HYBRID EXTERNAL FIXATOR FOR THE TREATMENT OF UNICAMERAL BONE CYSTS WITH PATHOLOGICAL FRACTURE IN THE PROXIMAL HUMERUS

Objective: Unicameral bone cyst is a nonneoplasticbone lesion characterized by its tenacity and risk ofrecurrence. Pathological fracture is common and is often the presenting symptom. The objective of the present study was to evaluate the results of hybrid external fixator for thetreatment of a unicameral bone cyst with a pathologicalfracture. Methods: Hybrid external fixator for thetreatment of a unicameral bone cyst was performed intwelve patients. These patients presented with a pathological fracture and were managed immediately with hybridexternal fixator, of whom four had been managedconservatively at other clinics before they were referred toour department. The cyst was located in the proximalhumerus in all patients. The mean age of the patients at the time of surgery was 8.7 years, and the mean duration offollow-up was 32.6 months. Radiographic evaluation wasperformed according to the criteria of Capanna et al., andthe cyst was classified as completely healed, healed withresidual radiolucency (osteolysis), recurred, or having noresponse. Results: The healing period ranged from three to eight months. Eight cysts healed completely, and threehealed with residual radiolucent areas visible onradiographs. There was recurrence of one cyst that hadhealed with residual radiolucency. All of the cysts in thepresent study responded to treatment. A modulation ofhybrid external fixator was necessary in three patients, asthe bars had become too short after bone growth or the pins had been loose. No major complications were observed.Conclusion: Hybrid external fixator provides earlystability, which allows early mobilization and thus obviates the need for a plaster cast. This method of treatment alsoallows for an early return to normal activity.

Polymethylmethacrylate bone cements and additives: A review of the literature

Polymethylmethacrylate(PMMA) bone cement technology has progressed from industrial Plexiglass administration in the 1950 s to the recent advent of nanoparticle additives. Additives have been trialed to address problems with modern bone cements such as the loosening of prosthesis, high post-operative infection rates, and inflammatory reduction in interface integrity. This review aims to assess current additives used in PMMA bone cements and offer an insight regarding future directions for this biomaterial. Low index(< 15%) vitamin E and low index(< 5 g) antibiotic impregnated additives significantly address infection and inflammatory problems, with only modest reductions in mechanical strength. Chitosan(15% w/w PMMA) and silver(1% w/w PMMA) nanoparticles have strong antibacterial activity with no significant reduction in mechanical strength. Future work on PMMA bone cements should focus on trialing combinations of these additives as this may enhance favourable properties.

Treatment of tibial defect and bone nonunion with limb shortening with external fixator and reconstituted bone xenograft

Objective: To explore the effect of external fixator and reconstituted bone xenograft (RBX) in the treatment of tibial bone defect, tibial bone nonunion and congenital pseudarthrosis of the tibia with limb shortening. Methods: Twenty patients ( 13 males and 7 females) with tibial bone defect, tibial bone nonunion or congenital pseudarthrosis of the tibia with limb shortening were treated with external fixation. Two kinds of external fixators were used: a half ring sulcated external fixator used in 13 patients and a combined external fixator in 7 patients. Foot-drop was corrected at the same time with external fixation in 4 patients. The shortened length of the tibia was in the range of 2-9 cm, with an average of 4.8 cm. For bone grafting, RBX was used in 12 patients, autogenous ilium was used in 3 patients and autogenous fibula was implanted as a bone plug into the medullary canal in 1 case, and no bone graft was used in 4 patients. Results: All the 20 patients were followed-up for 8 months to 7 years, averaging 51 months. Satisfactory function of the affected extremities was obtained. All the shortened extremities were lengthened to the expected length. For all the lengthening area and the fracture sites, bone union was obtained at the last. The average healing time of 12 patients treated with RBX was 4.8 months. Conclusions: Both the half ring sulcated external fixator and the combined external fixator have the advantages of small trauma, simple operation, elastic fixation without stress shielding and non-limitation from local soft tissue conditions, and there is satisfactory functional recovery of affected extremities in the treatment of tibial bone defects, tibial bone nonunion and congenital pseudarthrosis of the tibia combined with limb shortening. RBX has good biocompatibility and does not cause immunological rejections. It can also be safely used in treatment of bone nonunion and has reliable effect to promote bone healing.

