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Endoscopic vs external dacryocystorhinostomy-comparison from the patients' aspect 被引量:5
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作者 Serdar Ozer Pinar A. Ozer 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2014年第4期689-696,共8页
·AIM: To compare the success and complication rates,duration of surgeries and clinical comfort after endoscopic dacryocystorhinostomy(END-DCR) or external dacryocysto-rhinostomy(EXT-DCR).·METHODS: Fifty pati... ·AIM: To compare the success and complication rates,duration of surgeries and clinical comfort after endoscopic dacryocystorhinostomy(END-DCR) or external dacryocysto-rhinostomy(EXT-DCR).·METHODS: Fifty patients who underwent EXT- or END-DCR between January 2010-2012 were involved in the study. A questionnaire was applied to patients preoperatively, and postoperatively. Subjective success was defined by absence of epiphora, objective success by a normal nasolacrimal lavage and a positive functional endoscopic dye test(FEDT). Postoperative pain and cosmetic result of surgery were interpreted by the patients, who were also asked whether they would offer this surgery to a friend or would prefer this surgery once more if necessary.·RESULTS: Twenty-five patients underwent END-DCR and 25 underwent EXT-DCR. Mean duration of surgeries were 35 min both for EXT-DCR(30-50) and END-DCR(35-50)(P =0.778). Intraoperative bleeding were documented in 48% of EXT-DCR and 4% of END-DCR cases(P 【0.001). In total 96% of EXT-DCR and 100% of END-DCR patients had subjective success. Objective success was 100% in each group. There was no significant difference between the epiphora scorings and FDDT results in postoperative visits among the groups.END-DCR group reported less pain in first week and month(P 【0.05, P 【0.05). More patients in END-DCR group were happy with the cosmetic result in first week and month(P 【0.001, P 【0.001). More patients in END-DCR group offered this surgery to a friend(P 【0.001). All patients in END-DCR group preferred this surgery once more if necessary, only 48% in EXT-DCR preferred the same method(P 【0.001).·CONCLUSION: Although both END- and EXT-DCRs provide satisfactory outcomes with similar objective andsubjective success rates, we demonstrated that the endonasal approach caused significantly less pain in early postoperative period than the external approach.Clinical comfort defined by the patients was quite higher in END-DCR group, in which patients mainly were pleased to encounter a sutureless surgical area. 展开更多
关键词 endoscopicdacryocystorhinostomy externa dacryocystorhinostomy subjective success objective success nasolacrimal lavage functional endoscopic dye test
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An update on microbiological causes of canine otitis externa in Campania Region,Italy
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作者 Luisa De Martino Francesca Paola Nocera +5 位作者 Karina Mallardo Sandra Nizza Eleonora Masturzo Filomena Fiorito Giuseppe Iovane Piergiorgio Catalanotti 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2016年第5期384-389,共6页
Objective: To update the recent knowledge of the microbiological causes of canine otitis externa in Campania Region(Italy) and the antibiotic susceptibility patterns of the isolated strains.Methods: A total of 122 dog... Objective: To update the recent knowledge of the microbiological causes of canine otitis externa in Campania Region(Italy) and the antibiotic susceptibility patterns of the isolated strains.Methods: A total of 122 dogs were examined by otoscopy, and auricular swab samples were collected from both ears in 74 dogs presenting clinical bilateral otitis and from single ears in 48 dogs displaying clinical unilateral otitis. Cytological examination,bacteriological analysis and antimicrobial susceptibility tests were performed.Results: Thirty-one out of 122 dogs were positive for yeast species(25.4%, 95% confidence interval(CI): 18.2%–34.2%) with a higher prevalence of Malassezia pachydermatis(21/31 isolates, 67.7%, CI: 