Cardiac extracellular matrix undergoes extensive and continuous turnover involved in the lesion reparation process, such as in cardiac remodeling, in hypertensive cardiac hypertrophy, in dilated cardiomyopathy, after ...Cardiac extracellular matrix undergoes extensive and continuous turnover involved in the lesion reparation process, such as in cardiac remodeling, in hypertensive cardiac hypertrophy, in dilated cardiomyopathy, after myocardial infarction in the transition to heart failure, and during the progression of left ventricular dysfunction. This report discusses most recent experimental findings and focuses on the alterations in nonmyocytic elements that are a part of heart involvement. Particular attention was given to factors that are responsible for exaggerated myocardial deposition of collagen that may be responsible for ventricular dysfunction.展开更多
文摘Cardiac extracellular matrix undergoes extensive and continuous turnover involved in the lesion reparation process, such as in cardiac remodeling, in hypertensive cardiac hypertrophy, in dilated cardiomyopathy, after myocardial infarction in the transition to heart failure, and during the progression of left ventricular dysfunction. This report discusses most recent experimental findings and focuses on the alterations in nonmyocytic elements that are a part of heart involvement. Particular attention was given to factors that are responsible for exaggerated myocardial deposition of collagen that may be responsible for ventricular dysfunction.
