Because ring-stiffened cylindrical shell structures have many merits, they are widely used in many areas. However, as the strength of steel increase continuously, ensuring of the structure stability is becoming more a...Because ring-stiffened cylindrical shell structures have many merits, they are widely used in many areas. However, as the strength of steel increase continuously, ensuring of the structure stability is becoming more and more important. Therefore, it is necessary to carry on a more particular analysis. Based on the understanding and analysis of the characteristics of stability for a ring-stiffened cylindrical shell under uniform external pressure and under external single pressure, the characteristics under different cross uniform external pressures are analyzed, and the regularity of it is also gotten. The curve of stability given various geometrical parameters under different cross uniform external pressures is protracted by the analysis of the theory. The conclusion not only improves the theory structural mechanics, it also was important effects on engineering calculation and design.展开更多
The objective of the present study was to investigate our novel methods for the repair of massive cartilage defects by joint distraction and motion using an external fixator. In this study, we used a rabbit model of m...The objective of the present study was to investigate our novel methods for the repair of massive cartilage defects by joint distraction and motion using an external fixator. In this study, we used a rabbit model of massive articular cartilage defect in order to evaluate the effectiveness of using joint distraction and motion with a ring-type external fixator. This external fixator has a hinged joint with a center of rotation along the femoral transepicondylar axis, which allows the knee joint to freely flex and extend. Mesenchymal cells from bone marrow, induced by spongialization, were differentiated into mature chondrocytes and formed hyaline-like cartilage as a result of joint distraction and movement. The transplantation of autologous cells expanded from bone-marrow-derived mesenchymal cells, concentrated autologous bone marrow aspirate, and concentrated autologous peripheral blood cells were all effective in promoting cartilage repair. The quality of the cartilage after long-term joint distraction for 6 months was inferior to that after 12 weeks. In general, weight bearing on the regenerated cartilage promoted cartilage repair, although this effect differed based on when gradual weight bearing was begun. Specifically, gradual weight bearing beginning at 9 weeks produced superior results to that beginning at 6 weeks. Our methods provide an optimal environment for cartilage regeneration.展开更多
BACKGROUND Current research lacks a model of knee extension contracture in rats.AIM To elucidate the formation process of knee extension contracture.METHODS We developed a rat model using an aluminum external fixator....BACKGROUND Current research lacks a model of knee extension contracture in rats.AIM To elucidate the formation process of knee extension contracture.METHODS We developed a rat model using an aluminum external fixator.Sixty male Sprague-Dawley rats with mature bones were divided into the control group(n=6)and groups that had the left knee immobilized with an aluminum external fixator for 1,2,and 3 d,and 1,2,3,4,6,and 8 wk(n=6 in each group).The passive extension range of motion,histology,and expression of fibrosis-related proteins were compared between the control group and the immobilization groups.RESULTS Myogenic contracture progressed very quickly during the initial 2 wk of immobilization.After 2 wk,the contracture gradually changed from myogenic to arthrogenic.The arthrogenic contracture progressed slowly during the 1^(st) week,rapidly progressed until the 3^(rd) week,and then showed a steady progression until the 4^(rd) week.Histological analyses confirmed that the anterior joint capsule of the extended fixed knee became increasingly thicker over time.Correspondingly,the level of transforming growth factor beta 1(TGF-β1)and phosphorylated mothers against decapentaplegic homolog 2(p-Smad2)in the anterior joint capsule also increased with the immobilization time.Over time,the cross-sectional area of muscle fibers gradually decreased,while the amount of intermuscular collagen and TGF-β1,p-Smad2,and p-Smad3 was increased.Unexpectedly,the amount of intermuscular collagen and TGF-β1,p-Smad2,and p-Smad3 was decreased during the late stage of immobilization(6-8 wk).The myogenic contracture was stabilized after 2 wk of immobilization,whereas the arthrogenic contracture was stabilized after 3 wk of immobilization and completely stable in 4 wk.CONCLUSION This rat model may be a useful tool to study the etiology of joint contracture and establish therapeutic approaches.展开更多
