Extension of Chemoprevention of Seasonal Malaria to Five Cycles and to Children from the Age of 6 to 9 Years in Africa: Analysis of Its Acceptability, Feasibility, Cost and Impact A Systematic Review

Introduction: Seasonal Malaria Chemoprevention (SMC) aims at preventing malaria in children during the high transmission season. It has been recommended by the WHO since 2013 for children from the age of 3-59 months. However, despite the impact of this intervention, a peak in the prevalence and incidence of malaria is observed in children from the age of 5-9 years. The aim of this study is to determine from the current literature the feasibility, impact and cost-effectiveness of extending SMC to five cycles and to older children. Methods: A litterature search of PubMed/Medline, NCBI and Google scholar identified 1333 articles. After reading the titles and abstracts by two authors, 24 articles were selected and submitted for full reading. Random control studies on the extension of SMC, malaria, feasibility of SMC, impact of SMC and cost-effectiveness of SMC were selected. A total of 16 articles were included for the qualitative synthesis after excluding 8 studies. Results: Following the summary of the evidence, we conclude that the extension is feasible but will be confronted with the unavailability of older children. The intervention period coincides with field work. SMC is effective in reducing the prevalence and incidence of malaria and the parasite density in children. The financial cost of administering SMC is lower than that of treating a child suffering from malaria. Conclusion: After analysing the information, it was found that the majority of the African population supports the extension of the SMC to the number of cycles and the age group in order to alleviate the high mortality and morbidity rates among children due to malaria.

Research on the feasibility of storage and estimation model of storage capacity of CO_(2)in fissures of coal mine old goaf

The concept of the carbon cycle in the old goaf of a coal mine based on CO_(2)utilization and storage was put forward adhering to the principle of low-carbon development,utilization of space resources in old goafs,and associated gas resources development.Firstly,the evolution characteristics of overburden fissures in the goaf of the case was studied using a two-dimensional physical similarity simulation test,the sealing performance of the caprocks after stabilization was analyzed,and the fissures were counted and classi-fied.Then,the process of gaseous CO_(2)injection in the connected fissure was simulated by Ansys Fluent software,and the migration law and distribution characteristics of CO_(2)under the condition of gaseous CO_(2)injection were analyzed.Finally,the estimation models of free CO_(2)storage capacity in the old goaf were constructed considering the proportion of connected fissure and the effectiveness of CO_(2)injection.The CO_(2)storage capacity in the old goaf of the case coal mine was estimated.The results showed that a caprock group of“hard-thickness low-permeability hard-thickness”was formed after the caprock-fissures system in the goaf of the case tended to be stable vertically.The connected fissure,occlude cracks,and micro-fractures in the goaf accounted for 85.5%,8.5%,and 6%of the total fissures,respectively.Gaseous CO_(2)first migrated to the bottom of the connected fissure after CO_(2)was injected into the goaf,then spread horizontally along the bottom of the connected fissure after reaching the bottom,and finally spread longitudinally after filling the bottom of the entire connected fissure.The theoretical and effective storage capacities of free CO_(2)at normal temperature and pressure in the old goaf of the case were 9757 and 7477 t,respectively.The effective storage capacity of free CO_(2)at normal temperature and pressure in the old goaf after all minefield mined was 193404 t.The research can provide some reference for the coal mining industry to help the goal of“carbon peaking and carbon neutrality”.

New hybrid inertial CQ projection algorithms with line-search process for the split feasibility problem

In this paper, we propose two hybrid inertial CQ projection algorithms with linesearch process for the split feasibility problem. Based on the hybrid CQ projection algorithm, we firstly add the inertial term into the iteration to accelerate the convergence of the algorithm, and adopt flexible rules for selecting the stepsize and the shrinking projection region, which makes an optimal stepsize available at each iteration. The shrinking projection region is the intersection of three sets, which are the set C and two hyperplanes. Furthermore, we modify the Armijo-type line-search step in the presented algorithm to get a new algorithm.The algorithms are shown to be convergent under certain mild assumptions. Besides, numerical examples are given to show that the proposed algorithms have better performance than the general CQ algorithm.

