Protective effects of oleic acid and polyphenols in extra virgin olive oil on cardiovascular diseases

The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular disease.Extra virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which have been shown to have noteworthy nutritional value and positive impact on human health.It is worth noting that EVOO owes its superior nutritional value to its bioactive composition.The main component of EVOO is monounsaturated fatty acids(MUFAs)in the form of oleic acid.Oleic acid accounts for up to 70%-80%of EVOO.Secondly,EVOO contains approximately more than 30 phenolic compounds,of which HT is essential for the protection against cardiovascular diseases.In this review,we focused on the potential mechanisms of oleic acid and polyphenols combat cardiovascular diseases risk in terms of oxidative stress,inflammation,blood pressure,endothelial function and cholesterol.This review might provide a reference for the studies on cardiovascular protective effects of EVOO.

Clinical outcomes in patients diagnosed with extra-nodal Hodgkin lymphoma: a 20-year retrospective analysis of the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database

Background:Hodgkin lymphoma refers to a malignancy of the lymphatic tissue.Extra-nodal Hodgkin lymphoma(ENHL)is a rare variant consisting of Hodgkin lymphoma occurring outside the lymphatic system.Studies investigating the epidemiology associated with ENHL are rare.Methods:618 ENHL cases were analyzed using the National Cancer Institute’s Surveillance,Epidemiology,and End Results(SEER)database(2000–2020).Demographics including sex,race/ethnicity,rural-urban continuum,age group(categorized as adolescent and young adult(AYA)if between years of 15 and 39,and adult if over the age of 40),and living status(alive/deceased)were examined,with survival status as the main outcome.Results:This study included 335 males(54.2%)and 283 females(45.8%).Of this total,47.9%were in the AYA group.In terms of ethnicity the distribution was 12.5%non-Hispanic Black,67.5%non-Hispanic White,5.2%non-Hispanic Asian/Pacific Islander,and 14.9%Hispanic.Bivariate analyses evidenced significant differences in survival by age group with 91.6%in AYA vs.72.4%in adults(P<0.001)alive by the end of the study period.Multivariable analyses identified age as a key predictor of survival,as the AYA patients had a lower odds ratio for death(odds ratio=0.25,P<0.001).In addition,survival outcomes were also impacted by race,with non-Hispanic Blacks showing higher survival probabilities.Regarding treatment,27.0%of patients underwent surgery,with 10.2%receiving post-surgery radiation,reducing odds of mortality(odds ratio=0.32,P=0.046).Conclusion:The background research as such,tends to affirm that these two factors–age and race are quite crucial in the prognosis as well as management of ENHL.Compared to adults,AYA patients had significantly lower odds of death,while non-Hispanic Black individuals exhibited reduced survival probabilities.It should be noted that 27.0%of patients underwent surgery with 10.2%receiving post-operative radiation which led to decrease in mortality rates.Thus,these results reiterate the necessity for tailor-made treatment methods according to demographic characteristics to boost patient outcomes effectively.For better ENHL care,future studies could shed light on these disparities and improve treatment regimens as needed.

Extra-Axial Anaplastic Pleomorphic Xanthoastrocytoma Mimicking Meningioma: A Case Report with Literature Review

Background: A number of meningeal neoplastic lesions may radiologically and clinically simulate meningioma, include hemangiopericytomas, solitary fibrous tumors, schwannomas, hematolymphoid lesions, metastases, and others very rarely, also may clinically mimic meningiomas. Case Description: We present the case of A 28-year-old male patient, with no notable medical history, who presented with worsening headaches for 3 months, imbalance, and visual deficits, An initial MRI revealed extra-axial lesion involving the right Parieto-occipital, The tumor was hypointense on T1-weighted MR images, hyperintense signals on T2-weightedMR images, and heterogeneously enhanced suggestive of a meningioma, total resection was achieved, and the histopathological analysis confirmed the diagnosis of an angioblastic meningioma. However, 15 months later, the patient presented with the same initial visual complaints. A subsequent MRI showed lesion recurrence, leading to a second surgical intervention. The histopathological analysis confirmed the diagnosis of an anaplastic xanthoastrocytoma. Conclusion: This represents an unusual location for an anaplastic pleomorphic xanthoastrocytoma, which should broaden the differential diagnosis of extra-axial lesions.

