Although AI and quantum computing (QC) are fast emerging as key enablers of the future Internet, experts believe they pose an existential threat to humanity. Responding to the frenzied release of ChatGPT/GPT-4, thousa...Although AI and quantum computing (QC) are fast emerging as key enablers of the future Internet, experts believe they pose an existential threat to humanity. Responding to the frenzied release of ChatGPT/GPT-4, thousands of alarmed tech leaders recently signed an open letter to pause AI research to prepare for the catastrophic threats to humanity from uncontrolled AGI (Artificial General Intelligence). Perceived as an “epistemological nightmare”, AGI is believed to be on the anvil with GPT-5. Two computing rules appear responsible for these risks. 1) Mandatory third-party permissions that allow computers to run applications at the expense of introducing vulnerabilities. 2) The Halting Problem of Turing-complete AI programming languages potentially renders AGI unstoppable. The double whammy of these inherent weaknesses remains invincible under the legacy systems. A recent cybersecurity breakthrough shows that banning all permissions reduces the computer attack surface to zero, delivering a new zero vulnerability computing (ZVC) paradigm. Deploying ZVC and blockchain, this paper formulates and supports a hypothesis: “Safe, secure, ethical, controllable AGI/QC is possible by conquering the two unassailable rules of computability.” Pursued by a European consortium, testing/proving the proposed hypothesis will have a groundbreaking impact on the future digital infrastructure when AGI/QC starts powering the 75 billion internet devices by 2025.展开更多
Michelangelo Antonioni is one of the notable Italian movie directors in the 20th century.He put the issue of human survival and the inner world high on his agenda.These concerns were precisely the existentialism in ph...Michelangelo Antonioni is one of the notable Italian movie directors in the 20th century.He put the issue of human survival and the inner world high on his agenda.These concerns were precisely the existentialism in philosophy,which provoked a strong reaction in the world at that time.He relied on his sharp perspective to observe social phenomena and conveyed his thoughts through his movies,thus creating an ideal world characterized by his own thoughts.The existentialism theory he employed also contributed to the development of the film industry,endowing the film with a broader sense of beauty.展开更多
BACKGROUND:Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides.Chlorfenapyr poisoning has a high mortality rate and is difficult to treat.This article aims to review the mechanisms...BACKGROUND:Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides.Chlorfenapyr poisoning has a high mortality rate and is difficult to treat.This article aims to review the mechanisms,clinical presentations,and treatment strategies for chlorfenapyr poisoning.DATA RESOURCES:We conducted a review of the literature using PubMed,Web of Science,and SpringerLink from their beginnings to the end of October 2023.The inclusion criteria were systematic reviews,clinical guidelines,retrospective studies,and case reports on chlorfenapyr poisoning that focused on its mechanisms,clinical presentations,and treatment strategies.The references in the included studies were also examined to identify additional sources.RESULTS:We included 57 studies in this review.Chlorfenapyr can be degraded into tralopyril,which is more toxic and reduces energy production by inhibiting the conversion of adenosine diphosphate to adenosine triphosphate.High fever and altered mental status are characteristic clinical presentations of chlorfenapyr poisoning.Once it occurs,respiratory failure occurs immediately,ultimately leading to cardiac arrest and death.Chlorfenapyr poisoning is diflcult to treat,and there is no specific antidote.CONCLUSION:Chlorfenapyr is a new pyrrole pesticide.Although it has been identified as a moderately toxic pesticide by the World Health Organization(WHO),the mortality rate of poisoned patients is extremely high.There is no specific antidote for chlorfenapyr poisoning.Therefore,based on the literature review,future efforts to explore rapid and effective detoxification methods,reconstitute intracellular oxidative phosphorylation couplings,identify early biomarkers of chlorfenapyr poisoning,and block the conversion of chlorfenapyr to tralopyril may be helpful for emergency physicians in the diagnosis and treatment of this disease.展开更多
Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in redu...Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in reduced blood flow and oxygen to the brain, leading to progressive symptoms and potential complications. The underlying pathophysiological mechanism remains elucidated. However, recent studies have highlighted numerous etiologic factors: abnormal immune complex responses, susceptibility genes, branched-chain amino acids, antibodies, heritable diseases, and acquired diseases, which may be the great potential triggers for the development of moyamoya disease. Its clinical presentation has varying degrees from transient asymptomatic events to significant neurological deficits. Moyamoya disease (MMD) shows different patterns in children and adults. Children with MMD are more susceptible to ischemic events due to decreased blood flow to the brain. Conversely, adults with MMD are more prone to hemorrhagic events involving brain bleeding. Children with MMD may experience a range of symptoms including motor impairments, sensory issues, seizures, headaches, dizziness, cognitive delays, or ongoing neurological problems. Although adults may present with similar clinical symptoms as children, they are more prone to experiencing sudden onset intraventricular, subarachnoid, or intracerebral hemorrhages. One of the challenges in moyamoya disease is the potential for misdiagnosis or delayed diagnosis, particularly when physicians fail to consider MMD as a possible cause in stroke patients. This review aims to provide a comprehensive overview of recent global studies on the pathophysiology of MMD, along with advancements in its management. Additionally, the review will delve into various surgical treatment options for MMD, as well as its rare occurrence alongside atrioventricular malformations. Exciting prospects include the use of autologous bone marrow transplant and the potential role of Connexin 43 protein treatment in the development of moyamoya disease.展开更多
