Laboratory Life:Twenty Years of Experimental Research with Locals and New Comers in Remote Rural Areas

Through the Latour concept of philosophy of science of laboratory life,the life course of a(geo)ethnographer researcher is analyzed,in order to establish the emotional or more personal dimensions that do not usually appear in research papers,but that have notable relevance in qualitative research.The text is structured in three large parts:A conceptual vision of the new experimental geography;the experimental geo-ethnography in old social,new social and place scenarios;and finally,the most personal and emotional dimension of the research.The first part establishes the geo-ethnographic experimental context and the assumptions in fieldwork,in addition to the geo-ethnographic reconciliation process.In the second part,the main qualitative research problems related to mobility,resistance and dynamics in place are established.Finally,in the third part the research perceptions,the personal experiences,and the emotional dimension of the research in remote rural areas are established.The laboratory life of a researcher,allows one to establish scalar conclusions and rigor in qualitative research.

Experimental Research on Gas-Liquid Two-Phase Spiral Flow in Horizontal Pipe

In view of the importance of gas-liquid two-phase spiral flow and the few research reports at home and abroad,the gas-liquid two-phase spiral flow patterns have been researched in a horizontal pipe with different parameters investigated by means of observation and a high-speed camera.Since the appearance of spiral flow makes the distribution of twophase flow more complicated,the flow patterns appearing in the experiments were divided into the Spiral Wavy Stratified Flow(SWS),the Spiral Bubble Flow(SB),the Spiral Slug Flow(SS),the Spiral Linear Flow(SL),the Spiral Axial Flow(SA),and the Spiral Dispersed Flow(SD) by the observations and with reference to the predecessors' research achievements.A flow pattern map has been drawn up.The influence of velocity,vane angle and vane area on flow pattern conversion boundary and pressure drop has been studied,with a solid foundation laid for the future research work.

The latest advances of experimental research on targeted gene therapy for prostate cancer

The absence of effective therapies for castration-resistant prostate cancer(CRPC) establishes the need to develop novel therapeutic modality, such as targeted gene therapy, which is ideal for the treatment of CRPC. But its application has been limited due to lack of favorable gene vector and the reduction of "bystander effect". Consequently, scientists all over the world focus their main experimental research on the following four aspects: targeted gene, vector, transfer means and comprehensive therapy. In this paper, we reviewed the latest advances of experimental research on targeted gene therapy for prostate cancer.

EXPERIMENTAL RESEARCH ON THE ANTI-CANCER IMMUNOMODULA-TIVE EFFECT OF THE POLYSOCOHARIBE-PEPTIDE OF CORIOLUS VERSICOLOR

Polysocoharibe-peptide of Coriolus Versicolor (PSP) is a new anti-cancer immunomodulative drug. The present paper reports on the experimental research done with this drug. It was found that PSP had the ability to recover hemolysin HC50, to increase the weight of the thymus, and increase the alexin of serum C3 and the IgG content of tumor bearing mice. FSP also significantly raised the pha-gocytic activity of macrophages in normal mice. PSP had a significant inhibitory effect on P38S and S180 cells. At the concentration of 1 mg/ml, PSP inhibited the proliferating activity of some human tumor call lines, such as SGC 7901, SPC, SLY and Mei. It had a direct toxic effect on SPC cells. PSP significantly inhibited the synthesis of nucleic acids of Ehrlich ascites carcinoma cells. In addition, PSP was antagonistic to the side effects of chemotherapy and radiotherapy.

Experimental Research on Lower Hybrid Current Drive in Superconducting Tokamak HT-7

?Fundamental experiments on lower hybrid current drive (LHCD) have been undertaken on HT-7 superconducting tokamak. The experiments on LHCD efficiency reveal its depen- deuce on plasma density and the toroidal magnetic field. Furthermore, the experiments on HT-7 successfully demonstrate the ability for LHCD to sustain long pulse tokamak discharges, such as discharges with full non-inductive current drive for several seconds. The experimental study to improve plasma confinements by LHCD suggests that the improvement should be due to the change o f current profile. It has also been demonstrated by the experiments that the lower hybrid wave may lead to an enhanced ionization of particles in the region where the wave is deposited.