The Local Joint Flexibility(_(LJF))of steel K-joints reinforced with external plates under axial loads is investigated in this paper.For this aim,firstly,a finite element(FE)model was produced and verified with the re...The Local Joint Flexibility(_(LJF))of steel K-joints reinforced with external plates under axial loads is investigated in this paper.For this aim,firstly,a finite element(FE)model was produced and verified with the results of several experimental tests.In the next step,a set of 150 FE models was generated to assess the effect of the brace angle(θ),the stiffener plate size(ηandλ),and the joint geometry(γ,τ,ξ,andβ)on the_(LJF)factor(f_(LJF)).The results showed that using the external plates can decrease 81%of the f_(LJF).Moreover,the reinforcing effect of the reinforcing plate on the f_(LJF)is more remarkable in the joints with smallerβ.Also,the effect of theγon the f_(LJF)ratio can be ignored.Despite the important effect of the f_(LJF)on the behavior of tubular joints,there is not available any study or equation on the f_(LJF)in any reinforced K-joints under axial load.Consequently,using the present FE results,a design parametric equation is proposed.The equation can reasonably predict the f_(LJF)in the reinforced K-joints under axial load.展开更多
Titanium tube and stainless steel tube plate were welded by an innovative friction welding of tube to tube plate using an external tool (FWTPET). Copper was used as an interlayer for joining the dissimilar materials a...Titanium tube and stainless steel tube plate were welded by an innovative friction welding of tube to tube plate using an external tool (FWTPET). Copper was used as an interlayer for joining the dissimilar materials and also to minimize the effect of intermetallics formed at the joint interface. The process parameters that govern FWTPET process are plunge rate, rotational speed, plunge depth, axial load and flash trap profile. Among them, the flash trap profile of the tube has a significant influence on the joint integrity. Various flash trap profiles like vertical slots, holes, zig-zag holes, and petals were made on the titanium tube welded to the stainless steel tube plate. Macroscopic and microscopic studies reveal defect-free joints. The presence of copper interlayer and intermetallics was evident from X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) studies. The microhardness survey was presented across and along the interface. A novel test procedure called “plunge shear test” was developed to evaluate the joint properties of the welded joints. The highest shear fracture load of 31.58 kN was observed on the sample having petals as flash trap profile. The sheared surfaces were further characterized using SEM for fractography.展开更多
Since the commencement of the International Health Regulations in 2007,global public health security has been faced with numerous emerging and ongoing events.Moreover,the Joint External Evaluation is a voluntary tool ...Since the commencement of the International Health Regulations in 2007,global public health security has been faced with numerous emerging and ongoing events.Moreover,the Joint External Evaluation is a voluntary tool developed in compliance with the Global Health Security Agenda that represents the high responsibility of international health community towards the increased incidence of emerging and re-emerging diseases.Against this background,between 29th May and 2nd June 2016,a team of World Health Organization consultants arrived to the State of Qatar to assess,in collaboration with national experts,the country’s capacity to prevent,detect,and rapidly respond to threats of public health aspect.They identified areas of strength,weakness,and recommendations for improving national health security of Qatar in anticipation of the 2022 FIFA World Cup event.Qatar has demonstrated a leading role in the region through its commitment to International Health Regulations(2005)and population health.Similarly,the Qatar was the first Arab state and seventh volunteering country globally to undergo the Joint External evaluation process.In this review,we highlighted Qatar’s achievements and shortcomings of International Health Regulations’core capacities to inform healthcare professionals and the scientific community about the country’s contribution toward global health security.展开更多
Subtalar dislocation is described as the simultaneous dislocation of the talo-calcaneal and talo-navicular joints without any tibio-talar or talar neck associated fractures. This injury is rare, and represents 1% of d...Subtalar dislocation is described as the simultaneous dislocation of the talo-calcaneal and talo-navicular joints without any tibio-talar or talar neck associated fractures. This injury is rare, and represents 1% of dislocations. We report the case of 28-year-old male patient, without any medical history, who had been involved in a sport accident causing a rare closed external subtalar dislocation without any bone fracture. An open reduction was indicated after failure of closed reduction and the X-ray control showed good joint congruence;the fixation was maintained for 6 weeks and then the rehabilitation was started. The evaluation was favorable, and we noted good functional results after a decline of 12 months.展开更多