48.5%–82.7%), and a total of 91 out of 122 dogs were positive for bacterial species(74.6%; CI: 65.8%–81.8%) with a higher prevalence of Staphylococcus pseudintermedius(45/143 isolates, 31.5%, CI: 24.1%–39.8%). These results are the first description of Streptococcus agalactiae-associated otitis. The yeasts isolated showed high levels of susceptibility to all antifungal agents tested; on the contrary all the isolated bacterial strains were highly resistant to at least four out of ten antimicrobial classes. Both Gram-positive and Gram-negative bacteria showed high resistance to amoxicillin/clavulanate and kanamycin hence they are not recommended as initial empirical therapy for the otitis treatment.Conclusions: This update illustrates an increase in antibiotic resistances providing an insight into the current knowledge of the therapeutic procedures followed on canine otitis externa in Italy. It also emphasizes the importance of considering the results of the microbiological and sensitivity tests to decide on an appropriate antibiotic therapy. 展开更多
关键词 CANINE OTITIS externa MALASSEZIA pachydermatis STAPHYLOCOCCUS pseudintermedius Antimicrobial resistance
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Human ophthalmomyiasis externa caused by the sheep botfly Oestrus ovis:a case report from Karachi,Pakistan
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作者 Naima Fasih Kanza Noor Qaiser +2 位作者 Syeda Aisha Bokhari Bushra Jamil Mohammad Asim Beg 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2014年第10期835-837,共3页
Ocular myiasis due to Oestrus ovis larvae infestation is an eye infection in humans.A case of ophthalmomyiasis externa in a young male from Karachi,Pakistan in winter(December 2012),without history of close proximity ... Ocular myiasis due to Oestrus ovis larvae infestation is an eye infection in humans.A case of ophthalmomyiasis externa in a young male from Karachi,Pakistan in winter(December 2012),without history of close proximity to domestic animals or visit to any rural area was reported.The condition is self-limiting and the disease is confined to the conjunctiva.The eye was locally anesthetized and washed with 5%povidine iodine solution.A total number of 27 first instar larvae of Oestrus ovis were removed with fine forceps.The patient received 0.5%moxifloxacin and diclofenac eye drops for one week.His eye was examined after one day,one week and one month and the recovery status was favorable.The present case raise the awareness among ophthalmologists regarding larval conjunctivitis as one of the causes of conjunctivitis and it can occur throughout the year in any season including winter.Moreover,it can occurr in any area either rural or urban with or without close proximity to domestic animals especially in subtropical regions with high parasitic burden. 展开更多
关键词 Ophthalmomyiasis externa Oestrus OVIS Pakistan Eye INFECTIONS
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Necrotising otitis externa:A single centre experience
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作者 Mehdi Hasnaoui Asma Ben Mabrouk +4 位作者 Jihene Chelli Fatma Larbi Ammari Rihab Lahmar Adnene Toumi Khalifa Mighri 《Journal of Otology》 CSCD 2021年第1期22-26,共5页
Introduction:Necrotising otitis externa(NOE)is a rare infection of the ear canal with frequent bone erosion.This study’s objective is to describe the different features of NOE as well as its management in an ear-nose... Introduction:Necrotising otitis externa(NOE)is a rare infection of the ear canal with frequent bone erosion.This study’s objective is to describe the different features of NOE as well as its management in an ear-nose-throat department.We also tried to identify the particularities of the fungal infection.Patients and methods:It is an observational cohort that included all the patients hospitalised for the management of NOE.The study was carried out in the ear-nose-throat Department of Mahdia University Hospital in Tunisia between January 2006 and december 2019.Results:A total of 40 patients were included.The mean age was 