The explosive reaction degree and protection from explosions are concerns in the military field.In this work,the reaction degree of the composition B explosive was investigated experimentally.Multi-layered compound st...The explosive reaction degree and protection from explosions are concerns in the military field.In this work,the reaction degree of the composition B explosive was investigated experimentally.Multi-layered compound structures were used as barriers to weaken the blast loads.A comprehensive experiment using a high-speed camera and image processing techniques,side witness plates,and bottom witness plates was presented.Using the experimental fragment velocities,fragment piercing patterns,and damage characteristics,the reaction degree of the explosive impeded by different multi-layered compound structures could be precisely differentiated.Reaction parameters of the explosive obstructed by compound structures were obtained by theoretical analysis and numerical simulations.Unlike the common method in which the explosive reaction degree is only distinguished based on the initial pressure amplitude transmitted into the explosive,a following shock wave reflected from the side steel casing was also considered.Different detonation growth paths in the explosive formed.Therefore,all these shock wave propagation characteristics must be considered to analyze the explosive response impeded by compound structures.展开更多
The experimental research on protection capability of the flying-whip multifunctional explosive reactive armor (ERA) was performed, in which the comparison experiment was made on the damage effect of the flying-whip...The experimental research on protection capability of the flying-whip multifunctional explosive reactive armor (ERA) was performed, in which the comparison experiment was made on the damage effect of the flying-whip's geometrical figuration, material property and driven velocity on the long-rod armor-piercing-projectile. The moving velocity of the flying-whip driven by different explosives and the pressure attenuation law of shock wave travelling in the back plate were measured respectively with the electric probe method and the manganin piezoresistive gauge technique. The following conclusions based on a great quantity of experimental data were drawn: compared with the sandwich ERA the flying-whip multifunctional ERA has very good protection function against the long-rod armor-piercing-projectile, the shaped charge warhead and the anti-armor tandem warhead. In addition, the composite plate made of the armor-steel and rubber plate can lessen the vibration and shock of the main armor caused by the explosion of the charge..展开更多
IntroductionEarthquake location is one of the inverse problems in seismology. The accurate earthquake source location is the basis of studies of earthquake images, the relation analysis between seismicity and tectonic...IntroductionEarthquake location is one of the inverse problems in seismology. The accurate earthquake source location is the basis of studies of earthquake images, the relation analysis between seismicity and tectonics, and the important parameters of earthquakes. It is also the basic data used to study the space distribution of aftershocks after a strong earthquake. The earthquake location accuracy mainly depends on reliability of the velocity models for the earth¢s crust, the reasonable design of the seismograph network, the accuracy of arrival time, and the location method used (ZHAO, 1983; ZHU, ZHAO, 1997; LI, et al, 1999). The reliability of the velocity model directly influences loca-tion results. The reasonable seismograph network design can improve the location accuracy; otherwise it will in-troduce ill-conditioned equations and large location error. If arrival time is not accurate, for example, if the seismic phase is wrongly identified or the time service is inaccurate, large arrival time error will be produced, and the location results and real hypocenters will be discordant. Different location algorithms adopted will produce differ-ent location errors. The residual criterion chosen has influence on location results. Besides, whether the event is correctly associated also influences the location quality. In practice, it can often be seen that large location devia-tion introduced by wrong event association.展开更多
