BACKGROUND There are few cases of pulmonary granulomatous changes secondary to primary biliary cirrhosis(PBC).No case of granulomatous lung disease secondary to PBC misdiagnosed as lung cancer had been reported.CASE S...BACKGROUND There are few cases of pulmonary granulomatous changes secondary to primary biliary cirrhosis(PBC).No case of granulomatous lung disease secondary to PBC misdiagnosed as lung cancer had been reported.CASE SUMMARY A middle-aged woman presented with lung nodules and was misdiagnosed with lung cancer by positron emission tomography/computed tomography.She underwent left lobectomy,and the pathology of the nodules showed granulomatous inflammation,which was then treated with antibiotics.However,a new nodule appeared.Further investigation with lung biopsy and liver serology led to the diagnosis of PBC,and chest computed tomography indicated significant reduction in the pulmonary nodule by treatment with methylprednisolone and ursodeoxycholic acid.CONCLUSION Diagnosis of pulmonary nodules requires integrating various clinical data to avoid unnecessary pulmonary lobectomy.展开更多
Background Lung cancer is the most common cancer worldwide and remains the leading cause of cancer-related mortality.A method that can be used for the early detection and diagnosis of non-small-cell lung cancer(NSCLC)...Background Lung cancer is the most common cancer worldwide and remains the leading cause of cancer-related mortality.A method that can be used for the early detection and diagnosis of non-small-cell lung cancer(NSCLC)is urgently needed.Materials and Methods We identified differentially expressed genes based on RNA sequencing data for NSCLC from The Cancer Genome Atlas(TCGA)database.Then,we conducted receiver operating characteristic(ROC)curve and survival analyses to determine which genes had diagnostic and/or prognostic value.Results A total of 24991 genes were included in the TCGA database,and a differential gene expression analysis was conducted for 971 NSCLC and 108 normal samples.There were 1709 differentially expressed genes identified using three methods.It was noted that 29 of the 1709 genes were enriched in the“Transcriptional misregulation in cancer”pathway,such as HOXA11,HOXA10,HMGA2,MMP3,and MMP9.Based on the ROC curve and survival analyses,27 of the 1709 differentially expressed genes were with exact diagnostic and prognostic value for NSCLC,such as SLC2A1,LGR4,EMP2,CLDN5,PRC1,ANLN,GAPDH.GAPDH took the center position in the protein-protein interaction(PPI)network.Conclusion Twenty-seven differentially expressed genes with diagnostic and prognostic value were identified that can serve as potential biomarkers for NSCLC.展开更多
目的分析放射性荧光脱氧葡萄糖(18F-FDG)正电子发射断层扫描(PET)/计算机断层扫描(CT)显像在肺癌术前分期诊断及复发转移预测中的应用价值。方法 回顾性分析2022年9月至2023年6月期间80例初诊肺癌患者的临床和影像学数据,所有患者均在术...目的分析放射性荧光脱氧葡萄糖(18F-FDG)正电子发射断层扫描(PET)/计算机断层扫描(CT)显像在肺癌术前分期诊断及复发转移预测中的应用价值。方法 回顾性分析2022年9月至2023年6月期间80例初诊肺癌患者的临床和影像学数据,所有患者均在术前1周内进行了18F-F DG P ET/CT显像检查,并在术后3~6个月内进行了复查,监测复发或转移情况。术前的TNM分期和术后的复发转移情况均以手术病理结果或临床随访结果为金标准进行评估。结果术前分期诊断中,18F-FD(G P ET/CT显像的T分期、N分期和M分期的符合率分别为86.59%、81.93%和100%,一致性检验Kappa值分别为0.834、0.793和1.000。术后的复发转移检测中,18F-FDG PET/CT显像在术后6个月内成功检出了22例(88.00%)的复发转移病例,其诊断灵敏度为88.00%,特异度为100.00%。结论18F-FDG PET/CT显像在肺癌术前分期以及术后复发转移的预测中具有较高的准确性和可靠性,该方法可以为临床提供有效的参考信息,有助于医生制定更准确的治疗方案和更有效的随访策略。展开更多
基金The Special Health Project of the Department of Finance of Jilin Province,China,No.2020SCZT023 and No.3D5177713429.
