Computational Experiments for Complex Social Systems:Experiment Design and Generative Explanation

Powered by advanced information technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).In this context,computational experiments method has emerged as a novel approach for the design,analysis,management,control,and integration of CPSS,which can realize the causal analysis of complex systems by means of“algorithmization”of“counterfactuals”.However,because CPSS involve human and social factors(e.g.,autonomy,initiative,and sociality),it is difficult for traditional design of experiment(DOE)methods to achieve the generative explanation of system emergence.To address this challenge,this paper proposes an integrated approach to the design of computational experiments,incorporating three key modules:1)Descriptive module:Determining the influencing factors and response variables of the system by means of the modeling of an artificial society;2)Interpretative module:Selecting factorial experimental design solution to identify the relationship between influencing factors and macro phenomena;3)Predictive module:Building a meta-model that is equivalent to artificial society to explore its operating laws.Finally,a case study of crowd-sourcing platforms is presented to illustrate the application process and effectiveness of the proposed approach,which can reveal the social impact of algorithmic behavior on“rider race”.

Design and analysis of an advanced thermal management system for the solar close observations and proximity experiments spacecraft

In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.

Study on the effect and mechanism of Swertia mussotii Franch. in the treatment of primary biliary cholangitis based on bioinformatics and in vitro experiments

Background:Primary biliary cholangitis(PBC)is a chronic biliary autoimmune liver disease characterized by intrahepatic cholestasis.Swertia mussotii Franch.(SMF)is a Tibetan medicine with hepatoprotective and anti-inflammatory activities.In this study,the therapeutic effect and potential mechanisms of SMF on PBC were investigated by bioinformatics analysis and in vitro experimental validation,with the aim of promoting the progress of SMF and PBC research.Methods:We first explored the therapeutic effects and key targets of SMF on PBC using a network pharmacology approach,further screened the core targets using the GSE79850 dataset,and finally validated the results using molecular docking techniques and in vitro experiments.Results:By bioinformatics analysis,we identified core targets of SMF for PBC treatment(STAT3,JAK2,TNF-α,and IL-1β)and important signaling pathways:JAK-STAT,TNF,and PI3K-AKT.The molecular docking results showed that the significant components of SMF had good binding properties to the core targets.In vitro experiments showed that SMF extracts improved the extent of epithelial-mesenchymal transition in human intrahepatic biliary epithelial cells and had a significant reversal effect on epithelial-mesenchymal transition process markers and potential targets in PBC.Conclusion:SMF may exert its therapeutic effects on PBC by acting on important targets such as STAT3,JAK2,TNF-α,IL-1β,Vimentin,and E-cadherin and the pathways in which they are involved.

Teaching Status and Teaching Reform Ideas of Physical Chemistry Experiments for Food Quality and Safety Major

Physical chemistry experiments are an important branch of chemical experiments.In view of problems and shortcomings in physical chemistry experiment teaching of food quality and safety major in Chengdu University,the teaching methods of physical chemistry experiment course of food quality and safety major were explored and practiced,aiming to arouse students enthusiasm for experiments and cultivate their ability of independent learning,comprehensive thinking and independent problem solving.

Exploration of playa surface crusts in Qehan Lake, China through field investigation and wind tunnel experiments

Globally,many lakes are drying up,leaving exposed lakebeds where wind erosion releases dust and sand rich in salt and harmful heavy metals into the atmosphere.Therefore,understanding the characteristics and spatial distribution of playa surface crusts is important to recognize the manifestation of salt dust storms.The objective of this study was to explore the playa surface crust types as well as their spatial distribution and evolution of Qehan Lake in Inner Mongolia Autonomous Region,China to understand the salt dust release potential of different types of playa surface crusts.Various crust characteristics were investigated by field sampling in Qehan Lake,and playa surface crusts were further divided into five types:vegetated areas,salt crusts,clay flats,curly crusts,and margins.It should be noted that curly crusts were distributed in clay flats and covered only a small area in Qehan Lake.The spatial distribution characteristics of playa surface crust types were obtained by supervised classification of remote sensing images,and the salt dust release potential of crusts was explored by the wind tunnel experiments.The field investigation of Qehan Lake revealed that playa surface crust types had a circum-lake band distribution from the inside to the outside of this lake,which were successively vegetated areas,clay flats,salt crusts,and margins.The spatial distribution patterns of playa surface crust types were mainly controlled by the hydrodynamics of the playa,soil texture,and groundwater.There was a significant negative correlation between crust thickness and electrical conductivity.The results of the wind tunnel experiments showed that the initial threshold of friction wind velocity for the salt dust release was higher in clay flats(0.7–0.8 m/s)than in salt crusts(0.5–0.6 m/s).Moreover,the particle leap impact processes occurring under natural conditions may reduce this threshold value.Salinity was the main factor controlling the difference in the initial threshold of friction wind velocity for the salt dust release of clay flats and salt crusts.This study provides a scientific reference for understanding how salt dust is released from a lakebed,which may be used for ecological restoration of dry salt lakes.