The thermodynamic instability of zinc anodes in aqueous electrolytes leads to issues such as corrosion,hydrogen evolution reactions(HER), and dendrite growth, severely hindering the practical application of zinc-based...The thermodynamic instability of zinc anodes in aqueous electrolytes leads to issues such as corrosion,hydrogen evolution reactions(HER), and dendrite growth, severely hindering the practical application of zinc-based aqueous energy storage devices. To address these challenges, this work proposes a dualfunction zinc anode protective layer, composed of Zn-Al-In layered double oxides(ILDO) by rationally designing Zn-Al layered double hydroxides(Zn-Al LDHs) for the first time. Differing from previous works on the LDHs coatings, firstly, the ILDO layer accelerates zinc-ion desolvation and also captures and anchors SO_(4)^(2-). Secondly, the in-situ formation of the Zn-In alloy phase effectively lowers the nucleation energy barrier, thereby regulating zinc nucleation. Consequently, the zinc anode with the ILDO protective layer demonstrates long-term stability exceeding 1900 h and low voltage hysteresis of 7.5 m V at 0.5 m A cm^(-2) and 0.5 m A h cm^(-2). Additionally, it significantly enhances the rate capability and cycling performance of Zn@ILDO//MnO_(2) full batteries and Zn@ILDO//activated carbon zinc-ion hybrid capacitors.This simple and effective dual-function protective layer strategy offers a promising approach for achieving high-performance zinc-ion batteries.展开更多
Background:Ischemia-reperfusion can worsen myocardial damage and increase the risk of death.Studies have revealed that ischemic preconditioning provides the best endogenous protection against myocardial ischemia-reper...Background:Ischemia-reperfusion can worsen myocardial damage and increase the risk of death.Studies have revealed that ischemic preconditioning provides the best endogenous protection against myocardial ischemia-reperfusion injury(MIRI),and the principle of electroacupuncture(EA)preconditioning is comparable to that of myocardial ischemic preconditioning adaption.Our earlier research demonstrated that EA pretreatment inhibits the expression of calmodulin-dependent protein kinase IIδ(CaMKIIδ),sodium/calcium exchanger 1(NCX1),and cyclophilin D,hence providing protection against MIRI.However,the exact mechanism is still unknown.The expression of NCX1 mRNA is directly regulated by microRNA-214(miR-214).Moreover,it suppresses the levels of CaMKIIδand cyclophilin D.Whether these variables contribute to EA preconditioning to improve MIRI needs to be investigated,though.This study aimed to preliminarily determine whether EA pretreatment ameliorates MIRI by modulating the miR-214-3p/NCX1 axis.Methods:We used a rat MIRI model to investigate the effect of EA pretreatment on MIRI and the expression of miR-214-3p.In addition,adenovirus injection inhibited miR-214-3p expression in the rat MIRI model,and the influence of EA pretreatment towards MIRI was observed in the context of blocked miR-214-3p expression.Both the myocardial histological abnormalities and the alterations in the ST segment of the rat electrocardiogram were analyzed.NCX1 mRNA,cyclophilin D,and CaMKIIδexpression levels were also analyzed.Results:EA pretreatment improved MIRI.In rats with MIRI,EA administration increased miR-214-3p expression while decreasing NCX1 mRNA,cyclophilin D,and CaMKIIδproteins in cardiac tissues.The beneficial effect of EA pretreatment against MIRI was reversed,coupled with elevated levels of NCX1 mRNA,cyclophilin D,and CaMKIIδprotein expression,when an adenovirus injection disrupted the expression of miR-214-3p.Conclusions:Our findings preliminarily show that EA pretreatment inhibits the expression of NCX1 mRNA,cyclophilin D,and CaMKIIδproteins via miR-214-3p,hence exerting MIRI protection.展开更多
Herein an estimation is given to the efficiency of nuclear explosive devices in a space-rocket complex to withdraw Hazardous Space Objects (HS0)-asteroids and cometary nuclei from the trajectories leading to their d...Herein an estimation is given to the efficiency of nuclear explosive devices in a space-rocket complex to withdraw Hazardous Space Objects (HS0)-asteroids and cometary nuclei from the trajectories leading to their dangerous entry to the atmosphere and falling to the Earth. A conceptual choice of parameters and schemes of application of nuclear explosive devices in impact modules of space-rocket complexes to ensure asteroidal-cometary safety was made.展开更多
To explore new light-weight integrated thermal protection system panel configuration and gain good insight into the responses mechanism,heat transfer and structural field analysis for one single-layer and four double-...To explore new light-weight integrated thermal protection system panel configuration and gain good insight into the responses mechanism,heat transfer and structural field analysis for one single-layer and four double-layer corrugated core panels were performed. The obtained the temperature,buckling,stress and deflection responses were compared,and the deflection and stress distributions as well as thermal buckling mode at the time were discussed for the considered configurations when the temperature difference between the top and bottom face sheet was maximum. The results demonstrated that the non-orthogonal and hat-stiffened double-layer structures provide superior performance to resist thermal buckling deformation in comparison with other configurations. The useful information is provided for the forthcoming optimization in which thermal buckling is considered as critical design driver.展开更多