A Feasibility Study of Using Geothermal Energy to Enhance Natural Gas Production from Offshore Gas Hydrate Reservoirs by CO_(2) Swapping

The energy industry faces a significant challenge in extracting natural gas from offshore natural gas hydrate(NGH)reservoirs,primarily due to the low productivity of wells and the high operational costs involved.The present study offers an assessment of the feasibility of utilizing geothermal energy to augment the production of natural gas from offshore gas hydrate reservoirs through the implementation of the methane-CO_(2)swapping technique.The present study expands the research scope of the authors beyond their previous publication,which exclusively examined the generation of methane from marine gas hydrates.Specifically,the current investigation explores the feasibility of utilizing the void spaces created by the extracted methane in the hydrate reservoir for carbon dioxide storage.Analytical models were employed to forecast the heat transfer from a geothermal zone to an NGH reservoir.A study was conducted utilizing data obtained from a reservoir situated in the Shenhu region of the Northern South China Sea.The findings of the model indicate that the implementation of geothermal heating can lead to a substantial enhancement in the productivity of wells located in heated reservoirs during CO_(2)swapping procedures.The non-linear relationship between the temperature of the heated reservoir and the rate of fold increase has been observed.It is anticipated that the fold of increase will surpass 5 when the gas hydrate reservoir undergoes a temperature rise from 6℃ to 16℃.The mathematical models utilized in this study did not incorporate the impact of heat convection resulting from CO_(2)flow into the gas reservoir.This factor has the potential to enhance well productivity.The mathematical models’deviation assumptions may cause over-prediction of well productivity in geothermal-stimulated reservoirs.Additional research is required to examine the impacts of temperature drawdown,heat convection resulting from depressurization,heat-induced gas pressure increment,and the presence of free gas in the formation containing hydrates.The process of CH4-CO_(2)swapping,which has been investigated,involves the utilization of geothermal stimulation.This method is highly encouraging as it enables the efficient injection of CO_(2)into gas hydrate reservoirs,resulting in the permanent sequestration of CO_(2)in a solid state.Additional research is warranted to examine the rate of mass transfer of CO_(2)within reservoirs of gas hydrates.

Hybrid IPOM: A Novel Technique for the Management of Incisional Hernia

Background and Aim: The incidence of incisional hernias has been reported to be around 15%. In the present scenario, a wide array of surgical procedures are available for their better management. In this study, we intend to share our experience with one novel technique, “Hybrid IPOM (Intraperitoneal onlay meshplasty)” as a management option for a selected cohort of patients. Methods: This prospective study was undertaken during January 2019 to July 2023 at King Abdullah medical city, Makkah. A total of 51 cases were selected for Hybrid IPOM repair as per inclusion criteria;medium sized (4 - 10 cm) hernia defects;uncomplicated hernias;age more than 18 years. The follow-up period of the patients varied from 6 months to 4 years. The operation commenced with open hernia dissection, mesh deployment into abdomen, defect closure and then conversion to laparoscopy for the posterior mesh placement. Results: A total of 51 cases were repaired successfully with this technique. 48 out of 51 cases were incisional hernias secondary to some primary procedure done either for hernias itself or some other intra-abdominal pathology. The three cases were primary hernias falling in medium to large category with unaesthetic overlying skin. The age range was 19 to 72 years. The mean (range) operative time was 135 (90 - 240) min, and the average blood loss was 70 ml. The mean (range) hospital stay was 3 (2 - 11) days. All patients returned to routine work within 2 - 3 weeks of surgery. The median follow-up was 15 (6 - 48) months. Of the 51 cases, 3 patients developed seroma (managed conservatively), 1 patient developed a large hematoma (needed evacuation), and 1 patient developed superficial wound infection (managed with antibiotics). Two patients had recurrences;one patient had previously failed multiple repairs, and the other developed a postoperative hematoma. None of our patients had an iatrogenic bowel injury. Conclusion: Hybrid IPOM technique is a safe, feasible and easily reproducible technique. It may prove easier especially for beginners in laparoscopy, as it achieves faster and easy adhesiolysis thereby reducing operative time and easier establishment of the pneumoperitoneum. Besides, it gives the chance to excise ugly scars and improve the cosmesis.

