The application of PV faades emerges greatly in recent years and however its calculation methods and analysis remains insufficient under the weather conditions of China. In such demand,this paper investigates PV fa...The application of PV faades emerges greatly in recent years and however its calculation methods and analysis remains insufficient under the weather conditions of China. In such demand,this paper investigates PV faade in terms of PV electricity generation in different arrangements and weather conditions of four major cities in China. The calculation models for PV faade are developed and validated by comparing the results with the measured data from the field experiments. A parametric study is carried out to provide a reference for the optimal design of the PV faades. The results show that with various cities,building orientations,building forms,materials and arrangements of PV modules,there is a distinct difference in the electrical output energy of PV faades. Weather conditions play a very important role in terms of PV generation performance of PV faades.展开更多
Over time,the traditional house in central Iran,which Tehran geographically belongs to,has undergone deep physical and morphological changes as a result of technological,social and economic transformations,passing fro...Over time,the traditional house in central Iran,which Tehran geographically belongs to,has undergone deep physical and morphological changes as a result of technological,social and economic transformations,passing from the characteristics of an introverted house enclosed by walls overlooking an inner courtyard to the multi-storey condominium with an extroverted outlook.Here the façade becomes a key element:it is a threshold between urban and private,outdoor and indoor.The article shows a mosaic of patterns and materials of the new mid-rise residential building façades via photographs and diagrams to emphasize the strict connection between contemporary design and local tradition.展开更多
The manual visual inspections of façade building defects are posing a high and increasing cost for building asset managers,particularly when inspections delay projects or require asset outages,visits to decommiss...The manual visual inspections of façade building defects are posing a high and increasing cost for building asset managers,particularly when inspections delay projects or require asset outages,visits to decommissioned sites or work within hazardous environments.This paper reports on the development,testing and delivery of a working mobile app prototype to facilitate the inspections and documentation of building facade condition monitoring.The work presented builds upon the development of an online platform for remote building inspection based on the integration of methodologies and tools,including VR(virtual reality),and digital photogrammetry to collect real-time data that support automated decision making.The mobile app:(i)allows the user to import 3D models and 2D building plans;(ii)provides the means of first-person exploration of models via a VR headset;and(iii)captures,records and catalogues images of façade defect types,and the date and time.An inspection case study was used to demonstrate and evaluate the mobile app prototype.The Building Inspector app allows building professionals to manage inspections and to track past and ongoing monitoring of the condition of building façades.展开更多
The present research aims to identify the possibilities of rehabilitation of building facades in the centre of Chisinau, through the use of high-performance materials, use of high-performance technologies in exec...The present research aims to identify the possibilities of rehabilitation of building facades in the centre of Chisinau, through the use of high-performance materials, use of high-performance technologies in execution, reduction of facade renovation costs, etc. In the process of organising the rehabilitation works of historical buildings of architectural value, we are dealing with the following: the value of the rehabilitation works of a historical building is very high, the duration of the rehabilitation is important, the attitude of the society is insufficient, the lack of strategies for the rehabilitation of buildings at the municipality level. In order to achieve this objective, we propose to research the following tasks: definition of the concept of rehabilitation of buildings in the Historic Centre of Chisinau;legislative, normative assurance of rehabilitation of historical heritage in the Republic of Moldova;analysis of the situation in Chisinau on the example of historical buildings with limestone finishes and examination by non-destructive methods of facades;solutions for rehabilitation of facades of historical buildings by comparing two types of technologies. In conclusion, emphasis will be placed on the choice of the most efficient method in terms of material, technology and cost.展开更多
Multidisciplinary, integrated planning approach by architects, engineers, scientists and manufacturers to reduce energy consumption of buildings. The CIIRC Complex, located on the main campus of Czech Technical Univer...Multidisciplinary, integrated planning approach by architects, engineers, scientists and manufacturers to reduce energy consumption of buildings. The CIIRC Complex, located on the main campus of Czech Technical University in Prague consists of two buildings, newly constructed building and adaptive reuse of existing building. CIIRC—Czech Institute of Informatics, Robotics and Cybernetics is a contemporary teaching facility of new generation and use for scientific research teams. New building has ten above-ground floors, on the bottom 4 floors of laboratories, scientist modules, classrooms, above are offices, meeting rooms, teaching and research modules for professors and students. Offices of the rector are on the last two floors of the building. On the top floor is congress type auditorium, in the basement is fully automatic car park. Double skin pneumatic cushions facade. In the project are introduced series of architectural and technical features and innovations. Probably the most visible is the double skin facade facing south-transparent double layer membrane ETFE (Ethylen-TetraFluorEthylen) cushions with triple glazed modular system assembly. Acting as solar collector, recuperating of hot air on the top floors, saving up to 30% of an energy consumption.展开更多