Background: Globally, PRAKI is among the leading causes of death in pregnant women. The prevalence, causes and outcome of this condition vary among countries due to differences in environmental, socioeconomic, and hea...Background: Globally, PRAKI is among the leading causes of death in pregnant women. The prevalence, causes and outcome of this condition vary among countries due to differences in environmental, socioeconomic, and health delivery systems. The common causes that have been reported in several studies are PIH, Haemorrhages and Sepsis while the outcomes may be either complete renal recovery, progression to CKD and hence dialysis dependency or death. This study aimed at determining clinical presentation and treatment outcomes of Pregnancy-Related Acute Kidney Injury in Pregnant women admitted at the Benjamin Mkapa Hospital, Dodoma, Tanzania. Results: Out of 4007 pregnant women who were admitted to the maternity ward 51 pregnant women were found to have PRAKI. Of those with PRAKI, 74.5% were between 21 to 25 years. The leading causes of PRAKI were PPH 12 (23.53%), Eclampsia 12 (23.53%), and pre-eclampsia 12 (23.5%). Hemodialysis therapy was provided to 22 (43.1%) patients, 15 (29.4%) individuals recovered spontaneously with medical management and 14 (27.5%) missed haemodialysis therapy due to various reasons. The mortality due to PRAKI was 17 (33.3%). Conclusion and Recommendation: Pre-eclampsia/eclampsia and post-partum haemorrhage were found to be the main causes of PRAKI. The mortality related to PRAKI is high and Hemodialysis therapy is vital help to prevent deaths for pregnant women with PRAKI. Pregnant women who develop acute kidney injury should be followed closely and a nephrologist should be consulted early. Early referral should be done by the lower level facilities for all at-risk pregnant women to a specialized multidisciplinary health facility.展开更多
In the new era when demands for flexible intellectual skills are increasing,strengthening the cultivation of critical thinking ability of students has become one of the key purposes of higher education.This paper inte...In the new era when demands for flexible intellectual skills are increasing,strengthening the cultivation of critical thinking ability of students has become one of the key purposes of higher education.This paper intends to discuss how to cultivate students’critical thinking ability through English classroom presentations.It points out that during the whole process,teachers’guidance plays an indispensable role.Only when both teachers and students are aware that classroom presentations are a golden opportunity for the cultivation of students’critical thinking ability and carry this awareness into their English classes,can English presentations be brought into full play.展开更多
Based on the empirical investigation of presentation in college English classes for junior non-English majors in science and engineering universities,the author explains her own thinking on how to improve presentation...Based on the empirical investigation of presentation in college English classes for junior non-English majors in science and engineering universities,the author explains her own thinking on how to improve presentation teaching from four aspects:setting teaching objectives,selecting teaching contents,using teaching methods,and evaluating and implementing methods.展开更多
A heterogeneous information network,which is composed of various types of nodes and edges,has a complex structure and rich information content,and is widely used in social networks,academic networks,e-commerce,and oth...A heterogeneous information network,which is composed of various types of nodes and edges,has a complex structure and rich information content,and is widely used in social networks,academic networks,e-commerce,and other fields.Link prediction,as a key task to reveal the unobserved relationships in the network,is of great significance in heterogeneous information networks.This paper reviews the application of presentation-based learning methods in link prediction of heterogeneous information networks.This paper introduces the basic concepts of heterogeneous information networks,and the theoretical basis of representation learning,and discusses the specific application of the deep learning model in node embedding learning and link prediction in detail.The effectiveness and superiority of these methods on multiple real data sets are demonstrated by experimental verification.展开更多
The elements of Sartre's existentialism are shown in Shirley Jackson's The Lottery: The world abounds with absurdities and bitterness; people can be the hell to each other; an individual has a free choice and ...The elements of Sartre's existentialism are shown in Shirley Jackson's The Lottery: The world abounds with absurdities and bitterness; people can be the hell to each other; an individual has a free choice and act, but should be responsible for his or her behavior. Shirley discusses the problem of the existence of an individual in the complex web of society and environment in The Lottery, just as Sartre in his works of existentialism.展开更多
The End of the Road is John Barth's least discussed novel but it foreshadows his later themes and styles,both great achievements in American literature.By studying the parody of Existentialism embodied in the nove...The End of the Road is John Barth's least discussed novel but it foreshadows his later themes and styles,both great achievements in American literature.By studying the parody of Existentialism embodied in the novel and exploring Sartre's slogan:"existence precedes essence",It is obvious that human being's existence has become a key issue for people to reflect on.展开更多
By contrast with Sartre's existentialism,The Time Traveler's Wife depicts another humanistic world.Moreover,such things as meaning,reason,compensation and peace are indispensable in this world.