Safety and feasibility of enhanced recovery after surgery-based management model for ambulatory pediatric surgical procedures

BACKGROUND There is still some room for optimizing ambulatory pediatric surgical procedures,and the preoperative and postoperative management quality for pediatric patients needs to be improved.AIM To discuss the safety and feasibility of the enhanced recovery after surgery(ERAS)-based management model for ambulatory pediatric surgical procedures.METHODS We selected 320 pediatric patients undergoing ambulatory surgery from June 2023 to January 2024 at The First People’s Hospital of Liangshan Yi Autonomous Prefecture.Of these,220 received ERAS-based management(research group)and 100 received routine management(control group).General information,postoperative ambulation activities,surgical outcomes(operation time,postoperative gastro-intestinal ventilation time,and hospital stay),postoperative pain visual analogue scale,postoperative complications(incision infection,abdominal distension,fever,nausea,and vomiting),and family satisfaction were compared.RESULTS The general information of the research group(sex,age,disease type,single parent,family history,etc.)was comparable to that of the control group(P>0.05),but the rate of postoperative(2 h,4 h,and 6 h after surgery)ambulation activities was statistically higher(P<0.01),and operation time,postoperative gastrointestinal ventilation time,and hospital stay were markedly shorter(P<0.05).The research group had lower visual analogue scale scores(P<0.01)at 12 h and 24 h after surgery and a lower incidence of total postoperative complications than the control group(P=0.001).The research group had higher family satisfaction than the control group(P=0.007).CONCLUSION The ERAS-based management model was safe and feasible in ambulatory pediatric surgical procedures and worthy of clinical promotion.

Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous growth.Currently reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and disadvantages.We have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since 2010.AIM To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of IPNB.METHODS Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were included.PTCS-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with electrocautery.The primary outcome was its feasibility,indicated by technical success.The secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and safety.RESULTS Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were included.Low-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,respectively.Repeated cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type IPNB.All five patients achieved technical success of PTCS-BP.Four patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN had residual tumors.All four patients with mucin-hypersecreting IPNB achieved clinical success.The patient with polypoid type IPNB achieved curative resection.There were no PTCS-BP-related serious adverse events.CONCLUSION PTCS-BP appears to be feasible,efficacious,and safe for local palliative treatment of both mucin-hypersecreting cast-like and polypoid type IPNB.

Potential applications of 7 Tesla magnetic resonance imaging in paediatric neuroimaging:Feasibility and challenges

The integration of 7 Tesla magnetic resonance imaging(7 T MRI)in adult patients has marked a revolutionary stride in radiology.In this article we explore the feasibility of 7 T MRI in paediatric practice,emphasizing its feasibility,applications,challenges,and safety considerations.The heightened resolution and tissue contrast of 7 T MRI offer unprecedented diagnostic accuracy,particularly in neuroimaging.Applications range from neuro-oncology to neonatal brain imaging,showcasing its efficacy in detecting subtle structural abnormalities and providing enhanced insights into neurological conditions.Despite the promise,challenges such as high cost,discomfort,and safety concerns necessitate careful consideration.Research suggests that,with precautions,7 T MRI is feasible in paediatrics,yet ongoing studies and safety assessments are imperative.

Feasibility and Path Analysis of Integrating Innovation and Entrepreneurship Education into“One-Stop”Student Communities

The“one-stop”student community provides new support for innovation and entrepreneurship education in universities.Integrating innovation and entrepreneurship education into the“one-stop”student community work enriches course materials,integrates teacher resources,improves students’participation in innovation and entrepreneurship,and solves problems such as low student participation,lack of course resources,insufficient teacher resources,and single evaluation methods in traditional classrooms.Through various means such as exploring course resources,innovating management models,and strengthening team construction,the role of“one-stop”student communities in innovation and entrepreneurship education has been fully utilized,promoting the development of innovation and entrepreneurship education.

The Feasibility Study of Career English Teaching Reform in Higher Vocational Colleges

It has been proved that traditional public English teaching can‘t meet the society requirements for the high skilled talent-ed,while Career English teaching can help students connect English learning with their future career,which better reflects occupa-tional and practical characteristics of higher vocational education.The paper puts forwards three feasibilities in Career Englishteaching reform in order to promote teaching quality of public English teaching in higher vocational colleges further.

Feasibility analysis of coronary angiography by transradial approach with 4F catheter

Objective:To assess the feasibility of coronary angiography by transradial approach with 4F catheter.Methods:The procedural details,picture quality,local complication were recorded for coronary by transradial approach with 4F catheter in 138 patients.Results:The success rate of angiography was 97.7%;fluoroscopy time was(5.05±3.23)minutes,total procedural time was(20.51±3.37)minutes;the incidence of dislodgement,excessive engagement of either coronary artery was 7.8%,9.4%,repectively;the angiographic scores for left anterior descending,circumflex and right coronary arteries were(2.87±0.40),(2.88±0.39),(2.90±0.35),respectively.The spasm complication occurred 4.3% in radial artery and 1.5% in coronary artery.There were no occlusion of radial artery during follow up.Conclusion:4F catheter could be the first chosen in some selecting patients for its nice maneuverability,fine images and fewer vascular complications.