It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventual...It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventually blow up or explode in finite time. If the drift and diffusion functions are globally Lipschitz, linear growth may still be experienced, as well as a possible blow-up of solutions in finite time. In this paper, a nonlinear scalar delay differential equation with a constant time lag is perturbed by a multiplicative Ito-type time - space white noise to form a stochastic Fokker-Planck delay differential equation. It is established that no explosion is possible in the presence of any intrinsically slow time - space white noise of Ito - type as manifested in the resulting stochastic Fokker- Planck delay differential equation. Time - space white noise has a role to play since the solution of the classical nonlinear equation without it still exhibits explosion.展开更多
A comprehensive protective structure with rigidity and flexibility was put forward and designed in view of the quality and safety problems for the double vertical explosive welding of large titanium/steel cladding pla...A comprehensive protective structure with rigidity and flexibility was put forward and designed in view of the quality and safety problems for the double vertical explosive welding of large titanium/steel cladding plate.The movement speed and displacement of the protective structure was calculated by establishing its physics model.The dynamics and stabilization properties were analyzed,and the protective structure parameters were optimized and devised.The comprehensive protective structure,which is composed of rigidity unit and flexibility wall,can bear the impact of detonation wave and the high-speed movement of the cladding plate.There are no damage and deformation in the protective structure and the cladding plate.The protective structure can be used many times.The bonding rate of the Ti/steel plate obtained was nearly 100%,and there is no deformation,surface cracks,and big wave and micro-defects.Therefore,the protective problems of the double vertical explosive welding can be solved effectively by the protective structure.展开更多
This paper presents a view of some of the challenges that are presented in investigating protection methodologies against explosive blast effects. In particular, the paper is concerned with experimental efforts that c...This paper presents a view of some of the challenges that are presented in investigating protection methodologies against explosive blast effects. In particular, the paper is concerned with experimental efforts that can aid in the understanding of complex blast effects in typical real world scenarios. Current progress in the implementation of blast mitigation methodologies in the landward defence environment is reviewed.展开更多
BACKGROUND: Studies have demonstrated that β-amyloid peptide (Aβ), a characteristic pathological product of Alzheimer's disease (AD), results in neuronal endoplasmic reticulum stress (ERS). However, the mech...BACKGROUND: Studies have demonstrated that β-amyloid peptide (Aβ), a characteristic pathological product of Alzheimer's disease (AD), results in neuronal endoplasmic reticulum stress (ERS). However, the mechanisms of traditional Chinese medicine against ERS in AD are poorly understood. OBJECTIVE: To measure expression levels of protective proteins (GRP78 and GRP94) of ER molecular partners and pro-apoptotic Caspase-12 ER membrane expression following application of traditional Chinese medicine natural cerebrolysin (NC) to treat Aβ1-40-induced ERS. DESIGN, TIME AND SETTING: A parallel-controlled study was performed at the Institute of Integrated Western and Traditional Chinese Medicine, Shenzhen Hospital of Southern Medical University between September 2006 and November 2008. MATERIALS: Sprague Dawley male rats, 6-8 weeks old, were used to harvest tibial and femoral bone marrow. Isolation and purification of mesenchymal stem cells (MSCs) were established from the whole bone marrow by removing non-adherent cells in primary and passage cultures. Aβ1-40 was provided by Sigma, USA. NC was provided by Shenzhen Institute of Integrated Chinese and Western Medicine, China. NC was predominantly composed of Renshen (Radix Ginseng), Tianma (Rhizoma Gastrodiae), and Yinxingye (Ginkgo Leaf) in a proportion of 1 : 2: 2. Following conventional water extraction technology, an extract (1 : 20) was prepared. Six adult, male, New Zealand rabbits underwent intragastric administration of NC extract (0.976 g/kg per day) for 1 month to prepare NC-positive serum, and the remaining 6 rabbits received intragastric administration of physiological saline to prepare normal blank serum. METHODS: A total of 500 