Counterfeit medicines are a growing problem in both developing and industrialised countries. In general the evaluation of these medicines is limited to the identification and the dosage of the active ingredients. In t...Counterfeit medicines are a growing problem in both developing and industrialised countries. In general the evaluation of these medicines is limited to the identification and the dosage of the active ingredients. In this study in vitro dissolution tests were conducted on two sets of counterfeit medicines containing PDE-5 inhibitors （sildenafil citrate and tadalafil）. The dissolution profiles were statistically compared to the ones of the genuine products using the f2-method and a comparison at each time point using the Cochran test. The results showed low equivalences between counterfeit and genuine products as well as higher variations around the mean dissolution value at the different time points for the counterfeit products.展开更多
利用C/A码单点定位对LEO(Low Earth Orbit)卫星上的电离层延迟改正方法———"电离层比例因子法"进行了分析研究.计算的CHAMP卫星的轨道结果表明:采用电子密度峰值高度(hmF2,F2 region maximum electron density height)平均...利用C/A码单点定位对LEO(Low Earth Orbit)卫星上的电离层延迟改正方法———"电离层比例因子法"进行了分析研究.计算的CHAMP卫星的轨道结果表明:采用电子密度峰值高度(hmF2,F2 region maximum electron density height)平均值和瞬时值计算的电离层比例因子α变化范围分别为0.3～0.4和0.2～0.65之间,两者最大差异可达0.3,相比较而言,hmF2瞬时值的结果更加合理,并且相应的大地高H方向的系统偏差要降低0.05～0.3 m左右;与双频无电离层组合的普通单点定位结果相比表明该方法能较好地消除电离层一阶项所引入的H方向上的系统偏差;该方法适用的LEO卫星轨道高度范围大致在200～600km之间,当轨道高度超过700 km时,该方法并不适用.展开更多
文摘Counterfeit medicines are a growing problem in both developing and industrialised countries. In general the evaluation of these medicines is limited to the identification and the dosage of the active ingredients. In this study in vitro dissolution tests were conducted on two sets of counterfeit medicines containing PDE-5 inhibitors （sildenafil citrate and tadalafil）. The dissolution profiles were statistically compared to the ones of the genuine products using the f2-method and a comparison at each time point using the Cochran test. The results showed low equivalences between counterfeit and genuine products as well as higher variations around the mean dissolution value at the different time points for the counterfeit products.
文摘利用C/A码单点定位对LEO(Low Earth Orbit)卫星上的电离层延迟改正方法———"电离层比例因子法"进行了分析研究.计算的CHAMP卫星的轨道结果表明:采用电子密度峰值高度(hmF2,F2 region maximum electron density height)平均值和瞬时值计算的电离层比例因子α变化范围分别为0.3～0.4和0.2～0.65之间,两者最大差异可达0.3,相比较而言,hmF2瞬时值的结果更加合理,并且相应的大地高H方向的系统偏差要降低0.05～0.3 m左右;与双频无电离层组合的普通单点定位结果相比表明该方法能较好地消除电离层一阶项所引入的H方向上的系统偏差;该方法适用的LEO卫星轨道高度范围大致在200～600km之间,当轨道高度超过700 km时,该方法并不适用.