Assessment of the trauma degree and bone metabolism after external fixation combined with vacuum sealing drainage treatment of open tibiofibula fracture

Objective: To evaluate the effect of external fixation combined with vacuum sealing drainage on the trauma degree and bone metabolism in patients with open tibiofibula fracture. Methods:A total of 116 patients with open tibiofibula fracture who received surgical treatment in Luzhou People's Hospital between February 2015 and January 2017 were divided into control group (n=58) and study group (n=58) by random number table. Control group received debridement + external fixation, and study group received debridement + external fixation +vacuum sealing drainage. The differences in the levels of trauma indexes and bone metabolism indexes were compared between the two groups before and after treatment. Results: Before surgery, there was no statistically significant difference in serum levels of trauma indexes and bone metabolism indexes between the two groups. 1 week after surgery, serum acute phase protein Tf level of study group was higher than that of control group whereas CER, Hp and CRP levels were lower than those of control group;stress indexes NE and Cor levels were lower than those of control group;bone metabolism indexes P1NP, BGP and BALP levels were higher than those of control group whereas β-CTX level was lower than that of control group. Conclusion: External fixation combined with vacuum sealing drainage can effectively reduce fracture trauma and promote fracture end healing in patients with open tibiofibula fracture.

Cortical bone trajectory fixation in cemented vertebrae in lumbar degenerative disease:A case report

BACKGROUND Percutaneous vertebroplasty(PVP)has been widely used in osteoporotic vertebral compression fracture(OVCF).Following surgery,the bone cement would be positioned permanently.However,in some cases of lumbar degenerative disease,the cemented vertebrae needs to be fixed after decompression and fusion procedure.It is difficult to implant traditional pedicle screws into the cemented vertebrae because of the bone cement filling.At present,the main treatment strategy is to skip the cemented vertebra and conduct a long segment fixation.This article presents a cortical bone trajectory(CBT)fixation technique for cemented vertebrae.CASE SUMMARY PVP involving the L3 and L4 was performed in an 82-year-old man due to OVCF.During the surgery,bone cement leakage occurred,resulting in compression of the root of the right L3 nerve.We performed a partial facetectomy to retrieve the leaked bone cement and to relieve the patient’s neurological symptoms.After 3 mo,the patient developed lumbar disc herniation in L3/4,potentially due to instability caused by the previous surgery.Therefore,it was necessary to perform intervertebral fusion and fixation.It was difficult to implant traditional trajectory pedicle screws in L3 and L4 because of the bone cement filling.Hence,we implanted CBT screws in the L3 and L4 vertebrae.As a result,the patient’s symptoms resolved and he reported satisfaction with the surgery at follow-up after 8 mo.CONCLUSION It is feasible to utilize CBT in cemented vertebrae for the treatment of lumbar degenerative disease.

抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折

目的:探讨抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折的临床疗效。方法:自2017年1月至2022年3月应用抗生素骨水泥被覆重建钢板治疗感染性骨盆前环骨折患者11例,男7例,女4例;年龄27~49岁;骨盆骨折Tile分型:C1型4例,C2型4例,C3型3例。2例前环内固定术后感染,9例患者均因早期清创不彻底导致前环感染,按创伤严重度评分标准(injury severity score,ISS)评分为24~38分。前环经扩大清创、冲洗、抗生素骨水泥被覆重建钢板内固定,后环骨折均采用闭合复位,骶髂螺钉内固定。结果:11例均获得随访,时间13~20个月。2例术后感染复发,1例经再次清创更换抗生素骨水泥涂层内固定,1例感染较轻,未累计髓腔,清创后保留钢板仅更换抗生素骨水泥,感染得到控制。2例出现切口渗液,术后3个月取出内固定后愈合。所有患者在随访期内未见骨盆骨折再移位、再发感染。最终11例均骨性愈合。末次随访,按照Matta骨折复位标准,优6例,良4例,可1例;按照Majeed功能评分,优6例,良3例,可2例。结论:抗生素骨水泥被覆重建钢板有效治疗感染性骨盆前环骨折,具有术中安全性高和感染复发率低的特点,有利于术后早期康复锻炼,明显缩短病程。

