As typical visual culture symbol of China, the visual image of Sun Wukong firstly appeared on the mural of Yulin Caves of Dunhuang in Western Xia regime and the story of Monk Tang and his prentices on the mural in Yua...As typical visual culture symbol of China, the visual image of Sun Wukong firstly appeared on the mural of Yulin Caves of Dunhuang in Western Xia regime and the story of Monk Tang and his prentices on the mural in Yuan Dynasty. Up to Yuan Dynasty, it became very popular. Since the novel Pilgrimage to the West was published, the visual image of Sun Wukong has appeared in the visual carriers of wood block, colored drawing, paper-cut, traditional Chinese opera, film, television, ad, cartoon and so on. European countries, America, Japan and South Korea use advanced film and TV technology and digital technology to deduce, model, adapt and simulate the visual image of Sun Wukong. This paper investigates the construction of the visual image of Sun Wukong in China and extraterritorial countries and regions, tries to explore Chinese ＂visual＂ experience in mediaeval times and especially modern times and seeks a clue for understanding Chinese problem of visual expression.展开更多
One feature of Golding' s works is to reveal the theme-the evil nature of man,through the characters' mystical experience.This is obvious in Darkness Visible and Lord of the Flies.This paper tries to find out ...One feature of Golding' s works is to reveal the theme-the evil nature of man,through the characters' mystical experience.This is obvious in Darkness Visible and Lord of the Flies.This paper tries to find out the resource for the writer to use mystical experience through biological approach.展开更多
In William Golding' s Darkness Visible,Sophy' s experience of " hysterical hallucination" plays an important role in the the matic expression.They point directly to the evil nature of man.Although th...In William Golding' s Darkness Visible,Sophy' s experience of " hysterical hallucination" plays an important role in the the matic expression.They point directly to the evil nature of man.Although the specific content of hallucinations is different,they possess a common characteristic-mystical experience.They worth further research.This paper examines Sophy' s mystical experience in her hyster ical hallucination,so as to find out the functions of mystical experience and its influences on the novel' s thematic expression.展开更多
目的探讨骨坏死康复丸治疗激素性股骨头坏死(Steroid-induced osteonecrosis of the femoral head,SONFH)的主要药理学基础和作用机制。方法通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Dat...目的探讨骨坏死康复丸治疗激素性股骨头坏死(Steroid-induced osteonecrosis of the femoral head,SONFH)的主要药理学基础和作用机制。方法通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)等数据库对骨坏死康复丸的有效成分和靶点进行筛选。基于人类在线孟德尔遗传数据库(Online Mendelian Inheritance in Man,OMIM)和GeneCards数据库筛选SONFH的靶点。采用加权基因共表达网络分析(Weighted gene co-expression network analysis,WGCNA)对SONFH基因模块和枢纽基因进行鉴定。取三者的交集,获得骨坏死康复丸治疗SONFH的潜在靶点,并利用Cytoscape软件构建的“活性成分-靶点”网络筛选关键活性成分;然后,利用STRING数据库构建蛋白相互作用网络,筛选关键靶点。进行基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)信号通路富集分析,探索“关键活性成分-关键靶点-关键信号通路”之间的关系。最后,进行了关键活性成分与关键靶点的分子对接,并使用SONFH大鼠模型进行实验验证。结果得到骨坏死康复丸的146个化合物和相应的346个靶点,获得了4187个SONFH靶点。此外,基于WGCNA筛选出SONFH的12个基因模块和2556个枢纽基因,得到槲皮素、木犀草素和山柰酚是骨坏死康复丸治疗SONFH的关键活性成分,涉及PI3K/AKT等多条信号通路。分子对接显示关键活性成分与关键靶点之间存在较好的结合活性。动物实验结果证明骨坏死康复丸可通过上调AKT1、PI3K、RUNX2,下调Caspase-3和IL-6的表达改善骨生物学改变(P<0.01),验证了网络药理学部分预测结果。结论通过网络药理学和动物实验分析了骨坏死康复丸治疗SONFH的潜在作用机制,可为进一步研究其药理基础和靶点提供参考。展开更多
基金Acknowledgements： This paper was sponsored by China National Social Science Foundation ＂Research on the Fundamental Problems of the Contemporary Aesthetics and Criticism Patterns＂ （15ZDB023）.
文摘As typical visual culture symbol of China, the visual image of Sun Wukong firstly appeared on the mural of Yulin Caves of Dunhuang in Western Xia regime and the story of Monk Tang and his prentices on the mural in Yuan Dynasty. Up to Yuan Dynasty, it became very popular. Since the novel Pilgrimage to the West was published, the visual image of Sun Wukong has appeared in the visual carriers of wood block, colored drawing, paper-cut, traditional Chinese opera, film, television, ad, cartoon and so on. European countries, America, Japan and South Korea use advanced film and TV technology and digital technology to deduce, model, adapt and simulate the visual image of Sun Wukong. This paper investigates the construction of the visual image of Sun Wukong in China and extraterritorial countries and regions, tries to explore Chinese ＂visual＂ experience in mediaeval times and especially modern times and seeks a clue for understanding Chinese problem of visual expression.
文摘One feature of Golding' s works is to reveal the theme-the evil nature of man,through the characters' mystical experience.This is obvious in Darkness Visible and Lord of the Flies.This paper tries to find out the resource for the writer to use mystical experience through biological approach.
文摘In William Golding' s Darkness Visible,Sophy' s experience of " hysterical hallucination" plays an important role in the the matic expression.They point directly to the evil nature of man.Although the specific content of hallucinations is different,they possess a common characteristic-mystical experience.They worth further research.This paper examines Sophy' s mystical experience in her hyster ical hallucination,so as to find out the functions of mystical experience and its influences on the novel' s thematic expression.
文摘目的探讨骨坏死康复丸治疗激素性股骨头坏死(Steroid-induced osteonecrosis of the femoral head,SONFH)的主要药理学基础和作用机制。方法通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)等数据库对骨坏死康复丸的有效成分和靶点进行筛选。基于人类在线孟德尔遗传数据库(Online Mendelian Inheritance in Man,OMIM)和GeneCards数据库筛选SONFH的靶点。采用加权基因共表达网络分析(Weighted gene co-expression network analysis,WGCNA)对SONFH基因模块和枢纽基因进行鉴定。取三者的交集,获得骨坏死康复丸治疗SONFH的潜在靶点,并利用Cytoscape软件构建的“活性成分-靶点”网络筛选关键活性成分;然后,利用STRING数据库构建蛋白相互作用网络,筛选关键靶点。进行基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)信号通路富集分析,探索“关键活性成分-关键靶点-关键信号通路”之间的关系。最后,进行了关键活性成分与关键靶点的分子对接,并使用SONFH大鼠模型进行实验验证。结果得到骨坏死康复丸的146个化合物和相应的346个靶点,获得了4187个SONFH靶点。此外,基于WGCNA筛选出SONFH的12个基因模块和2556个枢纽基因,得到槲皮素、木犀草素和山柰酚是骨坏死康复丸治疗SONFH的关键活性成分,涉及PI3K/AKT等多条信号通路。分子对接显示关键活性成分与关键靶点之间存在较好的结合活性。动物实验结果证明骨坏死康复丸可通过上调AKT1、PI3K、RUNX2,下调Caspase-3和IL-6的表达改善骨生物学改变(P<0.01),验证了网络药理学部分预测结果。结论通过网络药理学和动物实验分析了骨坏死康复丸治疗SONFH的潜在作用机制,可为进一步研究其药理基础和靶点提供参考。