The Feasibility Study on Developing General Education in Public English Courses of Higher Vocational Colleges

The implementation of general education is the only way to train higher vocational complex talents.Through analysis ofthe feasibility of developing general education in public English courses of higher vocational colleges,it is hoped that the reform ofpublic English will be promoted effectively.

The Feasibility of Strong Bilingual Education in International School

This essay discuses the feasibility of adopting strong bilingual education in some international schools in China. It will ex-plain the theory, pedagogical principles,benefits and assessment of CLIL pedagogy.

Endoscopic and anesthetic feasibility of EUS and ERCP combined in a single session versus two different sessions

AIM:To discuss the feasibility of single session endoscopic ultrasonography(EUS) to discuss and endoscopic retrograde cholangiopancreatography(ERCP) execution.METHODS:Retrospective endoscopic and anesthetic outcome comparison of performing both EUS and ERCP in a single endoscopic session(Group Ⅰ) versus performing each procedure in two different sessions(Group Ⅱ) was made.The following variables were evaluated:epidemiological variables,American Society of Anesthesiologists Physical Status Classification(ASA) level,procedural time,propofol dose,anesthetic complications,endoscopic complications and diagnostic yield,and therapeutic procedures on both groups.T-student,ChiSquare and Fisher test were used for comparison.RESULTS:We included 39 patients in Group Ⅰ(mean age:69.85 ± 9.25;27 men) and 46 in Group Ⅱ(mean age:67.46 ± 12.57;25 men).Procedural time did not differ significantly between both groups(Group Ⅰvs Group Ⅱ:93 ± 32.78 vs 98.98 ± 38.17;P >0.05) but the dose of propofol differed(Group Ⅰ vs Group Ⅱ:322.28 ± 250.54 mg vs 516.96 ± 289.06 mg;P = 0.001).Three patients had normal findings on both explorations.Three anesthetic complications [O2 desaturation(2),broncoaspiration(1)] and 9 endoscopic complications [pancreatitis(6),bleeding(1),perforation(1),cholangitis(1)] occurred without significant differences between both groups(P > 0.05).We did not find any significant difference regarding age,sex,ASA scale level,diagnostic yield or therapeutic maneuvers between both groups.CONCLUSION:The performance of EUS and ERCP in a single session offers a similar diagnostic and therapeutic yield,does not entail a higher complication risk and requires a significantly smaller dose of propofol for sedation compared with performing each exploration in a different session.

Feasibility Research of Using Phase Change Materials to Reduce the Inner Temperature Rise of Mass Concrete

In order to evaluate the feasibility of using phase change materials to reduce the inner temperature rise of mass concrete, the interior temperature of normal concrete specimen under semi-adiabatic curing condition was measured. The effect of embedding phase change material(PCM) and replacing water with suspension of phase change material(SPCM) as cooling fluid were compared in the experiment. The cooling effect and the affecting factors were analyzed and calculated. The research results showed that the peak of inner temperature could be decreased obviously by the method of pre-embeding PCM in concrete, however, this method is only effective in the initial stage of cement hydration process. Besides, the volume of PCM is rather big and the PCM can not be used circularly, which means that this method can only be used under special condition and the feasibility is low. When SPCM was used as cooling fluid, the interior temperature rise of mass concrete was reduced more effectively, and the temperature grads peak around the cooling pipe was also reduced. Besides, both the SPCM consumption amount and the circulation time were decreased, and most important is that the SPCM is recyclable. The technical and economical feasibility of using SPCM to reduce the inner temperature rise of mass concrete is high.

Application of the Landsat-5TM Image Data in the Feasibility Study of Mudflow Hazards in the Southern Taihang Mountains

The Taihang Mountains area is an area in North China where serious mudflow hazards take place frequently. The hazards often obstrust traffic and make it difficult to carry out conventional ground investigations of the mudflow hazards. This paper introduces the feasibility study of mudflow hazards by using Landsat-5TM data. The study has achieved a great success through adopting both the faint spectral enhancement technique for mudflow fans (or other depositional areas) and comprehensive study of the environmental background of pregnant mudflows. Thus, remote sensing as a fast, convenient, low-cost and effective technical method can be used to recognise the situation of mudflow hazards so that effective rescue can be provided.

