On the Unipolar Generator: An Experimental and Theoretical Study

When studying the phenomenon of the induced electromotive force, which originates from Faraday’s unipolar inductor, the contrast between Faraday’s view of the magnetic field dynamic lines and the theory of relativity is revealed. In order to remove this contradiction, this phenomenon was studied in depth, theoretically and experimentally, using an experimental setup similar to Faraday’s. Calculations of the induced electromotive force, based on relativity on the one hand and on Faraday’s view on the other were made with the help of measurements of the magnetic field components. Accurate magnetic field measurements are confirmed by analytical calculations. Precise-induced electromotive force measurements confirmed Faraday’s view and contradicted the theory of relativity.

Stepwise multiple regressions application in liposome orthogonal experiments

Aim New statistical method was applied in data analysis of orthogonal experiments to optimize the preparation of liposome. Method Particle size, zeta potential, encapsulation efficiency and physical stability of liposomes were selected by orthogonal design as evaluating indicators. Through three statistical methods （direct observation, variance analysis and stepwise multiple regression）, the optimized preparing conditions were acquired and validated by experiment. Results All of the four indicators were different by these analyses. The validation experiments indicated that the optimized conditions by stepwise multiple regressions were better than that by traditional analysis. Conclusion Experiment results suggested that multiple regressions could avoid the weakness of direct observation and variance analysis, but more work should be done in preparing liposomes.

Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.

Optimization of rheological parameter for micro-bubble drilling fluids by multiple regression experimental design

In order to optimize plastic viscosity of 18 mPa·s circulating micro-bubble drilling fluid formula,orthogonal and uniform experimental design methods were applied,and the plastic viscosities of 36 and 24 groups of agent were tested,respectively.It is found that these two experimental design methods show drawbacks,that is,the amount of agent is difficult to determine,and the results are not fully optimized.Therefore,multiple regression experimental method was used to design experimental formula.By randomly selecting arbitrary agent with the amount within the recommended range,17 groups of drilling fluid formula were designed,and the plastic viscosity of each experiment formula was measured.Set plastic viscosity as the objective function,through multiple regressions,then quadratic regression model is obtained,whose correlation coefficient meets the requirement.Set target values of plastic viscosity to be 18,20 and 22 mPa·s,respectively,with the trial method,5 drilling fluid formulas are obtained with accuracy of 0.000 3,0.000 1 and 0.000 3.Arbitrarily select target value of each of the two groups under the formula for experimental verification of drilling fluid,then the measurement errors between theoretical and tested plastic viscosity are less than 5%,confirming that regression model can be applied to optimizing the circulating of plastic-foam drilling fluid viscosity.In accordance with the precision of different formulations of drilling fluid for other constraints,the methods result in the optimization of the circulating micro-bubble drilling fluid parameters.

Process Characterization of the Transesterification of Rapeseed Oil to Biodiesel Using Design of Experiments and Infrared Spectroscopy

For optimization of production processes and product quality,often knowledge of the factors influencing the process outcome is compulsory.Thus,process analytical technology(PAT)that allows deeper insight into the process and results in a mathematical description of the process behavior as a simple function based on the most important process factors can help to achieve higher production efficiency and quality.The present study aims at characterizing a well-known industrial process,the transesterification reaction of rapeseed oil with methanol to produce fatty acid methyl esters(FAME)for usage as biodiesel in a continuous micro reactor set-up.To this end,a design of experiment approach is applied,where the effects of two process factors,the molar ratio and the total flow rate of the reactants,are investigated.The optimized process target response is the FAME mass fraction in the purified nonpolar phase of the product as a measure of reaction yield.The quantification is performed using attenuated total reflection infrared spectroscopy in combination with partial least squares regression.The data retrieved during the conduction of the DoE experimental plan were used for statistical analysis.A non-linear model indicating a synergistic interaction between the studied factors describes the reactor behavior with a high coefficient of determination(R^(2))of 0.9608.Thus,we applied a PAT approach to generate further insight into this established industrial process.