Analysis of the Risk of Water Breakout in the Bottom Plate of High-Intensity Mining of Extra-Thick Coal Seams

In order to clarify the danger of water breakout in the bottom plate of extra-thick coal seam mining, 2202 working face of a mine in the west is taken as the research object, and it is proposed to use the on-site monitoring means combining borehole peeping and microseismic monitoring, combined with the theoretical analysis to analyze the danger of water breakout in the bottom plate. The results show that: 1) the theoretically calculated maximum damage depth of the bottom plate is 27.5 m, and its layer is located above the Austrian ash aquifer, which has the danger of water breakout;2) the drill hole peeping at the bottom plate of the working face shows that the depth of the bottom plate fissure development reaches 26 m, and the integrity of the water barrier layer has been damaged, so there is the risk of water breakout;3) for the microseismic monitoring of the anomalous area, the bottom plate of the return air downstream channel occurs in the field with a one-week lag, which shows that microseismic monitoring events may reflect the water breakout of the underground. This shows that the microseismic monitoring events can reflect the changes of the underground flow field, which can provide a reference basis for the early warning of water breakout. The research results can provide reference for the prediction of sudden water hazard.

Novel Soft ComputingModel for Predicting Blast-Induced Ground Vibration in Open-Pit Mines Based on the Bagging and Sibling of Extra Trees Models

This study considered and predicted blast-induced ground vibration(PPV)in open-pit mines using bagging and sibling techniques under the rigorous combination of machine learning algorithms.Accordingly,four machine learning algorithms,including support vector regression(SVR),extra trees(ExTree),K-nearest neighbors(KNN),and decision tree regression(DTR),were used as the base models for the purposes of combination and PPV initial prediction.The bagging regressor(BA)was then applied to combine these base models with the efforts of variance reduction,overfitting elimination,and generating more robust predictive models,abbreviated as BA-ExTree,BAKNN,BA-SVR,and BA-DTR.It is emphasized that the ExTree model has not been considered for predicting blastinduced ground vibration before,and the bagging of ExTree is an innovation aiming to improve the accuracy of the inherently ExTree model,as well.In addition,two empirical models(i.e.,USBM and Ambraseys)were also treated and compared with the bagging models to gain a comprehensive assessment.With this aim,we collected 300 blasting events with different parameters at the Sin Quyen copper mine(Vietnam),and the produced PPV values were also measured.They were then compiled as the dataset to develop the PPV predictive models.The results revealed that the bagging models provided better performance than the empirical models,except for the BA-DTR model.Of those,the BA-ExTree is the best model with the highest accuracy(i.e.,88.8%).Whereas,the empirical models only provided the accuracy from 73.6%–76%.The details of comparisons and assessments were also presented in this study.

Primary Extra-Gastrointestinal Stromal Tumors (E-GIST) of the Liver, about Two Cases and Review of the Literature Oncology Hospital Experience at Chu Hassan II in FES

Introduction: Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation can range from asymptomatic to bleeding or manifestations of mass effect. Cancer surgery followed by adjuvant treatment with imatinib is the standard of care. However, in special circumstances, a cytoreductive approach may represent a therapeutic option. We describe here the case of two patients who presented with a painful and protruding epigastric mass, the first case was a localized E-GIST candidate for neoadjuvant treatment with imatinib with complete resection surgery thereafter with very good evolution, and the second is that of an E-GIST of the liver at an advanced stage with an evolution very quick to death. Conclusion: Primary liver E-GIST is a rare condition. Treatment is based on systemic therapy and total resection surgery. However, cytoreductive surgery will be required when complete resection is not possible.

The relationship between extra connectivity and t/k-diagnosability under the PMC model

It is well-known that connectivity is closely related to diagnosability.If the relationships be-tween them can be established,many kinds of diagnosability will be determined directly.So far,some notable relationships between connectivity and diagnosability had been revealed.This paper in-tends to find out the relationship between extra connectivity and t/k-diagnosability under the PMC(Preparata,Metze,and Chien)model.Then,applying this relationship,the t/k-diagnosability of bijective connection(BC)networks are determined conveniently.

Left atrium veno-arterial extra corporeal membrane oxygenation as temporary mechanical support for cardiogenic shock:A case report

