Clinical research report on traditional Chinese patent medicines and traditional Chinese classic famous prescriptions(2022)

Objective:The paper is to comprehensively summarize and analyze the basic situation and methodological quality of clinical randomized controlled trials(RCTs)of traditional Chinese patent medicines and traditional Chinese classic famous prescriptions published in 2022,to provide evidence and reasonable suggestions for the advancement of clinical research and the formulation of policies and guidelines.Methods:The Evidence Database System of clinical evidence-based evaluation of traditional Chinese medicine was searched,and data from China National Knowledge Infrastructure(CNKI),PubMed,and other databases were supplemented.The search duration was from January 1,2022,to December 31,2022.RCTs of traditional Chinese patent medicines and traditional Chinese classic famous prescriptions were included as the source of clinical evidence,and published information,sample size,intervention,control measures,treatment course,methodological quality,and key link report were analyzed and evaluated.Results:A total of 1,464 RCTs of traditional Chinese patent medicines were included,which comprised 667 types of traditional Chinese patent medicines;“traditional Chinese patent medicines+Western medicine vs.Western medicine”was the most widely used intervention and control setting,involving 417 RCTs(28.48%).A total of 245 RCTs of traditional Chinese classic famous prescriptions were included,comprising 55 types of traditional Chinese classic famous prescriptions.“Decoction+conventional treatment vs.conventional treatment”was the most widely used intervention and control setting,with 87 RCTs(35.51%).Published RCTs on traditional Chinese patent medicines and traditional Chinese classic famous prescriptions were limited by the study design and implementation.Most“allocation concealment”and“blinding of patients and personnel”were rated as medium to high risk.There are insufficient reports on key research links such as experimental registration and ethical approval.Conclusions:The number of RCTs on traditional Chinese patent medicines has decreased in 2022,but there has been a slight improvement in the research quality and impact.There are relatively few studies on traditional Chinese classic famous prescriptions.Measures must be taken to improve clinical trial design,implementation,and reporting.Methodological experts should be invited to provide professional technical guidance on the trial design.In the research implementation process,attention should be paid to quality control,particularly the standardization of the randomized execution.

Exploring the Application Effect of Flipped Classroom Combined with Problem-Based Learning Teaching Method in Clinical Skills Teaching of Standardized Training for Resident Doctors of Traditional Chinese Medicine

Objective: To explore the application effect of flipped classroom combined with problem-based learning teaching method in clinical skills teaching of standardized training for resident doctors of traditional Chinese Medicine. Methods: The study used the experimental control method. The study lasted from September to November 2022. The subjects of this study were 49 students of standardized training for resident doctors of traditional Chinese Medicine from grades 2020, 2021 and 2022 of Dazhou integrated TCM & Western Medicine Hospital. They were randomly divided into experiment group (25) and control group (24). The experiment group adopted flipped classroom combined with problem-based learning teaching method, and the control group adopted traditional teaching method. The teaching content was 4 basic clinical skill projects, including four diagnoses of traditional Chinese Medicine, cardiopulmonary resuscitation, dressing change procedure, acupuncture and massage. The evaluation method was carried out by comparing the students’ performance and a self-designed questionnaire was used to investigate the students’ evaluation of the teaching method. Results: The test scores of total scores in the experimental group (90.12 ± 5.89) were all higher than those in the control group (81.47 ± 7.96) (t = 4.53, P P Conclusions: The teaching process of the flipped classroom combined with problem-based learning teaching method is conducive to improving the efficiency of classroom teaching, cultivating students’ self-learning ability, and enhancing students’ willingness to learn.

Professor Liu Guobin used traditional Chinese medicine to cure a case of primary erythema limb pain

Primary erythema limb pain is a very rare disease,and its pathogenesis is not clear.Usually,the pain symptoms of patients exist for a long time,which seriously affect the daily life of patients and increase the economic burden of patients.Professor Liu Guobin,who has been engaged in the diagnosis and treatment of peripheral vascular diseases for nearly 30 years,believes that heat-toxin and blood stasis collaterals are closely related to the disease,and emphasizes the principle of heat-toxin and evil qi causing the disease.It is emphasized that clearing heat and detoxification,promoting blood circulation and dispersing blood stasis are the main treatment principles.This paper selects a typical case to describe Professor Liu's clinical experience in the treatment of primary erythema limb pain by oral and external use of traditional Chinese medicine,so as to provide an effective method of traditional Chinese medicine for the treatment of primary erythema limb pain.