ASD与非ASD语言发育迟缓儿童的语言行为能力差异分析

目的通过比较孤独症谱系障碍(autism spectrum disorder,ASD)与非ASD语言发育迟缓儿童的各项语言行为能力,分析两者的特征差异。方法回顾收集2020年1月至2022年12月就诊的确诊为ASD(98例)和非ASD(122例)语言发育迟缓儿童的年龄、性别、ABC量表和S-S量表得分资料,对两组儿童的结果先进行单因素分析,对单因素分析有统计学差异的项目进行多因素二元logistic回归分析。结果经单因素分析,两组儿童年龄无统计学差异,其他项目包括性别,S-S交流态度能力、S-S操作性课题能力、S-S语言理解能力、S-S语言表达能力和ABC总分均有统计学差异(均P<0.05)。采用输入法把两组有差异的性别、S-S交流态度能力、S-S操作性课题能力、S-S语言理解能力、S-S语言表达能力和ABC总分共6个项目进行多因素二元logistic回归分析,结果表明S-S交流态度能力和ABC总分两个项目是区分两组儿童的独立影响因素(均P<0.05),S-S交流态度不良和ABC总分高均是危险因素。结论S-S交流态度能力和ABC总分是区分ASD和非ASD语言发育迟缓儿童的独立影响因素,临床上对于S-S交流态度不良及ABC总分高的语言发育迟缓儿童要高度警惕是否ASD儿童。

Tiêu Equation Experimentation of Understanding by Energy Transfer Quantum Mechanics

Background: The Tiêu equation has a ground roots approach to the process of Quantum Biology and goes deeper through the incorporation of Quantum Mechanics. The process can be measured in plant, animal, and human usage through a variety of experimental or testing forms. Animal studies were conducted for which, in the first day of the study all the animals consistently gained dramatic weight, even as a toxic substance was introduced as described in the introduction of the paper to harm animal subjects which induced weight loss through toxicity. Tests can be made by incorporating blood report results. Human patients were also observed to show improvement to their health as administration of the substance was introduced to the biological mechanism and plants were initially exposed to the substance to observe results. This is consistent with the Tiêu equation which provides that wave function is created as the introduction of the substance to the biological mechanism which supports Quantum Mechanics. The Tiêu equation demonstrates that Quantum Mechanics moves a particle by temperature producing energy thru the blood-brain barrier for example. Methods: The methods for the Tiêu equation incorporate animal studies to include the substance administered through laboratory standards using Good Laboratory Practices under Title 40 C.F.R. § 158. Human patients were treated with the substance by medical professionals who are experts in their field and have knowledge to the response of patients. Plant applications were acquired for observation and guidance of ongoing experiments of animals’ representative for the biologics mechanism. Results: The animal studies along with patient blood testing results have been an impressive line that has followed the Tiêu equation to consistently show improvement in the introduction of the innovation to biologic mechanisms. The mechanism responds to the substance by producing energy to the mechanism with efficient effect. For plant observations, plant organisms responded, and were seen as showing improvement thru visual observation.

城市轨道交通S型曲线夹直线与长直线地段振动对比试验研究

夹直线在一定程度上可以保证线型连续和行车平顺,但过短的夹直线长度会导致振动叠加,影响旅客舒适度和列车运行的稳定性,增加运营维护成本。本文通过对城市轨道交通S型曲线夹直线与长直线地段振动对比试验研究,从时域、时频域、振动加速度级及地面Z振级等方面对获得的数据进行分析,解释了夹直线段振动叠加的产生机理,验证了车体垂向加速度峰值在缓直点处会出现峰值提前现象,并阐述了夹直线段的振动叠加现象对地面环境振动的影响。结论如下:车辆在通过S型曲线线形变化点时产生的冲击振动会通过钢轨以弹性波的形式向前传播,与车辆在夹直线段行驶产生的振动叠加;由于弹性波的形式传播的速度远高于车辆行驶速度,因此会导致夹直线段出现振动加速度峰值提前现象;S型曲线夹直线的垂向振动加速度的优势频率要高于长直线段,且更向高频分散;S型曲线夹直线产生的振动叠加现象不会对地面环境振动产生影响。

