This study aims to discuss anisotropic solutions that are spherically symmetric in the quintessence field,which describe compact stellar objects in the modified Rastall teleparallel theory of gravity.To achieve this g...This study aims to discuss anisotropic solutions that are spherically symmetric in the quintessence field,which describe compact stellar objects in the modified Rastall teleparallel theory of gravity.To achieve this goal,the Krori and Barua arrangement for spherically symmetric components of the line element is incorporated.We explore the field equations by selecting appropriate off-diagonal tetrad fields.Born-Infeld function of torsion f(T)=β√λT+1-1 and power law form h(T)=δTn are used.The Born-Infeld gravity was the first modified teleparallel gravity to discuss inflation.We use the linear equation of state pr=ξρto separate the quintessence density.After obtaining the field equations,we investigate different physical parameters that demonstrate the stability and physical acceptability of the stellar models.We use observational data,such as the mass and radius of the compact star candidates PSRJ 1416-2230,Cen X-3,&4U 1820-30,to ensure the physical plausibility of our findings.展开更多
Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucia...Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's disease.FIFO-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy metabolism.However,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea r.Therefore,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of PD.We found that CHCHD2 protected mitochondria from developing MPP^(+)-induced dysfunction.Under normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase assembly.In addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and F1FO-ATPase.Three weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this model.These findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function.展开更多
We explore the impact of the Sandage-Loeb （SL） test on the precision of cosmological constraints for f（T） gravity theories. The SL test is an important supplement to current cosmological observations because it me...We explore the impact of the Sandage-Loeb （SL） test on the precision of cosmological constraints for f（T） gravity theories. The SL test is an important supplement to current cosmological observations because it measures the redshift drift in the Lyman-α forest in the spectra of distant quasars, covering the ＂redshift desert＂ of 2 ≤ z ≤ 5. To avoid data inconsistency, we use the best-fit models based on current combined observational data as fiducial models to simulate 30 mock SL test data. We quantify the impact of these SL test data on parameter estimation for f（T） gravity theories. Two typical f（T） models are considered, the power-law model f（T）pL and the exponential-form model f（T）Exp. The results show that the SL test can effectively break the existing strong degeneracy between the present-day matter density Ωm and the Hubble constant Ho in other cosmological observations. For the considered f（T） models, a 30-year observation of the SL test can improve the constraint precision of Ωm and H0 enormously but cannot effectively improve the constraint precision of the model parameters.展开更多
Recently an f （T） gravity based on the modification of teleparallel gravity was proposed to ex-plain the accelerated expansion of the universe. We use observational data from type Ia supernovae, baryon acoustic osci...Recently an f （T） gravity based on the modification of teleparallel gravity was proposed to ex-plain the accelerated expansion of the universe. We use observational data from type Ia supernovae, baryon acoustic oscillations, and cosmic microwave background to constrain this f（T） theory and reconstruct the effective equation of state and the deceleration parameter. We obtain the best-fit values of parameters and find an interesting result that the constrained f（T） theory allows for the accelerated Hubble expansion to be a transient effect.展开更多
基金funded by the National Natural Science Foundation of China (Grant No. 11975145)
文摘This study aims to discuss anisotropic solutions that are spherically symmetric in the quintessence field,which describe compact stellar objects in the modified Rastall teleparallel theory of gravity.To achieve this goal,the Krori and Barua arrangement for spherically symmetric components of the line element is incorporated.We explore the field equations by selecting appropriate off-diagonal tetrad fields.Born-Infeld function of torsion f(T)=β√λT+1-1 and power law form h(T)=δTn are used.The Born-Infeld gravity was the first modified teleparallel gravity to discuss inflation.We use the linear equation of state pr=ξρto separate the quintessence density.After obtaining the field equations,we investigate different physical parameters that demonstrate the stability and physical acceptability of the stellar models.We use observational data,such as the mass and radius of the compact star candidates PSRJ 1416-2230,Cen X-3,&4U 1820-30,to ensure the physical plausibility of our findings.
基金supported by the National Natural Science Foundation of China(Youth Program),No.81901282(to XC)the National Natural Science Foundation of China,Nos.81401416(to PX),81870992(to PX),81870856(to XC and MZ)+3 种基金Guangdong Basic and Applied Basic Research Foundation the Science Foundation,No.2019A1515011189(to XC)Central Government Guiding Local Science and Technology Development Projects,No.ZYYD2022C17(to PX)Key Project of Guangzhou Health Commission,No.2019-ZD-09(to PX)Science and Technology Planning Project of Guangzhou,Nos.202102020029(to XC),202102010010(to PX)。
文摘Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's disease.FIFO-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy metabolism.However,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea r.Therefore,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of PD.We found that CHCHD2 protected mitochondria from developing MPP^(+)-induced dysfunction.Under normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase assembly.In addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and F1FO-ATPase.Three weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this model.These findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function.
基金This work was supported by the National Natural Science Foundation of China under Grant Nos. 11175042 and 11522540, the Provincial Department of Education of Liaon- ing under Grant No. L2012087, and the Fundamental Research Funds for the Central Universities under Grant Nos. N140505002, N140506002, and N140504007.
文摘We explore the impact of the Sandage-Loeb （SL） test on the precision of cosmological constraints for f（T） gravity theories. The SL test is an important supplement to current cosmological observations because it measures the redshift drift in the Lyman-α forest in the spectra of distant quasars, covering the ＂redshift desert＂ of 2 ≤ z ≤ 5. To avoid data inconsistency, we use the best-fit models based on current combined observational data as fiducial models to simulate 30 mock SL test data. We quantify the impact of these SL test data on parameter estimation for f（T） gravity theories. Two typical f（T） models are considered, the power-law model f（T）pL and the exponential-form model f（T）Exp. The results show that the SL test can effectively break the existing strong degeneracy between the present-day matter density Ωm and the Hubble constant Ho in other cosmological observations. For the considered f（T） models, a 30-year observation of the SL test can improve the constraint precision of Ωm and H0 enormously but cannot effectively improve the constraint precision of the model parameters.
基金supported by the National Natural Science Foundation of China(Grant Nos.11235003,11175019,11178007,11147028 and11273010)the Hebei Provincial Natural Science Foundation of China(Grant Nos.A2011201147 and A2014201068)
文摘Recently an f （T） gravity based on the modification of teleparallel gravity was proposed to ex-plain the accelerated expansion of the universe. We use observational data from type Ia supernovae, baryon acoustic oscillations, and cosmic microwave background to constrain this f（T） theory and reconstruct the effective equation of state and the deceleration parameter. We obtain the best-fit values of parameters and find an interesting result that the constrained f（T） theory allows for the accelerated Hubble expansion to be a transient effect.
