Objective:To explore the effectiveness and safety about the treatment of Caesarean Scar Pregnancy combined hysteroscopic surgery with extopic pregnancy Ⅱ decoction and methotrexate(MTX).Methods: A total of 80 cases o...Objective:To explore the effectiveness and safety about the treatment of Caesarean Scar Pregnancy combined hysteroscopic surgery with extopic pregnancy Ⅱ decoction and methotrexate(MTX).Methods: A total of 80 cases of CSP patients admitted by our hospital from January 2014 to March 2017 were selected as the subjects. According to the treatment way, the patients were divided into experimental group (n=40) and control group (n=40). The control group was given MTX 50 mg/m2, IM once;and the experimental group was given extopic pregnancy Ⅱ decoction on the basis of the treatment given to the control group;the 8th day hysteroscopic surgery. Routine treatment was given after surgery. Experimental group continued to take extopic pregnancy Ⅱ decoction until monitoring the serum beta-hcg level drops below normal. The general information and curative effect, HCG levels before and after 4, 7 and 11d of treatment;mass diameter before and after 11 d of treatment, menstruation recovery time and the incidence of adverse reactions in 2 groups were observed.Results:After hysteroscopic surgery pretreatment with extopic pregnancy Ⅱ decoction and MTX, HCG levels after 4, 7 and 11d were significantly lower than before, it gradually reduced by time prolonged, and research group was lower than control group, the differences were statistically significant. After treatment with different drugs, the size of pregnancy package in the observation group was significantly smaller than that in the control group. Compared with the control group, the he package block size, beta HCG time and vaginal bleeding time were significantly reduced.Conclusion: It has significant clinical effect of hysteroscopic surgery combined with ectopic pregnancy Ⅱ and MTX in the treatment of CSP. It has worthy of clinical promotion to control the amount of blood, avoid intrauterine adhesion caused by uterine artery embolization and infection et al and reduce burden of the physical and economic of patients.展开更多
Objective: This study was to investigate the invasiveness of pregnancy-induced hypertension (PIH) trophoblast cells and evaluate the effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion.Methods: Cytotrophoblast ce...Objective: This study was to investigate the invasiveness of pregnancy-induced hypertension (PIH) trophoblast cells and evaluate the effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion.Methods: Cytotrophoblast cells from normal and PIH placenta were separated and purified. Cytotrophoblast invasiveness of normal and PIH placenta was measured by in vitro invasion assay. Effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion were also studied.Results: In PIH group, cytotrophoblast invasiveness was dramatically decreased. In normal group, trophoblast invasiveness was significantly enhanced by IGF-Ⅱ but inhibited by TGF-β1. Neither IGF-Ⅱ nor TGF-β1 had statistically significant effects on PIH trophoblast invasion.Conclusions: PIH cytotrophoblast invasiveness dramatically decreases as compared to the normal level. IGF-Ⅱand TGF-β1 may play an important role in shallow trophoblast invasion on PIH.展开更多
传统的NSGA-Ⅱ(Non-dominated Sorting Genetic AlgorithmⅡ)算法使用拥挤度作为精英选择的第二指标,该方法在处理高维多目标优化问题时,常常由于选择压力不足,以及不同目标间优化冲突加剧等原因,很难维持种群收敛性和多样性的平衡。针...传统的NSGA-Ⅱ(Non-dominated Sorting Genetic AlgorithmⅡ)算法使用拥挤度作为精英选择的第二指标,该方法在处理高维多目标优化问题时,常常由于选择压力不足,以及不同目标间优化冲突加剧等原因,很难维持种群收敛性和多样性的平衡。针对上述问题,提出一种基于外部存档更新及截断机制的NSGA-Ⅱ改进算法NSGA-Ⅱ-UTEA(NSGA-Ⅱalgorithm based on Update and Truncation of External Archive)。该算法首先在精英选择中引入基于权重向量分解的外部存档机制,然后根据个体与所在权重向量及超平面距离之和更新外部存档,并基于个体间角度计算实现外部存档截断,进一步提升了算法在高维多目标优化问题中种群的收敛性和多样性。与NSGA-Ⅱ、NSGA-Ⅲ、MOEA/D(Multi-Objective Evolutionary Algorithm based on Decomposition)、NSGA-Ⅱ-ARSBX(NSGA-Ⅱwith Adaptive Rotation based Simulated Binary crossover)和RPD-NSGA-Ⅱ(Reference Point Dominance-based NSGA-Ⅱ)这5种先进的进化算法的对比实验结果表明,NSGA-Ⅱ-UTEA算法在10目标以上的高维DTLZ(Deb Thiele Laumanns Zitzler)和WFG(Walking Fish Group)系列测试函数上,各项性能指标整体优于其他算法,在解集的分布性和多样性方面具有显著优势。特别是在大部分高维WFG4~WFG7凹问题上都能取得最佳的性能指标值。与传统的NSGA-Ⅱ算法相比,NSGA-Ⅱ-UTEA算法在10目标以上的高维DTLZ系列测试函数上,反世代距离(IGD)性能平均提升了50.6%;在15目标以上的高维WFG系列测试函数上,超体积(HV)性能平均提升了60.7%。实验结果验证了NSGA-Ⅱ-UTEA算法改进的有效性。展开更多