Building surface cool materials are novel materials that can reduce urban heat island intensity and decrease building energy consumption.This study investigated the impact of radiative properties of materials,faç...Building surface cool materials are novel materials that can reduce urban heat island intensity and decrease building energy consumption.This study investigated the impact of radiative properties of materials,façade orientation,and morphological parameters on energy consumption in six typical residential neighborhoods in Nanjing,China.The neighborhood energy consumption of 16 application schemes considering the façade orientation factor is compared to determine the best energy-saving scheme.Seasonal and annual energy-saving rates,savings in electricity costs,and the price ceiling for materials per unit area are analyzed.The results show that for low-rise buildings,using cool materials only on the roof can reduce the annual energy consumption by 1%.When cool or super cool materials are also used on the building façade,the annual energy saving rate can be up to 3.4%and 4.3%,respectively.Using cool materials on the south façade of buildings is not recommended due to significant heat loss in winter.Considering savings in electricity costs and the price ceiling for materials per unit area,the price of cool and super cool materials should be less than 3.0 and 3.7 RMB/m2,respectively,assuming a lifespan of eight years in Nanjing.展开更多
Building-Integrated Photovoltaic(BIPV)on vertical façades is a potential PV application in today’s buildings.The performance of BIPV on façades is significantly influenced by the façade orientation.For...Building-Integrated Photovoltaic(BIPV)on vertical façades is a potential PV application in today’s buildings.The performance of BIPV on façades is significantly influenced by the façade orientation.For tropical cities,the optimum façade orientation,in terms of maximum energy yield and daylight performance,cannot be simply determined,due to relatively symmetrical sun path throughout the day.This study therefore aims to determine the optimum orientation for BIPV on tropical building façades.To achieve the objective,experiment,modelling,and computational simulation are conducted to evaluate the BIPV energy yield and to predict the indoor daylight performance in a scale-model building with a 105Wp monocrystalline silicon PV,facing each cardinal orienta-tion in Bandung,Indonesia.The South orientation yields practically zero ASE_(1000,250),providing the best annual daylight performance,and yielding the most desirable value in four out of five daylight metrics.The greatest annual energy yield is at the North orientation,providing 179-186 kWh(95%prediction interval)per year,but with larger uncertainty compared to that at the South,due to direct sunlight occurrence.Based on three different objective functions,the South orientation is considered optimum for placing the BIPV panel on the prototype façade in the location.展开更多
Okadaic acid: Okadaic acid (OKA), a polyether (C38 fatty acid) toxin, is a potent and selective inhibitor of protein phosphatase, PP1 and protein phosphatase 2A (PP2A). It is mainly extracted from a black spong...Okadaic acid: Okadaic acid (OKA), a polyether (C38 fatty acid) toxin, is a potent and selective inhibitor of protein phosphatase, PP1 and protein phosphatase 2A (PP2A). It is mainly extracted from a black sponge Hallichondria okadaii and has been suggested to play a potent probe for studying the various molecular, cellular, biochemical and mechanism of neurotoxicity. It is known as a selective and potent in- hibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. It has been reported that Alzheimer's disease (AD) is a complex multi- factorial neurodegenerative disorder and hyperphosphor- ylated tau protein is a major pathological hallmark of AD. The reduced activity of phosphatases like, PP2A has been implicated in the brain of AD patients. OKA also induced inhibition of protein phosphatases cause neurofibrillary tangles (NFTs) like pathological changes and tau hyperphos- phorylation seen in AD pathology. Our and others reports inferred that OKA induces neurodegeneration along with tau hyperphosphorylation, GSK3β activation, oxidative stress, neuroinflammation and neurotoxicity which are char- acteristic of AD pathology (Figure 1).展开更多
