Chaperonins are known to facilitate the productive folding of numerous misfolded proteins. Despite their established importance, the mechanism of chaperonin-assisted protein folding remains unknown. In the present art...Chaperonins are known to facilitate the productive folding of numerous misfolded proteins. Despite their established importance, the mechanism of chaperonin-assisted protein folding remains unknown. In the present article, all-atom explicit solvent molecular dynamics （MD） simulations have been performed for the first time on rhodanese folding in a series of cavity-size and cavity-charge chaperonin mutants. A compromise between stability and flexibility of chaperonin structure during the substrate folding has been observed and the key factors affecting this dynamic process are discussed.展开更多
In this paper, deep grove ball bearing GB6206 has been chosen as research object, and the explicit dynamics analysis method in ANSYS/LS-DYNA has been used to study features of fault bearing which with a tiny pit in th...In this paper, deep grove ball bearing GB6206 has been chosen as research object, and the explicit dynamics analysis method in ANSYS/LS-DYNA has been used to study features of fault bearing which with a tiny pit in the inner ring raceway. In the process of building this bearing FEM, the following parameters have been well considered, such as boundary conditions, friction, contaction, loads and so on. Through simulation, the corresponding equivalent stress nephograms and acceleration of nodes on the inner ring raceway has been obtained. According to features of acceleration which occurs neighbor to fault pit, bearing＇s fault diagnosis has been realized. This paper provides a new way in monitoring bearing status and diagnosing fault of bearing.展开更多
基金supported by the Knowledge Innovation Programof Chinese Academy of Sciences under the Grant Nos. O82811 and KGCX2-YW-124National Natural Science Foundation of Chinaunder the Grant Nos. 20490201 and 20221603
文摘Chaperonins are known to facilitate the productive folding of numerous misfolded proteins. Despite their established importance, the mechanism of chaperonin-assisted protein folding remains unknown. In the present article, all-atom explicit solvent molecular dynamics （MD） simulations have been performed for the first time on rhodanese folding in a series of cavity-size and cavity-charge chaperonin mutants. A compromise between stability and flexibility of chaperonin structure during the substrate folding has been observed and the key factors affecting this dynamic process are discussed.
文摘In this paper, deep grove ball bearing GB6206 has been chosen as research object, and the explicit dynamics analysis method in ANSYS/LS-DYNA has been used to study features of fault bearing which with a tiny pit in the inner ring raceway. In the process of building this bearing FEM, the following parameters have been well considered, such as boundary conditions, friction, contaction, loads and so on. Through simulation, the corresponding equivalent stress nephograms and acceleration of nodes on the inner ring raceway has been obtained. According to features of acceleration which occurs neighbor to fault pit, bearing＇s fault diagnosis has been realized. This paper provides a new way in monitoring bearing status and diagnosing fault of bearing.