梓醇-川芎嗪方对SAMP8小鼠认知功能的改善作用及机制

目的:探讨梓醇-川芎嗪方(CT)对快速老化(SAMP8)小鼠认知功能的改善作用及其机制。方法:将50只14周龄SAMP8小鼠随机分为模型(Model)组、梓醇-川芎嗪方低剂量(CT-L)组、中剂量(CT-M)组、高剂量(CT-H)组、盐酸多奈哌齐组(DH组),10只14周龄快速衰老模型对照(SAMR1)小鼠作为对照(Control)组。Control组及Model组均以生理盐水灌胃,各用药组以相应药物灌胃,每日1次,连续8周。采用自主活动实验、筑巢行为实验、新物体辨别实验、Morris水迷宫实验等行为学观察。行为学观察后,检测各组小鼠海马组织超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、β-淀粉样蛋白(Aβ)1-42、p-Tau、核因子-κB(NF-κB)p65、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)及活性氧(ROS)水平,检测各组小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS含量。结果:与Model组比较,DH、CT-M、CT-H组小鼠自主活动次数、筑巢行为评分升高、对新物体辨别时间增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与CT-L组比较,CT-M组、CT-H组、DH组小鼠的自由活动次数、筑巢行为评分升高、探索新物体辨别时间明显增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与CT-M组比较,CT-H组小鼠的自由活动次数、筑巢行为评分升高、探索新物体辨别时间增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与DH组比较,CT-H组小鼠的自由活动次数、筑巢行为评分升高、探索新物体辨别时间增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与Model组比较,DH组和CT-M、CT-H组小鼠海马组织中SOD及GSH水平升高,Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。与CT-L组比较,CT-M组、CT-H组、DH组小鼠海马组织中SOD及GSH水平升高,Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。与CT-M组比较,CT-H组小鼠海马组织中SOD及GSH水平升高、Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。与DH组比较,CT-H组小鼠海马组织中SOD及GSH水平升高、Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。结论:梓醇-川芎嗪方可能通过改善氧化/还原失衡状态,抑制脑内炎症反应从而改善SAMP8小鼠的认知功能障碍,且其量效关系呈正相关。

基于SVR的PFC微观参数辅助标定方法研究

PFC数值模拟所需的微观参数通常通过人工试算的方式进行标定,该方法受标定人员经验的影响,效率较低,难以快速处理大量岩石试件。以平行黏结模型为例,建立微观参数正交试验表并进行数值模拟,以此为样本分别使用支持向量回归机(SVR)和BP神经网络模型进行训练,对室内测得的宏观参数进行预测,得到的微观参数进行数值模拟分析预测效果,若效果不佳则将模拟数据加入样本继续训练直至获得理想的结果。研究表明:利用数值模拟和机器学习相结合的正反演方法,可以高效标定微观参数,其中BP神经网络模型需要试算7次,而支持向量机模型仅需试算3次,标定效率更高。因此,基于正反演结合的SVR微观参数辅助标定方法不仅效率高、可重复性强、不受标定人员经验影响,而且适用于批量试件的标定工作。

Effect of cooking conditions and oxygen-delignification on Bambusa tulda kraft pulping using experimental design and regression models

This study was concerned on the influence of cooking liquor parameters i.e. active alkali （AA） and sulfidity, on the properties of pulp produced from Thai bamboo by means of multivariate analysis. The investigated pulp properties were cooking yield and viscosity. The experiments were performed according to a face centered cube experimental design. Then, multiple linear regression （MLR） of independent and dependent variables were conducted with SPSS software using least square method. In order to optimize process, Pareto-Optimality method was employed. The obtained regression models were characterized by both descriptive and predictive ability （R^2 ≥ 95% and Rcv^2 ≥ 93%） and allowed the kraft pulping process with an acceptable viscosity （ 1110- 1 190 ml/g） and a total yield about 50% at a sulfidity level of 20-30% with 18% AA. Results indicated that high sulfidity at a lower AA could get high viscosity and relatively low kappa number for pulps. Also oxygen delignification was studied in this research.

基于ADS-B与Mode-SEHS联合观测的民航空域风场重建方法

准确实时的风场数据对保障民航飞行安全有着重要作用,针对风场的精确重构问题,提出了一种基于飞行器监测数据的风场重建方法。旨在利用广播式自动相关监视和S模式增强型监视联合观测数据计算空域内的风观测值,并结合机器学习中的高斯过程回归模型,利用时间和空间上离散的风观测值进行模型训练,完整重建目标空域风场。实验结果表明,重建的风场风速的平均绝对误差为2.72m/s,相对误差为8.21%,风向的平均绝对误差为3.66°,证明了方法能够快速地完成准确实时的风场重建。