EXPERIMENTAL RESEARCH AND DESIGN ON HEAT TRANSFER OF EVAPORATOR USED IN THE LARGE QUICK FREEZE PLANT

The evaporator is the main part of a quick-freeze equipment. There are many factors influencing the heat transfer coefficient of an evaporator. The most important factors among them are the fin shape, tube diameter, distance of fin space, frost, and velocity of air flow etc. They mainly influence the thermal efficiency of an evaporator, and therefore its thermal efficiency has direct relationship with the whole efficiency of the quick freeze plant. Evaporators with different structural types have different heat transfer efficiency, in order to obtain high efficiency structure of evaporator, 8 evaporator models with different fin shape, tube diameter and tube arrangement are analyzed and compared. The calculation results show that the integral waved fins, equilateral-triangle arranged small diameter tubes and varying fin-spacing has the highest heat transfer coefficient. The experimental result also shows that the evaporator with this type of structure has better thermal efficiency. The experimental result is in good agreement with the calculation result, it can instruct engineering design for usual designer. A real quick-freeze equipment is designed and put into production. The result shows that, compared with traditional domestic quick-freeze equipments, this equipment decreases by 40% in size and by 20% in energy consumption.

Calculated and Experimental Research of Sheet Resistances of Laser-Doped Silicon Solar Cells

The calculated and experimental research of sheet resistances of crystalline silicon solar cells by dry laser doping is investigated. The nonlinear numerical model on laser melting of crystalline silicon and liquid-phase diffusion of phosphorus atoms by dry laser doping is analyzed by the finite difference method implemented in MATLAB. The melting period and melting depth of crystalline silicon as a function of laser energy density is achieved. The effective liquid-phase diffusion of phosphorus atoms in melting silicon by dry laser doping is confirmed by the rapid decrease of sheet resistances in experimental measurement. The plateau of sheet resistances is reached at around 15 Ω/. The calculated sheet resistances as a function of laser energy density is obtained and the calculated results are in good agreement with the corresponding experimental measurement. Due to the successful verification by comparison between experimental measurement and calculated results, the simulation results could be used to optimize the virtual laser doping parameters.

Experimental Research of Hexagon Multihole Armour Block on Breakwater

This paper introduces a new kind of armour block - hexagon multihole block on sloping breakwater. It has great characteristics such as good interlocking, strong resistance against waves and saving concrete. Through the hydraulic model test, the mechanism of stability of the block has been proved and the relations between stability and wave height, wave period, water depth, slope, laying method, porosity and cushion have been found. The effect of weight on steadiness have also been discovered. Finally, the method of design and some formulas are given.

Biomimetic Experimental Research on Hexapod Robot's Locomotion Planning

To provide hexapod robots with strategies of locomotion planning, observation experiments were operated on a kind of ant with the use of high speed digital photography and computer assistant analysis. Through digitalization of original analog video, locomotion characters of ants were obtained, the biomimetic foundation was laid for polynomial trajectory planning of multi-legged robots, which was deduced with mathematics method. In addition, five rules were concluded, which apply to hexapod robots marching locomotion planning. The first one is the fundamental strategy of multi-legged robots＇ leg trajectory planning. The second one helps to enhance the static and dynamic stability of multi-legged robots. The third one can improve the validity and feasibility of legs＇ falling points. The last two give criterions of multi-legged robots＇ toe trajectory figures and practical recommendatory constraints. These five rules give a good method for marching locomotion planning of multi-legged robots, and can be expended to turning planning and any other special locomotion.

Experimental Research of Automotive Needlepunched Carpets at Thermoforming Temperatures

Tensile properties with different thermoforming conditions and deformation mechanism at thermoforming temperatures of automotive needlepunched carpets made up of three layers of different materials were reported.Investigations on the tensile properties were performed as a function of thermoforming temperature,extensile speed and fiber orientation based on an orthogonal experiment design.The experimental results show that the automotive carpets are rate-dependent anisotropic one and very sensitive to the forming temperature.The tensile properties are strongly depended on the forming temperature when compared with the extensile speed and the fiber orientation.Experiments only varying with the temperature were performed because of the dominative effect of the temperature.Different deformation performances were observed with different temperatures.Deformation mechanisms at the thermoforming temperatures were presented to explain the nonlinear trend of the ultimate elongation with the temperatures based on the combination of the experimental observations and the corresponding polymer theories.