The Feasibility and Acceptability of LISTEN for Loneliness

Purpose: The purpose of this paper is to present the initial feasibility and acceptability of LISTEN (Loneliness Intervention using Story Theory to Enhance Nursing-sensitive outcomes), a new intervention for loneliness. Loneliness is a significant stressor and known contributor to multiple chronic health conditions in varied populations. In addition, loneliness is reported as predictive of functional decline and mortality in large samples of older adults from multiple cultures. Currently, there are no standard therapies recommended as effective treatments for loneliness. The paucity of interventions has limited the ability of healthcare providers to translate what we know about the problem of loneliness to active planning of clinical care that results in diminished loneliness. LISTEN was developed using the process for complex intervention development suggested by the Medical Research Council (MRC) [1] [2]. Methods: Feasibility and acceptability of LISTEN were evaluated as the first objective of a longitudinal randomized trial which was set in a university based family medicine center in a rural southeastern community in Appalachia. Twenty-seven older adults [(24 women and 3 men, mean age: 75 (SD 7.50)] who were lonely, community-dwelling, and experiencing chronic illness, participated. Feasibility was evaluated by tracking recruitment efforts, enrollment, attendance to intervention sessions, attrition, and with feedback evaluations from study personnel. Acceptability was assessed using quantitative and qualitative evaluation data from participants. Results: LISTEN was evaluated as feasible to deliver with no attrition and near perfect attendance. Participants ranked LISTEN as highly acceptable for diminishing loneliness with participants requesting a continuation of the program or development of additional sessions. Conclusions: LISTEN is feasible to deliver in a primary healthcare setting and has the potential to diminish loneliness which could result in improvement of the long-term negative known sequelae of loneliness such as hypertension, depression, functional decline, and mortality. Feedback from study participants is being used to inform future trials of LISTEN with consideration for developing additional sessions. Longitudinal randomized trials are needed in varied populations to assess long-term health and healthcare system benefits of diminishing loneliness, and to assess the potential scalability of LISTEN as a reimbursable treatment for loneliness.

Primary Exploration of the Feasibility of Passive Houses in Korea and China

The transferability of European experiences with design,planning,construction and service of Passive-Houses to the specific conditions in China and Korea is investigated by the adaptation of the PassiveHouse principle to typical Korean and Chinese residential building,by the use of locally available building materials,components and building practices as well as under consideration of specific and typical ways of living in the two countries and cultures. The starting basis for the research is the analysis and evaluation of specific climate conditions,architecture,building practice as well as specific comfort criteria. The additional effort for the construction and service of Passive-Houses in Korea and China compared with typical contemporary residential buildings is investigated on the basis of a comparison of designs for Passive-Houses and for common buildings,including issues like the heating and cooling energy demand,heat and cool load as well as the required materials and components. The research results show that the described modifications of typical contemporary residential building constructions in China and Korea are realizable with locally available materials and feasible effort. They can reduce the energy demand for the service of domestic housing significantly and are in the range of European Passive Houses.

An Extrapolated Parallel Subgradient Projection Algorithm with Centering Technique for the Convex Feasibility Problem

In this paper,we present an extrapolated parallel subgradient projection method with the centering technique for the convex feasibility problem,the algorithm improves the convergence by reason of using centering techniques which reduce the oscillation of the corresponding sequence.To prove the convergence in a simply way,we transmit the parallel algorithm in the original space to a sequential one in a newly constructed product space.Thus,the convergence of the parallel algorithm is derived with the help of the sequential one under some suitable conditions.Numerical results show that the new algorithm has better convergence than the existing algorithms.

A Quick Method for Judging the Feasibility of Security-Constrained Unit Commitment Problems within Lagrangian Relaxation Framework

Generally, the procedure for Solving Security constrained unit commitment (SCUC) problems within Lagrangian Relaxation framework is partitioned into two stages: one is to obtain feasible SCUC states;the other is to solve the economic dispatch of generation power among all the generating units. The core of the two stages is how to determine the feasibility of SCUC states. The existence of ramp rate constraints and security constraints increases the difficulty of obtaining an analytical necessary and sufficient condition for determining the quasi-feasibility of SCUC states at each scheduling time. However, a numerical necessary and sufficient numerical condition is proposed and proven rigorously based on Benders Decomposition Theorem. Testing numerical example shows the effectiveness and efficiency of the condition.