nmol/L Aβ1-40 was used to establish ERS models of primary cultured MSCs. AD cell models were incubated with different doses of NC-positive serum (2.5%, 5%, and 10%). MSCs treated with normal blank serum served as normal blank controls. MAIN OUTCOME MEASURES: Reverse transcription-polymerase chain reaction and fluorescent immunocytochemistry were respectively used to measure mRNA and protein expression levels of GRP78, GRP94, and Caspase-12 in MSCs. RESULTS: Following Aβ1-40 exposure, mRNA and protein expression levels of GRP78 and GRP94, as well as Caspase-12, significantly increased (P 〈 0.05), suggesting successful establishment of ERS models. Following NC-positive serum application, mRNA and protein expression levels of GRP78 and GRP94 in MSCs significantly increased (P 〈 0.05 or P 〈 0.01). However, mRNA and protein expression levels of Caspase-12 significantly decreased (P 〈 0.05, or P 〈 0.01) compared with the ERS model group. These effects were dose-dependent. CONCLUSION: NC downregulated Caspase-12 expression and upregulated GRP78 and GRP94 expression in MSCs in a dose-dependent manner under the state of Aβ1-40-induced ERS.展开更多
A novel polymer-bound 1,2-diol, 3-polystyrylsulfonyl-1,2-propanediol (6) had been prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3-chl...A novel polymer-bound 1,2-diol, 3-polystyrylsulfonyl-1,2-propanediol (6) had been prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3-chloro-1,2-propanediol in the presence of a phase transfer catalyst, n-tetrabutylammonium iodide. The capacity of resin 6 for terephthaidehyde reached 1.43 mmol/g. The aldehydic groups attached to polymer 6 reacted with hydroxylamine hydrochloride or reduced by sodium borohydride giving p-formylbenzaldoxime (yield: 89%)and p-formyl-benzalcohol (yield: 734%), respectively. The high yields of these polymer-supported reactions showed that the polymer 6 possessed the effective isolation of its reactive sites.展开更多
In order to lighten the weight of the special vehicles and improve their mobility and flexibility, the weight of all subsystems of the whole vehicle must be reduced in the general planning. A fire explosion suppressio...In order to lighten the weight of the special vehicles and improve their mobility and flexibility, the weight of all subsystems of the whole vehicle must be reduced in the general planning. A fire explosion suppression system is an important subsystem for the self-protection of vehicle, protection of crews and safety of a vehicle. The performances of the special vehicles determine their survival ability and combat capability. The composite bottle is made of aluminum alloy with externally wrapped carbon fiber ; it has been proven by a large number of tests that the new type explosion suppression fire distinguisher made of such composite materials applied in the special vehicle has reliable performance, each of its technical indexes is higher or equal to that of a steel distinguisher, and the composites can also optimize the assembly structure of the bottle, and improve the reliability and corrosion resistance. Most important is that the composite materials can effectively lighten the weight of the fire explosion suppression system to reach the target of weight reduction of the subsystem in general planning.展开更多
Diaper dermatit is among the widely seen inflamatory skin diseases in neonatals and small 0 - 18 month old children. Control of causative agents as well as providing good genital care may prevent or reduce the risk of...Diaper dermatit is among the widely seen inflamatory skin diseases in neonatals and small 0 - 18 month old children. Control of causative agents as well as providing good genital care may prevent or reduce the risk of the disease. The aim of this study is find out the effect of protective genital care on reducing the diaper dermatit development in 0 - 18 months old inpatient 0 - 18 month old children who are using antibiotic. The study was conducted as prospective half-experimetal using control-experimental groups. Our samples comprise of 0 - 18 month old children admitted at Dokuz Eylul University Practical and Research Hospital, pediatric clinic between January and May 2009, 41 0 - 18 month old children as a control group were not under protective genital care, and 42 0 - 18 month old children as an experimental group were under the protecion and using vaseline. The mothers of the experimental group 0 - 18 month old children were given education. All 0 - 18 month old children were followed-up 3 - 7 days and the collected data were evaluated in computer using Pearson’s chisquare, Fisher’s exact chi-square and Yatest-corrected chi-square tests. The diaper dermatit develop- ment ratio was 34.1% in the control group and 7.1% in the experimental group展开更多
基金The authors are very grateful for the support received from the National Natural Science Foundation of China(No.11872121).
