<strong>Background:</strong> Facial isometric exercise is a static contraction of facial muscles without any visible movement in the angle of the joints. To examine the effects of facial isometric exercise...<strong>Background:</strong> Facial isometric exercise is a static contraction of facial muscles without any visible movement in the angle of the joints. To examine the effects of facial isometric exercise on subjective stress and oxidative stress/antioxidant capacity. <strong>Methods:</strong> In this study, we included 13 participants (6 males, 7 females;average age, 44.8 ± 19.6 years;age range: 20 - 74 years) who were exposed to constant temperature and humidity in a room. Fifteen minutes after entering the room, the force was measured before and after facial isometric exercise of the target muscles: upper lip levator, small zygomatic, large zygomatic, levator animus, laughing, buccal, muzzle, mental, temporal, masseter, and cervical muscles), and further evaluated by comparing the facial isometric exercise group and control (non-facial isometric exercise) group (crossover test). <strong>Results:</strong> Subjective stress significantly improved by 8.7 ± 16.3 in the facial isometric exercise group, and no significant difference in oxidative stress level was observed in both the groups. However, the antioxidant capacity significantly increased by 126.8 ± 168.1 μmol/l in the facial isometric exercise group. <strong>Conclusion:</strong> The results of this study suggest that facial isometric exercise is an exercise therapy that can provide mental stability and antiaging effects due to improvement in subjective stress and biological antioxidant potential.展开更多
Parkinson's disease is a neurodegenerative disease.Oxidative stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in ...Parkinson's disease is a neurodegenerative disease.Oxidative stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this disease.Physical exercise can regulate oxidative stress.The purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's disease.The aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise program.Our results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's disease.Compared with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session.Our results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme activity.These results could better help understand the target of oxidative stress in Parkinson's disease.This study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).展开更多
Purpose: The purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status,neurotrophic factor expression, and blood-brain barrier(BBB) disruption.Meth...Purpose: The purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status,neurotrophic factor expression, and blood-brain barrier(BBB) disruption.Methods: Twenty-four healthy, untrained men(12 non-obese(mean 14.9% body fat) and 12 obese subjects(mean 29.8% body fat)) performed20 min of continuous submaximal aerobic exercise at 85% maximal oxygen consumption. Blood sampling was performed to examine the oxidant-antioxidant status(reactive oxygen species(ROS) and superoxide dismutase(SOD)), neurotrophic factors(brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF)), and BBB disruption(S100β and neuron-specific enolase) before and after acute exercise.Results: The obese group showed significantly higher pre-exercise serum ROS levels and significantly lower pre-exercise serum SOD levels than the non-obese group(p < 0.05). Serum ROS, SOD, BDNF, NGF, and S100β levels were significantly increased post-exercise compared with pre-exercise levels in both the non-obese and the obese groups(p < 0.05). The obese group showed significantly higher serum ROS, BDNF, NGF,and S100β levels post-exercise compared to the non-obese group(p < 0.05).Conclusion: Our study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption,and it is assumed that oxidative stress was the main cause of this BBB disruption.展开更多