Summary of Zhang Hongxing's Experience in Treating Refractory Angina Pectoris with Traditional Chinese Medicine

As a famous traditional Chinese medicine(TCM)expert in Shandong province and a famous veteran TCM expert in Dezhou city,Zhang Hongxing has been engaged in cardiovascular clinical work for more than 30 years.He has unique experience in the treatment of refractory angina pectoris.This paper comprehensively explains from the aspects of etiology and pathogenesis.His treatment is mostly based on syndrome differentiation,combined with the basic pharmacology of modem Chinese medicine to formulate prescriptions and drugs,and at the same time values the use of insect drugs.We hereby attach the clinical records,hoping to provide reference for clinical workers,which is conducive to the inheritance and development of famous Chinese medical academic experience.

Humanistic Spirit Contained in Traditional Chinese Medicine should Be Valued

Medicine is a science studying human's health and diseases as well as the regularity between them. Its research subject is human, who possess natural attribute, psychological attribute and social attribute. Therefore, medicine is bound to possess humanistic attribute. Rooted in Chinese traditional culture, Traditional Chinese Medicine contains abundant humanistic thoughts, for instance, pursuing the unity of human and nature, advocating the vital importance of life, sticking to the virtue of "medicine being humane art", abiding by the principle of "Benevolence prior to interest", complying with the medical rule of "Respecting peers". These are the very concrete reflections of medical humanistic spirit. In this article we aim to explore the humanistic thoughts contained in Traditional Chinese Medicine, and try to inherit and carry forward the spirit to better relieve the tensions between doctors and patients and improve the quality of medical services.

Herbal medicine prescribing patterns from contemporary famous old TCM doctors for treating coronary heart disease: an analysis based on data mining

To analyze the herbal medicine prescribing patterns of contemporary famous old traditional Chinese medicine doctors in treating coronary heart disease,based on data mining technology,so as to provide useful insights into the clinical practice.Methods:Databases,including Medline(January 1966 to December 2019),Wanfang(January 1982 to December 2019),VIP Database(January 1989 to December 2019),CNKI(January 1979 to December 2019),CBMdisc(January 1978 to December 2019),and Classic Case Collection from Contemporary Famous Old Traditional Chinese Medicine Doctors were searched,and 224 eligible studies involving 416 patients were entered into the case study database after data processing.Frequency analysis and association rule analysis were used to investigate the prescribing patterns of contemporary famous old traditional Chinese medicine doctors in treating coronary heart disease.Results:In total 290 kinds of Chinese herbal drugs and 19 core drugs were used in the cases studied.The most commonly used categories were“Qi-Tonifying Drugs”,“Blood-Activating Drugs”,and“Phlegm-Eliminating Drugs”.The association rule analysis identified 14 commonly used herbal pairs,19 three-drug combinations,and 1 four-drug combination.Conclusion:Contemporary famous old traditional Chinese medicine doctors considered warming heart yang as an extremely important approach to treat coronary heart disease based on Zhang Zhongjing’s treatment for chest painful obstruction caused by“Inactivity of Chest Yang”(blockade of phlegm turbidity).Both symptoms and root causes were addressed in the formulas prescribed by these doctors.“Tonifying Qi,Nourishing Yin,Activating Blood,and Eliminating Phlegm”were the most commonly used therapeutic methods for patients with coronary heart disease.