文摘BACKGROUND There are few cases of pulmonary granulomatous changes secondary to primary biliary cirrhosis(PBC).No case of granulomatous lung disease secondary to PBC misdiagnosed as lung cancer had been reported.CASE SUMMARY A middle-aged woman presented with lung nodules and was misdiagnosed with lung cancer by positron emission tomography/computed tomography.She underwent left lobectomy,and the pathology of the nodules showed granulomatous inflammation,which was then treated with antibiotics.However,a new nodule appeared.Further investigation with lung biopsy and liver serology led to the diagnosis of PBC,and chest computed tomography indicated significant reduction in the pulmonary nodule by treatment with methylprednisolone and ursodeoxycholic acid.CONCLUSION Diagnosis of pulmonary nodules requires integrating various clinical data to avoid unnecessary pulmonary lobectomy.
基金the National Natural Science Foundation of China(No.81472782)the Natural Science Foundation of Jiangsu Province(No.BK20141491)the project of National Key Research and Development Plan of China(No.2017YFC 1309201).
文摘Background Lung cancer is the most common cancer worldwide and remains the leading cause of cancer-related mortality.A method that can be used for the early detection and diagnosis of non-small-cell lung cancer(NSCLC)is urgently needed.Materials and Methods We identified differentially expressed genes based on RNA sequencing data for NSCLC from The Cancer Genome Atlas(TCGA)database.Then,we conducted receiver operating characteristic(ROC)curve and survival analyses to determine which genes had diagnostic and/or prognostic value.Results A total of 24991 genes were included in the TCGA database,and a differential gene expression analysis was conducted for 971 NSCLC and 108 normal samples.There were 1709 differentially expressed genes identified using three methods.It was noted that 29 of the 1709 genes were enriched in the“Transcriptional misregulation in cancer”pathway,such as HOXA11,HOXA10,HMGA2,MMP3,and MMP9.Based on the ROC curve and survival analyses,27 of the 1709 differentially expressed genes were with exact diagnostic and prognostic value for NSCLC,such as SLC2A1,LGR4,EMP2,CLDN5,PRC1,ANLN,GAPDH.GAPDH took the center position in the protein-protein interaction(PPI)network.Conclusion Twenty-seven differentially expressed genes with diagnostic and prognostic value were identified that can serve as potential biomarkers for NSCLC.
文摘目的分析放射性荧光脱氧葡萄糖(18F-FDG)正电子发射断层扫描(PET)/计算机断层扫描(CT)显像在肺癌术前分期诊断及复发转移预测中的应用价值。方法 回顾性分析2022年9月至2023年6月期间80例初诊肺癌患者的临床和影像学数据,所有患者均在术前1周内进行了18F-F DG P ET/CT显像检查,并在术后3~6个月内进行了复查,监测复发或转移情况。术前的TNM分期和术后的复发转移情况均以手术病理结果或临床随访结果为金标准进行评估。结果术前分期诊断中,18F-FD(G P ET/CT显像的T分期、N分期和M分期的符合率分别为86.59%、81.93%和100%,一致性检验Kappa值分别为0.834、0.793和1.000。术后的复发转移检测中,18F-FDG PET/CT显像在术后6个月内成功检出了22例(88.00%)的复发转移病例,其诊断灵敏度为88.00%,特异度为100.00%。结论18F-FDG PET/CT显像在肺癌术前分期以及术后复发转移的预测中具有较高的准确性和可靠性,该方法可以为临床提供有效的参考信息,有助于医生制定更准确的治疗方案和更有效的随访策略。