The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understo...The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understood.Exercise increases the levels of reactive oxygen species(ROS)through various mechanisms.This triggers the activation of Nrf2,a redox-sensitive transcription factor activated by increases in oxidative stress.Activation of Nrf2 mitigates oxidative stress by increasing the nuclear transcription of many antioxidant genes while also mediating additional beneficial effects through the cytoprotective nature of Nrf2 signaling.Understanding the transcriptional patterns of Nrf2 caused by exercise can help in the design of pharmacological mimicry of the process in patients who are unable to exercise for various reasons.展开更多
目的探究Ⅰ期心脏运动康复对冠心病监护病房(coronary care unit,CCU)内经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者心功能及心血管...目的探究Ⅰ期心脏运动康复对冠心病监护病房(coronary care unit,CCU)内经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者心功能及心血管不良事件(major adverse cardiovascular events,MACE)发生率的影响。方法选取2021年5月—2022年10月厦门大学附属第一医院CCU收治的需行PCI术治疗的138例急性STEMI患者为研究对象,采用随机数字表法将其分为观察组(PCI术后常规护理与Ⅰ期心脏运动康复干预,69例)及对照组(PCI术后常规护理,69例)。比较两组术前及出院时的心功能、心脏自主神经功能、抗氧化能力指标;记录两组术后1个月MACE发生率。结果出院时两组左室射血分数(left ventricular ejection fraction,LVEF)较术前明显提高,心肌肌钙蛋白(cardiac troponini,cTnI)、N末端脑钠肽前体(N-terminal-pro brain natriuretic peptide,NT-proBNP)水平较术前明显降低;观察组LVEF、NT-proBNP水平明显优于对照组,比较差异有统计学意义(P<0.05),两组cTnI水平比较差异无统计学意义(P>0.05)。两组出院时的相邻RR间期差值均方根(root mean square of successive differences,RMSSD)、相邻NN差>50 ms个数占总心跳的百分数(the percentage of adjacent NN difference>50 ms in total heartbeat,pNN50)、窦性RR间期标准差(standard deviation of NN intervals,SDNN)水平较术前明显升高,且观察组均高于对照组,比较差异有统计学意义(P<0.05)。两组出院时的血清超氧化物歧化酶(superoxide dismutase,SOD)、总抗氧化能力(total antioxidant capacity,T-AOC)水平较术前明显升高,丙二醛(malonic dialdehyde,MAD)水平明显降低,且观察组SOD、T-AOC水平明显高于对照组,MAD水平明显低于对照组,比较差异均有统计学意义(P<0.05)。观察组术后1个月MACE发生率为7.25%,对照组为11.59%,比较差异无统计学意义(P>0.05)。结论CCU内急性STEMI患者行PCI术后进行Ⅰ期心脏运动康复干预可改善其心功能及心脏自主神经功能,提高机体抗氧化能力,不增加MACE发生风险。展开更多
文摘<strong>Background:</strong> Facial isometric exercise is a static contraction of facial muscles without any visible movement in the angle of the joints. To examine the effects of facial isometric exercise on subjective stress and oxidative stress/antioxidant capacity. <strong>Methods:</strong> In this study, we included 13 participants (6 males, 7 females;average age, 44.8 ± 19.6 years;age range: 20 - 74 years) who were exposed to constant temperature and humidity in a room. Fifteen minutes after entering the room, the force was measured before and after facial isometric exercise of the target muscles: upper lip levator, small zygomatic, large zygomatic, levator animus, laughing, buccal, muzzle, mental, temporal, masseter, and cervical muscles), and further evaluated by comparing the facial isometric exercise group and control (non-facial isometric exercise) group (crossover test). <strong>Results:</strong> Subjective stress significantly improved by 8.7 ± 16.3 in the facial isometric exercise group, and no significant difference in oxidative stress level was observed in both the groups. However, the antioxidant capacity significantly increased by 126.8 ± 168.1 μmol/l in the facial isometric exercise group. <strong>Conclusion:</strong> The results of this study suggest that facial isometric exercise is an exercise therapy that can provide mental stability and antiaging effects due to improvement in subjective stress and biological antioxidant potential.
基金financially supported by Coordenacao de Aperfei a oamento de Pessoal de Nível Superior(CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Fundacao de AmparoàPesquisa do Estado do Rio Grande do Sul(FAPERGS)for financial support。
文摘Parkinson's disease is a neurodegenerative disease.Oxidative stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this disease.Physical exercise can regulate oxidative stress.The purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's disease.The aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise program.Our results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's disease.Compared with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session.Our results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme activity.These results could better help understand the target of oxidative stress in Parkinson's disease.This study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).
