参蝎止痛胶囊联合董氏奇穴对寒湿痹阻型膝骨关节炎患者的临床疗效

目的 探讨参蝎止痛胶囊联合董氏奇穴对寒湿痹阻型膝骨关节炎患者的临床疗效。方法 80例患者随机分为对照组和观察组,每组40例,对照组给予董氏奇穴,观察组在对照组基础上加用参蝎止痛胶囊,疗程1个月。检测临床疗效、中医证候评分、LKSS评分、WOMAC评分、NRS评分、AIMS2-SF评分、sIL-4R、TNF-α、HMGBl、TLR-4、BALP、BGP、β-CTX变化。结果 观察组总有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、WOMAC评分、NRS评分、sIL-4R、TNF-α、HMGBl、TLR-4、β-CTX降低(P<0.05),LKSS评分、AIMS2-SF评分、BALP、BGP升高(P<0.05),以观察组更明显(P<0.05)。结论 参蝎止痛胶囊联合董氏奇穴可抑制寒湿痹阻型膝骨关节炎患者机体炎症反应,改善骨代谢,缓解膝关节疼痛及临床症状。

基于“脏腑别通”理论运用加味小柴胡汤结合捏脊法治疗心肌炎的实验研究

本研究旨在探明加味小柴胡汤结合捏脊法治疗心肌炎(MC)的作用机制。方法:将30只小鼠随机分成空白组、模型组、西药组、柴治组、捏治组、合治组共6组,每组5只。空白组不造模,其余各组均制成自身免疫性MC模型。各组施以相应处理7 d,结束后取心肌组织和血清分别检测肿瘤坏死因子-ɑ(TNF-ɑ)、白细胞介素-1β(IL-1β)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)、Toll样受体4(TLR4)、核因子-κB p65(NF-κB p65)、B淋巴细胞瘤-2基因(Bcl-2)、Bcl-2相关X蛋白(Bax)、半胱氨酸天冬氨酸蛋白酶-3(Caspase-3)的含量及心肌切片观察。结果:中医各治疗组对阻断心肌TLR4/NF-κB p65炎症通路及抑制心肌细胞凋亡的作用均优于西药组(P<0.05),且合治组在降低NF-κB p65、TNF-ɑ、Bax、Caspase-3和升高Bcl-2中的作用较其余治疗组为优(P<0.05);同时,与西药组比较,各中医治疗组心肌切片显示心肌细胞排列紊乱均有不同程度改善,心肌间隙炎细胞浸润较少,以合治组表现最佳。结论:加味小柴胡汤结合捏脊法可能通过抑制心肌TLR4/核因子-κB(NF-κB)信号通路阻止心肌炎症反应,同时抑制凋亡因子减少心肌凋亡来发挥对MC的治疗作用;二者结合运用能发挥良好的协同作用。

基于奇经、络脉理论的“通督安神”针灸法治疗抑郁症探微

章程鹏教授根据古今文献记载并结合多年临床诊疗经验,认为抑郁症为奇经、络脉同病,以奇阳亏乏,形神失和为发病之本,以络脉虚滞,心脑失养为病机关键;提出“通督安神”针灸法,以督脉为核心着眼点,注重奇络同治、身心共调,“通督”与“安神”并举。通督以补虚通滞,改善躯体化症状;安神以调养心脑之神明,安定畅达情志。二者合用可有效缓解患者心身症状。

金纳米圆孔阵列异常光学透射模拟研究

利用COMSOL Multiphysics对金纳米圆孔阵列的物理场进行模拟,分析不同金属膜厚度、孔径、周期下阵列的光谱和电场分布,探究异常光学透射(extraordinary optical transmission,EOT)的成因.通过分析发现透射峰主要有3个成因:一是材料本身的带间跃迁特性会导致透射峰;二是金属阵列产生的表面波会激发金属膜背侧的局域表面等离激元,通过散射形成透射峰;三是耦合的表面等离激元转化成波导模式,沿着圆孔传输造成透射峰,该透射峰的频率低于表面等离激元的频率.

