus,R(n/p)and R(^(3)H∕^(3)He)from peripheral collisions were suggested as experimental probes for extracting the neutron or proton skin thicknesses of non-extreme neutron-rich nuclei from different isotopic chains.