A randomized double-blind intervention trial was carried determine whether oral calcium supplementation could lower the proliferation of epithelial cells of the esophagus. 41 subjects identified with precancerous lesi...A randomized double-blind intervention trial was carried determine whether oral calcium supplementation could lower the proliferation of epithelial cells of the esophagus. 41 subjects identified with precancerous lesions by histopathology were randomized to receive oral supplementation of their conventional diets with 0.6 g of calcium as calcium carbonate or placebo. Both at the entry to the study and at the end of the treatment, seven months later, the subjects were examined, with an emphasis on the frequency and distribution of proliferating epithelial cells of the esophagus. Patterns of cell proliferation was defined by dividing the esophageal epithelium into cell columns oriented perpendicularly to the basal cell layer and by comparing the numbers and fractions of tritiated thymidine-labeled epithelial cells in the various cell columns and cell compartments.Before dietary supplementation with calcium, the profile of proliferating epithelial cells in the esophageal compartments in calcium group is similar to that in the placebo group, which is comparable to that previously observed in subjects with high risk for esophageal cancer. Seven months after supplementation having been started, in calcium group, proliferation was significantly reduced and the profile of the esophageal columns approached to that previously observed in subjects at low risk for esophageal cancer, however, in the placebo group, the proliferation and profile maintain at the same level as that before supplementation. Our findings indicate that oral calcium supplementation induces a more quiescent equilibrium in epithelial-cell proliferation in the esophageal mucosa of the subjects at high-risk for esophageal cancer, similar to that observed in subjects at low risk.展开更多
目的系统评价fas基因启动子区-1377G/A和-670A/G多态性与乳腺癌发病风险的相关性。方法检索电子数据库PubMed、Embase、Web of Science、CNKI、Wanfang Data和CBM,截止日期为2017年2月10日,按纳入与排除标准筛选文献。采用Stata13.0软...目的系统评价fas基因启动子区-1377G/A和-670A/G多态性与乳腺癌发病风险的相关性。方法检索电子数据库PubMed、Embase、Web of Science、CNKI、Wanfang Data和CBM,截止日期为2017年2月10日,按纳入与排除标准筛选文献。采用Stata13.0软件进行Meta分析,评估发表偏倚并进行敏感度分析。结果共纳入11篇研究,合并结果显示:未发现fas基因启动子区-1377G/A和-670A/G多态性与乳腺癌发病风险有关联;Egger′s线性回归分析显示不存在发表偏倚(P>0.05);逐个剔除研究后,发现Meta分析结果受单个研究的影响较小。结论 fas基因启动子区-1377G/A和-670A/G多态性可能与乳腺癌的发病风险无关。展开更多
It remains challenging to conduct an efficient dynamic façade design.In this article authors try to address this issue introducing the façade daylighting performance improvement(FDPI)indicator aimed to evalu...It remains challenging to conduct an efficient dynamic façade design.In this article authors try to address this issue introducing the façade daylighting performance improvement(FDPI)indicator aimed to evaluate the performance of a dynamic(adaptive)façade from its daylighting performance point of view.To illustrate the FDPI application the authors introduced the preliminary dynamic façade concept for an office building located in Tel Aviv(Hot-summer Mediterranean Climate Csa)with further shape modification based on the daylighting performance analysis compared to the three alternatives representative of different typologies of dynamic façades.Al Bahr,One Ocean and The University of Southern Denmark façade systems were simulated under the same weather and building conditions of the preliminary dynamic façade concept and were considered as a benchmark for the study.The final dynamic façade concept elaborated by the authors in the preliminary comparative workflow showed noticeable daylight performance improvement with respect to the case studies comparative scenarios.The FDPI metric allowed to estimate a daylighting performance improvement of 43%of the final dynamic façade concept over the case study dynamic façade that showed the best performance in the daylighting simulations.展开更多
Celiac disease has been reported in up to 2% of some European populations. A similar risk has been identified in the America and Australia where immigration of Eu-ropeans has occurred. Moreover, an increasing number o...Celiac disease has been reported in up to 2% of some European populations. A similar risk has been identified in the America and Australia where immigration of Eu-ropeans has occurred. Moreover, an increasing number of celiac disease patients are being identified in many Asian countries, including China and India. Finally, celiac disease has also been detected in Asian immigrants and their descendants to other countries, such as Canada. Within these so-called "general" celiac populations, however, there are specific high risk groups that have an even higher prevalence of celiac disease. Indeed, the single most important risk factor for celiac disease is having a first-degree relative with already-defined celiac disease, particularly a sibling. A rate up to 20% or more has been noted. Risk is even greater if a specific family has 2 siblings affected, particularly if a male carries the human leukocyte antigen-DQ2. Both structural changes in the small bowel architecture occur along with func-tional changes in permeability, even in asymptomatic first-degree relatives. Even if celiac disease is not evident, the risk of other autoimmune disorders seems significantly increased in first-degree relatives as well as intestinal lymphoma. Identification of celiac disease is important since recent long-term studies have shown that the mortality of celiac disease is increased, if it is unrecognized and untreated.展开更多
基金Sponsored by the National Natural Science Foundation of China (Grant No.51008136)the Graduates’ Innovation and Enterprise Fund of HUST (Grant No.HF-11-12-2013)
文摘The application of PV faades emerges greatly in recent years and however its calculation methods and analysis remains insufficient under the weather conditions of China. In such demand,this paper investigates PV faade in terms of PV electricity generation in different arrangements and weather conditions of four major cities in China. The calculation models for PV faade are developed and validated by comparing the results with the measured data from the field experiments. A parametric study is carried out to provide a reference for the optimal design of the PV faades. The results show that with various cities,building orientations,building forms,materials and arrangements of PV modules,there is a distinct difference in the electrical output energy of PV faades. Weather conditions play a very important role in terms of PV generation performance of PV faades.