65±12.9 years and the sex ratio was 0.9.Ninety percent of the patients included were diabetics.The most common signs found were oedema of the external canal(97.5%)and auricular discharge(92.5%).The main pathogen isolated was Pseudomonas aeruginosa(61.7%).Fungi were isolated in 9 cases(26.47%).Computed tomography was performed for 32 patients(80%).Bone erosion was seen in 26 cases(81.3%).The main complications were cerebral venous thrombosis,retropharyngeal abscess and cerebral empyema.Thirty one patients received only antibiotics,2 received only antifungal treatment,and 7 received both antibiotics and antifungal treatment.All patients had a favorable outcome.Univariate analysis showed a higher median erythrocyte sedimentation rate was associated with fungal infections.No other differences were noted.Conclusion:Our management protocol seems to be efficient since all patients had initial favorable outcome.A higher median erythrocyte sedimentation rate was associated with fungal infections. 展开更多
关键词 Otitis externa FUNGI PSEUDOMONAS Diagnosis THERAPEUTICS
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Malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy:a report and review of literature
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作者 K Devaraja Dipak Ranjan Nayak 《Journal of Otology》 CSCD 2020年第3期112-116,共5页
Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa,which typically spreads to skull base to involve cranial nerves VII.Rarely can it also effect one ... Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa,which typically spreads to skull base to involve cranial nerves VII.Rarely can it also effect one or more of cranial nerves IX,X,XI,and XII.We present a case of malignant otitis externa which presented with symptomatic palsy of IX and XII nerves sparing the VII cranial nerve.The patient though later on had internal jugular vein thrombosis,which we presume is due to the involvement of the parapharyngeal space that prompted us to reconsider the diagnosis,and later on,to aggravate the therapy.With proper blood sugar control and appropriate long term antibiotics,not only that the patient is disease free at one year follow up,but the cranial nerve deficits also recovered.Apart from sharing the clinical and management details of this patient,we have reviewed the relevant literature in the discussion,which has shed some light onto some of the interesting facts about this condition and its prognosis. 展开更多
关键词 Skull base osteomyelitis Malignant otitis externa Hypoglossal palsy Diabetes mellitus Internal jugular vein
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Field Comparison of the Impact of Different Treatment Durations in the Treatment of Acute Otitis Externa
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作者 Erik Grandemange Florence Pillet +1 位作者 Olivier Roy Frédérique Woehrlé 《Open Journal of Veterinary Medicine》 2013年第6期289-296,共8页
Background: Acute otitis externa is a common multi-factorial disorder in the dog. Several topical preparations are available on the veterinary market, which are licensed for an either specified duration of treatment o... Background: Acute otitis externa is a common multi-factorial disorder in the dog. Several topical preparations are available on the veterinary market, which are licensed for an either specified duration of treatment or for a discretionary period that is determined by the clinician. Objectives: To compare the efficacy of two topical products, both licensed for the treatment of otitis externa in the dog, but with different treatment durations. Animal Population: One hundred and sixty dogs were enrolled in this multicentre field study from which 157 dogs were analysed in the Per Protocol sample (73 Aurizon?treated animals and 84 Easotic?treated animals). Method: Dogs were randomly assigned to Aurizon?or Easotic?treatment groups. Aurizon?(Vétoquinol SA: marbofloxacin, clotrimazole, dexamethasone) was administered daily in the affected ear(s) for 7 or 14 days, and was compared with a daily administration of Easotic?