Clinical characteristics of patients with early-and late-onset optic neuromyelitis optica spectrum disease

Objective:To analyze the different clinical features of patients with early-onset(EO-NMOSDs)and late-onset neuromyelitis optica spectrum diseases(LO-NMOSDs).Methods:A total of 51patients with neuromyelitis optica spectrum disease who were diagnosed in our hospital for the first time from January 2015 to December 2022 were included in the First Affiliated Hospital of Hainan Medical College and divided into 22 cases in the EO-NMOSDs group and 29 cases in the LO-NMOSDs group according to whether the age of onset was 50 years old.The basic data,Extended Disability Status Scale(EDSS)score,blood and cerebrospinal fluid test indicators of the two groups were statistically analyzed.Results:There were no significant differences in demographic characteristics,clinical features and serum AQP-4 antibody positivity rate between the two groups(all P>0.05),and there were significant differences in triglycerides(TG),low-density lipoprotein(LDL),apolipoprotein A(APOA),apolipoprotein B(APOB)and lipoprotein a(P=0.010,P=0.048,P=0.014,P=0.061,P=0.001,respectively),and cerebrospinal fluid LDH,There were significant differences between microprotein quantification and EDSS score(P=0.018,P=0.034,P=0.025,respectively),and the level of microprotein quantification in cerebrospinal fluid of LO-NMOSDs had a certain correlation with the degree of disability(r=0.52,P<0.03).Conclusion:LO-NMOSDs and EO-NMOSDs group patients have similar demographic characteristics,serum AQP-4 antibody positive rate and clinical features,but compared with EO-NMOSDs,patients in LO-NMOSDs group are prone to abnormal lipid metabolism,higher trace proteins in cerebrospinal fluid and more likely to be disabled,and among LO-NMOSDs,the higher the trace protein in the cerebrospinal fluid,the more severe the disability status of patients.

Optical encryption scheme based on spread spectrum ghost imaging

An optical encryption(OE) scheme based on the spread spectrum ghost imaging(SSGI), named as SSGI-OE, is proposed to obtain a high security with a smaller key. In the scheme, the randomly selected row number of a Hadamard matrix of order N is used as the secure key, and shared with the authorized user, Bob, through a private channel. Each corresponding row vector of the order-N Hadamard matrix is then used as the direct sequence code to modulate a speckle pattern for the ghost imaging system, and an image is encrypted with the help of the SSGI. The measurement results from the bucket detector, named as ciphertext, are then transmitted to Bob through a public channel. The illuminating speckle patterns are also shared with Bob by the public channel. With the correct secure key, Bob could reconstruct the image with the aid of the SSGI system, whereas the unauthorized user, Eve, could not obtain any useful information of the encrypted image. The numerical simulations and experimental results show that the proposed scheme is feasible with a higher security and a smaller key. For the 32 × 32 pixels image, the number of bits sent from Alice to Bob by using SSGIOE(M = 1024, N = 2048) scheme is only 0.0107 times over a computational ghost imaging optical encryption scheme.When the eavesdropping ratio(ER) is less than 40%, the eavesdropper cannot acquire any information of the encrypted image. The extreme circumstance for the proposed SSGI-OE scheme is also discussed, where the eavesdropper begins to extract the information when ER is up to 15%.

Local density of optical states calculated by the mode spectrum in stratified media

The local density of optical states(LDOS)is an important physical concept,which can characterize the spontaneous emission of microcavities.In order to calculate the LDOS,the relationship between the mode spectrum and the LDOS is established.Then,based on the transfer matrix method and the effective resonator model,the leaky loss of the leaky mode and the mode spectrum in the one-dimensional photonic bandgap crystal waveguide are calculated,results of which indicate that the mode spectrum can characterize the leaky loss of the leaky mode.At last,the density of optical states(DOS),and the LDOS in each layer are calculated.The partial DOS and the partial LDOS in the quantum well,related to the fundamental leaky mode,can be used to find out the optimal location of the quantum well in the defect layer to couple more useful photons into the lasing mode for lasers.