基金When I was in Tehran three years ago,I had the opportunity to visit and meet some architects:this was the starting point to investigate Iranian architecture,especially the residential sector.I would like to acknowledge the seven architectural firms which answered my call and sent me photos and diagrams of the case studies chosen:Admun Studio,Faezeh Hadian Design Studio,Alidoost&Partners,Keivani Architects,Ayeneh Office,TDC Office.Thanks also go to Parham Rashidi for his valuable support in contacting the architects.
文摘Over time,the traditional house in central Iran,which Tehran geographically belongs to,has undergone deep physical and morphological changes as a result of technological,social and economic transformations,passing from the characteristics of an introverted house enclosed by walls overlooking an inner courtyard to the multi-storey condominium with an extroverted outlook.Here the façade becomes a key element:it is a threshold between urban and private,outdoor and indoor.The article shows a mosaic of patterns and materials of the new mid-rise residential building façades via photographs and diagrams to emphasize the strict connection between contemporary design and local tradition.
文摘The manual visual inspections of façade building defects are posing a high and increasing cost for building asset managers,particularly when inspections delay projects or require asset outages,visits to decommissioned sites or work within hazardous environments.This paper reports on the development,testing and delivery of a working mobile app prototype to facilitate the inspections and documentation of building facade condition monitoring.The work presented builds upon the development of an online platform for remote building inspection based on the integration of methodologies and tools,including VR(virtual reality),and digital photogrammetry to collect real-time data that support automated decision making.The mobile app:(i)allows the user to import 3D models and 2D building plans;(ii)provides the means of first-person exploration of models via a VR headset;and(iii)captures,records and catalogues images of façade defect types,and the date and time.An inspection case study was used to demonstrate and evaluate the mobile app prototype.The Building Inspector app allows building professionals to manage inspections and to track past and ongoing monitoring of the condition of building façades.
文摘The present research aims to identify the possibilities of rehabilitation of building facades in the centre of Chisinau, through the use of high-performance materials, use of high-performance technologies in execution, reduction of facade renovation costs, etc. In the process of organising the rehabilitation works of historical buildings of architectural value, we are dealing with the following: the value of the rehabilitation works of a historical building is very high, the duration of the rehabilitation is important, the attitude of the society is insufficient, the lack of strategies for the rehabilitation of buildings at the municipality level. In order to achieve this objective, we propose to research the following tasks: definition of the concept of rehabilitation of buildings in the Historic Centre of Chisinau;legislative, normative assurance of rehabilitation of historical heritage in the Republic of Moldova;analysis of the situation in Chisinau on the example of historical buildings with limestone finishes and examination by non-destructive methods of facades;solutions for rehabilitation of facades of historical buildings by comparing two types of technologies. In conclusion, emphasis will be placed on the choice of the most efficient method in terms of material, technology and cost.