(Virbac SAS: gentamicin, miconazole, hydrocortisone aceponate) for 5 days. General and localised clinical signs were scored on days 0 (D0), 3 (D3), 7 (D7), 14 (D14) and 21 (D21). Results: Clinical cure rates at the end of treatment were 56.3% and 48.8% (p=0.35) in the Aurizon?and Easotic?groups respectively and 81.2% versus 74.7% one week after completing the course of treatment (p = 0.34). Twenty-one days after initially presenting for the study, cure rates were 84.3% in the Aurizon?group and 73.8% in the Easotic?(p=0.12). A relationship between severity of clinical signs and treatment duration was observed. Conclusion and Clinical Significance: At the end of the trial period, cure rates showed a tendency to be higher in the Aurizon?treated animals. The flexible dosage and the veterinary monitoring permitted treatment duration to be adjusted based upon the severity of otitis externa thus increasing the likelihood of clinical cure. 展开更多
关键词 ACUTE OTITIS externa TOPICAL EAR TREATMENT Efficacy FIELD Clinical Trial
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Double Blinded,Randomized and Controlled Comparative Study Evaluating the Cleaning Activity of Two Ear Cleaners in Client-Owned Dogs with Spontaneous Otitis Externa
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作者 Geneviève Marignac Jean Yanique Petit +6 位作者 Jean Francois Jamet Loic Desquilbet Jean Luc Petit Frédérique Woehrlé Tessa Trouchon Oscar Fantini Sébastien Perrot 《Open Journal of Veterinary Medicine》 2019年第6期67-78,共12页
Ear cleaning is a therapeutic component in the management of otitis externa in dogs. The objectives of this study were to evaluate the in vivo efficacy and safety of a new ear cleanser, Sonotix? against EpiOtic? Advan... Ear cleaning is a therapeutic component in the management of otitis externa in dogs. The objectives of this study were to evaluate the in vivo efficacy and safety of a new ear cleanser, Sonotix? against EpiOtic? Advanced for the management of canine otitis externa. Eighteen clients owned dogs with a diagnosis of erythemato-ceruminous or purulent otitis externa were prospectively included and randomized to two treatment group: EpiOtic? Advanced and Sonotix?. Cytology and video-otoscopic examination (erythema, amount of cerumen and thickness and surface of ear canal covered by cerumen) of all affected ears were done at D0, both before (T0) and 30 minutes (T0 + 30 min) after ear cleaning. Then an ear medication was applied (Aurizon?, Vetoquinol). Owners were instructed to clean affected ears daily and apply the ear medication 30 minutes later for 5 days (D1-D5). Dogs were seen again at D6 for cytology and video-otoscopic examination. At T0, no significant differences were found between both ear cleansers groups regarding macroscopic and microscopic scorings. At T0 + 30 min and D6 cytological and video-otoscopic scores were significantly decreased (Wilcoxon test;p < 0.01) compared to baseline in both groups. However, the cleaning activity of Sonotix? was statistically superior to Epiotic? as evidenced by the median global scores of video-otoscopic examination at T0 + 30 min (Mann Whitney Test, p < 0.01). Effective ear cleaning is an essential part of any treatment scheme because it favours the contact between the ointment and the lining ear epidermis and speeds resolution by the removal of cerumen, microbial organisms and cellular debris. In our study, the important reductions in yeast, cocci, and rod-shaped organism counts were demonstrated in smears at T0 + 30 min and D6 in both groups. Video-otoscopic examination performed 30 minutes after ear cleaning suggests that Sonotix? seems to be more effective in removing cerumen than EpiOtic? Advanced. 展开更多
关键词 Ear Cleaning Canine Ear Cleanser Otitis externa
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Haplotypic Variation of Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae) in Different Geographic Locations
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作者 Mariah Valente Baggio Sergio Freitas 《Journal of Agricultural Science and Technology(B)》 2014年第10期804-810,共7页
