目的:观察探讨0.03%他克莫司软膏联合多磺酸粘多糖乳膏治疗面部单纯糠疹的美学效果。方法:选取2019年11月-2022年1月门诊收治的105例面部单纯糠疹患儿为观察对象,通过随机数字法随机分为联合组(n=53)和对照组(n=52),对照组给予多磺酸粘...目的:观察探讨0.03%他克莫司软膏联合多磺酸粘多糖乳膏治疗面部单纯糠疹的美学效果。方法:选取2019年11月-2022年1月门诊收治的105例面部单纯糠疹患儿为观察对象,通过随机数字法随机分为联合组(n=53)和对照组(n=52),对照组给予多磺酸粘多糖乳膏治疗,联合组在对照组基础上加用0.03%他克莫司软膏治疗,比较两组治疗后的临床疗效、症状体征评分、皮肤生理功能指标[角质层含水量(Water content of stratum corneum,WCSC)、皮肤油脂(Skin sebum,SC)、经表皮水分流失(Transepidermal water loss,TEWL)]、复发情况、不良反应及美学效果满意度。结果:治疗4周后,联合组总有效率为88.68%,对照组为71.15%,差异有统计学意义(P<0.05)。治疗前两组患儿各项症状体征评分差异均无统计学意义(P>0.05);治疗4周后,两组患儿鳞屑、瘙痒、色素减退、皮损面积及皮损数量评分均较治疗前显著降低(P<0.05),且联合组各症状体征评分明显低于对照组(P<0.05);治疗前两组患儿皮肤生理功能指标差异均无统计学意义(P>0.05);治疗4周后,两组患儿WCSC和SC均显著升高(P<0.05),TEWL均显著降低(P<0.05),且联合组改善优于对照组(P<0.05);结束治疗随访4周,联合组患儿复发率(14.89%)低于对照组(27.03%),差异无统计学意义(P>0.05);治疗期间,两组患儿均未出现明显不良反应;联合组患儿美学效果总满意度(96.23%)显著高于对照组(82.69%)(P<0.05)。结论:0.03%他克莫司软膏联合多磺酸粘多糖乳膏治疗面部单纯糠疹疗效显著,可有效改善患儿皮损症状和皮肤生理功能,能有效预防复发,提高美学效果,且安全性好,值得临床推广应用。展开更多
It is generally recognized that Caucasians and Asians have different skin aging features. The aim of this study was to develop a facial wrinkle grading scale for Chinese women. Standard photographs were taken of 242 C...It is generally recognized that Caucasians and Asians have different skin aging features. The aim of this study was to develop a facial wrinkle grading scale for Chinese women. Standard photographs were taken of 242 Chinese women. Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected, including grading scales for resting and hyperkinetic crow＇s feet, frontalis lines, glabellar frown lines, and nasolabial folds. To identify the scale by objective quantitative measurement, skin surface measurements from the Visioscan~ VC98 were used. To test the reliability and validity of our wrinkle scale, a multi-rater consensus method was used. A double-blind, randomized, vehicle-controlled 12-week study was conducted to use this clinical photo-score to evaluate the efficacy and safety of Centella triterpenes cream~ in treating crow＇s feet. A newly developed 10-point photographic and descriptive scale emerged from this study. The final atlas of these photographs contained a total of 6 sets with 10 pictures each. From 0 to 9, surface evaluation of smoothness （SEsm） parametric measurements decreased progressively, indicating that the scale increased inversely. Weighted kappa coefficients for intra-assessor were between 0.75-0.87. The overall Kendall＇s coefficient is 0.86 on the first rating and 0.87 on the second rating. Thirty- six volunteers were recruited and 35 subjects completed a 12-week trial. Clinical photo-score by investigator showed a significant difference （P 〈 0.05） between the treatment side and control side after 4 weeks. Use of these scales in clinical settings to evaluate facial wrinkles in Asians individuals is recommended.展开更多
目的:探讨薇诺娜屏障特护霜对光动力治疗痤疮后炎症皮损的修复作用。方法:选取2020年10月-2021年2月笔者医院收治的76例痤疮患者,采用随机数字表法分为对照组和观察组,每组38例。对照组采用光动力治疗后外用创福康敷料,观察组在对照组...目的:探讨薇诺娜屏障特护霜对光动力治疗痤疮后炎症皮损的修复作用。方法:选取2020年10月-2021年2月笔者医院收治的76例痤疮患者,采用随机数字表法分为对照组和观察组,每组38例。对照组采用光动力治疗后外用创福康敷料,观察组在对照组治疗基础上予以薇诺娜屏障特护霜涂抹,两组均治疗3周,比较两组治疗效果、炎症反应症状消退时间以及治疗前后面部皮肤屏障功能。结果:观察组治疗有效率89.47%,对照组为86.84%,两组比较差异无统计学意义(P>0.05);观察组红肿、灼热、疼痛、干燥脱屑等炎症反应症状消退时间均短于对照组,差异有统计学意义(P<0.05);与治疗前比较,两组治疗后经皮水分丢失量(Transepidermal water loss,TEWL)均下降,且观察组低于对照组,差异有统计学意义(P<0.05);角质层含水量(The water content of the stratum corneum,WCSC)值均升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:对于光动力治疗痤疮后炎性皮损,在常规应用创福康胶原敷料的基础上外用薇诺娜屏障特护霜治疗可促进患者炎症反应症状的消退,更有利于面部炎性皮损的修复及皮肤屏障功能的改善,疗效确切。展开更多