文摘The explosive reaction degree and protection from explosions are concerns in the military field.In this work,the reaction degree of the composition B explosive was investigated experimentally.Multi-layered compound structures were used as barriers to weaken the blast loads.A comprehensive experiment using a high-speed camera and image processing techniques,side witness plates,and bottom witness plates was presented.Using the experimental fragment velocities,fragment piercing patterns,and damage characteristics,the reaction degree of the explosive impeded by different multi-layered compound structures could be precisely differentiated.Reaction parameters of the explosive obstructed by compound structures were obtained by theoretical analysis and numerical simulations.Unlike the common method in which the explosive reaction degree is only distinguished based on the initial pressure amplitude transmitted into the explosive,a following shock wave reflected from the side steel casing was also considered.Different detonation growth paths in the explosive formed.Therefore,all these shock wave propagation characteristics must be considered to analyze the explosive response impeded by compound structures.
文摘The experimental research on protection capability of the flying-whip multifunctional explosive reactive armor (ERA) was performed, in which the comparison experiment was made on the damage effect of the flying-whip's geometrical figuration, material property and driven velocity on the long-rod armor-piercing-projectile. The moving velocity of the flying-whip driven by different explosives and the pressure attenuation law of shock wave travelling in the back plate were measured respectively with the electric probe method and the manganin piezoresistive gauge technique. The following conclusions based on a great quantity of experimental data were drawn: compared with the sandwich ERA the flying-whip multifunctional ERA has very good protection function against the long-rod armor-piercing-projectile, the shaped charge warhead and the anti-armor tandem warhead. In addition, the composite plate made of the armor-steel and rubber plate can lessen the vibration and shock of the main armor caused by the explosion of the charge..
文摘IntroductionEarthquake location is one of the inverse problems in seismology. The accurate earthquake source location is the basis of studies of earthquake images, the relation analysis between seismicity and tectonics, and the important parameters of earthquakes. It is also the basic data used to study the space distribution of aftershocks after a strong earthquake. The earthquake location accuracy mainly depends on reliability of the velocity models for the earth¢s crust, the reasonable design of the seismograph network, the accuracy of arrival time, and the location method used (ZHAO, 1983; ZHU, ZHAO, 1997; LI, et al, 1999). The reliability of the velocity model directly influences loca-tion results. The reasonable seismograph network design can improve the location accuracy; otherwise it will in-troduce ill-conditioned equations and large location error. If arrival time is not accurate, for example, if the seismic phase is wrongly identified or the time service is inaccurate, large arrival time error will be produced, and the location results and real hypocenters will be discordant. Different location algorithms adopted will produce differ-ent location errors. The residual criterion chosen has influence on location results. Besides, whether the event is correctly associated also influences the location quality. In practice, it can often be seen that large location devia-tion introduced by wrong event association.