BACKGROUND Veno-arterial extra corporeal membrane oxygenation(VA-ECMO)support is commonly complicated with left ventricle(LV)distension in patients with cardiogenic shock.We resolved this problem by transeptally converting VAECMO to left atrium veno-arterial(LAVA)-ECMO that functioned as a temporary paracorporeal left ventricular assist device to resolve LV distension.In our case LAVA-ECMO was also functioning as a bridge-to-transplant device,a technique that has been scarcely reported in the literature.CASE SUMMARY A 65 year-old man suffered from acute myocardial injury that required percutaneous stents.Less than two weeks later,noncompliance to antiplatelet therapy led to stent thrombosis,cardiogenic shock,and cardiac arrest.Femorofemoral VA-ECMO support was started,and the patient underwent a second coronary angiography with re-stenting and intra-aortic balloon pump placement.The VA-ECMO support was complicated by left ventricular distension which we resolved via LAVA-ECMO.Unfortunately,episodes of bleeding and sepsis complicated the clinical picture and the patient passed away 27 d after initiating VA-ECMO.CONCLUSION This clinical case demonstrates that LAVA-ECMO is a viable strategy to unload the LV without another invasive percutaneous or surgical procedure.We also demonstrate that LAVA-ECMO can also be weaned to a left ventricular assist device system.A benefit of this technique is that the procedure is potentially reversible,should the patient require VA-ECMO support again.A transeptal LV venting approach like LAVA-ECMO may be indicated over ImpellaTM in cases where less LV unloading is required and where a restrictive myocardium could cause LV suctioning.Left ventricular over-distention is a well-known complication of peripheral VA-ECMO in cardiogenic shock and LAVA ECMO through transeptal cannulation offers a novel and safe approach for treating LV overloading,without the need of an additional percutaneous access.

基于h-extra边连通度的增强超立方体Qn,3的链路容错性分析

并行处理系统的设计和维护在很大程度上依赖于并行处理系统的可靠性评价.h-extra边连通度为评估这些系统在大规模故障链路下的互连网络的容错性和可靠性提供了一个更精确的参数.1991年Tzeng和Wei提出了(n,3)-增强超立方体Q_(n,3).研究了(n,3)-增强超立方体Q_(n,3)的h-extra边连通度,λh(Q_(n,3)),存在一个集中现象.对于整数「(11×2^(n−1))/48」≤h≤2^(n−1)和n≥9,λh(Q_(n,3))的精确值集中在2^(n−1)上.

Exploration of Traversable Wormholes Sustained by an Extra Spatial Dimension

The main goal of this paper is to determine the effect of an extra dimension on a traversable wormhole. Here an earlier study by the author [Phys. Rev. D 98, 064041 (2018)] is extended in several significant ways. To begin with, the extra spatial dimension is assumed to be time dependent, while the redshift and shape functions, as well as the extra dimension, are functions of both r and l, the respective radial and extra coordinates;the last of these is therefore a function of r, l, and t. The main objective is to determine the conditions that allow the throat of the wormhole to be threaded with ordinary matter (by respecting the null energy condition) and that the same conditions lead to a violation of the null energy condition in the fifth dimension, which is therefore responsible for sustaining the wormhole. The dependence of the extra dimension on l and t is subject to additional conditions that are subsequently analyzed in this paper. Finally, the extra dimension may be extremely small or even curled up.

基于VEPPSO-EXTRA混合算法的分布式直接定位技术

相对于集中式直接定位技术,分布式直接定位算法具有计算复杂度小和通信代价小等优点,但存在定位精度损失的问题。针对于此,该文提出一种基于VEPPSO-EXTRA混合算法的分布式直接定位技术。首先,基于子空间融合的直接定位算法,推导其分布式优化的数学模型;其次,基于多种群联合进化的思想,提出一种基于向量评估的并行粒子群算法(VEPPSO)实现全局寻优,由此得到辐射源迭代初始值;最后,引入分布式精确一阶算法(EXTRA)求解最终位置以降低分布式计算带来的精度损失。实验结果表明,相较于现有的分布式直接定位算法,该技术能解决定位精度损失的问题,且其计算复杂度与通信代价低于对应的集中式直接定位算法。

单孔腹腔镜治疗肠套叠中腹内复位与腹外复位的疗效对比

目的探讨单孔腹腔镜治疗肠套叠中腹内复位与腹外复位的疗效。方法将新乡医学院第一附属医院2018年10月至2021年11月以彩色多普勒超声仪确诊的81例肠套叠患儿作为研究对象,所有患儿均行单孔腹腔镜治疗,治疗过程中根据复位方法不同分为腹内复位组和腹外复位组。收集患儿临床指标:血便、阵发性哭闹或腹痛、呕吐、腹部包块、肠套叠类型、病程;记录患儿手术时间、术中出血量、住院时间、术后排气/排便时间;记录术后感染、出血、肠黏连、肠梗阻、肠穿孔、复发情况和患儿家属满意度情况。结果腹内复位组、腹外复位组临床特征、肠套叠类型、病程、术中出血量、术后排气/排便时间、住院时间、术后感染、出血、肠黏连、肠梗阻、肠穿孔情况差异均无统计学意义(P>0.05),两组患儿均未复发肠套叠;与腹内复位组相比,腹外复位组手术时间降低、患儿家属满意度增加(P<0.05)。结论单孔腹腔镜治疗肠套叠中腹外复位患儿手术时间短、患儿家属满意度高,值得临床推广。

求解连续Sylvester矩阵方程的E-extra迭代法

本文提出一种求解连续Sylvester方程的E-extra迭代法,分析该方法的收敛性,给出最优参数的选取方法.并通过几个数值实例验证了E-extra迭代法的有效性.

