以EVENS综合征为主要表现的高龄B细胞淋巴瘤1例

患者,男,89岁,因“发现血小板减少2天”于2022年12月5日来院就诊。血常规:WBC:5.10×10^(9)/L,Hb:84g/L,PLT:33×10^(9)/L,总胆红素36.3μmol/L,间接胆红素25.1μmol/L,LDH:1123 U/L,血清铁蛋白>1675.56 ng/m L,网织红细胞计数:0.155,网织红细胞比值:5.32%。

Sequencing a Juglans regia×J.microcarpa hybrid yields high-quality genome assemblies of parental species

Members of the genus Juglans are monecious wind-pollinated trees in the family Juglandaceae with highly heterozygous genomes,which greatly complicates genome sequence assembly.The genomes of interspecific hybrids are usually comprised of haploid genomes of parental species.We exploited this attribute of interspecific hybrids to avoid heterozygosity and sequenced an interspecific hybrid Juglans microcarpa×J.regia using a novel combination of single-molecule sequencing and optical genome mapping technologies.The resulting assemblies of both genomes were remarkably complete including chromosome termini and centromere regions.Chromosome termini consisted of arrays of telomeric repeats about 8 kb long and heterochromatic subtelomeric regions about 10 kb long.The centromeres consisted of arrays of a centromere-specific Gypsy retrotransposon and most contained genes,many of them transcribed.Juglans genomes evolved by a whole-genome-duplication dating back to the Cretaceous-Paleogene boundary and consist of two subgenomes,which were fractionated by numerous short gene deletions evenly distributed along the length of the chromosomes.Fractionation was shown to be asymmetric with one subgenome exhibiting greater gene loss than the other.The asymmetry of the process is ongoing and mirrors an asymmetry in gene expression between the subgenomes.Given the importance of J.microcarpa×J.regia hybrids as potential walnut rootstocks,we catalogued disease resistance genes in the parental genomes and studied their chromosomal distribution.We also estimated the molecular clock rates for woody perennials and deployed them in estimating divergence times of Juglans genomes and those of other woody perennials.

Micro-Nanometer Parasitic Crystal Growth and Photoluminescence Property of Unique Screw-Cone Like Zn_(2)GeO_(4)-ZnO by Combustion Oxidization

screw-cone-like Zn_(2)GeO_(4)-ZnO particles with a base diameter of approximately 400 nm and a height of 400–800 nm or so were successfully synthesised by combustion oxidation of zinc and germanium powder at 960℃.No catalyst or carrier gases were used.XRD and SEM analyses reveal that Zn_(2)GeO_(4) and ZnO grew to parasitic crystals evenly in interaction with each other.EDS images exhibit the homogeneity of the distribution of Ge and Zn.The formation mechanism is discussed and attributed to the unique growth process of the screw-cone-like Zn_(2)GeO_(4)-ZnO particles and its vapour-solid(VS)growth mechanism.In addition,the Zn_(2)GeO_(4)-ZnO particles could tune the energy level structure of nano-tetrapod ZnO,which leads to the emission peak redshift from 376 nm to 435 nm and enhances the light emission intensity in the visible light region.

APPLICATION OF JIANG YA PASTE ONTO YONGQUAN ACUPOINT FOR TREATMENT OF PRIMARY HYPERTENSION

Since 1988, the authors have appliedthe Jiangya (BP lowering) Paste preparedaccording to his empirical recipe onto bilat-eral Yongquan acupoints (K 1) for treat-ment of primary hypertension. Clinical ob-servations have demonstrated that themethod has a very good effect on loweringhypertension. The method of treatment andthe therapeutic results are reported as fol-lows.

Fine mapping and characterization of the awn inhibitor B1 locus in common wheat(Triticum aestivum L.)