原因自由行为的例外模式:反思、证成与适用

原因自由行为是无法避免“例外”的法律形象,前置模式无法回避不法认定的例外,例外模式也无法回避归责判断的例外。前置模式将原因自由行为视作不法问题而非归责问题,不仅存在本质性的错误,也难以真正贯彻到底。传统例外模式的缺陷在于立法依据的欠缺和理论基础的薄弱。对此,前者可以诉诸《刑法》第18条第4款的规定,将之视作处罚原因自由行为的“注意规定”;后者可以诉诸特别归责的思想并引入负担违反的概念。根据归责的“答责对话模式”,负担违反的后果是使行为人丧失援引归责阻却事由的权利。在例外模式中,成立故意犯罪无须“双重故意”,行为人对原因行为有避免可能、对嗣后实施的犯罪有预见可能即为已足,过失的原因自由行为仍有存在的必要。作为特别归责的体现,原因自由行为对于“先前过错”的归责具有建构性的意义。

对传统军事谋略的新思考

军事谋略,是东方兵学特有的内容,内容博大精深。总体上看,分合、虚实和奇正构成了军事谋略的核心内容,所谓术不过分合、形不过虚实、战不过奇正。智能化武器的广泛使用,赋予了传统军事谋略崭新的内容,传统军事谋略不论是在内容上还是在形式上都发生了重大变化,对战争和战争指导都产生了重大甚至颠覆性的影响。研究这些变化和影响,对于提高指挥员的谋略水平,具有重要的现实意义。

周代的“孝道”论与“孝治”观

周代是一个以人为本的道德觉醒时代。在周代的道德观念中,“孝”是一个极为重要的概念。“孝”指对父母、长辈的供养、尊敬。周代继承从上古到夏商祭祖活动中的“孝行”并加以改造,从中抽象出自觉的、理性的“孝道”观念。《尚书·周书》《诗经》明确记载了西周的孝道观念。春秋末期,孔子、曾子对此作了重要发展。在此基础上,《孝经》提出以孝平天下的“孝治”观,孟子对“孝道”涵义作了进一步发展。战国后期,《礼记》《荀子》对“孝道”内涵作了补充和深化。《左传》《战国策》以赞美的态度记录了春秋战国时期的孝行,彰显着儒家“孝道”观念在这个时期思想界的影响和地位。战国末期的《吕氏春秋》综合周代的孝道、孝治思想,提出“务本莫贵于孝”。文章基于对周代典籍的个案研究,对散见于其中的孝道思想做了集中的分析评述,对今天的家庭伦理、社会和谐建设具有重要的参考意义。

深圳河流域2023年“9·7”极端特大暴雨分析及洪涝治理思考

城市暴雨洪涝灾害是目前我国城市最突出的水患灾害。2023年9月7日,深圳市发生极端特大暴雨,深圳河流域处于暴雨中心,造成较严重洪涝灾害,本次暴雨洪涝灾害为流域水安全保障敲响了警钟。通过全面总结深圳河流域暴雨洪涝特性及防御情况,分析暴雨洪涝灾害成因,在此基础上,从提高河道泄洪能力、增大流域洪水调蓄能力、加强城市排水防涝能力建设、强化超标准暴雨应急管理能力等方面提出洪涝治理对策,思考城市洪涝治理方式和理念,为系统解决洪涝问题、提升高密度城市洪涝防御能力提供参考。

深圳市2023年“9·7”极端特大暴雨洪涝复盘模拟分析——以深圳龙华区观澜河流域为例

2023年9月7—8日,深圳市出现超历史纪录的特大暴雨,龙岗河、深圳河、观澜河等流域遭受严重洪涝灾害。以龙华区观澜河流域为例,采用洪水分析软件HydroMPM构建城市暴雨洪涝模型,对龙华区观澜河流域2023年“9·7”极端特大暴雨洪涝情况进行了模拟,分析了河道漫溢水淹及城区积水情况,为揭示洪涝灾害成因和提出防治对策提供依据。

Refraction of extraordinary rays and ordinary rays in the Savart polariscope

The refraction of rays in the Savart polariscope is different from the isotropic medium. We have analysed and discussed the refraction of rays in the Savart polariscope on the basis of the Snell law. The refraction formulae of the extraordinary rays and ordinary rays were derived. Results obtained may provide theoretical and practical guide lines for studying, developing and engineering of polarization interference imaging spectrometer.

