The Influence of Family Factors on the Mental Health of College Students was Analyzed Combined with Literature and Cases

Through the combing of relevant literature and the analysis of relevant psychological students’cases,the composition of family factors affecting college students’mental health is analyzed,the specific manifestations of college students’psychological problems are summarized,and the influence of family factors on college students’mental health status is analyzed in detail.The article finally puts forward suggestions and recommendations for strengthening college students’family education and tries to explore how to promote college students’mental health through improving family education.

Evaluating modified effects of family factors on intervention to protect primary school students from the impact of heatwave

Identifying the factors that may impact intervention effectiveness of primary students is crucial for developing targeted intervention strategies on heatwave adaption.The purpose of the study was to assess how the family factors could affect the intervention effects of primary school students to adapt heatwave,using the data from a previously conducted primary school-based intervention study.The study recruited 648 students(9-13 years old)and their parents from two primary schools in Dongtai of Jiangsu province,China.From May to September 2017,a 5-mon intervention for enhancing knowledge,attitude and practice(KAP)was implemented at the intervention school.The students'KAP scores and the family-related information were measured by designed self-administered questionnaires at intervention school and control school separately before and after intervention.The effects of the intervention were explored through the propensity score matching and difference-in-difference method(PSM-DID),and stratifed analysis were conducted by family factors.The overall KAP score increased by 2.391(95%CI:1.881,2.902)after intervention,which shows that the intervention was effective.The students whose parents with higher school educational attainment,parents with employment,and household number≤3 achieved significantly higher increment of KAP scores than their counterparts.Although students whose parents in marriage achieved higher score increasing than parents not in marriage,the difference was non-significant.Our findings indicated that parental education status,working status and the household size were the influence factors of heatwave adaption interventions for primary school students.Future interventions should take parental education status,working status and household size into account to improve the effectiveness of heatwave adaption intervention for primary school students.

Diagnostic value evaluation of trefoil factors family 3 for the early detection of colorectal cancer

AIM The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3(TFF3) for the early detection of colorectal cancer(CC). METHODS Serum TFF3 and carcino-embryonic antigen(CEA) were detected in 527 individuals, including 115 healthy control(HC), 198 colorectal adenoma(CA), and 214 CC individuals in the training group. RESULTS Serum TFF3 showed no significant correlation with age, gender, or tumor location but showed significant correlation with the tumor stage. Serum TFF3 in the CC group was significantly higher than in the HC or CA group. The AUC values of TFF3 for discriminating between HC and CC and between CA and CC were 0.930(0.903, 0.958) and 0.834(0.796, 0.873). A multivariate model combining TFF3 and CEA was built. Compared to TFF3 or CEA alone, the multivariate model showed significant improvement(P < 0.001). For discriminating between HC and CC, HC and early stage CC, HC and advanced stage CC, CA and CC, CA and early stage CC, and CA and advanced stage CC in the training group, the sensitivities were 92.99%, 91.46%, 93.18%, 73.83%, 76.83%, and 81.82%, and the specificities were 91.30%, 91.30%, 93.91%, 88.38%, 77.27%, and 88.38%, respectively. After validation, the sensitivities were 89.39%, 85.71%, 90.79%, 72.73%, 71.43%, and 78.95%, and the specificities were 87.85%, 87.85%, 2.52%, 87.85%, 80.77%, and 87.50%, respectively. CONCLUSION The multivariate diagnostic model that included TFF3 and CEA showed significant improvement over the conventional biomarker CEA and might provide a potential method for the early detection of CC.

Family-relatedFactorsThatInfluenceChildren’sAcademicAchievementsinSchool

This essay studies various family-related factors that influence a child’s academic achievement in school in P.R. China. The factors are illustrated under three categories: the family’s social class and education, early home environment and family material condition. The author discusses the relevant factors by way of relating the knowledge of social environment to his own experiences as a student and then teacher in China. The essay closes with a discussion directing the public’s attention to the concern about home-related factors influencing a child’s academic achievements in school.

“Do Big Hands Guide Small Hands?”or“do Small Hands Guide Big Hands”:The intergenerational interactions in environmental behaviors and family influencing factors