梓醇-川芎嗪方调控STAT3改善阿尔茨海默病神经可塑性的机制研究

目的:探讨梓醇-川芎嗪(CT)方对阿尔茨海默病(AD)的作用及转录激活蛋白3(STAT3)的影响。方法:将野生型C57BL/6J小鼠作为对照组(Control),同时将粉样前体蛋白/早老素1双转染小鼠按照随机数字表法随机分为模型组(Model)、低剂量梓醇-川芎嗪方组(CT-L)、高剂量梓醇-川芎嗪方组(CT-H),每组6只。CT-L组和CT-H组分别给予梓醇-川芎嗪方药50、100 mg/kg灌胃处理。Control组和Model组均给予等体积的生理盐水灌胃。每日1次,连续灌胃8周。水迷宫实验探索梓醇-川芎嗪对AD小鼠学习记忆能力的影响,免疫组化检测海马组织中生长相关蛋白43(GAP-43)的表达。海马神经元HT-22细胞分为空白对照组(Control组)、模型组(Model组)、低剂量梓醇-川芎嗪方组(CT-L组)、高剂量梓醇-川芎嗪方组(CT-H组)、STAT3敲除+梓醇-川芎嗪方组(CT+siSTAT3组)。通过Aβ_(1-42)构建体外AD模型,通过转染siSTAT3构建STAT3沉默的神经元模型,并加入高、低剂量的梓醇-川芎嗪方培养24 h,细胞活性检测(CCK-8)检测细胞活力,蛋白免疫印迹法(Western Blot)检测Cyclin D1、Ki-67、B细胞淋巴瘤/白血病-2(Bcl-2)、Bcl-2相关X蛋白(Bax)、NF200、GAP-43、STAT3和磷酸化的STAT3(p-STAT3)蛋白表达水平,Brdu检测细胞增殖,流式细胞术和末端脱氧核苷酸转移酶介导的dUTP缺口末端标记测定法(TUNEL)染色检测细胞凋亡。结果:梓醇-川芎嗪方可以明显缩短APP/PS1双转染小鼠的逃避潜伏期,提高目标象限停留时间和目标象限停留次数,上调海马组织GAP-43的表达,其中高剂量的梓醇-川芎嗪方作用更显著(P<0.05或P<0.01)。梓醇-川芎嗪方可以恢复AD模型细胞的活力和增殖能力,上调Cyclin D1、Ki-67、NF200、GAP-43和STAT3蛋白的表达,下调凋亡相关蛋白Bax的表达并恢复了抗凋亡Bcl-2蛋白的水平,其中高剂量梓醇-川芎嗪方的作用更显著(P<0.05或P<0.01)。而沉默STAT3逆转了梓醇-川芎嗪方对AD神经元增殖和对NF200、GAP-43蛋白表达的促进作用,阻断了梓醇-川芎嗪方对AD神经元的抗凋亡作用(P<0.05或P<0.01)。结论:梓醇-川芎嗪方可以显著改善AD模型小鼠的认知和记忆能力,且其效应具有剂量依赖性。其作用机制可能与促进神经元细胞的增殖,降低凋亡,调控STAT3的表达从而促进神经元的可塑性有关。

Kupffer cell and apoptosis in experimental HCC

INTRODUCTION Our previous study has proved that Kupffer cellsmay have an inhibitory effect on the process ofhepatocarcinogenesis,however,their inhibitorymechanism needs exploring deeply.We performed acomparative study on the expression of PCNA,Bax,P53 and apoptosis of liver cancer cells usingimmunohistochemical technology and terminaldeoxynucleotidyl transferase (TdT)-mediateddUTP-digoxigenin nick end labeling(TUNEL)

Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements

Excitation parameter preferences are key factors a ecting the performance of magnetic frequency mixing detection.A uniform experimental design method was used to analyze this influence.Using fuzzy theory,a comprehensive model is established for evaluating the e ect of magnetic frequency mixing.A polynomial is selected as the regression function to express explicitly the correlation between the excitation parameters and the frequency-mixing e ect.The excitation parameters were then optimized using genetic algorithm.Magnetic frequency mixing experiments were conducted to measure the surface hardness of some ferromagnetic materials.Frequency mixing is further enhanced under the optimal settings,resulting in an improvement in the measurement sensitivity.The results of this study support the application of the magnetic frequency mixing technique in non-destructive testing.