Experimental studies of extraordinary light transmission through periodic arrays of subwavelength square and rectangular holes in metal films

We fabricate a series of periodic arrays of subwavelength square and rectangular air holes on gold films, and measure the transmission spectra of these metallic nanostructures. By changing some geometrical and physical parameters, such as array period, air hole size and shape, and the incident light polarization, we verify that both global surface plasmon resonance and localized waveguide mode resonance are influential on enhancing the transmission of light through nanostructured metal films. These two resonances induce different behaviours of transmission peak shift. The transmission through the rectangular air-hole structures exhibits an obvious polarization effect dependent on the morphology. Numerical simulations are also made by a plane-wave transfer-matrix method and in good consistency with the experimental results.

Effects of interplay between metal subwavelength slits on extraordinary optical transmission

In this paper we study the extraordinary optical transmission of one-dimensional multi-slits in an ideal metal film.The transmissivity is calculated as a function of various structural parameters.The transmissivity oscillates,with the period being just the light wavelength,as a function of the spacing between slits.As the number of slits increases,the transmissivity varies in one of three ways.It can increase,attenuate,or remain basically unchanged,depending on the spacing between slits.Each way is in an oscillatory manner.The slit interaction responsible for the oscillating transmission strength that depends on slit spacing is the subject of more detailed investigation.The interaction most intuitively manifests as a current distribution in the metal surface between slits.We find that this current is attenuated in an oscillating fashion from the slit corners to the center of the region between two adjacent slits,and we present a mathematical expression for its waveform.

One-dimensional ordinary–slow extraordinary–Bernstein mode conversion in the electron cyclotron range of frequencies

The ordinary–slow extraordinary–Bernstein（O-SX-B） mode conversion in the electron cyclotron range of frequencies（ECRF） is revisited in slab geometry. The analytical formula of the O-SX conversion efficiency by Mj？lhus is upgraded to include the magnetic field gradient, and the analytical expression of the SX-B conversion efficiency by Ram and Schultz is generalized for the case of oblique injection. Therefore, the conversion efficiency and optimal parallel refractive index for the whole O-SX-B conversion are obtained analytically and a shift of optimal parallel refractive index due to SX-FX loss is found. Full wave calculations are also presented to be compared with the analytical results.

Extraordinary tunable dynamic range of electrochemical aptasensor for accurate detection of ochratoxin A in food samples

We report the design of a sensitive,electrochemical aptasensor for detection of ochratoxin A(OTA)with an extraordinary tunable dynamic sensing range.This electrochemical aptasensor is constructed based on the target induced aptamer-folding detection mechanism and the recognition between OTA and its aptamers results in the conformational change of the aptamer probe and thus signal changes for measurement.The dynamic sensing range of the electrochemical aptasensor is successfully tuned by introduction of free assistant aptamer probes in the sensing system.Our electrochemical aptasensor shows an extraordinary dynamic sensing range of 11-order magnitude of OTA concentration from 10^−8 to 10^2 ng/g.Of great significance,the signal response in all OTA concentration ranges is at the same current scale,demonstrating that our sensing protocol in this research could be applied for accurate detections of OTA in a broad range without using any complicated treatment of signal amplification.Finally,OTA spiked red wine and maize samples in different dynamic sensing ranges are determined with the electrochemical aptasensor under optimized sensing conditions.This tuning strategy of dynamic sensing range may offer a promising platform for electrochemical aptasensor optimizations in practical applications.

Examination of Extraordinary Transmission of Waves Propagation through Gaps of Vertical Thin Barriers in Channels by A Hypersingular Boundary Element Method

The extraordinary transmission (ET) phenomenon is examined for waves propagating through gaps of vertical thin barriers in channels with a hypersingular boundary element method model on the linear potential theory, and an estimate formula based on small gap approximation for predicting the number of ET frequencies is proposed. Numerical computations are carried out to examine the influences of barrier number, barrier interval, gap size, gap position and barrier arrangement on extraordinary transmission and wave height in the channel. It shows that all of those factors evidently affect the extraordinary transmission frequencies. The contours of wave amplitude show that very high waves can be excited in the basins between barriers at the extraordinary transmission frequencies. Proper arrangement of barriers in a channel can avoid the occurrence of ET phenomenon and reduce wave height in the channel.