Families'large pollution and energy consumption cannot be underestimated.In order to realize and internalize environmental awareness as a social consensus,it is imperative for every member of a household to be involved in transforming everyday behavior.Intergenerational interactions are of paramount importance.Accordingly,the focus of this study was on parent-adolescent interactions,their reciprocal impact on environmental behaviors,and the factors that have an influence on these processes.Questionnaires were employed to collect information of 684 families in 10 districts of Jinan,the capital of Shandong Province.Subsequently,interviews were conducted with 15 of these families to comprehend the tangible reasons underlying intergenerational interactions in environmental behaviors.First,a paired sample T-test was employed to compare the frequency of these interactions.The data showed that while the T values were positive in all eight compared groups,there were significant differences in seven of them.These results suggest that the impact of intergenerational interactions on environmental behaviors is not symmetrical:parents'instructions are far more frequent than adolescents'back-feeding of ecological notions.The interviews revealed that this phenomenon was generated primarily by unequal experiences between parents and adolescents because the latter do not participate in housework and family projects.Furthermore,the traditional concept of intergenerational order appears to be permanent.Second,two linear regression models,a Parent-to-Adolescent model and an Adolescent-to-Parent model that encompassed several factors including family structure,intergenerational relationships,living environment,and families'social class were developed.Among these factors,the intergenerational relationship variable played a particularly significant role:the more equal and open-minded dialogs are incorporated into parent-adolescent communication,the more favorable interactions may occur for development of their environmental behaviors.Thus,when an environmental education system with families is constructed,it is imperative to promote a parent's ecological awareness with the help of grass-roots organizations by means of reasonable rewards and punishments to redress their former behaviors so as to let Big Hands Guide Small Hands.It is also crucial to enhance a more equal intergenerational relationship through parents'schooling or other relevant services so as to create a favorable atmosphere for Small Hands Guide Big Hands.

MicroRNA-584-5p/RUNX family transcription factor 2 axis mediates hypoxia-induced osteogenic differentiation of periosteal stem cells

BACKGROUND The hypoxic environment during bone healing is important in regulating the differentiation of periosteal stem cells(PSCs)into osteoblasts or chondrocytes;however,the underlying mechanisms remain unclear.AIM To determine the effect of hypoxia on PSCs,and the expression of microRNA-584-5p(miR-584-5p)and RUNX family transcription factor 2(RUNX2)in PSCs was modulated to explore the impact of the miR-584-5p/RUNX2 axis on hypoxiainduced osteogenic differentiation of PSCs.METHODS In this study,we isolated primary mouse PSCs and stimulated them with hypoxia,and the characteristics and functional genes related to PSC osteogenic differentiation were assessed.Constructs expressing miR-584-5p and RUNX2 were established to determine PSC osteogenic differentiation.RESULTS Hypoxic stimulation induced PSC osteogenic differentiation and significantly increased calcified nodules,intracellular calcium ion levels,and alkaline phosphatase(ALP)activity in PSCs.Osteogenic differentiation-related factors such as RUNX2,bone morphogenetic protein 2,hypoxia-inducible factor 1-alpha,and ALP were upregulated;in contrast,miR-584-5p was downregulated in these cells.Furthermore,upregulation of miR-584-5p significantly inhibited RUNX2 expression and hypoxia-induced PSC osteogenic differentiation.RUNX2 was the target gene of miR-584-5p,antagonizing miR-584-5p inhibition in hypoxia-induced PSC osteogenic differentiation.CONCLUSION Our study showed that the interaction of miR-584-5p and RUNX2 could mediate PSC osteogenic differentiation induced by hypoxia.

Mendelian randomization provides evidence for a causal effect of serum insulin-like growth factor family concentration on risk of atrial fibrillation

BACKGROUND Atrial fibrillation(AF)is one of the most common persistent arrhythmias among adult cardiovascular diseases.It is important to identify potential risk factors for AF.Members of the insulin-like growth factor(IGF)family exert a variety of effects on various cell types in the context of the pathogenesis of cardiovascular diseases,and previous population-based studies indicate associations between IGF family members and AF.However,the causal effects of IGF family members in AF have not been evaluated.assess genetic relationships between IGF family members and AF.METHODS MR was performed based on genome-wide association study(GWAS)datasets,and concentration levels of 14 IGF family members were retrieved.An initial MR analysis was conducted to identify single nucleotide polymorphisms potentially associated with IGF serum concentrations.A GWAS meta-analysis including 60620 AF cases and 970216 control participants of European ancestry was then conducted to identify AF causal effects.Two-sample MR packages were used to perform MR analysis in R.MR-Egger,weighted median(WM),and inverse va-riance weighted(IVW)methods were used.RESULTS Core Tip:Due to the high prevalence of atrial fibrillation(AF),and adverse outcomes related to it,it is important to identify risk factors associated with development of the condition.Insulin-like growth factor(IGF)family members exert a variety of effects on various cell types in the context of the pathogenesis of cardiovascular diseases,and previous population-based studies indicate associations between IGF family members and AF.However,the causal effects of IGF family members in AF have not been evaluated.The results of the current study provide novel insights on the pathogenesis of AF,and implic-ations of serum IGF family member concentrations when assessing the risk of AF.The study generated evidence on the potential roles of developmental pathological effects in the pathogenesis of AF.Further observational and experimental studies are critically needed.