Process Characterization of the Transesterification of Rapeseed Oil to Biodiesel Using Design of Experiments and Infrared Spectroscopy

For optimization of production processes and product quality,often knowledge of the factors influencing the process outcome is compulsory.Thus,process analytical technology(PAT)that allows deeper insight into the process and results in a mathematical description of the process behavior as a simple function based on the most important process factors can help to achieve higher production efficiency and quality.The present study aims at characterizing a well-known industrial process,the transesterification reaction of rapeseed oil with methanol to produce fatty acid methyl esters(FAME)for usage as biodiesel in a continuous micro reactor set-up.To this end,a design of experiment approach is applied,where the effects of two process factors,the molar ratio and the total flow rate of the reactants,are investigated.The optimized process target response is the FAME mass fraction in the purified nonpolar phase of the product as a measure of reaction yield.The quantification is performed using attenuated total reflection infrared spectroscopy in combination with partial least squares regression.The data retrieved during the conduction of the DoE experimental plan were used for statistical analysis.A non-linear model indicating a synergistic interaction between the studied factors describes the reactor behavior with a high coefficient of determination(R^(2))of 0.9608.Thus,we applied a PAT approach to generate further insight into this established industrial process.

A framework for equipment systems-of-systems effectiveness evaluation using parallel experiments approach

Equipment systems-of-systems （SOS） effectiveness evaluation can provide important reference for construction and optimization of the equipment SoS. After discussing the basic theory and methods of parallel experiments, we depict an SoS effectiveness analysis and evaluation method using parallel expe- riments theory in detail. A case study is carried out which takes the missile defense system as an example. An artificial system of the missile defense system is constructed with the multi-agent modeling method. Then, single factor, multiple factors and defense position deployment computational experiments are carried out and evaluated with the statistical analysis method. Experiment re- sults show that the altitude of the secondary interception missile is not the key factor which affects SoS effectiveness and putting the defense position ahead will increase defense effectiveness. The case study demonstrates the feasibility of the proposed method.

Review on cyclic plasticity of magnesium alloys:Experiments and constitutive models

Fatigue analysis has always been a concern in the design and assessment of Mg alloy structure components subjected to cyclic loading,and research on the cyclic plasticity is fundamental to investigate the corresponding fatigue failure.Thus,this work reviews the progress in the cyclic plasticity of Mg alloys.First,the existing macroscopic and microscopic experimental results of Mg alloys are summarized.Then,corresponding macroscopic phenomenological constitutive models and crystal plasticity-based models are reviewed.Finally,some conclusions and recommended topics on the cyclic plasticity of Mg alloys are provided to boost the further development and application of Mg alloys.

Structure and kinematic analysis of the deepwater area of the Qiongdongnan Basin through a seismic interpretation and analogue modeling experiments

Located at the northwest continental slope of the South China Sea, the Qiongdongnan Basin bears valley-shaped bathymetry deepening toward east. It is separated from the Yinggehai Basin through NW-trending Indo-China-Red River shear zone, and connected with NW subsea basin through the Xisha Trough. Along with the rapid progress of the deepwater exploration, large amounts of high resolution geophysical and geological data were accumulated. Scientific researches about deepwater basins kept revealing brand new tectonic and sedimentary discoveries. In order to summarize the structural features and main controlling factors of the deepwater Qiongdongnan Basin, a series of researches on basin architecture, fault activities, tectonic deformation and evolution were carried out. In reference to analogue modeling experiments, a tectonic situation and a basin formation mechanism were discussed. The researches indicate that：the northern boundary of the Qiongdongnan Basin is strongly controlled by No. 2 fault. The overlapping control of two stress fields from the east and the west made the central depression zone extremely thinned. Combined with the changed stress field, the segmentation of a preexisting weakness zone made the sags in the east experiencing different rifting histories from the west ones. The NE-trending west segment of the Qiongdongnan Basin experienced strong rifting during Eocene, while the roughly EW-trending sags in the east segment show strong rifting during late Eocene and early Oligocene. Local structures such as NW-trending basal fault and inherited uplifts controlled the lateral segmentation. So first order factors such as regional stress field and preexisting weakness zone controlled the basin zonation, while the second order factors determined the segmentation from east to west.