基金Natural Science Foundation of Hunan Province (No.2020JJ4734)High Performance Computing Center of Central South University。
文摘The thermodynamic instability of zinc anodes in aqueous electrolytes leads to issues such as corrosion,hydrogen evolution reactions(HER), and dendrite growth, severely hindering the practical application of zinc-based aqueous energy storage devices. To address these challenges, this work proposes a dualfunction zinc anode protective layer, composed of Zn-Al-In layered double oxides(ILDO) by rationally designing Zn-Al layered double hydroxides(Zn-Al LDHs) for the first time. Differing from previous works on the LDHs coatings, firstly, the ILDO layer accelerates zinc-ion desolvation and also captures and anchors SO_(4)^(2-). Secondly, the in-situ formation of the Zn-In alloy phase effectively lowers the nucleation energy barrier, thereby regulating zinc nucleation. Consequently, the zinc anode with the ILDO protective layer demonstrates long-term stability exceeding 1900 h and low voltage hysteresis of 7.5 m V at 0.5 m A cm^(-2) and 0.5 m A h cm^(-2). Additionally, it significantly enhances the rate capability and cycling performance of Zn@ILDO//MnO_(2) full batteries and Zn@ILDO//activated carbon zinc-ion hybrid capacitors.This simple and effective dual-function protective layer strategy offers a promising approach for achieving high-performance zinc-ion batteries.
基金supported fiancially by the Natural Science Foundation of Inner Mongolia Autonomous Region in China(Grant No.2018MS08043)Inner Mongolia Autonomous Region Scientific and Technological Achievements Transformation Guidance Project in China(2020PT0030).
文摘Background:Ischemia-reperfusion can worsen myocardial damage and increase the risk of death.Studies have revealed that ischemic preconditioning provides the best endogenous protection against myocardial ischemia-reperfusion injury(MIRI),and the principle of electroacupuncture(EA)preconditioning is comparable to that of myocardial ischemic preconditioning adaption.Our earlier research demonstrated that EA pretreatment inhibits the expression of calmodulin-dependent protein kinase IIδ(CaMKIIδ),sodium/calcium exchanger 1(NCX1),and cyclophilin D,hence providing protection against MIRI.However,the exact mechanism is still unknown.The expression of NCX1 mRNA is directly regulated by microRNA-214(miR-214).Moreover,it suppresses the levels of CaMKIIδand cyclophilin D.Whether these variables contribute to EA preconditioning to improve MIRI needs to be investigated,though.This study aimed to preliminarily determine whether EA pretreatment ameliorates MIRI by modulating the miR-214-3p/NCX1 axis.Methods:We used a rat MIRI model to investigate the effect of EA pretreatment on MIRI and the expression of miR-214-3p.In addition,adenovirus injection inhibited miR-214-3p expression in the rat MIRI model,and the influence of EA pretreatment towards MIRI was observed in the context of blocked miR-214-3p expression.Both the myocardial histological abnormalities and the alterations in the ST segment of the rat electrocardiogram were analyzed.NCX1 mRNA,cyclophilin D,and CaMKIIδexpression levels were also analyzed.Results:EA pretreatment improved MIRI.In rats with MIRI,EA administration increased miR-214-3p expression while decreasing NCX1 mRNA,cyclophilin D,and CaMKIIδproteins in cardiac tissues.The beneficial effect of EA pretreatment against MIRI was reversed,coupled with elevated levels of NCX1 mRNA,cyclophilin D,and CaMKIIδprotein expression,when an adenovirus injection disrupted the expression of miR-214-3p.Conclusions:Our findings preliminarily show that EA pretreatment inhibits the expression of NCX1 mRNA,cyclophilin D,and CaMKIIδproteins via miR-214-3p,hence exerting MIRI protection.
文摘Herein an estimation is given to the efficiency of nuclear explosive devices in a space-rocket complex to withdraw Hazardous Space Objects (HS0)-asteroids and cometary nuclei from the trajectories leading to their dangerous entry to the atmosphere and falling to the Earth. A conceptual choice of parameters and schemes of application of nuclear explosive devices in impact modules of space-rocket complexes to ensure asteroidal-cometary safety was made.