In order to obtain the strength design equations for internally ring-stiffened circular hollowsection tubular DT( double tee)-joints subjected to brace axial compression or tension, theoretical and numerical studies...In order to obtain the strength design equations for internally ring-stiffened circular hollowsection tubular DT( double tee)-joints subjected to brace axial compression or tension, theoretical and numerical studies on 800 stiffened joints were conducted. Based on the failure mechanism of the stiffened joints, four theoretical models and corresponding equations for predicting the strength of the stiffeners are proposed. Combined with existing unstiffened DT-joint design equations, a design equation for the stiffened joints is proposed. The finite element analysis shows that the failure of the stiffened joints under brace axial loads can be characterized by plastic hinges forming in the stiffener and chord wall yielding in the vicinity of the brace-chord intersection. The reliability of the proposed stiffener strength equations is demonstrated by a reliability analysis. Good agreement is achieved between the stiffened joint strength calculated from the proposed joint strength equation and that obtained from finite element analysis.展开更多
Emotion cause extraction(ECE)task that aims at extracting potential trigger events of certain emotions has attracted extensive attention recently.However,current work neglects the implicit emotion expressed without an...Emotion cause extraction(ECE)task that aims at extracting potential trigger events of certain emotions has attracted extensive attention recently.However,current work neglects the implicit emotion expressed without any explicit emotional keywords,which appears more frequently in application scenarios.The lack of explicit emotion information makes it extremely hard to extract emotion causes only with the local context.Moreover,an entire event is usually across multiple clauses,while existing work merely extracts cause events at clause level and cannot effectively capture complete cause event information.To address these issues,the events are first redefined at the tuple level and a span-based tuple-level algorithm is proposed to extract events from different clauses.Based on it,a corpus for implicit emotion cause extraction that tries to extract causes of implicit emotions is constructed.The authors propose a knowledge-enriched jointlearning model of implicit emotion recognition and implicit emotion cause extraction tasks(KJ-IECE),which leverages commonsense knowledge from ConceptNet and NRC_VAD to better capture connections between emotion and corresponding cause events.Experiments on both implicit and explicit emotion cause extraction datasets demonstrate the effectiveness of the proposed model.展开更多
文摘Because ring-stiffened cylindrical shell structures have many merits, they are widely used in many areas. However, as the strength of steel increase continuously, ensuring of the structure stability is becoming more and more important. Therefore, it is necessary to carry on a more particular analysis. Based on the understanding and analysis of the characteristics of stability for a ring-stiffened cylindrical shell under uniform external pressure and under external single pressure, the characteristics under different cross uniform external pressures are analyzed, and the regularity of it is also gotten. The curve of stability given various geometrical parameters under different cross uniform external pressures is protracted by the analysis of the theory. The conclusion not only improves the theory structural mechanics, it also was important effects on engineering calculation and design.
文摘The objective of the present study was to investigate our novel methods for the repair of massive cartilage defects by joint distraction and motion using an external fixator. In this study, we used a rabbit model of massive articular cartilage defect in order to evaluate the effectiveness of using joint distraction and motion with a ring-type external fixator. This external fixator has a hinged joint with a center of rotation along the femoral transepicondylar axis, which allows the knee joint to freely flex and extend. Mesenchymal cells from bone marrow, induced by spongialization, were differentiated into mature chondrocytes and formed hyaline-like cartilage as a result of joint distraction and movement. The transplantation of autologous cells expanded from bone-marrow-derived mesenchymal cells, concentrated autologous bone marrow aspirate, and concentrated autologous peripheral blood cells were all effective in promoting cartilage repair. The quality of the cartilage after long-term joint distraction for 6 months was inferior to that after 12 weeks. In general, weight bearing on the regenerated cartilage promoted cartilage repair, although this effect differed based on when gradual weight bearing was begun. Specifically, gradual weight bearing beginning at 9 weeks produced superior results to that beginning at 6 weeks. Our methods provide an optimal environment for cartilage regeneration.
