Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene

Far-infrared ray (FIR) is electromagnetic wave between 4 and 1000 μm. FIR causes heating, but how it affects cells is not well understood. In this study, we developed a culture incubator that can continuously irradiate cells with FIR and examined the effects of FIR on five human cancer cell lines, namely A431 (vulva), A549 (lung), HSC3 (tongue), MCF7 (breast) and Sa3 (gingiva). We found that FIR inhibits cell proliferation and induces cell hypertrophy without apoptosis in A549, HSC3 and Sa3 cells. Flow cytometry revealed that the inhibition of proliferation was due to G2/M arrest. Contrary, FIR did not inhibit cell proliferation and cause cell hypertrophy in A431 or MCF7 cells. Microarray analysis revealed that FIR suppressed the expression of cell proliferation-related and stress-responsive genes in FIR-sensitive cell lines (A549, HSC3 and Sa3). ATF3 in particular was identified as a key mediator of the FIR effect. Over-expression of ATF3 inhibited cell proliferation and knockdown of ATF3 mRNA using an antisense oligonucleotide suppressed FIR-induced growth arrest. These results indicate that a body temperature range of FIR radiation suppresses the proliferation of A549, HSC3, Sa3 cells and it appears that ATF3 play important roles in this effect.

远红外辐射保温台与婴儿培养箱保暖对早产儿生命体征及体质量的影响

目的探讨远红外辐射保温台保暖与婴儿培养箱保暖对早产儿生命体征及体质量的影响。方法深圳市宝安区石岩人民医院新生儿科2013年1月至2014年5月收治早产儿80例,随机分为观察组和对照组各40例。观察组采用婴儿培养箱进行保暖,对照组采用远红外辐射保温台进行保暖。比较两组患儿各时期(入院时、入院4d、入院7d、入院14d)的呼吸及心率生命体征及奶量、体质量。结果两组患儿的心率、呼吸体征在入院时、入院4d、入院7d,入院14d4个时期比较差异无统计学意义(P>0.05)。入院时两组患儿奶量及体质量比较差异无统计学意义(P>0.05);入院后经过不同的保暖方式护理,入院4、7、14d3个时期观察组奶量及体质量显著高于对照组,差异有统计学意义(P<0.05)。结论相对于远红外辐射保暖台,婴儿培养箱更适合早产儿保暖护理,可有效提升早产儿呼吸及心率频次,临床效果显著。

Mathematical Overview of Hypersphere World-Universe Model

The Hypersphere World-Universe Model (WUM) provides a mathematical framework that allows calculating the primary cosmological parameters of the World which are in good agreement with the most recent measurements and observations. WUM explains the experimental data accumulated in the field of Cosmology and Astroparticle Physics over the last decades: the age of the World and critical energy density;the gravitational parameter and Hubble’s parameter;temperatures of the cosmic microwave background radiation and the peak of the far-infrared background radiation;the concentration of intergalactic plasma and time delay of Fast Radio Bursts. Additionally, the model predicts masses of dark matter particles, photons, and neutrinos;proposes new types of particle interactions (Super Weak and Extremely Weak);shows inter-connectivity of primary cosmological parameters of the World. WUM proposes to introduce a new fundamental parameter Q in the CODATA internationally recommended values. This paper is the summary of the mathematical results obtained in [1]-[4].

Overview of Hypersphere World-Universe Model

This paper provides an overview of the Hypersphere World-Universe Model (WUM). WUM unifies and simplifies existing cosmological models and results into a single coherent picture, and proceeds to discuss the origin, evolution, structure, ultimate fate, and primary parameters of the World. WUM explains the experimental data accumulated in the field of Cosmology and Astroparticle Physics over the last decades: the age of the world and critical energy density;the gravitational parameter and Hubble’s parameter;temperatures of the cosmic microwave background radiation and the peak of the far-infrared background radiation;gamma-ray background and cosmic neutrino background;macrostructure of the world and macroobjects structure. Additionally, the model makes predictions pertaining to masses of dark matter particles, photons, and neutrinos, proposes new types of particle interactions (Super Weak and Extremely Weak), and shows inter-connectivity of primary cosmological parameters of the world and the rise of the solar luminosity during the last 4.6 Byr. The model proposes to introduce a new fundamental parameter Q in the CODATA internationally recommended values.