This article intends to analyze the protagnist the underground man in Notes from Underground from a new angle-existentialism.Through the analysis it displays the actual situation of the individual existence in modern ...This article intends to analyze the protagnist the underground man in Notes from Underground from a new angle-existentialism.Through the analysis it displays the actual situation of the individual existence in modern society and the tension between the individual existence and the social existence.展开更多
The Ballad of the Sad Caféis one of Mc Cullers’masterpieces.By depicting the triangle love story among the main characters—Miss Amelia,hunchbacked Cousin Lymon and Marvin Macy,the novella reveals the incredible...The Ballad of the Sad Caféis one of Mc Cullers’masterpieces.By depicting the triangle love story among the main characters—Miss Amelia,hunchbacked Cousin Lymon and Marvin Macy,the novella reveals the incredible complexity of human nature.By analyzing the absurd town,Miss Amelia’s free choices and the hellish relationship between its main characters from the Existentialist perspective,the main propositions of Existentialism have also been vividly reflected and also help to reveal the philosophical and social realistic significances behind the novella.展开更多
This thesis analyses Death of a Salesman from the perspective of existentialism.By probing into the story with Sartre's theory of freedom,this thesis concludes that the protagonist's living environment and his...This thesis analyses Death of a Salesman from the perspective of existentialism.By probing into the story with Sartre's theory of freedom,this thesis concludes that the protagonist's living environment and his choice are both responsible for his death.But it also tells us no matter how difficult our situation is,we always have freedom to choose.Everyone can live a mean ingful life through his choice.展开更多
As a special construction,existential sentences(ES) are wildly used in English.However,the Chinese,having different grammatical system,master this construction with much attention,occurring different levels of mistake...As a special construction,existential sentences(ES) are wildly used in English.However,the Chinese,having different grammatical system,master this construction with much attention,occurring different levels of mistakes during each period of learning.In this paper,the author tries to study on ES from the syntactic perspective and provide some help for English teaching through the result of an experiment.展开更多
文摘Although AI and quantum computing (QC) are fast emerging as key enablers of the future Internet, experts believe they pose an existential threat to humanity. Responding to the frenzied release of ChatGPT/GPT-4, thousands of alarmed tech leaders recently signed an open letter to pause AI research to prepare for the catastrophic threats to humanity from uncontrolled AGI (Artificial General Intelligence). Perceived as an “epistemological nightmare”, AGI is believed to be on the anvil with GPT-5. Two computing rules appear responsible for these risks. 1) Mandatory third-party permissions that allow computers to run applications at the expense of introducing vulnerabilities. 2) The Halting Problem of Turing-complete AI programming languages potentially renders AGI unstoppable. The double whammy of these inherent weaknesses remains invincible under the legacy systems. A recent cybersecurity breakthrough shows that banning all permissions reduces the computer attack surface to zero, delivering a new zero vulnerability computing (ZVC) paradigm. Deploying ZVC and blockchain, this paper formulates and supports a hypothesis: “Safe, secure, ethical, controllable AGI/QC is possible by conquering the two unassailable rules of computability.” Pursued by a European consortium, testing/proving the proposed hypothesis will have a groundbreaking impact on the future digital infrastructure when AGI/QC starts powering the 75 billion internet devices by 2025.