关键词 单倍型 外耳炎 地理位置 草蛉 脉翅目 细胞色素C氧化酶 线粒体基因 基因突变
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The diagnostic conundrum in necrotizing otitis externa
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作者 Abiya A.Ahmed Shaan Rashid +2 位作者 Vinay K.Gupta Neil C.Molony Keshav K.Gupta 《World Journal of Otorhinolaryngology-Head and Neck Surgery》 CAS CSCD 2024年第1期59-65,共7页
Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory canal.Late diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and trea... Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory canal.Late diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and treatment are paramount.NOE is a notoriously challenging diagnosis to make.It is therefore important to understand what diagnostic modalities are available and how otolaryngologists can use them to accurately treat such an aggressive disease.This review aims to evaluate the different diagnostic options available in NOE and discuss their advantages and limitations,thus,providing an up‐to‐date picture of the multimodal approach required in the diagnosis of this disease. 展开更多
关键词 DIAGNOSTIC malignant otitis externa NECROTIZING OSTEOMYELITIS skull base osteomyelitis temporal bone osteomyelitis
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Hyperbaric oxygen therapy in malignant otitis externa:A systematic review of the literature
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作者 Young Jae Byun Jaimin Patel +1 位作者 Shaun A.Nguyen Paul R.Lambert 《World Journal of Otorhinolaryngology-Head and Neck Surgery》 2021年第4期296-302,共7页
Objective:To review the role of adjuvant hyperbaric oxygen therapy(HBOT)in the treatment of malignant otitis externa(MOE).Data sources:PubMed,Scopus,Web of Science,Science Direct,and Cochrane Library were searched for... Objective:To review the role of adjuvant hyperbaric oxygen therapy(HBOT)in the treatment of malignant otitis externa(MOE).Data sources:PubMed,Scopus,Web of Science,Science Direct,and Cochrane Library were searched for the following concepts:“hyperbaric oxygen”and“malignant or necrotizing otitis externa.”Methods:Studies were included if they contained(1)patients with reported evidence of MOE,(2)employment of adjuvant HBOT,(3)details on patients’medical condition,and(4)documented survival outcomes.Extracted information included patient demographics,underlying medical conditions,infectious etiology,signs and symptoms,medical and surgical treatments,duration of medical treatment,mean follow up time,HBOT setting,number of HBOT sessions,complications,survival rate,and all-cause mortality.Results:A total of 16 studies comprising 58 patients(mean age 68.0 years)were included.Diabetes was present in 94.7%of cases and Pseudomonas spp(64.3%)was the most common infectious agent.Cranial nerve VII was involved in 55.2%of cases.Overall,the disease cure rate with adjuvant HBOT was 91.4%and all-cause mortality was 8.6%.Among those who had cranial nerve VII involvement,72.0%had return of function and 93.8%of them survived.Conclusion:HBOT may be an effective treatment option for refractory or advanced MOE but its efficacy remains unproven due to lack of strong scientific evidence.However,its therapeutic value should not be underestimated given good results and few adverse events reported in this study. 展开更多
关键词 Malignant otitis externa Necrotizing otitis externa Diabetes mellitus Hyperbaric oxygen THERAPY OSTEOMYELITIS
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佩戴耳塞的外耳道炎临床表现及危险因素分析
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作者 金悠悠 刘昊天 +9 位作者 华薇 李利 郭成辰 姚心怡 张湘玲 李梅 张潇云 汪欣 时若瑄 郑芸 《中华耳科学杂志》 CSCD 北大核心 2024年第1期104-108,共5页
目的本研究旨在调查佩戴耳塞(插入式耳机)外耳道炎患者的临床表现及危险因素。方法横断面选取2022年11月—2023年11月四川大学华西医院耳鼻咽喉头颈外科临床诊断为外耳道炎的患者291例,按照有无佩戴耳塞将患者分为佩戴耳塞组128例和无... 目的本研究旨在调查佩戴耳塞(插入式耳机)外耳道炎患者的临床表现及危险因素。方法横断面选取2022年11月—2023年11月四川大学华西医院耳鼻咽喉头颈外科临床诊断为外耳道炎的患者291例,按照有无佩戴耳塞将患者分为佩戴耳塞组128例和无佩戴耳塞组163例。佩戴耳塞组根据佩戴后是否有外耳道炎临床表现分为有外耳道炎临床表现87例和无临床表现41例。采用logistic回归分析佩戴耳塞外耳道炎患者的临床表现及可能危险因素。结果87例(67.97%)自述在佩戴耳塞后出现外耳道炎临床表现为非特异性,包括佩戴后耳痒、耳痛、溢液流脓等症状。单因素分析结果显示,佩戴耳塞的外耳道炎临床表现与既往外耳道疾病史、皮肤油脂分泌旺盛表现、耳塞材质、佩戴耳塞目的有关。多因素logistic回归分析结果显示,皮肤油脂分泌旺盛表现是佩戴耳塞的外耳道炎临床表现的独立危险因素(OR=0.399,95%CI:0.172~0.926)。结论佩戴耳塞的外耳道炎临床表现为非特异性,其危险因素为既往外耳道疾病史、皮脂分泌旺盛、耳塞材质和佩戴目的。 展开更多
