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Hypocoagulation induced by broadspectrum antibiotics in extensive burn patients 被引量:4
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作者 Jian Liu Yiqing Liu +4 位作者 Shengjun Liu Qin Zhang Jiexin Zheng Yiwen Niu Xuefeng Wang 《Burns & Trauma》 SCIE 2019年第1期118-124,共7页
Background:Patients with extensive burns usually develop pro-coagulation soon after the injury if there is no sepsis occurred.We describe the case of an extensive burn adult suffering from hypocoagulation not related ... Background:Patients with extensive burns usually develop pro-coagulation soon after the injury if there is no sepsis occurred.We describe the case of an extensive burn adult suffering from hypocoagulation not related to sepsis,but secondary to antibiotic treatment.Case presentation:Here,we report a case of an adult male patient suffering from flame burns of 45%total body surface area(40%full thickness)combined with inhalation injury.Hypocoagulopathy with soaring prolonged activated partial thromboplastin time value occurred on third week post-burn while systemic infection had been under control by application of broad-spectrum antibiotics.Investigations showed that not the infection but vitamin K-related coagulation factor deficiency were responsible for unexpected bleeding.However,supplemental vitamin K was not the key as we expected,which prompted us trying to decode the underlying cause of coagulation disturbance in this patient and pick out the most effective treatment for live-saving.After the withdrawal of highly suspected broad-spectrum antibiotic,Meropenem^(■),disturbed vitamin K related coagulation factors gradually restored to their optimal levels so as to maintain normal coagulation status.Therefore,surgical procedures without further risk of bleeding could be carried out in time for wound recovery.The patient was discharged on post-burn day 67 and transferred to a secondary hospital for his rehabilitation.Conclusion:Hypocoagulopathy may be devoted to different reasons other than sepsis in extensive burns.Early recognition of the cause for coagulation disturbance is critical to make appropriate treatment and save patients’lives.This case illustrated the importance of unveiling the mist cause for coagulation disturbance occurred in extensive burn patient,which paved the way for optimal life-saving treatments.And we also recommend burn surgeons to be alerted to antibiotic-induced vitamin K deficiency-related coagulopathy among critical burn patients. 展开更多
关键词 Hypocoagulation extensive burns Vitamin K deficiency Antibiotic-induced coagulopathy
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EXTENSIVE WOUND EXCISION IN SHOCK STAGE INPATIENTS WITH MAJOR BURNS
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作者 郭振荣 盛志勇 +4 位作者 刁力 高维谊 杨红明 林洪远 韩家林 《Chinese Medical Journal》 SCIE CAS CSCD 1995年第4期35-39,共5页
To stop excessive plasma loss,alleviate noxious effcets of devitalized tissues on the body and shorten the hospitalization time,we performed extensive escharectomy during the shock period in extensively burned patie... To stop excessive plasma loss,alleviate noxious effcets of devitalized tissues on the body and shorten the hospitalization time,we performed extensive escharectomy during the shock period in extensively burned patients. 展开更多
关键词 TBSA IO CI CO extensive WOUND EXCISION IN SHOCK STAGE INPATIENTS WITH MAJOR burnS ABP
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