改良分次骨水泥推注在骨质疏松性腰椎压缩性骨折内固定术中的应用效果

目的探讨改良分次骨水泥推注在骨质疏松性腰椎压缩性骨折内固定术中的应用效果。方法骨质疏松性腰椎压缩性骨折患者66例随机均分为对照组和研究组,两组均行经皮椎弓根螺钉内固定术及椎体成形术,其中对照组采取一次骨水泥注射椎体成形术、研究组采取改良分次骨水泥推注椎体成形术,术后均给与抗骨质疏松及抗感染等治疗,并随访6个月;记录两组患者手术耗时、骨水泥推注量及骨水泥渗漏发生情况,于术前、术后第3天及末次随访时视觉模拟评分法(VAS)评估疼痛程度,对比伤椎椎体前缘高度及后凸Cobb角,用Oswestry功能障碍指数(ODI)评估患者的脊柱功能障碍程度。结果研究组患者手术耗时、骨水泥推注量与对照组比较,差异无统计学意义(P>0.05);研究组骨水泥渗漏率低于对照组(P<0.05);两组患者术后第3天、末次随访时的VAS评分、ODI评分均低于术前(P<0.05),末次随访时VAS评分、ODI评分均较术后第3天降低(P<0.05);两组患者术后第3天、末次随访时伤椎椎体前缘高度均高于术前(P<0.05),后凸Cobb角均小于术前(P<0.05);两组间不同时间点的VAS评分、ODI评分、伤椎椎体前缘高度及后凸Cobb角比较,差异无统计学意义(P>0.05)。结论与传统一次骨水泥注射比较,改良分次骨水泥推注椎体成形术骨水泥渗透发生率较低。

病灶清除植骨融合联合外支架治疗晚期腕关节结核疗效观察

目的:观察病灶清除植骨融合联合外固定架治疗腕关节结核的临床疗效。方法:2015年10月至2019年5月,采用病灶清除植骨融合联合外固定术治疗25例晚期腕关节结核患者,男14例,女11例;年龄40~74 (60.72±8.45)岁;病程5~24 (11.52±7.61)个月;左腕结核11例,右腕结核14例,合并窦道形成者5例。术后继续规律抗结核,观察患者治疗前后视觉模拟疼痛评分(vasual analogue scale,VAS)、炎症指标、Gartland-Werley腕关节功能评分、上肢功能评分(disabilities of the arm,shoulder and hand,DASH)。结果:25例患者获得随访,时间12~36(19.7±6.3)个月,末次随访患者切口愈合可,均无结核、感染复发。术前1周与术后3个月VAS分别为(5.16±1.14)、(1.68±0.80)分,红细胞沉降率(enythrocyte sedimentation rate,ESR)分别为(44.20±20.56)、(14.44±1.14) mm·h^(-1),C反应蛋白(C-reactive protein,CRP)为(12.37±7.95)、(4.30±3.37) mg·L^(-1),各时间点比较差异均有统计学意义(P<0.01)。术前1周与术后1年Gartland-Werley腕关节功能评分分别为(21.32±3.44)、(14.96±1.37)分,两者比较差异有统计学意义(P<0.01);DASH由术前1周的(70.52±7.95)分,提高至术后1年的(28.84±2.30)分(P<0.01)。末次随访所有患者结核病无复发。结论:采用病灶清除植骨融合联合外固定术治疗腕关节结核近期临床疗效满意。