Application of Hydrothermal Diamond Anvil Cell to Homogenization Experiments of Silicate Melt Inclusions

The homogenization of silicate melt inclusions （SMIs）,small droplets of silicate melt trapped in magmatic minerals,is an important component of petrogenetic and magmatic research.Conventional homogenization experiments on SMIs use microscope-mounted heating stages capable of producing high temperatures at 1 atm and cold-seal high-pressure vessels.Heating stages are generally used for SMIs with low internal pressures and allow in situ observations of the homogenization processes.In contrast,cold-seal high-pressure vessels are generally used to heat SMIs that have high internal pressures,although the homogenized SMIs can only be observed after quenching in this approach.Here we outline an alternative approach that uses a hydrothermal diamond anvil cell （HDAC） apparatus to homogenize SMIs.This is the only current method wherein phase changes in high-internal-pressure SMIs can be observed in situ during homogenization experiments,which represents an advantage over other conventional methods.Using an HDAC apparatus prevents high-internal-pressure SMIs from decrepitating during heating by elevating their external pressure,in addition to allowing in situ observations of SMIs.The type-V HDAC that is currently being used has a shorter distance between the sample chamber and the observation window than earlier types,potentially enabling continuous observation of the processes involved in heating and SMI homogenization through an objective lens with a long working distance.Homogenization experiments using HDAC require that a number of steps,including HDAC preparation,sample preparation,sample loading,preheating,and formal heating,be carefully followed.Homogenization experiments on SMIs within granite samples from the Jiajika pegmatite deposit （Sichuan,China） are best performed using an HDAC-based approach,because the elevated proper external pressure of these SMIs,combined with a short heating duration,helps to suppress material leakage and any reactions within the SMIs,in addition to allowing in situ observations during homogenization experiments.Furthermore,using the HDAC approach has other benefits：heating rates can be precisely controlled,wafer oxidization can be prevented,and samples can be subjected to in situ microbeam analysis.In summary,homogenization using HDAC provides more reliable results than those obtained using conventional heating equipment.Future developments will include improvements to the quenching method and temperature controls for the HDAC apparatus,thereby improving the utility of this approach for SMI homogenization experiments.

Walnut Tree Grafting Experiments in Different Areas in Yunnan Province

Yunnan has an area of 2.88 million hm2 walnut trees. Due to freezing in- jury and rapid growth, however, there are a lot of iron walnuts or inferior-quality walnuts ready for grafting. In five years, we conducted experiments in Kunming （Yunnan Academy of Forestry）, Gongshan County, Gucheng City, Luliang County, and Ludian County by cleft grafting, veneer grafting, bark grafting and whip grafting. The grafting approaches should be selected according to grafting requirements, characteristics, and survival rate. For example, with a low survival rate, cleft grafting can be abandoned, and the rest approaches might be chosen as per practical demands.

Efficiency of white lupin in the removal of mercury from contaminated soils: Soil and hydroponic experiments

This study examined the ability of the white lupin to remove mercury （Hg） from a hydroponic system （Hg concentrations 0, 1.25, 2.5, 5 and 10 μmol/L） and from soil in pots and lysimeters （total Hg concentration （19.2 ± 1.9） mg/kg availability 0.07%, and （28.9 ± 0.4） mg/kg availability 0.09%, respectively）, and investigated the accumulation and distribution of Hg in different parts of the plant. White lupin roots efficiently took up Hg, but its translocation to the harvestable parts of the plant was low. The Hg concentration in the seeds posed no risk to human health according to the recommendations of the World Health Organization, but the shoots should not be used as fodder for livestock, at least when unmixed with other fodder crops. The accumulation of Hg in the hydroponically-grown plants was linear over the concentration range tested. The amount of Hg retained in the roots, relative to the shoots, was almost constant irrespective of Hg dose （90%）. In the soil experiments, Hg accumulation increased with exposure time and was the greater in the lysimeter than in the pot experiments. Although Hg removal was the greater in the hydroponic system, revealing the potential of the white lupin to extract Hg, bioaccumulation was the greatest in the lysimeter-grown plants; the latter system more likely reflects the true behaviour of white lupin in the field when Hg availability is a factor that limits Hg removal. The present results suggest that the white lupin could be used in long-term soil reclamation strategies that include the goal of profitable land use in Hg-polluted areas.