World-Universe Model Predictions

In 2013, World-Universe Model (WUM) proposed a principally different way to solve the problem of Newtonian Constant of Gravitation measurement precision. WUM revealed a self-consistent set of time-varying values of Primary Cosmological parameters of the World: Gravitation parameter, Hubble’s parameter, Age of the World, Temperature of the Microwave Background Radiation, and the concentration of Intergalactic plasma. Based on the inter-connectivity of these parameters, WUM solved the Missing Baryon problem and predicted the values of the following Cosmological parameters: gravitation G, concentration of Intergalactic plasma, relative energy density of protons in the Medium, and the minimum energy of photons, which were experimentally confirmed in 2015-2018. Between 2013 and 2018, the relative standard uncertainty of G measurements decreased x6. The set of values obtained by WUM was recommended for consideration in CODATA Recommended Values of the Fundamental Physical Constants 2014.

5D World-Universe Model. Neutrinos. The World

In this manuscript we discuss mass-varying neutrinos and propose their energy density to exceed that of baryonic and dark matter. We introduce cosmic Large Grains whose mass is about Planck mass, and their temperature is around 29 K. Large Grains are in fact Bose-Einstein condensates of proposed dineutrinos, and are responsible for the cosmic Far-Infrared Background (FIRB) radiation. The distribution of the energy density of all components of the World (protons, electrons, photons, neutrinos, and dark matter particles) is considered. We present an overview of the World- Universe Model (WUM) and pay particular attention to the self-consistent set of time-varying values of basic parameters of the World: the age and critical energy density;Newtonian parameter of gravitation and Hubble’s parameter;temperatures of the cosmic Microwave Background radiation and the peak of the cosmic FIRB radiation;Fermi coupling parameter and coupling parameters of the proposed Super-Weak and Extremely-Weak interactions. Additionally, WUM forecasts the masses of dark matter particles, axions, and neutrinos;proposes two fundamental parameters of the World: fine-structure constant α and the quantity Q which is the dimensionless value of the fifth coordinate, and three fundamental physical units: basic unit of momentum, energy density, and energy flux density. WUM suggests that all time-dependent parameters of the World are inter- connected and in fact dependent on Q. We recommend adding the quantity Q to the list of the CODATA-recommended values.

World-Universe Model—Alternative to Big Bang Model

This manuscript provides a comparison of the Hypersphere World-Universe Model (WUM) with the prevailing Big Bang Model (BBM) of the Standard Cosmology. The performed analysis of BBM shows that the Four Pillars of the Standard Cosmology are model-dependent and not strong enough to support the model. The angular momentum problem is one of the most critical problems in BBM. Standard Cosmology cannot explain how Galaxies and Extra Solar systems obtained their substantial orbital and rotational angular momenta, and why the orbital momentum of Jupiter is considerably larger than the rotational momentum of the Sun. WUM is the only cosmological model in existence that is consistent with the Law of Conservation of Angular Momentum. To be consistent with this Fundamental Law, WUM discusses in detail the Beginning of the World. The Model introduces Dark Epoch (spanning from the Beginning of the World for 0.4 billion years) when only Dark Matter Particles (DMPs) existed, and Luminous Epoch (ever since for 13.8 billion years). Big Bang discussed in Standard Cosmology is, in our view, transition from Dark Epoch to Luminous Epoch due to Rotational Fission of Overspinning Dark Matter (DM) Supercluster’s Cores. WUM envisions Matter carried from the Universe into the World from the fourth spatial dimension by DMPs. Ordinary Matter is a byproduct of DM annihilation. WUM solves a number of physical problems in contemporary Cosmology and Astrophysics through DMPs and their interactions: Angular Momentum problem in birth and subsequent evolution of Galaxies and Extrasolar systems—how do they obtain it;Fermi Bubbles—two large structures in gamma-rays and X-rays above and below Galactic center;Diversity of Gravitationally-Rounded Objects in Solar system;some problems in Solar and Geophysics [1]. WUM reveals Inter-Connectivity of Primary Cosmological Parameters and calculates their values, which are in good agreement with the latest results of their measurements.