关键词 外耳道炎 耳塞 危险因素 临床表现
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Comparative effects of insecticides with different mechanisms of action on Chrysoperla externa (Neuroptera" Chrysopidae)" Lethal, sublethal and dose-response effects 被引量:3
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作者 Moises Joao Zotti Anderson Dionel Grutzmacher +1 位作者 Isac Heres Lopes Guy Smagghe 《Insect Science》 SCIE CAS CSCD 2013年第6期743-752,共10页
The comprehensive knowledge that the delayed systemic and reproduction side effects can be even more deleterious than acute toxicity, has caused a shift in focus toward sublethal effects assessment on physiology and b... The comprehensive knowledge that the delayed systemic and reproduction side effects can be even more deleterious than acute toxicity, has caused a shift in focus toward sublethal effects assessment on physiology and behavior of beneficial insects. In this study, we assessed the risks posed by some insecticides with different mode of action through lethal and delayed systemic sublethal effects on the pupation, adult emergence, and repro- duction of the chrysopid Chrysoperla externa (Hagen, 1861; Neuroptera: Chrysopidae), an important predator in pest biological control. The maximum field recommended dose (MFRD) and twice (2xMFRD) for chlorantraniliprole, tebufenozide, and pyriproxyfen were harmless to C. externa. In contrast, all the tested chitin synthesis inhibitors (CSIs) were highly detrimental to the predator, despite of their lack of acute lethal toxicity. There- fore, the safety assumed by using IGRs toward beneficial insects is not valid for chrysopids. Dose-response data showed that although all CSIs have a similar mechanism of action, the relative extent of toxicity may differ (novaluron 〉 lufenuron 〉 teflubenzuron). For CSIs, the delayed systemic effects became obvious at adult emergence, where the predicted no observable effect dose (NOED) was 1/2 048 of the MFRD for novaluron (0.085 ng/insect), and 1/256 of the MFRD for both lufenuron (0.25 ng/insect) and teflubenzuron (0.6 ng/insect). Finally, this work emphasized the significance of performing toxicity risk assessments with an adequate posttreatment period to avoid underestimating the toxicities of insecticides, as the acute lethal toxicity assays may not provide accurate information regarding the long-range effects of hazardous compounds. 展开更多
关键词 Chrysoperla externa dose-response effects ecotoxicology IGRs insecti-cide risk assessment topical application
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曲安奈德益康唑乳膏联合硝酸咪康唑治疗真菌性外耳道炎的效果及对菌群抑制作用、炎性因子的影响
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作者 张倩 王丹婷 王景景 《临床医学研究与实践》 2024年第16期92-95,共4页
目的分析曲安奈德益康唑乳膏联合硝酸咪康唑治疗真菌性外耳道炎的效果及对菌群抑制作用、炎性因子的影响。方法选择2018年7月至2021年12月收治的90例真菌性外耳道炎患者为研究对象,以随机数字表法将其分为对照组、观察组,各45例。对照... 目的分析曲安奈德益康唑乳膏联合硝酸咪康唑治疗真菌性外耳道炎的效果及对菌群抑制作用、炎性因子的影响。方法选择2018年7月至2021年12月收治的90例真菌性外耳道炎患者为研究对象,以随机数字表法将其分为对照组、观察组,各45例。对照组接受硝酸咪康唑治疗,观察组在对照组基础上加施曲安奈德益康唑乳膏治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组的真菌转阴率高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的巨噬细胞炎症蛋白-2(MIP-2)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-18(IL-18)水平比较,差异无统计学意义(P>0.05);治疗后,观察组的MIP-2、TNF-α、IFN-γ、IL-18水平均低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的气导听阈、气骨导差比较,差异无统计学意义(P>0.05);治疗后,观察组的气导听阈、气骨导差均低于对照组,差异具有统计学意义(P<0.05)。结论曲安奈德益康唑乳膏联合硝酸咪康唑治疗真菌性外耳道炎可提高真菌转阴率,调节炎性因子水平,提高听力功能,提升治疗效果,值得推广。 展开更多
关键词 曲安奈德益康唑乳膏 硝酸咪康唑 真菌性外耳道炎 菌群抑制 炎性因子
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Methicillin-resistant Staphylococcus aureus in acute otitis externa
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作者 Maria J.Duarte Elliott D.Kozin +3 位作者 Paulo J.M.Bispo Andreas H.Mitchell Michael S.Gilmore Aaron K.Remenschneider 《World Journal of Otorhinolaryngology-Head and Neck Surgery》 2018年第4期246-252,共7页
