Preweaning period is a critical window for rumen microbial regulation of average daily gain in Holstein heifer calves

Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different ADG.Twelve calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host phenotype.Results During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,P<0.05).Enrichment of these bacteria resulted in increased levels of propionate,a gluconeogenic precursor,in preweaning HADG calves(adjusted P<0.05),which consequently raised serum glucose concentrations(adjusted P<0.05).In contrast,the relative abundances of rumen bacteria in post-weaning HADG calves did not exert this effect.Moreover,no significant differences were observed in rumen fermentation parameters and serum indices between the two groups.Conclusions The findings of this study revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.

Design of a Low Power Low-Noise Amplifier with Improved Gain/Noise Ratio

This work details the development of a broad-spectrum LNA (Low Noise Amplifier) circuit using a 65 nm CMOS technology. The design incorporates an inductive degeneracy circuit, employing a theoretical approach to enhance gain, minimize noise levels, and uphold low power consumption. The progression includes a shift to a cascode structure to further refine LNA parameters. Ultimately, with a 1.8 V bias, the achieved performance showcases a gain-to-noise figure ratio of 16 dB/0.5 dB, an IIP3 linearity at 5.1 dBm, and a power consumption of 3 mW. This architecture is adept at operating across a wide frequency band spanning from 0.5 GHz to 6 GHz, rendering it applicable in diverse RF scenarios.

Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating glia.In the central nervous system,this role is taken up by oligodendrocytes.Oligodendrocytes are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal stages.While the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor pool.Therefore,the timing of myelination and maintenance of the OPC pool both need to be precisely regulated.Different transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling pathways.How the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental cues.Relevant insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCR)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

Analysis of the Effects of Maternal Body Mass Index and Gestational Weight Gain on Maternal and Neonatal Outcomes in Twin Pregnancy

Objective:To investigate the effects of maternal body mass index(BMI)and gestational weight gain on maternal and neonatal outcomes in twin pregnancies.Methods:Five hundred cases of twin pregnancies were divided into a low body weight group(68 cases),a normal weight group(355 cases),an overweight group(65 cases),and an obesity group(12 cases)according to the World Health Organization(WHO)Body Mass Index(BMI)classification guidelines Results:Comparison of weight gain during different pregnancies revealed that pregnant women were mainly of low weight and average weight.The higher the BMI before pregnancy,the higher the incidence of excessive weight gain during pregnancy.The incidences of gestational diabetes mellitus(GDM)and premature rupture of membranes in women with low weight gain were significantly higher than those in women with average weight gain and high weight gain(P<0.05).The incidences of gestational hypertension,preeclampsia,and anemia in women with high weight gain were significantly higher than those in women with low weight gain and average weight gain(P<0.05).The incidence of neonatal birth weight,fetal distress,and macrosomia in the high weight gain group was significantly higher than those in the low weight gain and average weight gain groups(P<0.05).The birth weight of newborns in low-weight gain mothers was significantly lower than that of normal-weight gain mothers(P<0.05).Conclusion:Poor maternal and infant outcomes were common in women with insufficient or excessive weight gain during pregnancy.Therefore,for women with twin pregnancies,weight management is crucial to ensure maternal and infant health.

A Ka Broadband High Gain Monolithic LNA with a Noise Figure of 2dB

A four-stage monolithic microwave integrated circuits （MMIC） low noise amplifier （LNA） operating from 23 to 36GHz is reported using commercially available 0.15μm PHEMT technology. The LNA is self-biased. To achieve a low noise characteristic, careful optimizations of gate width are performed to reduce gate resistance. Absorption circuits and an elaborate bias structure with a resistor-capacitor network are employed to improve stability. Multiple resonance points and negative feedback technologies are used to widen the bandwidth. Measurements show a noise figure （NF） of less than 2.0dB,and the lowest NF is only 1.6dB at a frequency of 31GHz. In the whole operation band,the LNA has a gain of higher than 26dB,and an input return loss and output return loss of more than 11 and 13dB,respectively. The output power at ldB compression gain of 36GHz is about 14dBm. The chip area is 2.4mm ×1mm.