新生儿重症监护室常用医疗设备电源典型故障三例

随着新生儿重症监护室对监护仪、远红外辐射保温台及微量注射泵等设备的大量使用,快速高效处理这些设备故障对保障有序的诊疗活动至关重要。电源故障是这些设备最常见的故障之一。本文阐述了此类设备使用中出现的电源无输出或输出跳变的解决方案,通过对相关电路原理及具体电路的分析,经维修排查发现更换其特定电路中的振荡电容、反馈电阻等元件可快速解决电源故障。总结出维修此类故障的典型处理方法,能有效提高此类设备的维修效率,保障临床诊疗工作的顺利开展。

Drying characteristics,kinetics model and effective moisture diffusivity of vacuum far-infrared dried Rehmanniae

Vacuum far-infrared radiation(VFIR)drying has recently received many attentions because of its effective and successful applications in drying some agricultural products.The VFIR drying of Radix Rehmanniae was conducted and Weibull distribution function was applied to fit the drying kinetics in this study.The results showed that the increase of radiation heater temperature and the decrease of chamber pressure could reduce drying time obviously.Compared with single diffusion equation,Weibull distribution function had higher precision to fit the drying curves of VFIR drying of Rehmanniae.The effective moisture diffusivity(Deff)increased with the increase of heater temperature and the decrease of pressure.Scanning electron telescope(SEM)analysis showed that more porous surface could be observed after VFIR drying,which is beneficial to enhance moisture diffusivity and drying rate as well.

肤温探头温度现场校准方法的研究

肤温探头作为连接婴儿培养箱、婴儿辐射保暖台与婴儿的纽带,能实时监控婴儿皮肤温度,发现异常时可迅速判定,并提醒医务人员对婴儿进行进一步检查。虽然其结构简单,但对于温度的控制至关重要,能使婴儿培养箱、婴儿辐射保暖台保持良好的工作状态,降低使用风险。

Physiological benefits of ambient far infrared energy within the 4-24 micron range

Far infrared(FIR)radiation(3-100µm)is an electromagnetic spectrum commonly studied for biological effects.This article aims to discuss using Far infrared radiation with sub-division(4-24µm)of this waveband to stimulate tissues and cells and is considered an effective therapeutic modality for specific medical disorders.The IR application as a medical therapy has advanced rapidly in recent years.For example,IR therapy like IR-emitting apparel and materials that can be run solely by body heat(does not need an external power supply)have been developed.New methods for providing FIR radiation to the human body have emerged due to technological advancements.Specialty saunas and lamps that emit pure FIR radiation have become effective,safe,and widely used therapeutic sources.Fibers infused with thermide,FIR emitting ceramic nanomaterials and knitted into fabrics are used as clothes and apparel to produce FIR radiation and benefit from its effects.A deeper understanding of FIR's significant innovations and biological implications could aid in improving therapeutic efficacy or developing new methods that use FIR wavelengths.

基于伏气温病理论探讨放射性肺损伤的中医病机与治法

文章从伏气温病角度探讨放射性肺损伤的病机、临床表现和治疗原则。认为可以用伏气温病学说解释放射性肺损伤的发病规律、疾病性质、发病部位等,放射性肺损伤病机为火热深伏营血分,痰热壅肺,络脉瘀滞,导致气机阻滞,气虚无力祛邪外达,此与伏气温病的"怫热郁结"病机相一致。治以清热滋阴、理气化痰、活血化瘀、透热转气、补益为法则,治法关键在于透热转气。

Effects of the use of bioceramic wraps in patients with lower limb venous ulcers:A randomized double-blind placebo-controlled trial

Background:Venous ulcer represents the most advanced stage of chronic venous insufficiency.It is an important public health problem and has a significant impact on patients’quality of life due to chronic pain,inability to work,need for hospitalization and frequent outpatient follow-up.Objective:We investigated the treatment benefits of far-infrared ceramic(cFIR),in a 90-day study of lower limb venous ulcers and looked at ulcer healing scores,quality of life,serum bio-markers of oxidative stress and antioxidant defense enzymes.Design,setting,participants and interventions:This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul,Brazil.We included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 days.Main outcome measures:The following evaluations were conducted at baseline and after 15,30,60 and90 days:ulcer healing score,quality of life,and serum markers of oxidative stress and antioxidant enzyme activity.Results:Patients(n=24)with lower limb venous ulcers were randomized into two treatment groups.cFIR decreased the ulcer size on day 30(P=0.042)and 90(P=0.034)and the total ulcer healing scale scores on day 30(P=0.049)and 90(P=0.02)of the treatment,when compared to baseline.Additionally,cFIR improved tissue type(epithelial tissue)on day 60(P=0.022)when compared to baseline evaluation.Conclusion:cFIR clinically improved ulcer healing in patients with lower limb venous ulcers.Trial registration:RBR-8c7xzn on ReBEC.