Multi-cycle reconfigurable THz extraordinary optical transmission using chalcogenide metamaterials

Metamaterials composed of metallic antennae arrays are used as they possess extraordinary optical transmission(EOT)in the terahertz(THz)region,whereby a giant forward light propagation can be created using constructive interference of tunneling surface plasmonic waves.However,numerous applications of THz meta-devices demand an active manipula-tion of the THz beam in free space.Although some studies have been carried out to control the EOT for the THz region,few of these are based upon electrical modulation of the EOT phenomenon,and novel strategies are required for act-ively and dynamically reconfigurable EOT meta-devices.In this work,we experimentally present that the EOT resonance can be coupled to optically reconfigurable chalcogenide metamaterials which offers a reversible all-optical control of the THz light.A modulation efficiency of 88%in transmission at 0.85 THz is experimentally observed using the EOT metama-terials,which is composed of a gold(Au)circular aperture array sitting on a non-volatile chalcogenide phase change ma-terial(Ge2Sb2Te5)film.This comes up with a robust and ultrafast reconfigurable EOT over 20 times of switching,excited by a nanosecond pulsed laser.The measured data have a good agreement with finite-element-method numerical simula-tion.This work promises THz modulators with significant on/off ratios and fast speeds.

Manipulation of extraordinary acoustic transmission by a tunable bull's eye structure

Extraordinary acoustic transmission （EAT） has been investigated in a tunable bull＇s eye structure. We demonstrate that the transmission coefficient of acoustic waves can be modulated by a grating structure. When the grating is located at a distance of 0.5 mm from the base plate, the acoustic transmission shows an 8.77-fold enhancement compared to that by using a traditional bull＇s eye structure. When the distance increases to 1.5 mm, the transmission approaches zero, indicating a total reflection. Thus, we can make an efficient modulation of acoustic transmission from 0 to 877%. The EAT effects have been ascribed to the coupling of structure-induced resonance with the diffractive wave and the waveguide modes, as well as the Fabry-Perot resonances. As a potential application, the modulation of far-field collimation is illustrated in the proposed bull＇s eye structure.

Extraordinary Acoustic Transmission in a Helmholtz Resonance Cavity-Constructed Acoustic Grating

We investigate both experimentally and numerically a complex structure, where ＇face-to-face＇ Helmholtz resonance cavities （HRCs） are introduced to construct a one-dimensional acoustic grating. In this system, pairs of HRCs can intensely couple with each other in two forms： a bonding state and an anti-bonding state, analogous to the character of hydrogen molecule with two atoms due to the interference of wave functions of sound among the acoustic local-resonating structures. The bonding state is a ＇bright＇ state that interferes with the Fabry-Pbrot resonance mode, thereby causing this state to break up into two modes as the splitting of the extraordinary acoustic transmission peak. On the contrary, the anti-bonding state is a ＇dark＇ state in which the resonance mode remains entirely localized within the HRCs, and has no contribution to the acoustic transmission.

SiO2 stabilizes electrochemically active nitrogen in few-layer carbon electrodes of extraordinary capacitance

Pyrrolic and pyridinic N dopants can dramatically increase the electrochemical activities of carbon and conducting polymers.Although N-doped conducting polymers suffer from rapid degradation,their carbon counterpart of extraordinary capacitance has remarkable rate performance and cycling endurance thanks to carbon’s excellent electrical conductivity.But high nitrogen content and high electrical conductivity are difficult to achieve in a high-surface-area carbon,because the high chemical vapor deposition(CVD)temperature required for obtaining high conductivity also destabilizes under-coordinated pyrrolic and pyridinic nitrogen and tends to lower the surface area.Here we resolve this dilemma by using SiO2 as an effective N-fixation additive,which stabilizes the N-rich nano few-layer sp2-carbon construct in1000℃CVD.This enables a scalable sol-gel/CVD fabrication process for few-layer carbon electrodes of extraordinary capacitance(690 F g^-1).The electrodes have excellent rate performance and can maintain90%of their initial capacitance after 30,000 cycles,thus potentially suitable for practical applications.

Extraordinary terahertz transmission through subwavelength spindle-like apertures in NbN film

We studied numerically the temperature dependent extraordinary terahertz transmission through niobium nitride （NbN） film perforated with subwavelength spindle-like apertures. Both the resonant frequency and intensity of extraor- dinary terahertz transmission peaks can be greatly modified by the transition of NbN film from the normal state to the superconducting state. An enhancement of the （~1,0） NbN/magnesium oxide （MgO） peak intensity as high as 200% is demonstrated due to the combined contribution of both the superconducting transition and the excitation of localized surface plasmons （LSPs） around the apertures. The extraordinary terahertz transmission through spindle-fike hole arrays patterned on the NbN film can pave the way for us to explore novel active tuning devices.