Objective:Otologic methicillin-resistant Staphylococcus aureus(MRSA)infection has historically been rare,but given the rise in community-acquired MRSA carriage and infection at other body sites,prevalence rates may be... Objective:Otologic methicillin-resistant Staphylococcus aureus(MRSA)infection has historically been rare,but given the rise in community-acquired MRSA carriage and infection at other body sites,prevalence rates may be changing.The goal of this study was to determine the prevalence of MRSA in recent otologic cultures from patients with acute otitis externa(AOE).Study design:Retrospective review of an institutional microbiologic database.Methods:A retrospective analysis was performedon serial culture isolates taken fromthe ear at a quaternary care hospital from January 2014 to April 2016.The causative pathogen and antibiotic sensitivity was determined by culture isolation and end point mean inhibitory concentration(MIC)testing.Medical records were reviewed to document patient characteristics,chronicity of infection,symptomatology,and previous treatments.Results:Over the study period,173 patients were diagnosed with AOE and underwent otologic cultures of the ear.Fifty-three(30.6%)of cultures grew S.aureus(SA).Of SA infections,15(28.3%)were identified as MRSA.MRSA patients were typically older than patients with methicillin-sensitive SA(MSSA)(mean age 46.717.9 vs 2919.4,PZ0.003)and had more medical comorbidities(4 vs 1.7,PZ0.001).Compared to patients with MSSA,patients with MRSAwere significantly more likely to have had prior ototopical antibiotic exposure(37%vs 73%,PZ0.019).Conclusion:Contemporary ear culture isolates at quaternary care center show higher rates of MRSA compared to historical reports in the literature.Clinicians should consider ear cultures to identify MRSA AOE.Level of Evidence:IV. 展开更多
关键词 Acute otitis externa Staphylococcus aureus Methicillin-resistant Staphylococcus aureus MRSA
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微波联合碳酸氢钠注射液浸泡及外耳道冲洗治疗真菌性外耳道炎的效果
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作者 陈朝荣 《中外医药研究》 2024年第5期3-5,共3页
目的:探究微波联合碳酸氢钠注射液浸泡及外耳道冲洗治疗真菌性外耳道炎的效果。方法:选取2022年1月—2023年6月黔南布依族苗族自治州瓮安县中医院收治的真菌性外耳道炎患者70例为研究对象,采用单双号法将患者分为观察组和对照组,各35例... 目的:探究微波联合碳酸氢钠注射液浸泡及外耳道冲洗治疗真菌性外耳道炎的效果。方法:选取2022年1月—2023年6月黔南布依族苗族自治州瓮安县中医院收治的真菌性外耳道炎患者70例为研究对象,采用单双号法将患者分为观察组和对照组,各35例。对照组采用碳酸氢钠注射液浸泡联合外耳道冲洗治疗,观察组采用微波联合碳酸氢钠注射液浸泡及外耳道冲洗治疗。比较两组治疗前后白细胞介素-6(IL-6)、C反应蛋白(CRP)水平、治疗总有效率及不良反应发生率。结果:治疗前,两组IL-6、CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6、CRP水平降低,观察组IL-6、CRP水平低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.023)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:应用碳酸氢钠注射液浸泡、冲洗外耳道联合微波治疗真菌性外耳道炎效果较好,可有效改善机体内炎性因子水平。 展开更多
关键词 真菌性外耳道炎 碳酸氢钠注射液 外耳道冲洗 微波治疗
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Skull Base Osteomyelitis: A Rare Cause of Multiple Cranial Nerve Palsies—A Case Report from Ghana
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作者 Ekins Kuuzie Prince Kwabla Pekyi-Boateng +1 位作者 Annie Yennah Fiifi Duodu 《World Journal of Neuroscience》 2023年第4期257-265,共9页
Introduction: Skull Base Osteomyelitis (SBO) is an infectious inflammation of the skull bones that is often caused by malignant otitis externa (MOE) and affects the temporal bone. This condition commonly affects immun... Introduction: Skull Base Osteomyelitis (SBO) is an infectious inflammation of the skull bones that is often caused by malignant otitis externa (MOE) and affects the temporal bone. This condition commonly affects immunocompromised individuals and the elderly, particularly those with a history of diabetes mellitus. Diagnosis is challenging because of non-specific symptoms that lead to late detection and complications. This report discusses a case of SBO with multiple bilateral cranial nerve abnormalities and highlights the diagnostic and management challenges in high-risk individuals with subtle clinical signs. Case presentation: This report describes a 63-year-old patient with hypertension and diabetes who underwent surgical debridement of the left ear due to malignant otitis externa 4 months prior to presentation. The patient