小切口掌侧截骨结合骨水泥外固定支架治疗第5掌骨颈骨折畸形愈合

目的 探讨小切口掌侧截骨结合骨水泥外固定支架治疗第5掌骨颈骨折畸形愈合的临床效果。方法 采用小切口掌侧截骨结合骨水泥外固定支架治疗第5掌骨颈骨折畸形愈合患者27例,通过术后6个月以上随访,评价外观指标、功能指标以及总体满意度等。结果 术后随访时间6~12个月,平均(8.6±2.1)个月。所有患者术后8~21周均达到骨性愈合,未出现内固定物断裂、深部切口感染、骨折不愈合等并发症。术后第5掌骨长度、第5掌指关节伸直角度、第5掌指关节活动度、拇小指捏力、拇小指握力、患者满意度评分等指标均明显优于术前(P<0.05)。结论 小切口掌侧截骨结合骨水泥外固定支架治疗第5掌骨颈骨折畸形愈合,手术方法安全有效,极大改善了患者的手部外观及功能,值得推广。

自制简易外固定架治疗掌、指骨骨折

2020年4月~2022年6月,我科采用自制简易外固定架治疗17例掌、指骨骨折患者,效果良好,报道如下。1材料与方法1.1病例资料本组17例,男12例,女5例,年龄17~58岁。开放骨折12例,闭合骨折5例。单纯指骨或掌骨骨折13例,指骨合并掌骨骨折4例。患者入院后行骨折复位简易外固定架固定治疗。简易外固定架组成及使用所需材料包括一次性乳胶引流管、克氏针、一次性注射器、骨水泥液态单体、骨水泥粉剂,见图1。患者伤后至手术时间4 h~6 d。

骨水泥棒外固定支架治疗第五掌骨颈骨折的有限元分析

目的采用三维有限元数值模拟方法分析比较骨水泥棒外固定支架与交叉克氏针在力学稳定性方面的差异,为手术治疗第五掌骨颈骨折(特别是第五掌骨颈开放性骨折)提供理论依据。方法选取1名健康志愿者,采集其手腕关节的三维CT图像数据,首先利用Mimics Research 21.0、Geomagic Studio 2021软件进行三维图形数据处理,在此基础上应用Solidworks 2020软件构建第五掌骨颈骨折骨水泥棒外固定支架模型(A模型)和第五掌骨颈骨折交叉克氏针固定模型(B模型)。在ANSYS Workbench 17.0中对各模型的材料属性进行赋值、划分网格,建立三维有限元模型。最后通过在第五掌骨头远端关节面进行轴向施加和第五掌骨三点弯曲实验,计算得出两种施压方式的远端骨折块的最大位移,以此评价骨水泥棒外固定支架治疗第五掌骨颈骨折的稳定性。结果(1)轴向施压时,A模型远端骨折块的最大位移、最小位移和平均位移的值大于B模型,A模型近端骨折块的最大位移、最小位移和平均位移的值小于B模型,A模型最大相对位移、最小相对位移和平均相对位移大于B模型。(2)在三点折弯给力时,A模型远端骨折块最大位移小于B模型,远端骨折块最小位移等于B模型,近端骨折块的最大位移和最小位移的均值大于B模型,A模型最大相对位移、最小相对位移和平均相对位移大于B模型。(3)与B模型相比较,A模型的总体应力、固定物应力均明显较小。结论骨水泥棒外固定支架及克氏针交叉固定在治疗第五掌骨颈骨折方面,在轴向和纵向上的位移及总位移均未超过1 mm,差异较小;但骨水泥棒外固定支架在两种施力方式中与交叉克氏针相比应力更小,提示骨水泥棒外固定支架能提供可靠的力学稳定性。

