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人乳头瘤病毒多基因型检测对传统部分基因型宫颈癌筛查策略价值优化的敏感性分析 被引量:2
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作者 戎春宇 揭俊钦 +6 位作者 王贤吉 周萍 蒋虹丽 杜莉 祖恩晴 李欣 李真 《中国卫生资源》 CSCD 北大核心 2023年第4期330-338,共9页
目的评估薄层液基细胞学检查(thinprep cytologic test,TCT)筛查技术的有效性、部分宫颈癌诊断费用和初始人群中人乳头瘤病毒(human papilloma virus,HPV)低度风险基因型感染者占比对HPV多基因型和HPV部分(16/18)基因型检测初筛策略的... 目的评估薄层液基细胞学检查(thinprep cytologic test,TCT)筛查技术的有效性、部分宫颈癌诊断费用和初始人群中人乳头瘤病毒(human papilloma virus,HPV)低度风险基因型感染者占比对HPV多基因型和HPV部分(16/18)基因型检测初筛策略的成本效果影响,为公共卫生决策部门选择宫颈癌筛查策略提供参考。方法基于构建的Markov队列模型,以预防宫颈癌发病例数为效果指标,模型运行50年,对HPV多基因型和HPV部分(16/18)基因型筛查方案进行敏感性分析,分析TCT筛查技术的有效性、部分宫颈癌诊断费用,以及初始人群中HPV低度风险基因型感染者占比的变化对成本效果的影响。结果在设定的模型及各参数阈值下,敏感性分析发现:HPV低度风险基因型(HPV 51/35/39/68/56/59/66型)感染者(HPV感染状况或进展为CIN1/2/3状况)中TCT分流检测的灵敏度与特异度[以TCT结果为不典型鳞状上皮细胞病变(atypical squamous cells of undetermined significance,ASCUS)以上为判别标准]变化对两种筛查策略差距影响较大;TCT检测费用、阴道镜检测费用及组织病理学检测费用对两种筛查策略差距影响相对较小。上述各指标在设定阈值范围内变化时,HPV多基因型与部分基因型策略相比,效果差异甚微,成本差异有所变化,具有成本优势。此外,随着初始人群中HPV低度风险基因型感染者的比例增大,HPV多基因型策略的优势亦逐渐增强。结论进一步明确HPV不同基因型的致病风险对优化多基因型HPV筛查的后续管理路径具有重要意义,而进一步细分TCT检测的TBS(The Bethesda System)分级报告结果,提升TCT检测精度则是保障多基因型HPV筛查防治策略价值优化的关键。 展开更多
关键词 宫颈癌筛查cervical cancer screening 人乳头瘤病毒human papilloma virus HPV 多基因型检测extended genotyping testing 部分基因型检测partial genotyping testing 价值value 成本效果costeffectiveness 敏感性分析sensitivity analysis 薄层液基细胞学检查thinprep cytologic test TCT 不典型鳞状上皮细胞病变atypical squamous cells of undetermined significance ASCUS
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人乳头瘤病毒多基因型检测对传统部分基因型宫颈癌筛查策略的价值优化:基于Markov模型的分析 被引量:1
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作者 揭俊钦 戎春宇 +6 位作者 王贤吉 蒋虹丽 杜莉 周萍 李欣 祖恩晴 李真 《中国卫生资源》 CSCD 北大核心 2023年第4期323-329,338,共8页
目的比较人乳头瘤病毒(human papilloma virus,HPV)多基因型(extended genotyping)与HPV部分(16/18)基因型检测技术对宫颈癌筛查策略及其后续管理的影响,分析可能带来的价值变化。方法基于Markov队列模型,以预防宫颈癌发病例数为效果指... 目的比较人乳头瘤病毒(human papilloma virus,HPV)多基因型(extended genotyping)与HPV部分(16/18)基因型检测技术对宫颈癌筛查策略及其后续管理的影响,分析可能带来的价值变化。方法基于Markov队列模型,以预防宫颈癌发病例数为效果指标,模拟100万名初始年龄为15岁的健康妇女在10、20、30、40、50年内从健康状态到宫颈癌发病的疾病进程,基于2种检测技术的宫颈癌筛查-诊断-癌前病变诊疗路径构建模型,分析2种筛查技术不同累计年份下的效果指标、阴道镜检查次数、宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CIN)1/2/3状态的筛查率,并比较成本与成本效果,以此判定对价值的影响。结果模型模拟10、20、30、40、50年,HPV多基因型相对于HPV部分(16/18)基因型在成本上分别减少29.73万、75.55万、98.53万、111.23万、119.39万元,效果始终保持一致,阴道镜检测次数可分别减少1002、2726、3865、4605、5086人次,CIN1-3筛查率上,模型运行第10、20、30、40、50年时,HPV多基因型策略分别减少约4%的CIN1-3的筛查率。结论相比于HPV部分(16/18)基因型,HPV多基因型检测技术在保障预防效果的情况下,能降低筛查假阳性带来的阴道镜“过诊”率,提升阴道镜检查精度,优化卫生资源利用效能,一定程度上避免假阳性带来的心理负担,从而优化传统HPV部分(16/18)基因型的筛查价值。 展开更多
关键词 宫颈癌筛查cervical cancer screening 人乳头瘤病毒human papilloma virus HPV 多基因型检测extended genotyping testing 部分基因型检测partial genotyping testing 价值value 成本效果costeffectiveness 薄层液基细胞学检查thinprep cytologic test TCT 不典型鳞状上皮细胞病变atypical squamous cells of undetermined significance ASCUS
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New Exact Periodic Solitary-Wave Solutions for New (2+1)-Dimensional KdV Equation 被引量:4
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作者 WANG Chuan-Jia DAI Zheng-De MU Gui LIN Song-Qing 《Communications in Theoretical Physics》 SCIE CAS CSCD 2009年第11期862-864,共3页
The extended homoclinic test function method is a kind of classic, efficient and well-developed method to solve nonlinear evolution equations. In this paper, with the help of this approach, we obtain new exact solutio... The extended homoclinic test function method is a kind of classic, efficient and well-developed method to solve nonlinear evolution equations. In this paper, with the help of this approach, we obtain new exact solutions (including kinky periodic solitary-wave solutions, periodic soliton solutions, and cross kink-wave solutions) for the new (2+1)-dimensional KdV equation. These results enrich the variety of the dynamics of higher-dimensionai nonlinear wave field. 展开更多
关键词 kinky wave solution periodic soliton solution extended homoclinic test function method KdV equation bilinear form
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New Test Light Spectrum Design for L/U-Band Extended Optical Fiber Line Testing System
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作者 Nazuki Honda Noriyuki Araki +1 位作者 Hisashi Izumita Minoru Nakamura 《光学学报》 EI CAS CSCD 北大核心 2003年第S1期57-58,共2页
This paper describes a new design for the test light source of an L/U-band extended optical fiber line testing system and the side-band suppresser ratio of the test light should be more than 70 dB.