文摘Objective:To explore the effectiveness and safety about the treatment of Caesarean Scar Pregnancy combined hysteroscopic surgery with extopic pregnancy Ⅱ decoction and methotrexate(MTX).Methods: A total of 80 cases of CSP patients admitted by our hospital from January 2014 to March 2017 were selected as the subjects. According to the treatment way, the patients were divided into experimental group (n=40) and control group (n=40). The control group was given MTX 50 mg/m2, IM once;and the experimental group was given extopic pregnancy Ⅱ decoction on the basis of the treatment given to the control group;the 8th day hysteroscopic surgery. Routine treatment was given after surgery. Experimental group continued to take extopic pregnancy Ⅱ decoction until monitoring the serum beta-hcg level drops below normal. The general information and curative effect, HCG levels before and after 4, 7 and 11d of treatment;mass diameter before and after 11 d of treatment, menstruation recovery time and the incidence of adverse reactions in 2 groups were observed.Results:After hysteroscopic surgery pretreatment with extopic pregnancy Ⅱ decoction and MTX, HCG levels after 4, 7 and 11d were significantly lower than before, it gradually reduced by time prolonged, and research group was lower than control group, the differences were statistically significant. After treatment with different drugs, the size of pregnancy package in the observation group was significantly smaller than that in the control group. Compared with the control group, the he package block size, beta HCG time and vaginal bleeding time were significantly reduced.Conclusion: It has significant clinical effect of hysteroscopic surgery combined with ectopic pregnancy Ⅱ and MTX in the treatment of CSP. It has worthy of clinical promotion to control the amount of blood, avoid intrauterine adhesion caused by uterine artery embolization and infection et al and reduce burden of the physical and economic of patients.
文摘Objective: This study was to investigate the invasiveness of pregnancy-induced hypertension (PIH) trophoblast cells and evaluate the effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion.Methods: Cytotrophoblast cells from normal and PIH placenta were separated and purified. Cytotrophoblast invasiveness of normal and PIH placenta was measured by in vitro invasion assay. Effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion were also studied.Results: In PIH group, cytotrophoblast invasiveness was dramatically decreased. In normal group, trophoblast invasiveness was significantly enhanced by IGF-Ⅱ but inhibited by TGF-β1. Neither IGF-Ⅱ nor TGF-β1 had statistically significant effects on PIH trophoblast invasion.Conclusions: PIH cytotrophoblast invasiveness dramatically decreases as compared to the normal level. IGF-Ⅱand TGF-β1 may play an important role in shallow trophoblast invasion on PIH.
文摘传统的NSGA-Ⅱ(Non-dominated Sorting Genetic AlgorithmⅡ)算法使用拥挤度作为精英选择的第二指标,该方法在处理高维多目标优化问题时,常常由于选择压力不足,以及不同目标间优化冲突加剧等原因,很难维持种群收敛性和多样性的平衡。针对上述问题,提出一种基于外部存档更新及截断机制的NSGA-Ⅱ改进算法NSGA-Ⅱ-UTEA(NSGA-Ⅱalgorithm based on Update and Truncation of External Archive)。该算法首先在精英选择中引入基于权重向量分解的外部存档机制,然后根据个体与所在权重向量及超平面距离之和更新外部存档,并基于个体间角度计算实现外部存档截断,进一步提升了算法在高维多目标优化问题中种群的收敛性和多样性。与NSGA-Ⅱ、NSGA-Ⅲ、MOEA/D(Multi-Objective Evolutionary Algorithm based on Decomposition)、NSGA-Ⅱ-ARSBX(NSGA-Ⅱwith Adaptive Rotation based Simulated Binary crossover)和RPD-NSGA-Ⅱ(Reference Point Dominance-based NSGA-Ⅱ)这5种先进的进化算法的对比实验结果表明,NSGA-Ⅱ-UTEA算法在10目标以上的高维DTLZ(Deb Thiele Laumanns Zitzler)和WFG(Walking Fish Group)系列测试函数上,各项性能指标整体优于其他算法,在解集的分布性和多样性方面具有显著优势。特别是在大部分高维WFG4~WFG7凹问题上都能取得最佳的性能指标值。与传统的NSGA-Ⅱ算法相比,NSGA-Ⅱ-UTEA算法在10目标以上的高维DTLZ系列测试函数上,反世代距离(IGD)性能平均提升了50.6%;在15目标以上的高维WFG系列测试函数上,超体积(HV)性能平均提升了60.7%。实验结果验证了NSGA-Ⅱ-UTEA算法改进的有效性。