个体化单侧椎弓根外入路与双侧椎弓根入路椎体成形后骨水泥的弥散效果

背景:目前已有的临床研究认为,椎弓根外入路与椎弓根入路行椎体成形治疗均可改善脊柱压缩骨折患者的疼痛并改善其生活质量,相较于椎弓根入路相比,椎弓根外入路的穿刺角度更加自由,可通过调整穿刺外倾角获得良好的骨水泥弥散效果。目的:通过量化骨水泥弥散效果,对比个体化单侧椎弓根外入路与双侧椎弓根入路行椎体成形治疗脊柱压缩性骨折的效果。方法:纳入80例胸腰椎压缩骨折患者,采用随机数字表法分为2组,双侧椎弓根组(n=40)接受双侧椎弓根入路椎体成形手术,单侧椎弓根外组(n=40)接受个体化单侧椎弓根外入路椎体成形手术。术后3 d内拍摄患椎正侧位X射线片,评估骨水泥弥散效果、弥散类型。术前及术后1 d、7 d、1个月,评估患者目测类比评分、骨折周围压痛阈值、Oswestry功能障碍指数。结果与结论:①单侧椎弓根外组患者骨水泥弥散效果优于双侧椎弓根组(P<0.001),骨水泥灌注量多于双侧椎弓根组(P<0.001);双侧椎弓根入路组骨水泥弥散类型主要集中在Ⅰ型和Ⅲ型,单侧椎弓根外组骨水泥弥散类型主要集中在Ⅰ型和Ⅱ型,两组骨水泥弥散类型比较差异有显著性意义(P<0.001);②两组患者术后的目测类比评分、Oswestry功能障碍指数均低于术前(P<0.001),术后骨折周围压痛阈值呈现先降低后升高的趋势;治疗后相同时间点,两组间目测类比评分、Oswestry功能障碍指数、骨折周围压痛阈值比较差异均无显著性意义(P>0.05);③结果表明,个体化单侧椎弓根外入路椎体成形手术可获得更好的骨水泥弥散效果,并且治疗效果与经典双侧椎弓根入路椎体成形手术一致。

微通道植骨联合外固定架治疗桡骨远端C3型骨折的效果分析

目的分析微通道植骨联合外固定架治疗桡骨远端C3型骨折的临床效果。方法选取2021年6月至2023年6月收治的59例桡骨远端C3型骨折患者,将应用微通道植骨联合外固定架治疗的30例作为观察组,将应用闭合复位外固定架治疗的29例作为对照组,观察比较2组术后1个月、术后3个月、术后6个月桡骨茎突高度、掌倾角和尺偏角;术后腕功能恢复情况,住院时间、术后6个月骨折临床愈合率和术后随访情况。结果术后1个月、术后3个月、术后6个月2组桡骨茎突高度、掌倾角及尺偏角比较差异无统计学意义(P>0.05)。观察组术后腕关节Cooney功能优秀率为70.0%高于对照组的37.9%(P<0.05)。2组住院时间、术后6个月骨折临床愈合率比较差异均无统计学意义(P>0.05)。2组均无切口及钉道感染,骨折均愈合良好。观察组术后1个月复查X线显示桡骨远端断端对位对线良好。结论应用微通道植骨联合外固定架治疗桡骨远端C3型骨折,复位效果良好,桡骨关节面恢复平整,腕关节功能恢复良好。

单臂滑轨纵向加压外固定支架不植骨治疗肱骨干骨不连

目的探讨应用单臂滑轨纵向加压外固定架治疗肱骨干骨不连的临床应用方法和效果。方法2019年3月-2022年3月,对30例肱骨干骨不连患者(萎缩性骨不连、肥大性骨不连、感染性骨不连)采用切开骨折断端硬化骨、病灶骨切除,短缩复位后用单臂滑轨外固定架加压固定。结果30例全部随访,随访时间12~18个月,平均15个月,所有骨折均愈合(愈合率100%),影像学愈合时间4~8个月,平均6个月。术后随访术肢较健肢缩短3~5 cm,平均4 cm;按照Neer肩关节功能评分标准评分在85~95分,平均90分,优25例,良5例,优良率100%。按照Mayo肘关节功能评分标准评分[14]在90~95分,平均92.5分,优30例,优良率100%。结论采用切开骨折断端硬化骨、病灶骨切除,短缩复位后用单臂滑轨外固定架加压固定,适合各种骨不连的治疗,术中对断端周围软组织剥离少,不植骨,对骨折断端可以根据骨折愈合情况随时再加压,力臂长,固定稳定,可以早期进行功能训练,功能恢复好,骨折愈合后无需再次手术取内固定,减少并发症和致残率,临床效果满意,值得推广。