Gain and Noise Properties of Bidirectional EDFAs

The rate equation model is setup for the signal gain, pump absorption and output noise spectrum of bidirectional EDFA (Bi EDFA) including numbers of signals, pumps of arbitrary direction, amplified spontaneous emission (ASE) and inherent loss. The influence of erbium doped fiber length, input signal power, pump style and pump power on the gain characteristics of Bi EDFA is analyzed. Forward and backward noise figure for different pump style versus bidirectional input signal power is investigated.

Approximate Well Width and Optical Gain Formulas of 1 .555μm In_(1-x-y )Ga_y Al_x As Compressively Strained Quantum- Well Laser

Using Harrison's model and anisotropic parabolic approximation,the band structure of In1- x- y Gay Alx As compressively strained quantum wells is calculated.To design lasers with1.55μm wavelength,it is necessary to an- alyze the well width,differential gain,transparency carrier density and the characteristic gain for an arbitrary com- position.Some useful empirical formulas are also presented.

APPLICATION OF VELOCITY GAIN GUIDANCE TO FAR-DISTANCE RENDEZVOUS

Using impulse hypothesis to solve far-distance rendezvous is difficult to be realized in a real project and the guidance accuracy cannot be controlled. A two-maneuver guidance law is designed for the two-impulse rendezvous problem. The velocity gain guidance is applied to the first maneuver and the time-cut-off law is applied to the second one. Theoretical and simulation results show that the plan is credible. Accuracy requirements in fardistance rendezvous and in transform to close-in rendezous can be met.

A 1V,156.7μW,65.9dB Rail-to-Rail Operational Amplifier by Means of Negative Resistance Load and Replica-Amplifier Gain Enhancement

A low-voltage, low-power, and high-gain rail-to-rail operational amplifier （OpAmp） is presented. The replica-amplifier gain enhancement technique is applied to improve the DC gain of the amplifier, which does not degrade the output swing and is very suitable for low-voltage applications. In a 0. 18/μm standard CMOS process,a 1V OpAmp with rail-to-rail output is designed. For a load capacitance of 5 pF,simulation by HSPICE shows that this OpAmp achieves an effective open-loop DC gain of 65. 9dB,gain bandwidth of 70.28 MHz,and phase margin of 50 with a quiescent power dissipation of 156.7μW.

Optimal feedback gains of a delayed proportional-derivative(PD) control for balancing an inverted pendulum

In the dynamics analysis and synthesis of a controlled system, it is important to know for what feedback gains can the controlled system decay to the demanded steady state as fast as possible. This article presents a systematic method for finding the optimal feedback gains by taking the stability of an inverted pendulum system with a delayed proportional-derivative controller as an example. First, the condition for the existence and uniqueness of the stable region in the gain plane is obtained by using the D-subdivision method and the method of stability switch. Then the same procedure is used repeatedly to shrink the stable region by decreasing the real part of the rightmost characteristic root. Finally, the optimal feedback gains within the stable region that minimizes the real part of the rightmost root are expressed by an explicit formula. With the optimal feedback gains, the controlled inverted pendulum decays to its trivial equilibrium at the fastest speed when the initial values around the origin are fixed. The main results are checked by numerical simulation.

Performance gain bounds of coherently combining multiple radars in a target-based calibration manner

To achieve a high signal-to-noise ratio(SNR) while maintaining moderate radar antenna, a target-based calibration manner is available to coherently combine multiple radars. The key to this calibration manner is to estimate coherence parameters(CPs), i.e., time and phase calibration values in transmission and reception estimation, by separating the target returns into monostatic and bistatic echoes. However, CPs estimations exist uncertainties, which will affect the performance gain after multiradar coherent combination. The principle of coherently combining multiple radars is elaborated and the signal probability model for CPs estimation is established. On this basis, CPs Cramer-Rao bound(CRB) is derived in the closed-form, according to which the non-tight and tight upper bounds for multiple radars coherent combination performance gain are derived in the closed-form and via Monte Carlo(MC) simulations, respectively. Simulations validate the correctness of the derived CRB and gain bounds.