基金Sponsored by the National Natural Science Foundation of China(Grant No.11102054)Postdoctoral Science-research Developmental Foundation of Heilongjiang Province(Grant No.LBH-Q12101)the Fundamental Research Funds for the Central Universities(Grant No.HIT.NSRIF.2014026)
文摘To explore new light-weight integrated thermal protection system panel configuration and gain good insight into the responses mechanism,heat transfer and structural field analysis for one single-layer and four double-layer corrugated core panels were performed. The obtained the temperature,buckling,stress and deflection responses were compared,and the deflection and stress distributions as well as thermal buckling mode at the time were discussed for the considered configurations when the temperature difference between the top and bottom face sheet was maximum. The results demonstrated that the non-orthogonal and hat-stiffened double-layer structures provide superior performance to resist thermal buckling deformation in comparison with other configurations. The useful information is provided for the forthcoming optimization in which thermal buckling is considered as critical design driver.
文摘It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventually blow up or explode in finite time. If the drift and diffusion functions are globally Lipschitz, linear growth may still be experienced, as well as a possible blow-up of solutions in finite time. In this paper, a nonlinear scalar delay differential equation with a constant time lag is perturbed by a multiplicative Ito-type time - space white noise to form a stochastic Fokker-Planck delay differential equation. It is established that no explosion is possible in the presence of any intrinsically slow time - space white noise of Ito - type as manifested in the resulting stochastic Fokker- Planck delay differential equation. Time - space white noise has a role to play since the solution of the classical nonlinear equation without it still exhibits explosion.
基金Project was supported by the National Natural Science Foundation of China(Grant No.51541112).
文摘A comprehensive protective structure with rigidity and flexibility was put forward and designed in view of the quality and safety problems for the double vertical explosive welding of large titanium/steel cladding plate.The movement speed and displacement of the protective structure was calculated by establishing its physics model.The dynamics and stabilization properties were analyzed,and the protective structure parameters were optimized and devised.The comprehensive protective structure,which is composed of rigidity unit and flexibility wall,can bear the impact of detonation wave and the high-speed movement of the cladding plate.There are no damage and deformation in the protective structure and the cladding plate.The protective structure can be used many times.The bonding rate of the Ti/steel plate obtained was nearly 100%,and there is no deformation,surface cracks,and big wave and micro-defects.Therefore,the protective problems of the double vertical explosive welding can be solved effectively by the protective structure.
基金The defence research and development board is acknowledged for funding research efforts
文摘This paper presents a view of some of the challenges that are presented in investigating protection methodologies against explosive blast effects. In particular, the paper is concerned with experimental efforts that can aid in the understanding of complex blast effects in typical real world scenarios. Current progress in the implementation of blast mitigation methodologies in the landward defence environment is reviewed.
基金the National Natural Science Foundation of China, No. 30973779the National Special Planning Project for Traditional Chinese Medicine of China, No.02-03LP41the Key Program of Scientific Planning of Guangdong Province, No. 2006B35630007
文摘BACKGROUND: Studies have demonstrated that β-amyloid peptide (Aβ), a characteristic pathological product of Alzheimer's disease (AD), results in neuronal endoplasmic reticulum stress (ERS). However, the mechanisms of traditional Chinese medicine against ERS in AD are poorly understood. OBJECTIVE: To measure expression levels of protective proteins (GRP78 and GRP94) of ER molecular partners and pro-apoptotic Caspase-12 ER membrane expression following application of traditional Chinese medicine natural cerebrolysin (NC) to treat Aβ1-40-induced ERS. DESIGN, TIME AND SETTING: A parallel-controlled study was performed at the Institute of Integrated Western and Traditional Chinese Medicine, Shenzhen Hospital of Southern Medical University between September 2006 and November 2008. MATERIALS: Sprague Dawley male rats, 6-8 weeks old, were used to harvest tibial and femoral bone marrow. Isolation and purification of mesenchymal stem cells (MSCs) were established from the whole bone marrow by removing non-adherent cells in primary and