基金Supported by Anhui Key Research and Development Program-Population Health,No.201904a07020067Anhui Provincial Health Research Project,No.AHWJ2022b063+2 种基金Clinical Medicine Discipline Construction Project of Anhui Medical University in 2022(Clinic and Preliminary Co-Construction Discipline Project),No.2022 lcxkEFY0102022 National Natural Science Foundation Incubation Plan,No.2022GMFY05Clinical Medicine Discipline Construction Project of Anhui Medical University in 2022(High-Level Personnel Training Program),No.2022 lcxkEFY04,No.2022 lcxkEFY05.
文摘BACKGROUND Current research lacks a model of knee extension contracture in rats.AIM To elucidate the formation process of knee extension contracture.METHODS We developed a rat model using an aluminum external fixator.Sixty male Sprague-Dawley rats with mature bones were divided into the control group(n=6)and groups that had the left knee immobilized with an aluminum external fixator for 1,2,and 3 d,and 1,2,3,4,6,and 8 wk(n=6 in each group).The passive extension range of motion,histology,and expression of fibrosis-related proteins were compared between the control group and the immobilization groups.RESULTS Myogenic contracture progressed very quickly during the initial 2 wk of immobilization.After 2 wk,the contracture gradually changed from myogenic to arthrogenic.The arthrogenic contracture progressed slowly during the 1^(st) week,rapidly progressed until the 3^(rd) week,and then showed a steady progression until the 4^(rd) week.Histological analyses confirmed that the anterior joint capsule of the extended fixed knee became increasingly thicker over time.Correspondingly,the level of transforming growth factor beta 1(TGF-β1)and phosphorylated mothers against decapentaplegic homolog 2(p-Smad2)in the anterior joint capsule also increased with the immobilization time.Over time,the cross-sectional area of muscle fibers gradually decreased,while the amount of intermuscular collagen and TGF-β1,p-Smad2,and p-Smad3 was increased.Unexpectedly,the amount of intermuscular collagen and TGF-β1,p-Smad2,and p-Smad3 was decreased during the late stage of immobilization(6-8 wk).The myogenic contracture was stabilized after 2 wk of immobilization,whereas the arthrogenic contracture was stabilized after 3 wk of immobilization and completely stable in 4 wk.CONCLUSION This rat model may be a useful tool to study the etiology of joint contracture and establish therapeutic approaches.
文摘The Local Joint Flexibility(_(LJF))of steel K-joints reinforced with external plates under axial loads is investigated in this paper.For this aim,firstly,a finite element(FE)model was produced and verified with the results of several experimental tests.In the next step,a set of 150 FE models was generated to assess the effect of the brace angle(θ),the stiffener plate size(ηandλ),and the joint geometry(γ,τ,ξ,andβ)on the_(LJF)factor(f_(LJF)).The results showed that using the external plates can decrease 81%of the f_(LJF).Moreover,the reinforcing effect of the reinforcing plate on the f_(LJF)is more remarkable in the joints with smallerβ.Also,the effect of theγon the f_(LJF)ratio can be ignored.Despite the important effect of the f_(LJF)on the behavior of tubular joints,there is not available any study or equation on the f_(LJF)in any reinforced K-joints under axial load.Consequently,using the present FE results,a design parametric equation is proposed.The equation can reasonably predict the f_(LJF)in the reinforced K-joints under axial load.
基金financial support provided by UGC-DAE-CSR (CSR-KN/CRS-04/201213/738) through fellowship
文摘Titanium tube and stainless steel tube plate were welded by an innovative friction welding of tube to tube plate using an external tool (FWTPET). Copper was used as an interlayer for joining the dissimilar materials and also to minimize the effect of intermetallics formed at the joint interface. The process parameters that govern FWTPET process are plunge rate, rotational speed, plunge depth, axial load and flash trap profile. Among them, the flash trap profile of the tube has a significant influence on the joint integrity. Various flash trap profiles like vertical slots, holes, zig-zag holes, and petals were made on the titanium tube welded to the stainless steel tube plate. Macroscopic and microscopic studies reveal defect-free joints. The presence of copper interlayer and intermetallics was evident from X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) studies. The microhardness survey was presented across and along the interface. A novel test procedure called “plunge shear test” was developed to evaluate the joint properties of the welded joints. The highest shear fracture load of 31.58 kN was observed on the sample having petals as flash trap profile. The sheared surfaces were further characterized using SEM for fractography.