Hybrid Policy of Routing and Spectrum Assignment in Elastic Optical Networks

The major challenge in elastic optical networks is to determine the path of a connection and to allocate spectral resources on the links of this path. This problem consists of two sub-problems, routing and spectrum allocation. In the literature, these sub-problems are solved with a predefined order for all topology node pairs. Recent work proposes hybrid resolution algorithms based on connection demand and network state to provide a solution to these problems. However, the blocking rate of new connection requests has become problematic. In this work, we propose a hybrid routing and spectrum assignment policy to improve blocking rate of new connection requests. The proposed solution consists to change the routing policy of a pair node if the connection request is blocked. This algorithm improves the blocking rate of new connection requests.

Spectrum Correction in Study of Solvation Dynamics by Fluorescence Non-collinear Optical Parametric Amplification Spectroscopy

Femtosecond time-resolved fluorescence non-collinear optical parametric amplification spec- troscopy can extract the curve of spectral gain from its parametric superfluorescence. This unique spectrum correction method enables fluorescence non-collinear optical parametric amplification spectroscopy acquiring the genuine transient fluorescence spectrum of the studied system. In this work we employ fluorescence non-collinear optical parametric amplification spectroscopy technique to study the solvation dynamics of DCM dye in ethanol solution, and confirm that genuine solvation correlation function and shift of peak frequency can be derived from transient fluorescence spectra after the spectral gain correction. It demonstrates that fluorescence non-collinear optical parametric amplification spectroscopy can benefit the research fields, which focuses on both fluorescence intensity dynamics and fluorescence spectral shape evolution.

Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple sclerosis.Over the past 20 years,the search for biomarke rs for neuromyelitis optica has been ongoing.Here,we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis optica.Research in this area is consistently increasing,with China and the United States leading the way on the number of studies conducted.The Mayo Clinic is a highly reputable institution in the United States,and was identified as the most authoritative institution in this field.Furthermore,Professor Wingerchuk from the Mayo Clinic was the most authoritative expe rt in this field.Keyword analysis revealed that the terms "neuro myelitis optica"(261 times), "multiple sclerosis"(220 times), "neuromyelitis optica spectrum disorder"(132 times), "aquaporin4"(99 times),and "optical neuritis"(87 times) were the most frequently used keywords in literature related to this field.Comprehensive analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple sclerosis.Furthermore,aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum disorder.Myelin oligodendrocyte glycoprotein-IgG is a diagnostic biomarke r for myelin oligodendrocyte glycoprotein antibody-associated disease.Recent biomarkers for neuromyelitis optica in clude cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein,serum astrocyte damage biomarkers like FAM19A5,serum albumin,and gammaaminobutyric acid.The latest prospective clinical trials are exploring the potential of these biomarkers.Preliminary results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelitis optica spectrum disorder.The ultimate goal of future research is to identify non-invasive biomarkers with high sensitivity,specificity,and safety for the accurate diagnosis of neuro myelitis optica.

Simple and universal method in designs of high-efficiency diffractive optical elements for spectrum separation and beam concentration

Diffractive optical elements（DOEs） with spectrum separation and beam concentration（SSBC） functions have important applications in solar cell systems. With the SSBC DOEs, the sunlight radiation is divided into several wave bands so as to be effectively absorbed by photovoltaic materials with different band gaps. A new method is proposed for designing high-efficiency SSBC DOEs, which is physically simple, numerically fast, and universally applicable. The SSBC DOEs are designed by the new design method, and their performances are analyzed by the Fresnel diffraction integral method.The new design method takes two advantages over the previous design method. Firstly, the optical focusing efficiency is heightened by up to 10%. Secondly, focal positions of all the designed wavelengths can be designated arbitrarily and independently. It is believed that the designed SSBC DOEs should have practical applications to solar cell systems.

Clock-transition spectrum of ^(171)Yb atoms in a one-dimensional optical lattice

An optical atomic clock with 171yb atoms is devised and tested. By using a two-stage Doppler cooling technique, the 171Yb atoms are cooled down to a temperature of 6 ± 3 μK, which is close to the Doppler limit. Then, the cold 171Yb atoms are loaded into a one-dimensional optical lattice with a wavelength of 759 nm in the Lamb-Dicke regime. Furthermore, these cold 171yb atoms are excited from the ground-state 1S0 to the excited-state 3P0 by a clock laser with a wavelength of 578 nm. Finally, the 1S0-3P0 clock-transition spectrum of these 171yb atoms is obtained by measuring the dependence of the population of the ground-state 1 S0 upon the clock-laser detuning.

