This study examined the changes of activities of vitamin K-dependent clotting factors(VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage.Cli...This study examined the changes of activities of vitamin K-dependent clotting factors(VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage.Clinical data of 35 patients who were diagnosed as having acquired deficiency of VKDCF were retrospectively analyzed.Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects.The results showed that the average activities of VKDCFs were decreased in the patients in comparison to the control subjects and significantly increased after treatment of these patients with vitamin K and blood products.Multivariate regression analysis indicated that decreased activity of VKDCF was not an independent risk factor for bleeding disorders owing to deficiency or metabolic disturbance of vitamin K.It was concluded that acquired deficiency of VKDCF occurs under a variety of pathologic conditions and is closely associated with hemorrhagic events.Administration of vitamin K and transfusion of blood products containing high concentrations of VKDCFs helps alleviate the hemorrhagic diseases.展开更多
In this paper the properties of some maximum fractional [0, κ]-factors of graphs are presented. And consequently some results on fractional matchings and fractional 1-factors are generalized and a characterization of...In this paper the properties of some maximum fractional [0, κ]-factors of graphs are presented. And consequently some results on fractional matchings and fractional 1-factors are generalized and a characterization of fractional κ-factors is obtained.展开更多
Aiming at the intervention decision-making problem in manned/unmanned aerial vehicle(MAV/UAV) cooperative engagement, this paper carries out a research on allocation strategy of emergency discretion based on human fac...Aiming at the intervention decision-making problem in manned/unmanned aerial vehicle(MAV/UAV) cooperative engagement, this paper carries out a research on allocation strategy of emergency discretion based on human factors engineering(HFE).Firstly, based on the brief review of research status of HFE, it gives structural description to emergency in the process of cooperative engagement and analyzes intervention of commanders. After that,constraint conditions of intervention decision-making of commanders based on HFE(IDMCBHFE) are given, and the mathematical model, which takes the overall efficiency value of handling emergencies as the objective function, is established. Then, through combining K-best and variable neighborhood search(VNS) algorithm, a K-best optimization variable neighborhood search mixed algorithm(KBOVNSMA) is designed to solve the model. Finally,through three groups of simulation experiments, effectiveness and superiority of the proposed algorithm are verified.展开更多
基金supported by grants from the Ministry of Health of China(No.[2007]353)the National Natural Sciences Foundation of China (N0.30700332)+1 种基金the National Outstanding Youth Foundation(No.30825018)the National Basic Research Program(973 Program,No.2007CB935803)
文摘This study examined the changes of activities of vitamin K-dependent clotting factors(VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage.Clinical data of 35 patients who were diagnosed as having acquired deficiency of VKDCF were retrospectively analyzed.Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects.The results showed that the average activities of VKDCFs were decreased in the patients in comparison to the control subjects and significantly increased after treatment of these patients with vitamin K and blood products.Multivariate regression analysis indicated that decreased activity of VKDCF was not an independent risk factor for bleeding disorders owing to deficiency or metabolic disturbance of vitamin K.It was concluded that acquired deficiency of VKDCF occurs under a variety of pathologic conditions and is closely associated with hemorrhagic events.Administration of vitamin K and transfusion of blood products containing high concentrations of VKDCFs helps alleviate the hemorrhagic diseases.
基金This work is supported by NSFC (10471078.10201019)RSDP (20040422004) of China
文摘In this paper the properties of some maximum fractional [0, κ]-factors of graphs are presented. And consequently some results on fractional matchings and fractional 1-factors are generalized and a characterization of fractional κ-factors is obtained.
基金supported by the National Natural Science Foundation of China(61573017)the Doctoral Foundation of Air Force Engineering University(KGD08101604)
文摘Aiming at the intervention decision-making problem in manned/unmanned aerial vehicle(MAV/UAV) cooperative engagement, this paper carries out a research on allocation strategy of emergency discretion based on human factors engineering(HFE).Firstly, based on the brief review of research status of HFE, it gives structural description to emergency in the process of cooperative engagement and analyzes intervention of commanders. After that,constraint conditions of intervention decision-making of commanders based on HFE(IDMCBHFE) are given, and the mathematical model, which takes the overall efficiency value of handling emergencies as the objective function, is established. Then, through combining K-best and variable neighborhood search(VNS) algorithm, a K-best optimization variable neighborhood search mixed algorithm(KBOVNSMA) is designed to solve the model. Finally,through three groups of simulation experiments, effectiveness and superiority of the proposed algorithm are verified.