文摘Since the commencement of the International Health Regulations in 2007,global public health security has been faced with numerous emerging and ongoing events.Moreover,the Joint External Evaluation is a voluntary tool developed in compliance with the Global Health Security Agenda that represents the high responsibility of international health community towards the increased incidence of emerging and re-emerging diseases.Against this background,between 29th May and 2nd June 2016,a team of World Health Organization consultants arrived to the State of Qatar to assess,in collaboration with national experts,the country’s capacity to prevent,detect,and rapidly respond to threats of public health aspect.They identified areas of strength,weakness,and recommendations for improving national health security of Qatar in anticipation of the 2022 FIFA World Cup event.Qatar has demonstrated a leading role in the region through its commitment to International Health Regulations(2005)and population health.Similarly,the Qatar was the first Arab state and seventh volunteering country globally to undergo the Joint External evaluation process.In this review,we highlighted Qatar’s achievements and shortcomings of International Health Regulations’core capacities to inform healthcare professionals and the scientific community about the country’s contribution toward global health security.
文摘Subtalar dislocation is described as the simultaneous dislocation of the talo-calcaneal and talo-navicular joints without any tibio-talar or talar neck associated fractures. This injury is rare, and represents 1% of dislocations. We report the case of 28-year-old male patient, without any medical history, who had been involved in a sport accident causing a rare closed external subtalar dislocation without any bone fracture. An open reduction was indicated after failure of closed reduction and the X-ray control showed good joint congruence;the fixation was maintained for 6 weeks and then the rehabilitation was started. The evaluation was favorable, and we noted good functional results after a decline of 12 months.
基金The Open Project of State Key Laboratory of Subtropical Building Science,South China University of Technology(No.2014KB29,2015ZB30)
文摘In order to obtain the strength design equations for internally ring-stiffened circular hollowsection tubular DT( double tee)-joints subjected to brace axial compression or tension, theoretical and numerical studies on 800 stiffened joints were conducted. Based on the failure mechanism of the stiffened joints, four theoretical models and corresponding equations for predicting the strength of the stiffeners are proposed. Combined with existing unstiffened DT-joint design equations, a design equation for the stiffened joints is proposed. The finite element analysis shows that the failure of the stiffened joints under brace axial loads can be characterized by plastic hinges forming in the stiffener and chord wall yielding in the vicinity of the brace-chord intersection. The reliability of the proposed stiffener strength equations is demonstrated by a reliability analysis. Good agreement is achieved between the stiffened joint strength calculated from the proposed joint strength equation and that obtained from finite element analysis.
基金National Natural Science Foundation of China,Grant/Award Numbers:61671064,61732005National Key Research&Development Program,Grant/Award Number:2018YFC0831700。
文摘Emotion cause extraction(ECE)task that aims at extracting potential trigger events of certain emotions has attracted extensive attention recently.However,current work neglects the implicit emotion expressed without any explicit emotional keywords,which appears more frequently in application scenarios.The lack of explicit emotion information makes it extremely hard to extract emotion causes only with the local context.Moreover,an entire event is usually across multiple clauses,while existing work merely extracts cause events at clause level and cannot effectively capture complete cause event information.To address these issues,the events are first redefined at the tuple level and a span-based tuple-level algorithm is proposed to extract events from different clauses.Based on it,a corpus for implicit emotion cause extraction that tries to extract causes of implicit emotions is constructed.The authors propose a knowledge-enriched jointlearning model of implicit emotion recognition and implicit emotion cause extraction tasks(KJ-IECE),which leverages commonsense knowledge from ConceptNet and NRC_VAD to better capture connections between emotion and corresponding cause events.Experiments on both implicit and explicit emotion cause extraction datasets demonstrate the effectiveness of the proposed model.