passage cultures. Aβ1-40 was provided by Sigma, USA. NC was provided by Shenzhen Institute of Integrated Chinese and Western Medicine, China. NC was predominantly composed of Renshen (Radix Ginseng), Tianma (Rhizoma Gastrodiae), and Yinxingye (Ginkgo Leaf) in a proportion of 1 : 2: 2. Following conventional water extraction technology, an extract (1 : 20) was prepared. Six adult, male, New Zealand rabbits underwent intragastric administration of NC extract (0.976 g/kg per day) for 1 month to prepare NC-positive serum, and the remaining 6 rabbits received intragastric administration of physiological saline to prepare normal blank serum. METHODS: A total of 500 nmol/L Aβ1-40 was used to establish ERS models of primary cultured MSCs. AD cell models were incubated with different doses of NC-positive serum (2.5%, 5%, and 10%). MSCs treated with normal blank serum served as normal blank controls. MAIN OUTCOME MEASURES: Reverse transcription-polymerase chain reaction and fluorescent immunocytochemistry were respectively used to measure mRNA and protein expression levels of GRP78, GRP94, and Caspase-12 in MSCs. RESULTS: Following Aβ1-40 exposure, mRNA and protein expression levels of GRP78 and GRP94, as well as Caspase-12, significantly increased (P 〈 0.05), suggesting successful establishment of ERS models. Following NC-positive serum application, mRNA and protein expression levels of GRP78 and GRP94 in MSCs significantly increased (P 〈 0.05 or P 〈 0.01). However, mRNA and protein expression levels of Caspase-12 significantly decreased (P 〈 0.05, or P 〈 0.01) compared with the ERS model group. These effects were dose-dependent. CONCLUSION: NC downregulated Caspase-12 expression and upregulated GRP78 and GRP94 expression in MSCs in a dose-dependent manner under the state of Aβ1-40-induced ERS.
基金The project is supported by the National Natural Science Foundation of China.
文摘A novel polymer-bound 1,2-diol, 3-polystyrylsulfonyl-1,2-propanediol (6) had been prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3-chloro-1,2-propanediol in the presence of a phase transfer catalyst, n-tetrabutylammonium iodide. The capacity of resin 6 for terephthaidehyde reached 1.43 mmol/g. The aldehydic groups attached to polymer 6 reacted with hydroxylamine hydrochloride or reduced by sodium borohydride giving p-formylbenzaldoxime (yield: 89%)and p-formyl-benzalcohol (yield: 734%), respectively. The high yields of these polymer-supported reactions showed that the polymer 6 possessed the effective isolation of its reactive sites.
文摘In order to lighten the weight of the special vehicles and improve their mobility and flexibility, the weight of all subsystems of the whole vehicle must be reduced in the general planning. A fire explosion suppression system is an important subsystem for the self-protection of vehicle, protection of crews and safety of a vehicle. The performances of the special vehicles determine their survival ability and combat capability. The composite bottle is made of aluminum alloy with externally wrapped carbon fiber ; it has been proven by a large number of tests that the new type explosion suppression fire distinguisher made of such composite materials applied in the special vehicle has reliable performance, each of its technical indexes is higher or equal to that of a steel distinguisher, and the composites can also optimize the assembly structure of the bottle, and improve the reliability and corrosion resistance. Most important is that the composite materials can effectively lighten the weight of the fire explosion suppression system to reach the target of weight reduction of the subsystem in general planning.
文摘Diaper dermatit is among the widely seen inflamatory skin diseases in neonatals and small 0 - 18 month old children. Control of causative agents as well as providing good genital care may prevent or reduce the risk of the disease. The aim of this study is find out the effect of protective genital care on reducing the diaper dermatit development in 0 - 18 months old inpatient 0 - 18 month old children who are using antibiotic. The study was conducted as prospective half-experimetal using control-experimental groups. Our samples comprise of 0 - 18 month old children admitted at Dokuz Eylul University Practical and Research Hospital, pediatric clinic between January and May 2009, 41 0 - 18 month old children as a control group were not under protective genital care, and 42 0 - 18 month old children as an experimental group were under the protecion and using vaseline. The mothers of the experimental group 0 - 18 month old children were given education. All 0 - 18 month old children were followed-up 3 - 7 days and the collected data were evaluated in computer using Pearson’s chisquare, Fisher’s exact chi-square and Yatest-corrected chi-square tests. The diaper dermatit develop- ment ratio was 34.1% in the control group and 7.1% in the experimental group