文摘Michelangelo Antonioni is one of the notable Italian movie directors in the 20th century.He put the issue of human survival and the inner world high on his agenda.These concerns were precisely the existentialism in philosophy,which provoked a strong reaction in the world at that time.He relied on his sharp perspective to observe social phenomena and conveyed his thoughts through his movies,thus creating an ideal world characterized by his own thoughts.The existentialism theory he employed also contributed to the development of the film industry,endowing the film with a broader sense of beauty.
基金supported by the Research Foundation of Ningbo No.2 Hospital (2023HMKY49)Ningbo Key Support Medical Discipline (2022-F16)。
文摘BACKGROUND:Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides.Chlorfenapyr poisoning has a high mortality rate and is difficult to treat.This article aims to review the mechanisms,clinical presentations,and treatment strategies for chlorfenapyr poisoning.DATA RESOURCES:We conducted a review of the literature using PubMed,Web of Science,and SpringerLink from their beginnings to the end of October 2023.The inclusion criteria were systematic reviews,clinical guidelines,retrospective studies,and case reports on chlorfenapyr poisoning that focused on its mechanisms,clinical presentations,and treatment strategies.The references in the included studies were also examined to identify additional sources.RESULTS:We included 57 studies in this review.Chlorfenapyr can be degraded into tralopyril,which is more toxic and reduces energy production by inhibiting the conversion of adenosine diphosphate to adenosine triphosphate.High fever and altered mental status are characteristic clinical presentations of chlorfenapyr poisoning.Once it occurs,respiratory failure occurs immediately,ultimately leading to cardiac arrest and death.Chlorfenapyr poisoning is diflcult to treat,and there is no specific antidote.CONCLUSION:Chlorfenapyr is a new pyrrole pesticide.Although it has been identified as a moderately toxic pesticide by the World Health Organization(WHO),the mortality rate of poisoned patients is extremely high.There is no specific antidote for chlorfenapyr poisoning.Therefore,based on the literature review,future efforts to explore rapid and effective detoxification methods,reconstitute intracellular oxidative phosphorylation couplings,identify early biomarkers of chlorfenapyr poisoning,and block the conversion of chlorfenapyr to tralopyril may be helpful for emergency physicians in the diagnosis and treatment of this disease.
文摘Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in reduced blood flow and oxygen to the brain, leading to progressive symptoms and potential complications. The underlying pathophysiological mechanism remains elucidated. However, recent studies have highlighted numerous etiologic factors: abnormal immune complex responses, susceptibility genes, branched-chain amino acids, antibodies, heritable diseases, and acquired diseases, which may be the great potential triggers for the development of moyamoya disease. Its clinical presentation has varying degrees from transient asymptomatic events to significant neurological deficits. Moyamoya disease (MMD) shows different patterns in children and adults. Children with MMD are more susceptible to ischemic events due to decreased blood flow to the brain. Conversely, adults with MMD are more prone to hemorrhagic events involving brain bleeding. Children with MMD may experience a range of symptoms including motor impairments, sensory issues, seizures, headaches, dizziness, cognitive delays, or ongoing neurological problems. Although adults may present with similar clinical symptoms as children, they are more prone to experiencing sudden onset intraventricular, subarachnoid, or intracerebral hemorrhages. One of the challenges in moyamoya disease is the potential for misdiagnosis or delayed diagnosis, particularly when physicians fail to consider MMD as a possible cause in stroke patients. This review aims to provide a comprehensive overview of recent global studies on the pathophysiology of MMD, along with advancements in its management. Additionally, the review will delve into various surgical treatment options for MMD, as well as its rare occurrence alongside atrioventricular malformations. Exciting prospects include the use of autologous bone marrow transplant and the potential role of Connexin 43 protein treatment in the development of moyamoya disease.
