Dynamic interfacial properties are investigated for solvent extraction systems of metals by organophosphoric or phosphonic acid. The relationship between interfacial properties and kinetic parameters shows that the dy...Dynamic interfacial properties are investigated for solvent extraction systems of metals by organophosphoric or phosphonic acid. The relationship between interfacial properties and kinetic parameters shows that the dynamic interfacial properties are important to mass transfer processes in liquid-liquid extraction. The authors develop a two-film adsorption model which may offer a basis for researching interfacial activity in mass transfer processes.展开更多
Omeprazole sodium(OMS), a typical non-hydrogen bond donors API, is only available in solvates so far, including monohydrate, ethanol solvate and methanol solvate. The methanol solvate was found for the first time. Sol...Omeprazole sodium(OMS), a typical non-hydrogen bond donors API, is only available in solvates so far, including monohydrate, ethanol solvate and methanol solvate. The methanol solvate was found for the first time. Solvate transformation thermodynamics of OMS was studied in this paper. First, the ternary phase diagrams forming two solvates for OMS in binary solvent mixtures including methanol + water, ethanol + water, and methanol+ ethanol were measured at temperature ranging of T =(278.15 to 313.15) K under atmospheric pressure. Further, the standard equilibrium constants of the solvate transformation reactions were evaluated according to the chemical reaction isothermal equation. The standard molar Gibbs free energy, the standard molar enthalpy, and the standard molar entropy of solvate transformation reactions were then calculated based on van't Hoff equation. Moreover, the thermodynamic stability of the OMS solvate was analyzed based on phase diagram. The results are of great importance to develop a crystallization process for manufacturing OMS solvate, and could be helpful to other solvate transformation research.展开更多
文摘Dynamic interfacial properties are investigated for solvent extraction systems of metals by organophosphoric or phosphonic acid. The relationship between interfacial properties and kinetic parameters shows that the dynamic interfacial properties are important to mass transfer processes in liquid-liquid extraction. The authors develop a two-film adsorption model which may offer a basis for researching interfacial activity in mass transfer processes.
基金Supported by the National Natural Science Foundation of China(21776203 and 21576187)the Tianjin Municipal Natural Science Foundation(18JCYBJC21100)
文摘Omeprazole sodium(OMS), a typical non-hydrogen bond donors API, is only available in solvates so far, including monohydrate, ethanol solvate and methanol solvate. The methanol solvate was found for the first time. Solvate transformation thermodynamics of OMS was studied in this paper. First, the ternary phase diagrams forming two solvates for OMS in binary solvent mixtures including methanol + water, ethanol + water, and methanol+ ethanol were measured at temperature ranging of T =(278.15 to 313.15) K under atmospheric pressure. Further, the standard equilibrium constants of the solvate transformation reactions were evaluated according to the chemical reaction isothermal equation. The standard molar Gibbs free energy, the standard molar enthalpy, and the standard molar entropy of solvate transformation reactions were then calculated based on van't Hoff equation. Moreover, the thermodynamic stability of the OMS solvate was analyzed based on phase diagram. The results are of great importance to develop a crystallization process for manufacturing OMS solvate, and could be helpful to other solvate transformation research.