First-principles study of the bandgap renormalization and optical property ofβ-LiGaO_(2)

Theβ-LiGaO_(2)with an orthorhombic wurtzite-derived structure is a candidate ultrawide direct-bandgap semiconductor.In this work,using the non-adiabatic Allen-Heine-Cardona approach,we investigate the bandgap renormalization arising from electron-phonon coupling.We find a sizable zero-point motion correction of-0.362 eV to the gap atΓ,which is dominated by the contributions of long-wavelength longitudinal optical phonons.The bandgap ofβ-LiGaO_(2)decreases monotonically with increasing temperature.We investigate the optical spectra by comparing the model Bethe-Salpether equation method with the independent-particle approximation.The calculated optical spectra including electron-hole interactions exhibit strong excitonic effects,in qualitative agreement with the experiment.The contributing interband transitions and the binding energy for the excitonic states are analyzed.

Analysis of spectrum characteristics of optical scintillation in stack gas flow

Based on the analysis of spectrum characteristics of intensity fluctuations while light beams pass through stack gas flow in an industrial setting, this paper puts emphasis upon discussing the spectrum of optical intensity fluctuations by the variety of particle concentration in stack gas flow. This paper also gives the primary theoretical explanation of the measurement results in the stack of coal-fired utility boilers. Meanwhile, the cross-correlation formula is given as the theoretical basis of velocity measurement by using particle concentration scintillation.

Study on Band Structure of YbB_6 and Analysis of Its Optical Conductivity Spectrum

The electronic structure of YbB6 crystal was studied by means of density functional （GGA ＋ U） method. The calculations were performed by FLAPW method. The high accurate band structure was achieved. The correlation between the feature of the band structure and the Yb-B6 bonding in YbB6 was analyzed. On this basis, some optical constants of YbB6 such as reflectivity, dielectric function, optical conductivity, and energy-loss function were calculated. The results are in good agreement with the experiments. The real part of the optical conductivity spectrum and the energy-loss function spectrum were analyzed in detail. The assignments of the spectra were carried out to correlate the spectral peaks with the interband electronic transitions, which justify the reasonable part of previous empirical assignments and renew the missed or incorrect ones.

Universal form of the power spectrum of the aero-optical aberration caused by the supersonic turbulent boundary layer

Based on the measurement of one-dimensional （1D） optical path difference （OPD） of the supersonic turbulent bound- ary layer, an analytical form for the power spectrum of the two-dimensional （2D） OPD is obtained with its structure function and under the locally homogeneous isotropic assumption. The universality of this spectrum is argued, and its validity is checked by the comparison with experimental result. The potential applications of this model in theoretical and numerical studies are emphasized. Another contribution of this work is around the application of correlation function to analyzing the statistics of OPD. Based on our results and other results published elsewhere, we show that the OPD is often not stationary, and one should be cautious about using this tool.

Angular spectrum characters of high gain non-critical phase match optical parametric oscillators

The angular spectrum gain characters and the power magnification characters of high gain non-walk-off colinear optical parametric oscillators have been studied using the non-colinear phase match method for the first time. The experimental results of the KTiOAs04 and the KTiOP04 crystals are discussed in detail. At the high energy single resonant condition, low reflective ratio of the output mirror for the signal and long non-linear crystal are beneficial for small divergence angles. This method can also be used for other high gain non-walk-off phase match optical parametric orocesses.

Influence of Refractive Index Distribution on Brillouin Gain Spectrum in GeO_(2)-Doped Optical Fibers

GeO_(2) is commonly used as dopant to adjust the refractive index profile(RIP)and the acoustic velocity profile(AVP)in the fiber,thereby forming different Brillouin gain spectrum(BGS)characteristics such as Brillouin gain,acoustic mode number and peak intensity difference.When an optical fiber is used in optical fiber sensing or communication system,its BGS characteristics may play an important role in determining the performance of the system.In this paper,finite element analysis(FEA)method is used to study the influence of refractive index distribution and its corresponding AVP on the BGS in step-index,graded-index,and complex-index optical fibers.A new method has also been proposed to efficiently discriminate acoustic mode solution and obtain the new and full images of total Brillouin gain and acoustic modes number of the fiber as a function of the refractive index distribution,considering the influence of changing the refractive index difference and the geometric size simultaneously.For each type of optical fiber,the recommended parameter range is provided for optical fiber sensing and optical fiber communication.Moreover,the suitable optical fiber with close peak intensity in its multi-peak BGS is explored and achieved,which can be used in Brillouin beat spectrum detection systems to improve sensing accuracy.