文摘Background: Globally, PRAKI is among the leading causes of death in pregnant women. The prevalence, causes and outcome of this condition vary among countries due to differences in environmental, socioeconomic, and health delivery systems. The common causes that have been reported in several studies are PIH, Haemorrhages and Sepsis while the outcomes may be either complete renal recovery, progression to CKD and hence dialysis dependency or death. This study aimed at determining clinical presentation and treatment outcomes of Pregnancy-Related Acute Kidney Injury in Pregnant women admitted at the Benjamin Mkapa Hospital, Dodoma, Tanzania. Results: Out of 4007 pregnant women who were admitted to the maternity ward 51 pregnant women were found to have PRAKI. Of those with PRAKI, 74.5% were between 21 to 25 years. The leading causes of PRAKI were PPH 12 (23.53%), Eclampsia 12 (23.53%), and pre-eclampsia 12 (23.5%). Hemodialysis therapy was provided to 22 (43.1%) patients, 15 (29.4%) individuals recovered spontaneously with medical management and 14 (27.5%) missed haemodialysis therapy due to various reasons. The mortality due to PRAKI was 17 (33.3%). Conclusion and Recommendation: Pre-eclampsia/eclampsia and post-partum haemorrhage were found to be the main causes of PRAKI. The mortality related to PRAKI is high and Hemodialysis therapy is vital help to prevent deaths for pregnant women with PRAKI. Pregnant women who develop acute kidney injury should be followed closely and a nephrologist should be consulted early. Early referral should be done by the lower level facilities for all at-risk pregnant women to a specialized multidisciplinary health facility.
文摘In the new era when demands for flexible intellectual skills are increasing,strengthening the cultivation of critical thinking ability of students has become one of the key purposes of higher education.This paper intends to discuss how to cultivate students’critical thinking ability through English classroom presentations.It points out that during the whole process,teachers’guidance plays an indispensable role.Only when both teachers and students are aware that classroom presentations are a golden opportunity for the cultivation of students’critical thinking ability and carry this awareness into their English classes,can English presentations be brought into full play.
文摘Based on the empirical investigation of presentation in college English classes for junior non-English majors in science and engineering universities,the author explains her own thinking on how to improve presentation teaching from four aspects:setting teaching objectives,selecting teaching contents,using teaching methods,and evaluating and implementing methods.
基金Science and Technology Research Project of Jiangxi Provincial Department of Education(Project No.GJJ211348,GJJ211347 and GJJ2201056)。
文摘A heterogeneous information network,which is composed of various types of nodes and edges,has a complex structure and rich information content,and is widely used in social networks,academic networks,e-commerce,and other fields.Link prediction,as a key task to reveal the unobserved relationships in the network,is of great significance in heterogeneous information networks.This paper reviews the application of presentation-based learning methods in link prediction of heterogeneous information networks.This paper introduces the basic concepts of heterogeneous information networks,and the theoretical basis of representation learning,and discusses the specific application of the deep learning model in node embedding learning and link prediction in detail.The effectiveness and superiority of these methods on multiple real data sets are demonstrated by experimental verification.
文摘The elements of Sartre's existentialism are shown in Shirley Jackson's The Lottery: The world abounds with absurdities and bitterness; people can be the hell to each other; an individual has a free choice and act, but should be responsible for his or her behavior. Shirley discusses the problem of the existence of an individual in the complex web of society and environment in The Lottery, just as Sartre in his works of existentialism.
文摘The End of the Road is John Barth's least discussed novel but it foreshadows his later themes and styles,both great achievements in American literature.By studying the parody of Existentialism embodied in the novel and exploring Sartre's slogan:"existence precedes essence",It is obvious that human being's existence has become a key issue for people to reflect on.
文摘By contrast with Sartre's existentialism,The Time Traveler's Wife depicts another humanistic world.Moreover,such things as meaning,reason,compensation and peace are indispensable in this world.
文摘This article intends to analyze the protagnist the underground man in Notes from Underground from a new angle-existentialism.Through the analysis it displays the actual situation of the individual existence in modern society and the tension between the individual existence and the social existence.
文摘The Ballad of the Sad Caféis one of Mc Cullers’masterpieces.By depicting the triangle love story among the main characters—Miss Amelia,hunchbacked Cousin Lymon and Marvin Macy,the novella reveals the incredible complexity of human nature.By analyzing the absurd town,Miss Amelia’s free choices and the hellish relationship between its main characters from the Existentialist perspective,the main propositions of Existentialism have also been vividly reflected and also help to reveal the philosophical and social realistic significances behind the novella.
文摘This thesis analyses Death of a Salesman from the perspective of existentialism.By probing into the story with Sartre's theory of freedom,this thesis concludes that the protagonist's living environment and his choice are both responsible for his death.But it also tells us no matter how difficult our situation is,we always have freedom to choose.Everyone can live a mean ingful life through his choice.
文摘As a special construction,existential sentences(ES) are wildly used in English.However,the Chinese,having different grammatical system,master this construction with much attention,occurring different levels of mistakes during each period of learning.In this paper,the author tries to study on ES from the syntactic perspective and provide some help for English teaching through the result of an experiment.