文摘目的:观察探讨0.03%他克莫司软膏联合多磺酸粘多糖乳膏治疗面部单纯糠疹的美学效果。方法:选取2019年11月-2022年1月门诊收治的105例面部单纯糠疹患儿为观察对象,通过随机数字法随机分为联合组(n=53)和对照组(n=52),对照组给予多磺酸粘多糖乳膏治疗,联合组在对照组基础上加用0.03%他克莫司软膏治疗,比较两组治疗后的临床疗效、症状体征评分、皮肤生理功能指标[角质层含水量(Water content of stratum corneum,WCSC)、皮肤油脂(Skin sebum,SC)、经表皮水分流失(Transepidermal water loss,TEWL)]、复发情况、不良反应及美学效果满意度。结果:治疗4周后,联合组总有效率为88.68%,对照组为71.15%,差异有统计学意义(P<0.05)。治疗前两组患儿各项症状体征评分差异均无统计学意义(P>0.05);治疗4周后,两组患儿鳞屑、瘙痒、色素减退、皮损面积及皮损数量评分均较治疗前显著降低(P<0.05),且联合组各症状体征评分明显低于对照组(P<0.05);治疗前两组患儿皮肤生理功能指标差异均无统计学意义(P>0.05);治疗4周后,两组患儿WCSC和SC均显著升高(P<0.05),TEWL均显著降低(P<0.05),且联合组改善优于对照组(P<0.05);结束治疗随访4周,联合组患儿复发率(14.89%)低于对照组(27.03%),差异无统计学意义(P>0.05);治疗期间,两组患儿均未出现明显不良反应;联合组患儿美学效果总满意度(96.23%)显著高于对照组(82.69%)(P<0.05)。结论:0.03%他克莫司软膏联合多磺酸粘多糖乳膏治疗面部单纯糠疹疗效显著,可有效改善患儿皮损症状和皮肤生理功能,能有效预防复发,提高美学效果,且安全性好,值得临床推广应用。
文摘It is generally recognized that Caucasians and Asians have different skin aging features. The aim of this study was to develop a facial wrinkle grading scale for Chinese women. Standard photographs were taken of 242 Chinese women. Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected, including grading scales for resting and hyperkinetic crow＇s feet, frontalis lines, glabellar frown lines, and nasolabial folds. To identify the scale by objective quantitative measurement, skin surface measurements from the Visioscan~ VC98 were used. To test the reliability and validity of our wrinkle scale, a multi-rater consensus method was used. A double-blind, randomized, vehicle-controlled 12-week study was conducted to use this clinical photo-score to evaluate the efficacy and safety of Centella triterpenes cream~ in treating crow＇s feet. A newly developed 10-point photographic and descriptive scale emerged from this study. The final atlas of these photographs contained a total of 6 sets with 10 pictures each. From 0 to 9, surface evaluation of smoothness （SEsm） parametric measurements decreased progressively, indicating that the scale increased inversely. Weighted kappa coefficients for intra-assessor were between 0.75-0.87. The overall Kendall＇s coefficient is 0.86 on the first rating and 0.87 on the second rating. Thirty- six volunteers were recruited and 35 subjects completed a 12-week trial. Clinical photo-score by investigator showed a significant difference （P 〈 0.05） between the treatment side and control side after 4 weeks. Use of these scales in clinical settings to evaluate facial wrinkles in Asians individuals is recommended.
文摘目的:探讨薇诺娜屏障特护霜对光动力治疗痤疮后炎症皮损的修复作用。方法:选取2020年10月-2021年2月笔者医院收治的76例痤疮患者,采用随机数字表法分为对照组和观察组,每组38例。对照组采用光动力治疗后外用创福康敷料,观察组在对照组治疗基础上予以薇诺娜屏障特护霜涂抹,两组均治疗3周,比较两组治疗效果、炎症反应症状消退时间以及治疗前后面部皮肤屏障功能。结果:观察组治疗有效率89.47%,对照组为86.84%,两组比较差异无统计学意义(P>0.05);观察组红肿、灼热、疼痛、干燥脱屑等炎症反应症状消退时间均短于对照组,差异有统计学意义(P<0.05);与治疗前比较,两组治疗后经皮水分丢失量(Transepidermal water loss,TEWL)均下降,且观察组低于对照组,差异有统计学意义(P<0.05);角质层含水量(The water content of the stratum corneum,WCSC)值均升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:对于光动力治疗痤疮后炎性皮损,在常规应用创福康胶原敷料的基础上外用薇诺娜屏障特护霜治疗可促进患者炎症反应症状的消退,更有利于面部炎性皮损的修复及皮肤屏障功能的改善,疗效确切。
