Exclusive Hypothesis Testing for Cox's Proportional Hazards Model

Exclusive hypothesis testing is a new and special class of hypothesis testing.This kind of testing can be applied in survival analysis to understand the association between genomics information and clinical information about the survival time.Besides,it is well known that Cox's proportional hazards model is the most commonly used model for regression analysis of failure time.In this paper,the authors consider doing the exclusive hypothesis testing for Cox's proportional hazards model with right-censored data.The authors propose the comprehensive test statistics to make decision,and show that the corresponding decision rule can control the asymptotic TypeⅠerrors and have good powers in theory.The numerical studies indicate that the proposed approach works well for practical situations and it is applied to a set of real data arising from Rotterdam Breast Cancer Data study that motivated this study.

Testing noncommutative spacetimes and violations of the Pauli Exclusion Principle through underground experiments

We propose to deploy limits that arise from different tests of the Pauli Exclusion Principle： i） to provide theories of quantum gravity with experimental guidance; ii） to distinguish, among the plethora of possible models, the ones that are already ruled out by current data; iii） to direct future attempts to be in accordance with experimental constraints. We first review experimental bounds on nuclear processes forbidden by the Pauli Exclusion Principle,which have been derived by several experimental collaborations making use of various detector materials. Distinct features of the experimental devices entail sensitivities on the constraints hitherto achieved that may differ from one another by several orders of magnitude. We show that with choices of these limits, well-known examples of flat noncommutative space-time instantiations of quantum gravity can be heavily constrained, and eventually ruled out.We devote particular attention to the analysis of the κ-Minkowski and θ-Minkowski noncommutative spacetimes.These are deeply connected to some scenarios in string theory, loop quantum gravity, and noncommutative geometry.We emphasize that the severe constraints on these quantum spacetimes, although they cannot rule out theories of top-down quantum gravity to which they are connected in various ways, provide a powerful limitation for those models. Focus on this will be necessary in the future.