Experience inheritance from famous specialists based on real- world clinical research paradigm of traditional Chinese medicine

The current modes of experience inheritance from famous specialists in traditional Chinese medicine （TCM） include master and disciple, literature review, clinical-epidemiology-based clinical research observation, and analysis and data mining via computer and database technologies. Each mode has its advantages and disadvantages. However, a scientific and instructive experience inheritance mode has not been developed. The advent of the big data era as well as the formation and practice accumulation of the TCM clinical research paradigm in the real world have provided new perspectives, techniques, and methods for inheriting experience from famous TCM specialists. Through continuous exploration and practice, the research group proposes the innovation research mode based on the real-world TCM clinical research paradigm, which involves the inheritance and innovation of the existing modes. This mode is formulated in line with its own development regularity of TCM and is expected to become the main mode of experience inheritance in the clinical field.

Speech at the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instruction on Western Medicine Doctors Learning Traditional Chinese Medicine

Respected leaders,distinguished guests,venerable seniors and comrades, Today,the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong’s Important Instructions on Western Medicine Doctors Learning Traditional Chinese Medicine was inaugurated by the Chinese Association of Integrative Medicine, and it is also an important occasion to review the past and look forward to the future.

Discovery Studio软件在分析中药成分透过血脑屏障中的应用

血脑屏障是药物能否进入脑组织发挥作用的重要屏障。中药有效成分的结构与其透过血脑屏障的能力有一定的关系。Discovery Studio软件对非糖苷类成分通过血脑屏障的分析结果与文献报道基本吻合,而对糖苷类成分则无法准确预测。

中医外科特色临床思维能力培养在规培教学的运用

不同于中医内科,中医外科有独特的理论体系和辨证思维模式,包括辨证首辨阴阳、相对于辨证更重视辨病、相对于整体辨证更重视局部辨证以及灵活运用外治法、疾病的不同发展阶段分期论治等。中医特色住院医师规范化培训(简称“规培”)模式还处于不断探索阶段,对于如何培养规培学生的中医外科临床思维能力,此文主要做了以下几方面的探讨。首先,带教老师要以身作则,提高临床辨证思维能力;其次,跟名师、读经典,培养规培学生的动手能力;最后,注重提高非中医外科专业学生的学习热情。

Professor Zhang Jun's four methods for treating Children with purpuric nephritis

Based on the theory of children's TCM constitution"children are Zhi yang wei chong,and Zhi yin wei zhang",combined with the etiology and pathogenesis of TCM in children with purpuric nephritis,Professor Zhang Jun uses The four methods of"Clearing heat,dampness,tonicity,and stasis"are used to treat children with purpuric nephritis,and it is advocated that the method of"resolving blood stasis"runs through the entire treatment process,and the clinical results are quite good.

Brief Analysis of Treatment of Postpartum Body Pain by Professor Zhang Xiaofeng from the Viewpoint of “Liver Vital Deficiency and Yang Stagnation”

Postpartum body pain is a common gynecological disease in clinical setting.Its symptoms are complex and is difficult to treat.It is often treated in many ways but with poor results,which bring great pain to patients and their families.Professor Zhang Xiaofeng can effectively improve clinical treatment of this disease from the point of view of“liver vital deficiency and yang stagnation”.This paper mainly introduces the professional experience of Professor Zhang Xiaofeng in treating postpartum body pain.A clinical case was attached for reference as proof.

张婷婷治疗子宫腺肌症痛证经验

子宫腺肌症的发病率逐年上升,其治疗是临床的难点。张婷婷教授治疗子宫腺肌症痛证,根据“瘀阻于内,不通则痛”的基本病机,口服汤剂采用“柴芍方”以疏肝行气、活血止痛;“红藤方”以清热凉血、散瘀止痛;“清瘀温通方”以寒温并用、化瘀止痛;“扶正祛瘀方”以益气扶正、祛瘀止痛。张婷婷临证还结合灌肠、足浴的方法,内外合治,长期管理患者,效果显著。

时毓民教授治疗小儿慢性咳嗽临证经验

时毓民教授认为,慢性咳嗽的病位在肺脾肾,其本质在于肺脾肾虚。文章从降中有宣以调气机、分别清解肺之余邪、活血化瘀贯穿始终、润肺止咳相佐为用、重视温阳滋肾纳气、益气滋阴固本善后六个方面总结时教授论治小儿慢性咳嗽的临证经验,并附验案一则。