小转子固定和骨水泥强化在骨质疏松性股骨转子间骨折中的应用

目的探讨小转子固定和骨水泥强化技术对A2型老年骨质疏松性股骨转子间骨折股骨近端防旋髓内钉(proximal femoral nail antirotation,PFNA)内固定后稳定性的生物力学研究及比较。方法选取老年骨质疏松股骨标本24例,制作A2型股骨转子间不稳定骨折模型,采用随机数字表法将其分成骨水泥强化组(n=8)、小转子固定组(n=8)和对照组(n=8)。其中,骨水泥强化组完成PFNA固定后先通过螺旋刀片的中空管道注入骨水泥,小转子固定组在完成PFNA固定后先将环扎钢丝放置在小转子骨块顶端,再将股骨外侧拧紧后对小转子部位予以固定。对照组仅给予PFNA固定。通过生物力学机器测量三组标本骨折端间距、位移情况(滑动位移、压缩位移)和承载力(极限载荷力、最大载荷力),分析不同辅助技术对髓内钉固定后骨折稳定性的影响。结果压缩后骨水泥强化组、小转子固定组骨折端间距均大于对照组,其差异均具有统计学意义(均P<0.05),而骨水泥强化组和小转子固定组比较,其差异无统计学意义(P>0.05);骨水泥强化组和小转子固定组压缩位移均低于对照组,其差异均具有统计学意义(均P<0.05),骨水泥强化组和小转子固定组比较,其差异无统计学意义(P>0.05);而骨水泥强化组和小转子固定组滑动位移均低于对照组,小转子固定组滑动位移低于骨水泥强化组,其差异均具有统计学意义(均P<0.05);骨水泥强化组和小转子固定组极限载荷力和最大载荷力均高于对照组,其差异均具有统计学意义(均P<0.05),而骨水泥强化组和小转子固定组比较,其差异无统计学意义(P>0.05)。结论相对于普通PFNA,骨水泥强化型PFNA和小转子固定PFNA能够有效增加A2型老年股骨转子间不稳定骨折骨折端的稳定性,可以达到早期负重的目的,且小转子固定PFNA在防止骨折端滑动方面效果更优,临床可以结合患者具体情况使用合适的辅助技术。

微型外支架联合交叉克氏针固定治疗第5掌骨远端骨折

目的探讨微型外支架联合交叉克氏针固定治疗第5掌骨远端骨折的应用效果。方法对2020年1月-2022年1月在盱眙县人民医院接受治疗的30例第5掌骨远端骨折患者,均采用微型外支架联合交叉克氏针固定治疗,并统计术后功能优良率。结果30例术后均获得6个月完整随访,均未出现钉道感染及固定物松动,患手无疼痛、畸形,活动及肌力好,根据手指总主动活动度(TAM)评分标准评定手部功能:优26例,良4例。结论采用微型外支架联合交叉克氏针固定治疗第5掌骨远端骨折可取得满意的临床疗效,适宜临床推广使用。

Early complications of preoperative external traction fixation in the staged treatment of tibial fractures:A series of 402 cases

BACKGROUND Different external skeletal fixators have been widely used in preoperative traction of high-energy tibial fractures prior to a definitive surgical treatment.However,the early complications associated with this staged treatment for traction and soft tissue injury recovery have rarely been discussed.AIM To analyze the early complications associated with preoperative external traction fixation in the staged treatment of tibial fractures.METHODS A total of 402 patients with high-energy tibial fractures treated using preoperative external traction fixation at a Level 1 trauma center from 2014 to 2018 were enrolled in this retrospective study.Data regarding the demographic information,Tscherne soft tissue injury,fracture site,entry point placement,and duration of traction were recorded.Procedure-related complications such as movement and sensation disorder,vessel injury,discharge,infection,loosening,and iatrogenic fractures were analyzed.RESULTS The mean patient age was 42.5(18-71)years,and the mean duration of traction was 7.5(0-26)d.In total,19(4.7%)patients presented with procedure-related complications,including technique-associated complications in 6 patients and nursing-associated complications in 13.Differences in the incidence of complications with respect to sex,affected side,soft tissue injury classification,and fracture sites were not observed.However,the number of complications due to hammer insertion was significantly reduced than those due to drill insertions(2.9%vs 7.4%).CONCLUSION We found a low incidence of early complications related to the fixation.Furthermore,the complications were not significantly associated with the severity of the soft tissue injury and fracture site.Although relatively rough and more likely to cause pain,the number of complications associated with hammer insertion was significantly smaller than that of complications associated with drill insertion.