Experimental Research and Mathematical Modelling for Coal Reburning in Furnace

Reburning technology is one of the most cost-effective NOx reduction strategies for coal combustion systems. In this paper, a nitric oxide submodel incorporated into a comprehensive coal combustion model was developed for predicting NOx reduction in a 93 kW laboratory-scale coal combustion furnace by reburning. This NO submodel, including reburning mechanism, requires the solution of only two transport equations to model the behavior of NO reduction in the reburning process. A number of experiments have been performed in the same furnace, and the experimental data obtained from the optimized reburn configuration was used to validate the model. Measurements and predictions both show above 50% reduction of NO emissions for the optimized reburning process. Profile comparisons show that the predicted temperature and oxygen concentration match well with the measurements, and the general trend of predicted NO concentration is very similar to that measured. The results of this study show that the present nitric oxide submodel depicts quite well the observed behaviour of NO annihilation in the reburning process. It is expected that this usable and computationally economic model represents a useful tool to simulate the gaseous fuel reburning process for the researchers concerned with practical combustors.

An Experimental Research to Study the Microwaves transmission Characteristics of Ablating Material in Arc-Heated Plasma Flow

in this paper, an experimental research the effect of ablating material on the reflection and the transmission of microwaves in arc-heated plasma flow is presented by using the C band microwave measuring system. The results show that the ablating material with accidented surface and its high temperature have remarkably affected the reflection and the transmission of microwaves. The experiment proves that the system has outstanding precision and reliability.

To promote new energy development by top experimental research

Mr.Liu Zhenya,general manager of the State Grid and Mr.Fu Zhifang,executive vice governor of Hebei Province together with their colleagues jointly inspected the development of new energy project in Zhangbei County,Zhangjiakou City,Hebei Province.

Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice

Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue,and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines(CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in Pub Med, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance,and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR,EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application.

Numerical simulation and experimental research on the wheel brush sampling process of an asteroid sampler

To examine the environmental characteristics of the microgravity force and the weathered layer on an asteroid surface,a symmetric wheel brush asteroid sampler is proposed for the collection of particles on the asteroid surface.To study the influence of the wheel brush rotation speed on the sampling efficiency and the driving torque required for the wheel brush,the contact dynamics model between particles and sampling wheel brushes is established and a simulation and experimental verification of the sampling process are conducted.The parameter calibration of the sampled particles is studied first,and the calibrated particle parameters are used in the numerical simulation of the sampling process.The sampling results and the particle stream curves are obtained for the working conditions of different rotation speeds,and the effects of different parameter settings on the sampling efficiency are analyzed.In addition,a set of rotating symmetrical sampling wheel brush devices is built for the ground test,and the dynamic torque sensor is used to test the torque change of the wheel brush during the sampling process.The relationship between the speed of the wheel brush and the driving torque of the wheel brush motor is determined by comparing the simulation results with the test results.Results indicate that when the rotating speed of the wheel brush is faster,the sampling efficiency is higher,and the driving torque required for the sampling wheel brush is greater.Moreover,a numerical simulation analysis of the sampling process of the wheel brush sampler in a microgravity environment is conducted to determine the optimal speed condition,and the brushing test of the wheel brush sampler in the microgravity environment is verified with the drop tower method.This research proposes the structural optimization design and motor selection of a wheel brush asteroid sampler,which provides important reference value and engineering significance.

Experimental Research on Inlet Steady Swirl Distortion in an Axial Compressor with Non-Uniform Tip Clearance

The inlet swirl distortion and non-uniform tip clearance have great effects on aero-engine performance and stall margin.In this paper,the effects of paired swirl distortion on the aerodynamic stability and stall inception of a single stage axial compressor with non-uniform tip clearance are quantitatively analyzed by using the swirl distortion descriptors.The experimental results show that the paired swirl distortion dominated by co-rotating swirl improves the stability of the axial compressor.For a single-stage axial compressor with eccentricity of 100%,the stall inception starts at the maximum tip clearance with clean inlet.The initial position of the stall inception is determined by the maximum tip clearance when the small intensity paired swirl distortion exists at the compressor inlet.As the swirl intensity increases,it shifts towards the position of the counter rotating swirl vortex core.The inlet swirl will not change the type of stall inception.