ENCLOSURE EXPERIMENTS ON AND LACUSTRINE PRACTICE FOR ELIMINATING MICROCYSTIS BLOOM

Microcystis bloom, one of the most objectionable characteristics of eutrophication in tropical and subtropical waters, occurred in Donghu Lake (East Lake) of Wuhan every summer from the 1970s up to 1984, but from 1985 up to now failed to occur there. The cause of its disappearance remained in obscurity until recently. In situ enclosure experiments in the lake for three years showed that the stocking of the filter-feeding silver carp (Hypophthalmichthys molitrix) and big-head carp (Aristichthys nobilis) played a decisive role in eliminating Microcystis bloom from the lake; but that recurrence of the bloom is possible under certain conditions. This paper presents the details and the results of enclosure experiments. The authors’ analysis of fish biomass data obtained by echo-sounding and the fishery production of the lake over the years, revealed that the recurrence of Microcystis bloom can be prevented so long as the combined biomass of silver carp and big-head carp remains at or exceeds 50 g per cubic meter of lakewater, as was the case in the lake’s 1985 fish yield of 1015 t.

Main outcomes from in situ thermo-hydro-mechanical experiments programme to demonstrate feasibility of radioactive high-level waste disposal in the Callovo-Oxfordian claystone

In the context of radioactive waste disposal,an underground research laboratory(URL)is a facility in which experiments are conducted to demonstrate the feasibility of constructing and operating a radioactive waste disposal facility within a geological formation.The Meuse/Haute-Marne URL is a sitespecific facility planned to study the feasibility of a radioactive waste disposal in the Callovo-Oxfordian(COx)claystone.The thermo-hydro-mechanical(THM)behaviour of the host rock is significant for the design of the underground nuclear waste disposal facility and for its long-term safety.The French National Radioactive Waste Management Agency(Andra)has begun a research programme aiming to demonstrate the relevancy of the French high-level waste(HLW)concept.This paper presents the programme implemented from small-scale(small diameter)boreholes to full-scale demonstration experiments to study the THM effects of the thermal transient on the COx claystone and the strategy implemented in this new programme to demonstrate and optimise current disposal facility components for HLW.It shows that the French high-level waste concept is feasible and working in the COx claystone.It also exhibits that,as for other plastic clay or claystone,heating-induced pore pressure increases and that the THM behaviour is anisotropic.

Non-equilibrium between ions and electrons inside hot spots from National Ignition Facility experiments

The non-equilibrium between ions and electrons in the hot spot can relax the ignition conditions in inertial confinement fusion[Fan et al.,Phys.Plasmas 23,010703(2016)],and obvious ion-electron non-equilibrium could be observed by our simulations of high-foot implosions when the ion-electron relaxation is enlarged by a factor of 2.On the other hand,in many shots of high-foot implosions on the National Ignition Facility,the observed X-ray enhancement factors due to ablator mixing into the hot spot are less than unity assuming electrons and ions have the same temperature[Meezan et al.,Phys.Plasmas 22,062703(2015)],which is not self-consistent because it can lead to negative ablator mixing into the hot spot.Actually,this non-consistency implies ion-electron non-equilibrium within the hot spot.From our study,we can infer that ion-electron non-equilibrium exists in high-foot implosions and the ion temperature could be~9%larger than the equilibrium temperature in some NIF shots.

Passive walker that can walk down steps:simulations and experiments

A planar passive walking model with straight legs and round feet was discussed. This model can walk down steps, both on stairs with even steps and with random steps. Simulations showed that models with small moments of inertia can navigate large height steps. Period-doubling has been observed when the space between steps grows. This period-doubling has been validated by experiments, and the results of experiments were coincident with the simulation.

Determination of Elastic and Creep Properties of Thin-film Systems from indentation Experiments

Based on the detailed computer simulation of the indentation testing on the thin-film systems, the present paper explores the detailed procedure of determining elastic properties (elastic modulusE^(f) and Poisson ratio v(f)) and creep parameters (CCREEP^(f) and nCREEP^(f)) for a simple Norton law (ε=CCREEP^(f)σ^n CREE^(f), where e is creep strain rate, and a is the stress) material for a thin film coated on a creep substrate, whose elastic properties(E^(s) and v^(s)) and creep properties (CCREEP^(s) and nCREEP^(s)) of the substrate are known, from indentation elastic and creep testing,respectively. The influences of the thickness of the thin-film and the size of the indenter on the indentation behavior have been discussed. It is shown that the boundary between the thin film and the substrate has great influence on the indentation creep behavior. The relative sizes of indentation systems are chosen so that the behavior of the indentation on the film is influenced by the substrate. The two elastic parameters E^(f) and v^(f) of the film are coupled on the influence of the elastic behavior of indentation. With the two different size indenters, the two elastic parameters E^(f) and v^(f) of the film can be uniquely determined by the indentation experimental slopes of depth to applied net section stress results. The procedure of determining of the two Norton law parameters CCREEP^(f) and nCREEP^(f) includes the following steps by the steady indentation rate d. The first step to calculate the creep indentation rate on certain loads of the two different sizes of indenters on a set of assumed values of CCREEP^(f) and nCREEP^(f)Then to build relationship between the creep indentation rate and the assumed CCREEP^(f) and nCREEP^(f) With the experimental creep indentation rate to intersect two sets of which have the same values of d. The last step is to build the CCREEP^(f) and nCREEP^(f)curves from the intersection points for the two indenters. These two curves CCREEP^(f) and nCREEP^(f)