文摘Multidisciplinary, integrated planning approach by architects, engineers, scientists and manufacturers to reduce energy consumption of buildings. The CIIRC Complex, located on the main campus of Czech Technical University in Prague consists of two buildings, newly constructed building and adaptive reuse of existing building. CIIRC—Czech Institute of Informatics, Robotics and Cybernetics is a contemporary teaching facility of new generation and use for scientific research teams. New building has ten above-ground floors, on the bottom 4 floors of laboratories, scientist modules, classrooms, above are offices, meeting rooms, teaching and research modules for professors and students. Offices of the rector are on the last two floors of the building. On the top floor is congress type auditorium, in the basement is fully automatic car park. Double skin pneumatic cushions facade. In the project are introduced series of architectural and technical features and innovations. Probably the most visible is the double skin facade facing south-transparent double layer membrane ETFE (Ethylen-TetraFluorEthylen) cushions with triple glazed modular system assembly. Acting as solar collector, recuperating of hot air on the top floors, saving up to 30% of an energy consumption.
基金This study was financially supported by the National Natural Science Foundation of China(project No.52278110)the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(project No.KYCX23_0170).
文摘Building surface cool materials are novel materials that can reduce urban heat island intensity and decrease building energy consumption.This study investigated the impact of radiative properties of materials,façade orientation,and morphological parameters on energy consumption in six typical residential neighborhoods in Nanjing,China.The neighborhood energy consumption of 16 application schemes considering the façade orientation factor is compared to determine the best energy-saving scheme.Seasonal and annual energy-saving rates,savings in electricity costs,and the price ceiling for materials per unit area are analyzed.The results show that for low-rise buildings,using cool materials only on the roof can reduce the annual energy consumption by 1%.When cool or super cool materials are also used on the building façade,the annual energy saving rate can be up to 3.4%and 4.3%,respectively.Using cool materials on the south façade of buildings is not recommended due to significant heat loss in winter.Considering savings in electricity costs and the price ceiling for materials per unit area,the price of cool and super cool materials should be less than 3.0 and 3.7 RMB/m2,respectively,assuming a lifespan of eight years in Nanjing.
基金supported by the Ministry of Education,Culture,Research,and Technology of the Republic of Indonesia,through the In-donesia Collaboration Research Program(RKI)2022.
文摘Building-Integrated Photovoltaic(BIPV)on vertical façades is a potential PV application in today’s buildings.The performance of BIPV on façades is significantly influenced by the façade orientation.For tropical cities,the optimum façade orientation,in terms of maximum energy yield and daylight performance,cannot be simply determined,due to relatively symmetrical sun path throughout the day.This study therefore aims to determine the optimum orientation for BIPV on tropical building façades.To achieve the objective,experiment,modelling,and computational simulation are conducted to evaluate the BIPV energy yield and to predict the indoor daylight performance in a scale-model building with a 105Wp monocrystalline silicon PV,facing each cardinal orienta-tion in Bandung,Indonesia.The South orientation yields practically zero ASE_(1000,250),providing the best annual daylight performance,and yielding the most desirable value in four out of five daylight metrics.The greatest annual energy yield is at the North orientation,providing 179-186 kWh(95%prediction interval)per year,but with larger uncertainty compared to that at the South,due to direct sunlight occurrence.Based on three different objective functions,the South orientation is considered optimum for placing the BIPV panel on the prototype façade in the location.
基金supported in part by Council of Scientific and Industrial Research(CSIR),IndiaNational Institute of Health,USA
文摘Okadaic acid: Okadaic acid (OKA), a polyether (C38 fatty acid) toxin, is a potent and selective inhibitor of protein phosphatase, PP1 and protein phosphatase 2A (PP2A). It is mainly extracted from a black sponge Hallichondria okadaii and has been suggested to play a potent probe for studying the various molecular, cellular, biochemical and mechanism of neurotoxicity. It is known as a selective and potent in- hibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. It has been reported that Alzheimer's disease (AD) is a complex multi- factorial neurodegenerative disorder and hyperphosphor- ylated tau protein is a major pathological hallmark of AD. The reduced activity of phosphatases like, PP2A has been implicated in the brain of AD patients. OKA also induced inhibition of protein phosphatases cause neurofibrillary tangles (NFTs) like pathological changes and tau hyperphos- phorylation seen in AD pathology. Our and others reports inferred that OKA induces neurodegeneration along with tau hyperphosphorylation, GSK3β activation, oxidative stress, neuroinflammation and neurotoxicity which are char- acteristic of AD pathology (Figure 1).