深层碳酸盐岩储层酸压进展与展望

酸压改造是深层碳酸盐岩储层高效勘探开发的技术利器。随着勘探开发逐渐迈向特深层,厘清目前酸压技术发展现状与趋势至关重要。从酸压裂缝起裂与扩展、酸刻蚀水力裂缝与导流能力构建、酸压数值模拟技术3个方面阐释了酸压改造机理;分析了黏度控制型、生酸时间控制型、H+屏蔽吸附型、非盐酸基型等4类耐高温缓速酸液体系特点;系统梳理了我国深层碳酸盐岩酸压工艺技术发展的4个历程,剖析了目前9000 m以深特深层碳酸岩酸压面临的4个挑战:能否压开储层、地层温度突破酸液体系耐温极限、高温高压测试手段缺乏、储集体靶向沟通难度大。基于此,提出了5个酸压研究展望:特深井破裂压力精准预测、耐220℃多功能酸液体系研发、超高温高压实验平台构建、全在线酸压技术、超临界CO_(2)酸压技术探索,力求实现特深层碳酸盐岩高效立体开发。

纳米N-A降黏剂的制备及性能评价

针对普通纳米降黏剂对特稠油降黏效果差、洗油效率低等问题,制备了纳米N-A降黏剂,采用FTIR,TEM等方法表征了降黏剂的微观结构,考察了降黏剂的降黏效果、界面张力以及洗油效率。实验结果表明,纳米N-A降黏剂组成为:50%(w)纳米二氧化硅溶胶+40%(w)分散剂EB-1+4.2%(w)表面修饰剂+5.8%(w)增效剂。该降黏剂分散性能良好,粒径分布在20~60 nm之间,在降黏剂含量为1%(w)、油水质量比为7∶3、200℃,矿化度为0,8829.26 mg/L条件下老化48 h,特稠油降黏后黏度分别为6280,7213 mPa·s,降黏率分别达到83.77%,81.36%,降黏性能保持率分别为96.80%,95.39%。50℃下静置90 d后降黏性能保持率大于90%,可降低油水界面张力至0.076 mN/m,乳化液滴最大粒径9.5μm,洗油效率为30.9%,相对普通降黏剂,驱油效率提高22.3百分点。

特深井钻柱动力学特性模拟与分析

随着钻井深度不断增加,钻柱运动所涉及的力学问题变得更加复杂,钻柱动力学特性模拟及分析可为安全优质高效钻井提供支撑。为了探求特深井钻柱的运动特性,将钻柱运动的控制方程采用Newmark法对时间离散后,运用SOR节点迭代法,对每一时间步的钻柱整体构形进行求解,实现了总长超9000 m的钻柱动力学特性模拟,不仅给出了钻柱4个典型位置的涡动轨迹、涡动速度和横向加速度,还分析了钻柱的粘滑特性。分析结果表明,上部钻柱的涡动及粘滑现象不明显;随着位置下移,出现不规则涡动及不充分粘滑现象;近钻头位置的钻柱会出现较剧烈涡动,也会出现粘滑振动;中性点位置处钻柱的涡动最为剧烈、碰摩严重,可能给钻柱带来安全隐患。研究结果为特深井安全钻井提供了理论依据。

250 m级特高面板堆石坝混凝土面板顺坡向应力控制措施研究

面板应力变形控制是建设250 m级特高混凝土面板堆石坝的关键难题.大量工程实测案例和研究计算表明,特高面板坝压应力常处于较高水平,对于坝轴向应力来说,采用柔性缝降低压应力措施已被工程界普遍接受,然而,目前对于如何降低面板顺坡向压应力尚缺少有效的解决方法.本文以拟建的240 m级GS面板坝为研究对象,从特殊增模区布置、面板施工顺序、面板低高程柔性横缝、高压力区高强度混凝土材料等4个方面提出改善面板顺坡向应力的工程措施.文中通过三维有限元精细模拟方法分析了提出的顺坡向应力改善措施的效果,文中提出的措施可为250 m面板堆石坝面板应力控制提供借鉴.