Optimization of Grouping Evacuation Strategy in High-rise Building Fires Based on Graph Theory and Computational Experiments

It is difficult to rescue people from outside, and emergency evacuation is still a main measure to decrease casualties in high-rise building fires. To improve evacuation efficiency, a valid and easily manipulated grouping evacuation strategy is proposed. Occupants escape in groups according to the shortest evacuation route is determined by graph theory. In order to evaluate and find the optimal grouping, computational experiments are performed to design and simulate the evacuation processes. A case study shown the application in detail and quantitative research conclusions is obtained. The thoughts and approaches of this study can be used to guide actual high-rise building evacuation processes in future.

Experiments on thermo-hydro-mechanical behaviour of Opalinus Clay at Mont Terri rock laboratory, Switzerland

Repositories for deep geological disposal of radioactive waste rely on multi-barrier systems to isolate waste from the biosphere.A multi-barrier system typically comprises the natural geological barrier provided by the repository host rock e in our case the Opalinus Clay e and an engineered barrier system(EBS).The Swiss repository concept for spent fuel and vitrified high-level waste(HLW)consists of waste canisters,which are emplaced horizontally in the middle of an emplacement gallery and are separated from the gallery wall by granular backfill material(GBM).We describe here a selection of five in-situ experiments where characteristic hydro-mechanical(HM)and thermo-hydro-mechanical(THM)processes have been observed.The first example is a coupled HM and mine-by test where the evolution of the excavation damaged zone(EDZ)was monitored around a gallery in the Opalinus Clay(ED-B experiment).Measurements of pore-water pressures and convergences due to stress redistribution during excavation highlighted the HM behaviour.The same measurements were subsequently carried out in a heater test(HE-D)where we were able to characterise the Opalinus Clay in terms of its THM behaviour.These yielded detailed data to better understand the THM behaviours of the granular backfill and the natural host rock.For a presentation of the Swiss concept for HLW storage,we designed three demonstration experiments that were subsequently implemented in the Mont Terri rock laboratory:(1)the engineered barrier(EB)experiment,(2)the in-situ heater test on key-THM processes and parameters(HE-E)experiment,and(3)the full-scale emplacement(FE)experiment.The first demonstration experiment has been dismantled,but the last two ones are on-going.

Time-Modulated Hamiltonian for Interpreting Delayed-Choice Experiments via Mach-Zehnder Interferometers

Many delayed-choice experiments based on Mach-Zehnder interferometers （MZI） have been considered and made to address the fundamental problem of wave-particle duality. Conventional wisdom long holds that by inserting or removing the second beam splitter （BS2） in a controllable way, microscopic particles （photons, electrons, etc.） transporting within the MZI can lie in the quantum superposition of the wave and particle state as ψ= aw ψ wave ＋ ap ψ particle. Here we present an alternative interpretation to these delayed-choice experiments. We notice that as the BS2 is purely classical, the inserting and removing operation of the BS2 imposes a time- modulated Hamiltonian H mod （t） = a（t）Hin ＋ b（t）Hout, instead of a quantum superposition of H in and Hour as H = awHin ＋ apHout, to act upon the incident wave function. Solution of this quantum scattering problem, rather than the long held quantum eigen-problem yields a synchronically time-modulated output wave function as ψ mod （t） = a（t） ψ wave ＋b（t） ψ particle, instead of the stationary quantum superposition state ψ = aw ψ wave ＋ ap ψ particle. As a result, the probability of particle output from the MZI behaves as if they are in the superposition of the wave and particle state when many events over time accumulation are counted and averaged. We expect that these elementary but insightful analyses will shed a new light on exploring basic physics beyond the long-held wisdom of wave-particle duality and the principle of complementarity.