Effect of Ilizarov external fixation combined with negative pressure sealing drainage and antibiotics in the treatment of infective tibial nonunion

Objective:Observation on the effect of Ilizarov external fixation combined with vacuum pressure sealing drainage and antibiotics in the treatment of infective tibial nonunion.Methods:79 patients with tibial infective nonunion who were treated in our hospital from August 2016 to August 2018 were divided into two groups according to random number table,with 39 patients in the control group treated with Ilizarov external fixation technology and 40 patients in the study group treated with vacuum pressure sealing drainage and antibiotics on the basis of the control group.Bone healing time and daily walking were recorded.Rasmussen score,serum intercellular adhesion molecule-1(ICAM-1)and IL-6 levels,lower limb Fugl-Meyer motor function score and lower limb BI index score were compared at different time.Results:The daily walking condition of the study group was significantly better than that of the control group(P<0.05),and the healing time of bone was significantly shorter than that of the control group(P<0.05);the Rasmussen score of the study group was higher than that of the control group at 1 month,6 months and 12 months after treatment(P<0.05);the levels of serum ICAM-1 and IL-6 in the two groups after treatment were lower than those before treatment(P<0.05),and the levels of serum ICAM-1 and IL-6 in the study group were lower than those in the control group after treatment(P<0.05).The lower limb Fugl-Meyer motor function score and lower limb BI index score of the two groups after treatment were higher than those before treatment(P<0.05),and the lower limb Fugl-Meyer motor function score and lower limb BI index score of the study group after treatment were higher than those of the control group(P<0.05).Conclusions:Ilizarov external fixation combined with vacuum pressure sealing drainage and antibiotics can promote the bone healing of patients with infective tibial nonunion,significantly improving their daily walking condition,alleviating inflammation,and recovering the knee joint function and lower limb function well.

Changes of bioelectric potentials of experimental fracture healed under compressive external fixation

Experimental fracture was inflicted to the Junction of the upper and middle thirds of the tibia of 50 rabbits and the fracture was fixed with a half-ring sulcated external fixator to exert axial compression on the 2 fragments of the fracture. The changes

当归续骨汤加减结合手法复位联合新型夹板外固定治疗桡骨远端骨折患者的临床效果

目的探讨当归续骨汤加减结合手法复位联合新型夹板外固定治疗桡骨远端骨折患者的临床效果。方法将98例桡骨远端骨折患者随机分为观察组和对照组,每组49例。对照组采用手法复位联合新型夹板外固定治疗,观察组采用当归续骨汤加减结合手法复位联合新型夹板外固定治疗。比较两组患者的疗效,治疗前后的疼痛介质(P物质、β-内啡肽、血清前列腺素E_(2)、神经肽Y)、Gartland-Werley腕关节评分及骨代谢指标[总Ⅰ型前胶原氨基末端肽(P1NP)、Ⅰ型胶原羧基端肽β(β-CTX)、核因子κB受体活化因子(RANK)、核因子κB受体活化因子配体(RANKL)、抗酒石酸酸性磷酸酶5b(TRACP5b)]。结果观察组总有效率高于对照组(P<0.05)。治疗后,两组的血清P物质、β-内啡肽、前列腺素E_(2)、神经肽Y、P1NP、β-CTX水平及Gartland-Werley腕关节评分均较治疗前降低,血清RANK、RANKL、TRACP5b水平均较治疗前升高,且观察组上述指标均低于对照组(均P<0.05)。结论当归续骨汤加减结合手法复位联合新型夹板外固定治疗桡骨远端骨折患者的效果显著,可抑制破骨细胞功能,减轻疼痛,改善腕关节功能,疗效优于手法复位联合新型夹板外固定治疗。