Awns play an important role in seed dispersal and photosynthesis of spikes.Three major awn inhibitors(Hd,B1,and B2)are reported in wheat.However,the molecular mechanism underlying awnlessness remained unknown until recently.In this study,we identified two F8 recombinant inbred lines(RILs)that were segregating for awn length.In order to identify the causal gene for awn length in the heterozygous inbred families(HIFs),SNPs were called from RNA sequencing(RNA-Seq)data for HIF-derived progenies with long and short awns.SNPs between long and short awn plants were evenly distributed on chromosomes(chr)other than chromosome 5 A.SNPs on chr 5 A were clustered in a region distal 688 Mb on the long arm,where inhibitor B1 was located.This suggested that B1 was the causal segregating locus.We precisely mapped B1 to^1 Mb region using two HIF-derived families.Considering that the lines segregated for long,intermediate and short awn phenotypes we speculated that B1 should have a dosage effect on awn length.Two differentially expressed genes(DEGs)located in the candidate region were regarded as candidate genes for B1,because the molecular expression pattern was consistent with the phenotype.HIFs with long and short awns showed no difference on grain yield and other agronomic traits.

Preparation of TiO_(x)/γ-Al_(2)O_(3) Catalyst on Powdery γ-Al_(2)O_(3) by Using Reactive Sputtering Deposition

A layer of TiO_(x) was deposited on powdery γ-Al_(2)O_(3) by using Sat-target magnetron sputtering in microwave electron cyclotron resonance plasma.A vibrator was developed to coat the γ-Al_(2)O_(3) particles evenly by TiO_(x).The conversion efficiency of methane and both the yield and the selectivity of C_(2) hydrocarbons and C_(2)H_(2) were revealed to be superior to that by conventional chemical method.The use of vibrator is effective.

这个从句中的that起什么作用?

[问][387]新修订的《大学英语》(上海外语教育出版社,1997年12月第2版)精读第三册第8单元中有一个句子(p.175):Attitudes to wards daydreamingare changing in much the same way thatattitudes towards night dreaming havechanged.请问that在这里起什么作用呢?

Review of urban ecosystem services from 2010 to 2020:An analysis based on CiteSpace

This paper systematically combs 416 literature on urban ecosystem services (UES) in China and other countries from 2010 to 2020,and carefully interprets the abstracts of 383 effective literature.According to the classification method of the research perspectives of ecosystem services proposed by Luederitz C,the literature is divided into six categories:ecology,governance,methods / tools / guidelines,social networking,economy and planning,and Excel and CiteSpace software were used for data statistical analysis and visual processing.The research shows that:in terms of research perspectives,foreign researches are evenly distributed in six categories:ecology,governance,methods / tools / guidelines,social networking,economy and planning,while domestic research perspectives are relatively concentrated in three categories:economy,governance,methods / tools / guidelines,and the proportion of economic category is particularly significant.In terms of research contents,there are more studies on climate governance,decision-making mechanism and method innovation abroad,while there are more studies on the measurement of carbon sequestration and oxygen releasing,the evaluation of ecological security pattern and the quantitative evaluation of UES’s economic value in China,and there are less studies on institutional organization structure and policy tools,innovative methods of UES’s value evaluation,the potential role of UES on some social phenomena,the relationship between UES and residents’ behavior and perception.

How to Identify Leap Years

A leap year has 366 days.Most years,ofcourse,have only 365 days.Leap year occurs everyfour years.Years that can be divided evenly byfour are almost always leap years.For example,

A New Process For RE-Treated Steel

A new process to manufacture RE-containing heavy cast steel ingots hasbeen:co-developed by Anshan Iron andSteel Corporation,Beijing University ofScience and Technology and MetalInstitute,Academia Sinica.In the process,a special movableequipment is employed to inject REalloy powder and argon,the RE carrier,into a tube.The RE alloy is swiftlymelted in the tube and evenly dis-tributed in molten steel which is thencast into ingots.Test production formore than ten thousand tons of suchsteel proved that by adopting thisprocess better RE distribution andhigher RE recovery(over 50%)in thesteel were achieved in comparison withthe oresent available data.The ratio

素数与合数

若a和b是自然数,且a=bq其中q也是个自然数,则q叫做是由数a除以数b所得到的商,并记作q=a/b.也可以说a能被b整除,或b除a而无余数。能除尽a的任何一个数b都叫做a的因数.数a本身相对于它的因数来说叫做倍数.因此,b的倍数是b,2b,3b,…数2的任何倍数（也就是能被2除尽的数）叫做偶数,不能被2整除的数叫做奇数.每一个自然数或是偶数,或是奇数.若两数a1,a2都是b的倍数,则它们的和a1+a2也是b的倍数.这显然可从下列得到:

Combination therapy using evening primrose oil and electrical stimulation to improve nerve function following a crush injury of sciatic nerve in male rats

Peripheral nerve injuries with a poor prognosis are common.Evening primrose oil（EPO） has beneficial biological effects and immunomodulatory properties.Since electrical activity plays a major role in neural regeneration,the present study investigated the effects of electrical stimulation（ES）,combined with evening primrose oil（EPO）,on sciatic nerve function after a crush injury in rats.In anesthetized rats,the sciatic nerve was crushed using small haemostatic forceps followed by ES and/or EPO treatment for 4 weeks.Functional recovery of the sciatic nerve was assessed using the sciatic functional index.Histopathological changes of gastrocnemius muscle atrophy were investigated by light microscopy.Electrophysiological changes were assessed by the nerve conduction velocity of sciatic nerves.Immunohistochemistry was used to determine the remyelination of the sciatic nerve following the interventions.EPO ＋ ES,EPO,and ES obviously improved sciatic nerve function assessed by the sciatic functional index and nerve conduction velocity of the sciatic nerve at 28 days after operation.Expression of the peripheral nerve remyelination marker,protein zero（P0）,was increased in the treatment groups at 28 days after operation.Muscle atrophy severity was decreased significantly while the nerve conduction velocity was increased significantly in rats with sciatic nerve injury in the injury ＋ EPO ＋ ES group than in the EPO or ES group.Totally speaking,the combined use of EPO and ES may produce an improving effect on the function of sciatic nerves injured by a crush.The increased expression of P0 may have contributed to improving the functional effects of combination therapy with EPO and ES as well as the electrophysiological and histopathological features of the injured peripheral nerve.

Diversity of woody plant species and their relationship to physiographic factors in central Zagros forests (Case study： Perc forest, Khorramabad, Iran)

Topography is the most factor that has the greatest impact of all factor that affect the distribution. To study the diversity of trees and shrub species in the Perc forest situated in Khorramabad, Lorestan, 140 circular plots of 1200 m2 in a grid of 300 m × 250 m were surveyed, using a systematic random sampling method. In each plot, the Margalef richness index, Shannon-Wiener diversity index, Hill＇s N1 and Simpson indices and the evenness index of Simpson and Smith-Wilson were calculated and ordered on the basis of different classes of elevation, exposition and slope. The results indicated that slope did not have any significant effect on the indices. Exposition and elevation classes significant impacted the richness and diversity indices, but did not influence evenness. In general, the highest plant diversity was observed for slopes less than 15 %, northern aspects, without geographical direction, and elevations of 2100-2200 m. This information can be very useful in achieving the goals for sustainable management of forests. In addition to greater protection for regions with high diversity and reforestation （compatible species） in degraded area, we can help increase diversity in forests.

Pedodiversity: a controversial concept

The concept of pedodiversity and its measurement methodology proposed and developed by Ibá?ez research term is introduced. An attempt to apply pedodiversity to analyze spatial soil variation and distribution patterns on the global scale is briefly demonstrated. Furthermore, constructive comments and criticisms on pedodiversity and its measurement from the noted pedologists and ecologists are outlined. Finally, potential applications of pedodiversity in soil science and other relevant disciplines are discussed.

Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function

Hepatocellular carcinoma(HCC) is one of the deadliest cancers in the world and is associated with a high risk of recurrence. The development of a wide range of new therapies is therefore essential. In this study, from the perspective of supportive therapy for the prevention of HCC recurrence and preservation of liver function in HCC patients, we surveyed a variety of different therapeutic agents. We show that branched chain amino acids(BCAA) supplementation and late evening snack with BCAA, strategies that address issues of protein-energy malnutrition, are important for liver cirrhotic patients with HCC. For chemoprevention of HCC recurrence, we show that viral control after radical treatment is important. We also reviewed the therapeutic potential of antiviral drugs, sorafenib, peretinoin, iron chelators. Sorafenib is a kinase inhibitor and a standard therapy in the treatment of advanced HCC. Peretinoin is a vitamin A-like molecule that targets the retinoid nuclear receptor to induce apoptosis and inhibit tumor growth in HCC cells. Iron chelators, such as deferoxamine and deferasirox, act to prevent cancer cell growth. These chelators may have potential as combination therapies in conjunction with peretinoin. Finally, we review the potential inhibitory effect of bone marrow cells on hepatocarcinogenesis.