Effect of spontaneously generated coherence on inversionless lasing gain in an atomic system with Doppler broadening

We have studied the effect of the spontaneously generated coherence （SGC） on gain of lasing without inversion （LWI） in a closed three-level A-type atomic system with Doppler broadening. It is shown that, regardless of the driving and probe fields being co- or counter-propagating, at a suitable value of the Doppler width, we can obtain a much larger LWI gain with SGC than that without SGC; and the region of the LWI gain spectrum with SGC is obviously larger than that without SGC. When the Doppler width takes a constant value, the gain does not monotonically decrease or increase with increasing strength of SGC, the largest LWI gain can be obtained by adjusting strength of SGC. Generally speaking, the co-propagating probe and driving fields is favourable to obtain a larger LWI gain.

Adaptive adjustment of iterative learning control gain matrix in harsh noise environment

For the robustness problem of open-loop P-type iterative learning control under the influence of measurement noise which is inevitable in actual systems, an adaptive adjustment algorithm of iterative learning nonlinear gain matrix based on error amplitude is proposed and two nonlinear gain functions are given. Then with the help of Bellman-Gronwall lemma, the robustness proof is derived. At last, an example is simulated and analyzed. The results show that when there exists measurement noise, the proposed learning law adjusts the learning gain matrix on line based on error amplitude, thus can make a compromise between learning convergence rate and convergence accuracy to some extent： the fast convergence rate is achieved with high gain in initial learning stage, the strong robustness and high convergence accuracy are achieved at the same time with small gain in the end learning stage, thus better learning results are obtained.

Theoretical Analysis of Gain and Threshold Current Density for Long Wavelength GaAs-Based Quantum-Dot Lasers'

Quantum dot gain spectra based on harmonic oscillator model are calculated including and excluding excitons. The effects of non-equilibrium distributions are considered at low temperatures. The variations of threshold current density in a wide temperature range are analyzed and the negative characteristic temperature and oscillatory characteristic temperature appearing in that temperature range are discussed. Also,the improvement of quantum dot lasers＇ performance is investigated through vertical stacking and p-type doping and the optimal dot density, which corresponds to minimal threshold current density,is calculated.

Effects of Molasses-Urea Supplementation on Weight Gain,Ruminal Fermentation and Major Microbe Populations of Winter-Grazing Sheep in Inner Mongolia

The present experiment was conducted to determine the effects of Molasses-Urea Supplementation （MUS） on weight gain, ruminal fermentation and major microbial populations in sheep on a winter grazing regime in Inner Mongolia. Total 40 sheep, allowed free consumption of MUS after grazing, served as a treatment group, while 30 sheep, fed only by pasture grazing, served as a control group. Ruminal fermentation parameters, consisted of pH, Bacterial Crude Protein （BCP） and ammonia nitrogen （NH3-N） were measured. In addition, numbers of five symbiotic bacteria were investigated. The results showed as follows： the average daily weight gain, concentration of NH3-N and numbers of protozoa were significantly higher （p〈0.05） in the treatment group than those in the control group. Contrastingly, no significant difference was found in BCP concentration and pH between the two groups. At the end of the experiment, the populations of Selenomonas ruminantium, Anaerovibrio lipolytica, Fibrobacter succinogenes, Ruminococcus flaveciens and Ruminococcus albus in the treatment group were significantly higher than those of the control group （p〈0.05）. These results demonstrated that greater weight gain could be induced during winter in Inner Mongolia by improved nutritional status through promotion of microbial populations using urea and sugar.