Relationship between Family Characteristics and Aggressive Behaviors of Children and Adolescents

In order to identify family factors obviously relevant to aggression, and offer a theoretical foundation for the prevention of aggression, 4010 students from primary and secondary schools in 5 different areas in Hubei province were surveyed. The Child Behavior Checklist ＂ parents＂ form＂ （Chinese version） and the four scales of Family Environment Scale were used. A multiple logistic regression was used to identify risk factors of children＇s and adolescents＂ aggressive behavior. The results showed that maternal education, paternal occupation, family type, parental child-rearing attitude and patterns, students＂ interpersonal relationship were significantly associated with the childreffs and adolescents＂ aggression. The risk factors of aggression were parental child-rearing patterns, peer relationship, teacher-student relationship, and family conflicts.

Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes:A single-center experience

BACKGROUND Type 1 diabetes(T1D)contributes to altered lipid profiles and increases the risk of cardiovascular disease(CVD).Youth with T1D may have additional CVD risk factors within the first decade of diagnosis.AIM To examine risk factors for dyslipidemia in young subjects with T1D.METHODS Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D(86 males;baseline mean age 12.2±5.6 years and hemoglobin A1c 8.4%±1.4%)were followed in a single tertiary diabetes center for a median duration of 15 years.Predictors for outcomes of lipid profiles at last visit(total cholesterol[TC],triglycerides[TGs],low-density lipoprotein-cholesterol[LDL-c],and highdensity lipoprotein-cholesterol[HDL-c])were analyzed by stepwise linear regression models.RESULTS At baseline,79.5%of the patients had at least one additional CVD risk factor(borderline dyslipidemia/dyslipidemia[37.5%],pre-hypertension/hypertension[27.6%],and overweight/obesity[16.5%])and 41.6%had multiple(≥2)CVD risk factors.A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1%of the cohort.Predictors of elevated TC:family history of CVD(β[SE]=23.1[8.3],P=0.006);of elevated LDL-c:baseline diastolic blood pressure(DBP)(β[SE]=11.4[4.7],P=0.003)and family history of CVD(β[SE]=20.7[6.8],P=0.017);of elevated TGs:baseline DBP(β[SE]=23.8[9.1],P=0.010)and family history of CVD(β[SE]=31.0[13.1],P=0.020);and of low HDL-c levels:baseline DBP(β[SE]=4.8[2.1],P=0.022]).CONCLUSION Our findings suggest that elevated lipid profiles are associated with DBP and a positive family history of CVD.It is of utmost importance to prevent and control modifiable risk factors such as these,as early as childhood,given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia.

Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury

Old astrocyte specifically induced substance （OASIS） is an endoplasmic reticulum （ER） stress transducer specifically expressed in astrocytes and osteoblasts. OASIS regulates the differentiation of neural precursor cells into astrocytes in the central nervous system. This study aimed to elucidate the involvement of ER stress responses stimulated via OASIS in astrogliosis following spinal cord injury. In a mouse model of spinal cord contusion injury, OASIS mRNA and protein expression were evaluated at days 7 and 14. A significant increase in OASIS mRNA on day 7 and an increase in protein on days 7 and 14 was observed in injured spinal cords. Immunostaining on day 7 revealed co-localization of OASIS and astrocytes in the periphery of the injury site. Furthermore, anti-OASIS small interfering RNA （siRNA） was injected at the injury sites on day 5 to elucidate the function of OASIS. Treatment with anti-OASIS siRNA caused a significant decrease in OASIS mRNA on day 7 and protein on days 7 and 14, and was associated with the inhibition of astrogliosis and hindlimb motor function recovery. Results of our study show that OASIS expression synchronizes with astrogliosis and is functionally associated with astrogliosis after spinal cord injury.

Expression and Change of B Cell Activation Factor of the TNF Family(BAFF) Gene between Human Normal and Inflamed Fallopian Tubes

Objective To investigate the expression of B cell activation factor of the TNF family （BAFF） gene between human normal and inflamed fallopian tubes. Methods Tissue samples of human normal fallopian tube （n=20） and inflamed fallopian tube （n=20） were collected. The expression of BAFF gene was determined by the real- time reverse transcription polymerase chain reaction （RT-PCR） and immunohistochemistry. Results BAFF immunostaining appeared on the cellular membrane and in the cytoplasm of tubal epithelial cells. Both BAFF protein and mRNA in normal fallopian tubes had lower levels than those in inflamed fallopian tubes （P〈0.01）. Conclusion BAFF protein and mRNA are present in human tubal tissues. BAFF gene in human inflamed fallopian tube would have a high expression.

The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis

The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly understood.Functional analysis was performed on AtCOL4,an Arabidopsis thaliana L.CONSTANS-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation domain.Analyses of an AtCOL4 promoter-b-glucuronidase（GUS） construct revealed substantial GUS activity in whole seedlings.The expression of AtCOL4 was strongly induced by abscisic acid（ABA）,salt,and osmotic stress.Mutation in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening process.In contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild type.Interestingly,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 mutant.Thus,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling pathway.Taken together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress.e