Spatial pattern of tree diversity and evenness across forest types in Majella National Park,Italy

Background： Estimation of tree diversity at broader scale is important for conservation planning. Tree diversity should be measured and understood in terms of diversity and evenness, two integral components to describe the structure of a biological community. Variation of the tree diversity and evenness with elevation, topographic relief, aspect, terrain shape, slope, soil nutrient, solar radiation etc. are well documented. Methods： Present study explores the variation of tree diversity （measured as Shannon diversity and evenness indices） of Majella National Park, italy with five available forest types namely evergreen oak woods, deciduous oak woods, blacWaleppo pine stands, hop-hornbeam forest and beech forest, using satellite, environmental and field data. Results： Hop-hornbeam forest was found to be most diverse and even while evergreen Oak woods was the lowest diverse and even. Diversity and evenness of forest types were concurrent to each other i.e. forest type which was more diverse was also more even. As a broad pattern, majority portion of the study area belonged to medium diversity and high evenness class. Conclusions： Satellite images and other GIS data proved useful tools in monitoring variation of tree diversity and evenness across various forest types. Present study findings may have implications in prioritizing conservation zones of high tree diversity at Majella.

Effect of livestock grazing and human uses on herbaceous species diversity in oriental beech(Fagus orientalis Lipsky) forests, Guilan, Masal, northern Iran

Plant diversity plays key ecological roles in forest ecosystems, including influencing succession, resilience and nutrient cycling. This study was conducted to investigate the effect of livestock grazing and human uses on herbaceous species diversity. We surveyed 50 ha of protected area and 50 ha of unprotected area to evaluate herbaceous species diversity in oriental beech （Fagus orientalis Lipsky） forests in northern Iran. We calculated and compared three indices each of diversity and evenness, and species richness between the two areas. Herbaceous cover was higher in the unprotected area while leaf litter depth and tree canopy cover were higher in the protected area. The diversity indices, H （Shan- non-Wiener index ）, N~ （McArthur index）, N2 （Hill＇s index）, EQ （Modified Nee index）, E,ar （Smith-Wilson index）, E5 （modified index of Hill） and R=S （species richness） and species richness R=S were greater in the protected area than in the unprotected area, suggesting that protection from grazing results in increased numbers of plants and species. The effect of land protection on plant diversity was more pronounced for evenness than for species richness and the positive correlation between diversity and evenness indices was higher than that between diversity and richness.

Species Diversity Based on Vertical Structure as Indicators of Artificial Restoration for Coniferous Forests in Southwest China

Five indices of species richness, species diversity and species evenness were used to assess a diversity of four types of coniferous forests undergone different artificial regeneration time. The study was based on the vertical structure of forests, involving growth-forms of total plants as well as vertical layers of woody plants. The results showed that, except for the fourth layer of woody plants, the vertical structure of the four forests exhibited significant difference in terms of their species richness, species diversity and species evenness, suggesting that a species diversity index provided more detailed information and was a better index reflecting the regeneration processes in this region. It was recommended that silvicultural management of artificially regenerated forests should be strengthened to conserve the biodiversity of the forests, optimize forest structure and, in the long run, promote sustainable development of forest ecosystems.

英语中的逻辑主谓关系

英语中除了句子结构上的主谓关系外,还有其他形式的主谓关系,这就是存在于不同结构中通过各种形式体现出来的内在的意义上的逻辑主谓关系。正确认识这种逻辑主谓关系,对于理解原文,判断意义的正误乃至正确运用句子都是非常重要的。下面谈谈表现逻辑主谓关系的几种形式及用法。一、复合宾语中的逻辑主谓关系复合宾语由宾语和宾语补足语构成,它们在逻辑上是主语和谓语的关系,宾语是逻辑主语,宾语补语是逻辑谓语。