关键词 FBG nm TEST New Test Light Spectrum Design for L/U-Band extended Optical Fiber Line testing System for
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Epidemiological and antibiotic resistant study on extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Zhejiang Province
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作者 俞云松 周伟琳 +2 位作者 陈亚岗 丁永祥 马亦林 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第10期39-42,146,共5页
To investigate the epidemiological status of extended spectrum β lactamase (ESBL) producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) and the drug resistance profiles of such organisms ... To investigate the epidemiological status of extended spectrum β lactamase (ESBL) producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) and the drug resistance profiles of such organisms Methods A total of 282 clinical isolates of E coli and 180 of K pneumoniae were collected from different districts of Zhejiang Province Inhibitor potentiated broth dilution tests were performed for detecting extended spectrum β lactamases Etests were performed to detect the drug resistance of these strains against nine commonly used antibiotics Results The prevalence of extended spectrum β lactamases in E coli and K pneumoniae was 34 0% and 38 3%, respectively The average prevalence of extended spectrum β lactamases in E coli and K pneumoniae was 35 7% The resistance prevalence of extended spectrum β lactamase producing strains to ceftazidime and cefotaxime was 40% and 26% respectively, so were those to cefepime, cefoxitin, piperacillin tazobactam, cefoperazone sulbactam, amikacin and ciprofloxacin All these strains were sensitive to imipenem Conclusion The results in this study showed that the prevalence of extended spectrum β lactamases was high, while extended spectrum β lactamase producing strains were resistant to most antimicrobial agents except imipenem 展开更多
关键词 extended spectrum β lactamases · inhibitor potentiated broth dilution test · E test
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Breather-Type Periodic Soliton Solutions for (1+1)-Dimensional Sinh-Poisson Equation 被引量:2
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作者 许镇辉 陈翰林 鲜大权 《Communications in Theoretical Physics》 SCIE CAS CSCD 2012年第3期400-402,共3页
In this paper,by using bilinear form and extended homoclinic test approach,we obtain new breather-type periodic soliton solutions of the (1+1)-dimensional Sinh-Poisson equation.These results demonstrate that the nonli... In this paper,by using bilinear form and extended homoclinic test approach,we obtain new breather-type periodic soliton solutions of the (1+1)-dimensional Sinh-Poisson equation.These results demonstrate that the nonlinear evolution equation has rich dynamical behavior even if it is (1+1)-dimensional. 展开更多
关键词 Sinh-Poisson equation extended homoclinic test approach breather-type periodic soliton solution
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Integrability Test and Spatiotemporal Feature of Breather-Wave to the (2+1)-Dimensional Boussinesq Equation 被引量:1
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作者 LUO Hong-Ying WANG Chuan-Jian +1 位作者 LIU Jun DAI Zheng-De 《Communications in Theoretical Physics》 SCIE CAS CSCD 2013年第6期719-722,共4页
Painleve integrability has been tested for (2+1)D Boussinesq equation with disturbance term using the standard WTC approach after introducing the Kruskai's simplification. New breather solitary solutions depending... Painleve integrability has been tested for (2+1)D Boussinesq equation with disturbance term using the standard WTC approach after introducing the Kruskai's simplification. New breather solitary solutions depending on constant equilibrium solution are obtained by using Extended Homoclinic Test Method. Moreover, the spatiotemporal feature of breather solitary wave is exhibited. 展开更多
关键词 Boussinesq equation Painleve integrability extended Homoclinic test method breather wavesolution spatiotemporal feature
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New Non-TravellingWave Solutions of Calogero Equation 被引量:1
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作者 Xiaoming Peng Yadong Shang Xiaoxiao Zheng 《Advances in Applied Mathematics and Mechanics》 SCIE 2016年第6期1036-1049,共14页
In this paper,the idea of a combination of variable separation approach and the extended homoclinic test approach is proposed to seek non-travelling wave solutions of Calogero equation.The equation is reduced to some(... In this paper,the idea of a combination of variable separation approach and the extended homoclinic test approach is proposed to seek non-travelling wave solutions of Calogero equation.The equation is reduced to some(1+1)-dimensional nonlinear equations by applying the variable separation approach and solves reduced equations with the extended homoclinic test technique.Based on this idea and with the aid of symbolic computation,some new explicit solutions can be obtained. 展开更多
关键词 Variable separation approach extended homoclinic test approach non-travelling wave solution.
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