塔里木油田超深层钻井技术进展及难题探讨

当前,塔里木油田以超深特深层为代表的深地油气资源开发对满足我国经济发展需求和保障能源安全至关重要。经过数十年的探索和实践,塔里木油田创新形成了超深复杂井井身结构设计、超深难钻地层钻井提速、超深大斜度井水平井钻井、超深复杂地层钻完井液、超深复杂地层固井、高温高压井完整性、超深复杂井井控等一系列超深层钻井技术,保障深地油气勘探获得重大突破并创造多项纪录。伴随超深井数量持续增加,工程地质条件更加复杂,井下环境更加苛刻,超深层钻井过程势必面临新的工程难题和挑战,严重制约深地油气资源安全高效开发。为此,通过概括塔里木油田钻井工程技术发展历程,系统梳理了深地钻井工程技术取得的主要技术进展,并结合新的勘探开发形势与油气开发要求,指出了塔里木油田钻井工程技术从超深层迈入特深层新时期的焦点问题及攻关发展方向,为国内外深地复杂油气井安全高效钻进提供借鉴和参考。

四川盆地超深层钻完井技术进展及其对万米特深井的启示

四川盆地超深层海相碳酸盐岩油气资源丰富,是寻找特大型油气田、开拓油气增储上产新领域的重要方向,但超深层钻完井面临地层条件更加复杂、井筒环境更加极端等工程技术挑战。为进一步指导万米特深井的安全高效钻探,通过梳理超深层钻完井技术难点,系统总结了四川盆地超深层钻完井关键技术,并提出了下步钻完井技术的发展建议。研究结果表明:①形成的超深复杂地层三压力预测监测技术精确预测了复杂地层压力系统及地应力场分布,准确刻画断层、裂缝、溶洞等展布规律,结合非常用井身结构拓展技术,提高了井身结构设计应对复杂地层钻探的能力;②形成的钻—测—固—完全过程精细控压技术,解决了超深井、特殊复杂井钻井液安全密度窗口窄导致“溢漏共存”、固井质量低等难题;③研发的高效钻头与大扭矩螺杆、扭力冲击器等抗高温提速工具,解决了深部难钻地层钻井钻头易磨损、破岩效率低的工程难题;④研发的抗高温钻井液体系提升应对高温深井的钻井液技术保障能力,升级第二代韧性水泥,解决了工作液抗高温能力不足等难题,保障超深井建井质量。结论认为,超深层钻完井技术的发展与进步,使得深井钻深能力突破9000 m已经成为现实,形成的关键技术有力地支撑了四川盆地超深层油气资源的高效勘探开发,对于万米特深层科学钻探和油气增储上产新领域拓展具有重要技术支撑作用。

凝固酶阴性葡萄球菌相关神经外科术后脑膜炎风险因素的临床研究

目的研究与凝固酶阴性葡萄球菌(CoNS)相关的神经外科术后脑膜炎的风险因素,并探讨CoNS的流行病学特征和治疗方法。方法对2020年6月至2022年6月期间神经外科手术后脑膜炎患者进行回顾性研究,并采用多因素回归方法分析CoNS相关神经外科手术后脑膜炎的风险因素。结果共收集279例脑脊液培养CoNS阳性的神经外科术后脑膜炎患者,占神经外科手术后所有细菌感染患者的9.5%(279/2950)。其中146例患者被诊断为脑膜炎,133例患者被确诊为污染。CoNS相关神经外科手术后脑膜炎患者中最常见的分别是表皮葡萄球菌(51.37%,75/146)、人葡萄球菌(20.55%,30/146)和溶血葡萄球菌(17.81%,26/146)。药敏试验表明,CoNS对青霉素G、红霉素和苯唑西林的耐药性分别为85.7%、79.6%和74.8%,对万古霉素、替加环素和利奈唑胺的敏感性为100%。单因素分析显示,开颅手术、恶性肿瘤、手术时长、脑室外引流和手术切口类型在CoNS相关术后脑膜炎组与污染组存在显著性差异;多因素分析显示,恶性肿瘤(95%置信区间1.551~5.314,P=0.001)和脑室外引流(95%置信区间1.582~5.030,P<0.001)是CoNS相关神经外科术后脑膜炎的独立危险因素。结论CoNS相关神经外科术后脑膜炎与开颅手术、手术时长、手术伤口类型等多种因素密切相关,其中患者患有恶性肿瘤和脑室外引流是它的独立危险因素。