Modeling Approach and Analysis of the Structural Parameters of an Inductively Coupled Plasma Etcher Based on a Regression Orthogonal Design

The geometry of an inductively coupled plasma （ICP） etcher is usually considered to be an important factor for determining both plasma and process uniformity over a large wafer. During the past few decades, these parameters were determined by the ＂trial and error＂ method, resulting in wastes of time and funds. In this paper, a new approach of regression orthogonal design with plasma simulation experiments is proposed to investigate the sensitivity of the structural parameters on the uniformity of plasma characteristics. The tool for simulating plasma is CFD-ACE＋, which is commercial multi-physical modeling software that has been proven to be accurate for plasma simulation. The simulated experimental results are analyzed to get a regression equation on three structural parameters. Through this equation, engineers can compute the uniformity of the electron number density rapidly without modeling by CFD-ACE＋. An optimization performed at the end produces good results.

Experimental Study of the Interaction between Building Clusters and Flash Floods

In recent years, flash flood disasters have occurred frequently in southwest China due to the increased frequency of extreme climate events. To solve this problem, great efforts have been made in studying the process of flash flood. However, little attention was paid on bearing body of hazard, the clusters of buildings. Thus the real disaster mechanism of flash flood remains unclear.Accordingly, based on the experiments of artificial flash floods in a conceptual solid model, this paper focuses on the flood-impacted inundation characteristics of the building clusters at different locations of the gully model, in order to obtain a better understanding of the disaster process and the interaction between the flash floods and building clusters. The results showed that, in a typical smallscale flash flood gully with hot and dry climate, 1)clusters of buildings on an alluvial fan could reduce about 35% of the flooding area by blocking the diffusion of the flood to the depression areas, and could also promote the deposition in lower reaches of the river channel by blocking the overbank flow from going back into the channel, making the width-depth ratio of the channel larger. 2) The flash flood rates of disaster and hazard on the alluvial fan are generally higher than that of the inner gully. For the inner gully,buildings located on the beaches along the lower river and the transitional areas of the straight channel and channel bends can easily be affected because of their lower elevations. For the alluvial fan, buildings nearby the meanders suffer the greatest impacts because of bank collapsing and flooding. 3) The safe vertical distance from a building to the river channel is 13 m for the buildings in the inner gully under extreme floods. Below this threshold, the smaller the vertical distance is, the greater the risk exposure is. For the buildings on the alluvial fan, especially for the buildings near the concave bank of the top rush point,the horizontal distance is more important, and the safe value is 80 m under extreme floods.

A CASE STUDY IN THE APPLICATION OF SUPERSATURATED DESIGNS TO COMPUTER EXPERIMENTS

Supersaturated design is essentially a fractional factorial design in which the number of potential effects is greater than the number of runs. In this article, the supersaturated design is applied to a computer experiment through an example of steady current circuit model problem. A uniform mixed-level supersaturated design and the centered quadratic regression model are used. This example shows that supersaturated design and quadratic regression modeling method are very effective for screening effects and building the predictor. They are not only useful in computer experiments but also in industrial and other scientific experiments.

Simulation Experiments on the Reaction of CH_4-CaSO_4 and Its Carbon Kinetic Isotope Fractionation

Thermochemical sulfate reduction (TSR) in geological deposits can account for the accumulation of H2S in deep sour gas reservoirs. In this paper, thermal simulation experiments on the reaction of CH4-CaSO4 were carried out using an autoclave at high temperatures and high pressures. The products were characterized with analytical methods including carbon isotope analysis. It is found that the reaction can proceed to produce H2S, H2O and CaCO3 as the main products. Based on the experimental results, the carbon kinetic isotope fractionation was investigated, and the value of Ki (kinetic isotope effect) was calculated. The results obtained in this paper can provide useful information to explain the occurrence of H2S in deep carbonate gas reservoirs.

Experimental study on antitumor effect of arsenic trioxide in combination with cisplatin or doxorubicin on hepatocellular carcinoma

INTRODUCTIONThe main component of a traditional Chinese drug 'Pishuang'. arsenic trioxide (As2O3), has obviously selective anti-tumor effect on human hepatocellular carcinoma (HCC)in both in vitro and in vivo studies[1-5]. Due to limited effectiveness when any anti-carcinogen is used alone and obviously increased toxicity when the dose is raised, there is no exception for As2O3. Furthermore, combined chemotherapy contributes to improve therapeutic effectiveness, disperse toxicity and surmount drug-resistance,in which the combination of traditional Chinese and modern medicine has more advantages and characteristics. As a result,we made an experimental study on anti-tumor effect of As2O3in combination with cisplantin (PDD) or doxorubicin (ADM)on HCC. to investigate the possibility of AS2O3 in combination with PDD or ADM and nature of interaction between them,and to provide experimental basis for clinical application.