Two-dimensional analysis of the interface state effect on current gain for a 4H-SiC bipolar junction transistor

This paper studies two-dimensional analysis of the surface state effect on current gain for a 4H-SiC bipolar junction transistor （BJT）. Simulation results indicate the mechanism of current gain degradation, which is surface Fermi level pinning leading to a strong downward bending of the energy bands to form the channel of surface electron recombination current. The experimental results are well-matched with the simulation, which is modeled by exponential distributions of the interface state density replacing the single interface state trap. Furthermore, the simulation reveals that the oxide quality of the base emitter junction interface is very important for 4H-SiC BJT performance.

Gain Switch of an AlGaInP Red Light Semiconductor Laser Diode

We solve the single mode coupled rate equations by computer,simulate the behavior of a gain switch of an AlGaInP red light semiconductor laser diode,and find the characteristic of FWHM of pulses changing with the amplitude of modulation signal, the bias current, and the modulated frequency. On this basis, we conduct experiments. The experiment results accord with the simulations well.

Improved control of intelligent excavator using proportional-integral-plus gain scheduling

Consider the design and implementation of an electro-hydraulic control system for a robotic excavator, namely the Lancaster University computerized and intelligent excavator (LUCIE). The excavator was developed to autonomously dig trenches without human intervention. One stumbling block is the achievement of adequate, accurate, quick and smooth movement under automatic control, which is difficult for traditional control algorithm, e.g. PI/PID. A gain scheduling design, based on the true digital proportional-integral-plus (PIP) control methodology, was utilized to regulate the nonlinear joint dynamics. Simulation and initial field tests both demonstrated the feasibility and robustness of proposed technique to the uncertainties of parameters, time delay and load disturbances, with the excavator arm directed along specified trajectories in a smooth, fast and accurate manner. The tracking error magnitudes for oblique straight line and horizontal straight line are less than 20 mm and 50 mm, respectively, while the velocity reaches 9 m/min.

Excessive Weight Gain during Pregnancy and Prognosis of Childbirth in Douala (Cameroun)

The objective was to describe the maternofetal outcome of childbirth in women with excessive weight gain during pregnancy. We conducted a cross-sectional analytical study over a period of 03 months in the Obstetrics Department of Laquintinie Hospital in Douala (HLD). Our study population consisted of any pregnant in labor or waiting for a caesarean section. We compared two groups of pregnant women with excessive weight gain during pregnancy (exposed) and those without excessive weight gain during pregnancy (unexposed). We recorded 240 pregnant women who gave birth at the HLD maternity, 59 of whom had excessive weight gain during pregnancy, which gave us a proportion of 24.6%. The only sociodemographic characteristic associated with excessive weight gain during pregnancy was the married marital status of the pregnant women (OR: 2.0 (1.1 - 3.8) P = 0.023). Pregnant women with maternal complications associated with excessive weight gain had an average elevated uterine height of 35.4 (P = 0.007). The increase in caesarean section rate (P = 0.094) and the onset of pregnancy-related hypertension (HTA) showed differences close to significance (P = 0.063). Mean birth weight was higher (P = 0.023) in pregnant women with excessive weight gain during pregnancy. Ultimately, excessive weight gain during pregnancy has deleterious effects on the course of pregnancy and childbirth. It promotes the onset of pregnancy HTA and macrosomia.

Field plate structural optimization for enhancing the power gain of GaN-based HEMTs

A novel source-connected field plate structure, featuring the same photolithography mask as the gate electrode, is proposed as an improvement over the conventional field plate （FP） techniques to enhance the frequency performance in GaN-based HEMTs. The influences of the field plate on frequency and breakdown performance are investigated simul- taneously by using a two-dimensional physics-based simulation. Compared with the conventional T-gate structures with a field plate length of 1.2 gm, this field plate structure can induce the small signal power gain at 10 GHz to increase by 5-9.5 dB, which depends on the distance between source FP and dramatically shortened gate FE This technique minimizes the parasitic capacitances, especially the gate-to-drain capacitance, showing a substantial potential for millimeter-wave, high power applications.