慢性肾病中医诊疗的传承与创新——西苑医院名老中医学术思想与临床经验

中国中医科学院西苑医院是我国最早开始现代中医肾病系统研究的单位之一。60多年来在多位著名老中医的引领与传承下,深入挖掘中医药治疗肾病的优势,不断吸取现代医学技术,形成了较为完善的中医优势突出的慢性肾病中西医结合防治体系。西苑医院肾病学科名医辈出,临床诊治经验丰富,学术积淀深厚,其中岳美中、方药中、时振声、聂莉芳等名老中医为现代中医肾病学的奠基者和开创者。本文聚焦名老中医对中医肾病学发展的学术贡献,从中医肾病临床诊疗的思路、肾病的辨病与中医病名、肾病证候与治法研究、临证选方用药等方面进行简要介绍。

卢传坚教授从脾肾论治慢性荨麻疹经验撷英

介绍卢传坚教授从脾肾论治慢性荨麻疹的临床经验。认为慢性荨麻疹风团之标象,从病理角度看实际属于“水湿”范畴,其发生和反复发作与“水湿运化不利”密不可分,其根本责之于“脾肾阳虚”,慢性荨麻疹的核心病机为“脾肾阳虚为其本,风湿相搏为其标”;强调以“温肾健脾治其本、祛风化湿治其标”为治疗法则,并创制“固本抗敏方”为核心方进行辨证论治,疗效显著。并附验案1则。

名中医工作室在针灸推拿本科实习中的作用

目的观察针灸推拿专业实习生在名中医工作室的学习效果。方法选取安徽中医药大学第二临床医学院2017级针灸推拿专业实习生60名,按照随机数字表法分为观察组和对照组,各30名。观察组至安徽省名中医肖伟工作室学习,统一管理,包括跟师门诊学习、急救技能培训、针刺学习、推拿学习、中医古籍学习等,并参加工作室定期的内部学习活动,至少在肖伟教授所在科室轮转1个月;对照组实行常规实习教学和轮转。观察两组学生实习末的针灸学、推拿学、急救技能考试成绩以及出科评价成绩。结果观察组的针灸学、推拿学、急救技能成绩及出科评价成绩与对照组比较,差异有统计学意义(P<0.05)。结论名老中医工作室能提高针灸推拿专业实习生成绩,使学生理论知识更加扎实,提高学生的临床技能。

孙克伟教授辨证论治肝病的经验探析

孙克伟教授在长期临床诊治中总结发现,多种肝病殊途同归,提出“补脾土,疏肝解郁”“逐湿邪,热无所依”“补先天,解毒袪邪”“调气血,瘀滞得化”“温脾阳,截断逆挽”的学术经验,临床应用效果显著。该文将从以上五法探析孙克伟教授辨证论治肝病经验,旨在为肝病中医诊疗提供参考和借鉴。

国医大师夏桂成论中医女性生殖节律理论的“节”和“律”

分述女性生命中五种节律(昼夜节律、周节律、月节律、年节律、生命节律)特征以及夏桂成教授基于生殖节律理论治疗妇科临床疾病的经验。昼夜节律是生命节律的基本单位,白天活动振奋阳气,夜间安睡静养阴血是最基本的养生准则。七为少阳数,女性的经期常持续7天,阴分充足“锦丝带”(像锦缎一样的阴道分泌物)也可达7天,更有助成孕。月经周期节律上应月下应潮,夏教授提出了经典的四期月经周期节律学说,后为了更好地描述阴阳变化,又将经典的四期分为七期,以更好地指导临床。并附验案1则。

谢德聪治疗妇科痛证临证经验

妇科痛证发生在少腹,以胞宫为中心,为厥阴、少阴、冲任二脉循行部位,责之“不通则痛,不荣则痛”,病因多端,虚实错杂,属于妇科疑难杂症。谢德聪认为治疗妇科痛证,注重病机,明辨虚实,临证重视调肝,养血柔肝,理气止痛,调理冲任。并遵月经生理特点与气血阴阳消长转化分期调治,经前治实,经后补虚,临床疗效显著。其诊疗思路和用药经验颇具特色,有重要的借鉴意义。