文摘A randomized double-blind intervention trial was carried determine whether oral calcium supplementation could lower the proliferation of epithelial cells of the esophagus. 41 subjects identified with precancerous lesions by histopathology were randomized to receive oral supplementation of their conventional diets with 0.6 g of calcium as calcium carbonate or placebo. Both at the entry to the study and at the end of the treatment, seven months later, the subjects were examined, with an emphasis on the frequency and distribution of proliferating epithelial cells of the esophagus. Patterns of cell proliferation was defined by dividing the esophageal epithelium into cell columns oriented perpendicularly to the basal cell layer and by comparing the numbers and fractions of tritiated thymidine-labeled epithelial cells in the various cell columns and cell compartments.Before dietary supplementation with calcium, the profile of proliferating epithelial cells in the esophageal compartments in calcium group is similar to that in the placebo group, which is comparable to that previously observed in subjects with high risk for esophageal cancer. Seven months after supplementation having been started, in calcium group, proliferation was significantly reduced and the profile of the esophageal columns approached to that previously observed in subjects at low risk for esophageal cancer, however, in the placebo group, the proliferation and profile maintain at the same level as that before supplementation. Our findings indicate that oral calcium supplementation induces a more quiescent equilibrium in epithelial-cell proliferation in the esophageal mucosa of the subjects at high-risk for esophageal cancer, similar to that observed in subjects at low risk.
文摘目的系统评价fas基因启动子区-1377G/A和-670A/G多态性与乳腺癌发病风险的相关性。方法检索电子数据库PubMed、Embase、Web of Science、CNKI、Wanfang Data和CBM,截止日期为2017年2月10日,按纳入与排除标准筛选文献。采用Stata13.0软件进行Meta分析,评估发表偏倚并进行敏感度分析。结果共纳入11篇研究,合并结果显示:未发现fas基因启动子区-1377G/A和-670A/G多态性与乳腺癌发病风险有关联;Egger′s线性回归分析显示不存在发表偏倚(P>0.05);逐个剔除研究后,发现Meta分析结果受单个研究的影响较小。结论 fas基因启动子区-1377G/A和-670A/G多态性可能与乳腺癌的发病风险无关。
基金the Ministry of Science and Higher Education of the Russian Federation as part of the World-class Research Center program:Advanced Digital Technologies(contract No.075-15-2022-311 dated 20 April 2022).
文摘It remains challenging to conduct an efficient dynamic façade design.In this article authors try to address this issue introducing the façade daylighting performance improvement(FDPI)indicator aimed to evaluate the performance of a dynamic(adaptive)façade from its daylighting performance point of view.To illustrate the FDPI application the authors introduced the preliminary dynamic façade concept for an office building located in Tel Aviv(Hot-summer Mediterranean Climate Csa)with further shape modification based on the daylighting performance analysis compared to the three alternatives representative of different typologies of dynamic façades.Al Bahr,One Ocean and The University of Southern Denmark façade systems were simulated under the same weather and building conditions of the preliminary dynamic façade concept and were considered as a benchmark for the study.The final dynamic façade concept elaborated by the authors in the preliminary comparative workflow showed noticeable daylight performance improvement with respect to the case studies comparative scenarios.The FDPI metric allowed to estimate a daylighting performance improvement of 43%of the final dynamic façade concept over the case study dynamic façade that showed the best performance in the daylighting simulations.
文摘Celiac disease has been reported in up to 2% of some European populations. A similar risk has been identified in the America and Australia where immigration of Eu-ropeans has occurred. Moreover, an increasing number of celiac disease patients are being identified in many Asian countries, including China and India. Finally, celiac disease has also been detected in Asian immigrants and their descendants to other countries, such as Canada. Within these so-called "general" celiac populations, however, there are specific high risk groups that have an even higher prevalence of celiac disease. Indeed, the single most important risk factor for celiac disease is having a first-degree relative with already-defined celiac disease, particularly a sibling. A rate up to 20% or more has been noted. Risk is even greater if a specific family has 2 siblings affected, particularly if a male carries the human leukocyte antigen-DQ2. Both structural changes in the small bowel architecture occur along with func-tional changes in permeability, even in asymptomatic first-degree relatives. Even if celiac disease is not evident, the risk of other autoimmune disorders seems significantly increased in first-degree relatives as well as intestinal lymphoma. Identification of celiac disease is important since recent long-term studies have shown that the mortality of celiac disease is increased, if it is unrecognized and untreated.