基金supported by the Dong-A University (Busan, Korea) research fund
文摘Purpose: The purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status,neurotrophic factor expression, and blood-brain barrier(BBB) disruption.Methods: Twenty-four healthy, untrained men(12 non-obese(mean 14.9% body fat) and 12 obese subjects(mean 29.8% body fat)) performed20 min of continuous submaximal aerobic exercise at 85% maximal oxygen consumption. Blood sampling was performed to examine the oxidant-antioxidant status(reactive oxygen species(ROS) and superoxide dismutase(SOD)), neurotrophic factors(brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF)), and BBB disruption(S100β and neuron-specific enolase) before and after acute exercise.Results: The obese group showed significantly higher pre-exercise serum ROS levels and significantly lower pre-exercise serum SOD levels than the non-obese group(p < 0.05). Serum ROS, SOD, BDNF, NGF, and S100β levels were significantly increased post-exercise compared with pre-exercise levels in both the non-obese and the obese groups(p < 0.05). The obese group showed significantly higher serum ROS, BDNF, NGF,and S100β levels post-exercise compared to the non-obese group(p < 0.05).Conclusion: Our study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption,and it is assumed that oxidative stress was the main cause of this BBB disruption.
文摘The ability of physical activity to ameliorate cardiovascular disease and improve cardiovascular health is well accepted,but many aspects of the molecular mechanisms underlying these benefits are incompletely understood.Exercise increases the levels of reactive oxygen species(ROS)through various mechanisms.This triggers the activation of Nrf2,a redox-sensitive transcription factor activated by increases in oxidative stress.Activation of Nrf2 mitigates oxidative stress by increasing the nuclear transcription of many antioxidant genes while also mediating additional beneficial effects through the cytoprotective nature of Nrf2 signaling.Understanding the transcriptional patterns of Nrf2 caused by exercise can help in the design of pharmacological mimicry of the process in patients who are unable to exercise for various reasons.
文摘目的探究Ⅰ期心脏运动康复对冠心病监护病房(coronary care unit,CCU)内经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者心功能及心血管不良事件(major adverse cardiovascular events,MACE)发生率的影响。方法选取2021年5月—2022年10月厦门大学附属第一医院CCU收治的需行PCI术治疗的138例急性STEMI患者为研究对象,采用随机数字表法将其分为观察组(PCI术后常规护理与Ⅰ期心脏运动康复干预,69例)及对照组(PCI术后常规护理,69例)。比较两组术前及出院时的心功能、心脏自主神经功能、抗氧化能力指标;记录两组术后1个月MACE发生率。结果出院时两组左室射血分数(left ventricular ejection fraction,LVEF)较术前明显提高,心肌肌钙蛋白(cardiac troponini,cTnI)、N末端脑钠肽前体(N-terminal-pro brain natriuretic peptide,NT-proBNP)水平较术前明显降低;观察组LVEF、NT-proBNP水平明显优于对照组,比较差异有统计学意义(P<0.05),两组cTnI水平比较差异无统计学意义(P>0.05)。两组出院时的相邻RR间期差值均方根(root mean square of successive differences,RMSSD)、相邻NN差>50 ms个数占总心跳的百分数(the percentage of adjacent NN difference>50 ms in total heartbeat,pNN50)、窦性RR间期标准差(standard deviation of NN intervals,SDNN)水平较术前明显升高,且观察组均高于对照组,比较差异有统计学意义(P<0.05)。两组出院时的血清超氧化物歧化酶(superoxide dismutase,SOD)、总抗氧化能力(total antioxidant capacity,T-AOC)水平较术前明显升高,丙二醛(malonic dialdehyde,MAD)水平明显降低,且观察组SOD、T-AOC水平明显高于对照组,MAD水平明显低于对照组,比较差异均有统计学意义(P<0.05)。观察组术后1个月MACE发生率为7.25%,对照组为11.59%,比较差异无统计学意义(P>0.05)。结论CCU内急性STEMI患者行PCI术后进行Ⅰ期心脏运动康复干预可改善其心功能及心脏自主神经功能,提高机体抗氧化能力,不增加MACE发生风险。