Interrogation of optical Ramsey spectrum and stability study of an ^(87)Sr optical lattice clock

The optical Ramsey spectrum is experimentally realized in an ^(87)Sr optical lattice clock, and the measured linewidth agrees well with theoretical expectation. The coherence time between the clock laser and the atoms, which indicates the maximum free evolution period of using Ramsey detection to measure the atom-laser phase information, is determined as 340(23) ms by measuring the fringe contrasts of the Ramsey spectrum as a function of the free evolution period. Furthermore, with the same clock duty cycle of about 0.1, the clock stability is measured by using the Ramsey and Rabi spectra,respectively. The experimental and theoretical results show approximately the same stability as the two detection methods, which indicates that Ramsey detection cannot obviously improve the clock stability until the clock duty cycle is large enough. Thus, it is of great significance to choose the detection method of a specific clock.

Energy Spectrum of Two-Component Bose-Einstein Condensates in Optical Lattices

With the method of Green's function, we investigate the energy spectra of two-component ultracold bosonic atoms in optical lattices. We End that there are two energy bands for each component. The critical condition of the superfluid-Mott insulator phase transition is determined by the energy band structure. We also find that the nearest neighboring and on-site interactions fail to change the structure of energy bands, but shift the energy bands only. According to the conditions of the phase transitions, three stable superfluid and Mott insulating phases can be found by adjusting the experiment parameters. We also discuss the possibility of observing these new phases and their transitions in further experiments.

UV-Vis Spectrum and the Third-order Nonlinear Optical Properties of the Chiral Camphorderived β-diketonate Platinum Complexes

UV-Vis spectrum and the third-order nonlinear optical properties of the chiral camphor-derived β-diketonate have been studied at the B3LYP/6-31G＊ level. The results showed that the introduction of electron-drawing group -CF3 and -C3F7 on β-diketonate made the strongest absorption peak red-shift and the lowest energy absorption blue-shied. Introduction of -OC2H5 on the benzene or pyridine ring made the lowest energy absorption blue-shift. When the -C2H3 was introduced on the benzene or pyridine ring, the lowest energy absorption was red-shifted. Introduction of electron-donating group on β-diketonate can enlarge their nonlinear optical properties. On the contrary, the introduction of electron-drawing group dropped it down.

A single diffractive optical element implementing spectrum-splitting and beam-concentration functions simultaneously with high diffraction efficiency

In this paper,a novel method is proposed and employed to design a single diffractive optical element（DOE） for implementing spectrum-splitting and beam-concentration（SSBC） functions simultaneously.We develop an optimization algorithm,through which the SSBC DOE can be optimized within an arbitrary thickness range according to the limitations of modern photolithography technology.Theoretical simulation results reveal that the designed SSBC DOE has a high optical focusing efficiency.It is expected that the designed SSBC DOE should have practical applications in high-efficiency solar cell systems.

Optimization of Spectral Inverters in Optical Fiber Communication Systems with Mid-Span Spectrum Inversion

In this paper, signal distortions caused by spectral inverters which are used in 10Gb/s optical fiber communication systems with mid span spectrum inversion in terms of dispersion shift fibers are analyed numerically. It is shown that there exist the optimal input signal power, fiber length and fiblter bandwidth for the spectral in verters. System transmission penalty can be minimized by optimizing these parameters.

Energy Spectrum of Ground State and Excitation Spectrum of Quasi-particle for Hard-Core Boson in Optical Lattices

We investigate the energy spectrum of ground state and quasi-particle excitation spectrum of hard-core bosons, which behave very much like spinless noninteracting ferrnions, in optical lattices by means of the perturbation expansion and Bogoliubov approach. The results show that the energy spectrum has a single band structure, and the energy is lower near zero momentum; the excitation spectrum gives corresponding energy gap, and the system is in Mort-insulating state at Tonks limit. The analytic result of energy spectrum is in good agreement with that calculated in terms of Green＇s function at strong correlation limit.