Experimental Research of Surface Roughness Effects on Highly-Loaded Compressor Cascade Aerodynamics

Aircraft engines deteriorate during continuous operation under the action of external factors including fouling, corrosion, and abrasion. The increased surface roughness of compressor passage walls limits airflow and leads to flow loss. However, the partial increase of roughness may also restrain flow separation and reduce flow loss. It is necessary to explore methods that will lower compressor deterioration, thereby improving the overall performance. The experimental research on the effects of surface roughness on highly loaded compressor cascade aerodynamics has been conducted in a low-speed linear cascade wind tunnel. The different levels of roughness are arranged on the suction surface and pressure surface, respectively. Ink-trace flow visualization has been used to measure the flow field on the walls of cascades, and a five-hole probe has been traversed across one pitch at the outlet. By comparing the total pressure loss coefficient, the distributions of the secondary-flow speed vector, and flow fields of various cases, the effects of surface roughness on the aerodynamics of a highly loaded compressor cascade are analyzed and discussed. The results show that adding surface roughness on the suction surface and pressure surface make the loss decrease in most cases. Increasing the surface roughness on the suction surface causes reduced flow speed near the blade, which helps to decrease mixing loss at the cascades outlet. Meanwhile, adding surface roughness on the suction surface restrains flow separation, leading to less flow loss. Various levels of surface roughness mostly weaken the flow turning capacity to various degrees, except in specific cases.

Recent Highlights of Experimental Research for Inhibiting Tumor Growth by Using Chinese Medicine

ABSTRACT To give an overview of contemporary experimental research using Chinese medicine （CM） for the treatment of cancer. As an integral part of mainstream medicine in the People＇s Republic of China, CM emphasizes improvements in holistic physical condition instead of merely killing tumor cells, which is consistent with the current medical model that advocates patient-oriented treatment. Great progress has been made in experimental research, and the principle aspects include anti-tumor angiogenesis, inducing apoptosis and differentiation, reversing multi- drug resistance, and improving immune function. As a current hot topic in cancer research, tumor micreenvironment （TME） highlights the mutual and interdependent interaction between tumor cells and their surrounding tissues, and the CM treatment concept bears a striking resemblance to it. To date, primary points of TME include extracellular matrix remodeling, inflammation, hypoxia, and angiogenesis, but trials using CM with a focus on TME are rare. Despite considerable recent development, experimental research on CM for solving cancer issues appears insufficient. Greater efforts in this field are urgently needed.

EXPERIMENTAL RESEARCH ON INTERNAL WAVES GENERATED BY A MOVING BODY IN A STRATIFIED FLUID

Two-dimensional internal waves generated by a moving flat body in a continuous- ly stratified fluid are investigated by using three kinds of flow-visualization methods:electrolytic precipitation,hydrogen bubbles,and dye streaks.Attentions are paid mainly to the generation and propagation process in the upstream region under low internal Froude number(1/10π<F_r<1/2π).The features of the upstream disturbances as well as their relationship with stratification number K (K=1/F_r) are illustrated.The corresponding theoretical analysis is briefly presented,and by comparison,the experimental and theoretical results agree well.

Experimental research on cholesterol solution concentration sensing based on tilted fiber Bragg grating

The cholesterol solution concentration sensing characteristics based on tilted fiber Bragg grating(TFBG) are investigated by means of theoretical analysis and experiments. We prepare two groups of cholesterol solutions with the same concentration range and different refractive index ranges. The sensitivity of the two groups of solutions was 11.83 pm·m L/mg and 124.79 pm·m L/mg, respectively. The results show that the sensitivity of cholesterol solution can be improved by adjusting the refractive index range. This conclusion is valuable for measuring the concentration of fat-soluble solution.