presented with significant dysarthria, dysphagia, ptosis of the left eye with double vision, and hearing impairment in the left ear. Examination revealed bilateral CN VI palsy, right CN VII palsy, left CN VIII palsy, and a right CN XII deficit. Initial tests were unremarkable, but a high Fungitell assay and a second review of the CT scan and MRI revealed a pathological process in the base of the skull involving bony structures and cranial nerves bilaterally, which helped diagnose SBO. The patient was subsequently discharged with oral voriconazole and continued his usual medications. The patient requested further management abroad, because he did not notice resolution of his symptoms. Surgical treatment was employed abroad to relieve his symptoms, as he recovered slowly. Conclusion: This case report underscores the importance of a multidisciplinary approach to address SBO. Collaboration between specialists in infectious diseases, otolaryngology, radiology, and neurology plays a pivotal role in achieving an accurate diagnosis and developing a tailored treatment plan. Although SBO may be infrequent, this case report highlights the need to maintain heightened clinical suspicion in high-risk individuals. 展开更多
关键词 Skull Base Osteomyelitis Cranial Nerves Malignant Otitis externa Bulbar Palsy Fungal Infection
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中药外耳道灌洗治疗真菌性耳道炎疗效观察及对耳道环境菌群的影响 被引量:1
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作者 房庆鹏 王宗杰 +2 位作者 于若卉 高春 褚俊链 《西部中医药》 2023年第1期116-119,共4页
目的:探讨中药外耳道灌洗治疗真菌性耳道炎的临床疗效及对耳道环境菌群的影响。方法:将真菌性耳道炎患者120例随机分成观察组与对照组各60例。对照组采用常规耳道清理联合滴耳液耳浴治疗并护理,观察组在对照组基础上采用中药灌洗液进行... 目的:探讨中药外耳道灌洗治疗真菌性耳道炎的临床疗效及对耳道环境菌群的影响。方法:将真菌性耳道炎患者120例随机分成观察组与对照组各60例。对照组采用常规耳道清理联合滴耳液耳浴治疗并护理,观察组在对照组基础上采用中药灌洗液进行外耳道负压灌洗。治疗2个月后观察两组疗效、血清炎症因子水平、治疗前后真菌菌群变化以及不良反应发生情况。结果:观察组总有效率为83.33%,高于对照组的75.00%,差异具有统计学意义(P<0.05);治疗后两组患者血清白细胞介素1和白细胞介素6水平均较治疗前降低,观察组下降更明显(t=8.331,7.435,P<0.001);治疗后观察组患者耳道曲霉属和白色念珠菌序列数较对照组减少(t=7.331,7.535,P<0.001);两组不良反应比较差异无统计学意义(P>0.05)。结论:中药外耳道灌洗护理治疗能降低真菌性耳道炎患者炎症因子水平与真菌菌群含量,效果优于常规耳道清理联合滴耳液耳浴,且具有良好安全性。 展开更多
关键词 真菌性耳道炎 耳道菌群 中药灌洗 临床疗效
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5例手术治疗坏死性外耳道炎病例分析并文献复习
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作者 李亚茹 纪彩丽 +1 位作者 李霭峰 付涛 《中华耳科学杂志》 CSCD 北大核心 2023年第6期932-935,共4页
坏死性外耳道炎(necrotizing otitis externa,NOE)是一种临床上不常见但可危及生命的外耳道和颞骨感染性疾病,其最早由Meltzer和Keleman于1959年首先报道,又名恶性外耳道炎,是一种严重的可致死的外耳道感染性疾病,主要发病人群为老年人... 坏死性外耳道炎(necrotizing otitis externa,NOE)是一种临床上不常见但可危及生命的外耳道和颞骨感染性疾病,其最早由Meltzer和Keleman于1959年首先报道,又名恶性外耳道炎,是一种严重的可致死的外耳道感染性疾病,主要发病人群为老年人、糖尿病患者、免疫力低下的个体[1-2]. 展开更多
关键词 坏死性外耳道炎 治疗 糖尿病
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氟康唑注射液耳浴联合曲安奈德益康唑乳膏对真菌性外耳道炎疗效及血清TNF-α、CRP及IL-6影响 被引量:1
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作者 吴礽武 《药品评价》 CAS 2023年第4期452-455,共4页
目的评价氟康唑注射液耳浴联合曲安奈德益康唑乳膏对真菌性外耳道炎疗效及血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)及白细胞介素-6(IL-6)的影响。方法将2020年2月至2022年4月宜黄县人民医院收治的116例真菌性外耳道炎患者随机分为... 目的评价氟康唑注射液耳浴联合曲安奈德益康唑乳膏对真菌性外耳道炎疗效及血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)及白细胞介素-6(IL-6)的影响。方法将2020年2月至2022年4月宜黄县人民医院收治的116例真菌性外耳道炎患者随机分为实验组(n=58)和参比组(n=58)。参比组采用曲安奈德益康唑乳膏治疗,实验组采用氟康唑注射液耳浴联合曲安奈德益康唑乳膏进行治疗,对比两组患者的治疗前后血清TNF-α、CRP及IL-6的炎症因子水平差异以及治疗有效性。结果治疗前两组CRP、IL-6、TNF-α差异无统计学意义(P<0.05);治疗后两组CRP、IL-6、TNF-α均较治疗前低(均P<0.05)且实验组的CRP、IL-6、TNF-α均低于参比组(均P<0.05);实验组总有效率96.55%高于参比组的86.21%(P<0.05)。结论使用氟康唑注射液耳浴联合曲安奈德益康唑乳膏治疗真菌性外耳道炎可有效改善患者血清TNF-α、CRP及IL-6炎症因子水平,减轻患者症状,提高治疗有效性,可在临床上借鉴应用。 展开更多
关键词 耳真菌病 外耳炎 氟康唑注射液 耳浴治疗 曲安奈德益康唑乳膏 炎症因子
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犬猫马拉色菌性外耳炎研究进展
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作者 赵懿侔 张含露 +5 位作者 邱实 吕熙 王开开 赵梦杉 郭灿森 杨丰利 《现代畜牧兽医》 2023年第3期79-84,共6页
马拉色菌性外耳炎是一类由马拉色菌大量繁殖引起的犬猫耳道皮肤病,该病往往造成犬猫耳部红肿瘙痒并分泌大量黑褐色油性分泌物。马拉色菌属于人畜共患病原微生物,在伴侣动物越来越多地与人类亲密接触时,马拉色菌也在人和宠物之间交互传播... 马拉色菌性外耳炎是一类由马拉色菌大量繁殖引起的犬猫耳道皮肤病,该病往往造成犬猫耳部红肿瘙痒并分泌大量黑褐色油性分泌物。马拉色菌属于人畜共患病原微生物,在伴侣动物越来越多地与人类亲密接触时,马拉色菌也在人和宠物之间交互传播,为马拉色菌的传播、感染、流行创造了条件。文章拟对犬猫马拉色菌性外耳炎病原学、流行病学、致病机制、临床表现及诊疗现状等方面进行综述,旨在为犬猫马拉色菌性外耳炎诊断及治疗提供参考。 展开更多
关键词 马拉色菌 外耳炎 致病机制 宠物疾病诊疗
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