Factors influencing willingness to participate in ophthalmic clinical trials and strategies for effective recruitment

AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical trials.METHODS:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic Center,Sun Yat-sen University,in Guangzhou,China.The survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical trials.RESULTS:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical trials.Specific characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical trials.With the exception of age,these characteristics were significantly linked to a higher willingness.The primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key facilitator.CONCLUSION:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic factors.Variations in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment strategies.Importantly,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.

Network analysis of the relationships between depressive symptoms and social participation activities among Chinese older adults and its implications for nursing

Objective:Network analysis was used to explore the complex inter-relationships between social participation activities and depressive symptoms among the Chinese older population,and the differences in network structures among different genders,age groups,and urban-rural residency would be compared.Methods:Based on the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey(CLHLS),12,043 people aged 65 to 105 were included.The 10-item Center for Epidemiologic Studies Depression(CESD)Scale was used to assess depressive symptoms and 10 types of social participation activities were collected,including housework,tai-chi,square dancing,visiting and interacting with friends,garden work,reading newspapers or books,raising domestic animals,playing cards or mahjong,watching TV or listening to radio,and organized social activities.R 4.2.1 software was used to estimate the network model and calculate strength and bridge strength.Results:21.60%(2,601/12,043)of the participants had depressive symptoms.The total social participation score was negatively associated with depressive symptoms after adjusting for sociodemographic factors.The network of social participation and depressive symptoms showed that“D9(Inability to get going)”and“S9(Watching TV and/or listening to the radio)”had the highest strength within depressive symptoms and social participation communities,respectively,and“S1(Housework)”,“S9(Watching TV and/or listening to the radio)”,and“D5(Hopelessness)”were the most prominent bridging nodes between the two communities.Most edges linking the two communities were negative.“S5(Graden work)-D5(Hopelessness)”and“S6(Reading newspapers/books)-D4(Everything was an effort)”were the top 2 strongest negative edges.Older females had significantly denser network structures than older males.Compared to older people aged 65e80,the age group 81e105 showed higher network global strength.Conclusions:This study provides novel insights into the complex relationships between social participation and depressive symptoms.Except for doing housework,other social participation activities were found to be protective for depression levels.Different nursing strategies should be taken to prevent and alleviate depressive symptoms for different genders and older people of different ages.

Participatory Technique Supporting Environmental Management: A Systematic and Bibliometric Review

The increasing need to manage natural resources sustainably, driven by population growth, requires the simultaneous use of Participatory Techniques (PT) and landscape planning for structured decision-making. We conducted a bibliometric and systematic review to provide an overview of PT usage, identifying evolution in scientific production. We considered the number of publications and citations, prominent journals, and highly cited articles on scientific papers published in the Web of Science database between 1993 and 2023. A total of 415 articles related to PT were identified. After content evaluation, 19 critical articles were selected that underpin the growing combined use of models and indices with PT, enhancing the robustness and credibility of decision-making processes.

Participatory Land Rehabilitation Strategies in Angacha District, Kembata Zone, Central Ethiopia Region

Community participation has become widely incorporated into policies of many soil and water conservation organizations. The purpose of this study was to assess the community participation in the rehabilitation of degraded land. In order to achieve the objective of the study, both primary and secondary data were generated by employing qualitative and quantitative data. Purposive sampling was employed to select three study kebeles (the smallest administrative structure of the country) from 16 rural kebeles in Angecha District. Simple random sampling technique was used to select 183 household heads from the lists of farmers in the selected kebeles for detailed household survey. In addition to household survey, field observation and key informant interview were also conducted to collect the necessary data. The data were presented using descriptive statistic such as percentage, frequency, tables and figure. The data collected through the use of household survey questionnaires were analyzed using logit regression while data collected through field observation and key informant interview were analyzed and interpreted using qualitative description. The findings of the present study revealed that population pressure, soil erosion, deforestation, overgrazing, and over cultivation were the major causes for land degradation. Moreover, the results of this study indicated that the main causes of the low productivity of farmland were farmers’ involvement in off-farm activities, increase in size of human population, lack of full cooperation of family members to involve in land rehabilitation practices. Households participated in rehabilitation practices at different levels, with 43.7% respondents showing intermediate participation. However, 22.4% of the farm households clarified that there is low experience sharing and motivation to participate in the process of implementation of rehabilitation programs. It is recommended that, continuous training and experience sharing program, immediate action to increase the number of literate persons, to practicing compatible practices for the agro climatic zone such as soil bund, Fanyaaju, stone bunds, and tree planting, extending effective practices, create opportunities for alternative means of livelihood and promoting NGOs effort to involve in land rehabilitation practices in the highly degraded area.

Factors Impacting Benefits of Participatory Forest Management in Upper Imenti Forest, Meru County, Kenya

This study focused on identifying factors affecting the benefits of Participatory Forestry Management (PFM) income generating activities in Upper Imenti Forest and whether they are dependent on status of participation in forest management through membership of Community Forest Association (CFA) or not. Cross-sectional survey research design was applied for collecting quantitative data using a semi-structured questionnaire administered to 384 households stratified on the basis of PFM participation status. Qualitative data was collected through focused group discussions using a checklist and key informant interviews using an interview schedule. Using Statistical Package for Social Sciences version 25, Binomial regression with Wald Chi-square was analyzed to identify factors perceived to be significantly influencing benefits for PFM participants and Pearson Chi-square to compare factors perceived to be affecting PFM and non-PFM participants. CFA members participation in PFM was significantly and positively affected by benefits of PFM income generating activities and forest products accessed in the forest. Benefits linked to Plantation Establishment for Livelihood Improvement System (PELIS) for CFA members were significantly reduced by enforcement of moratorium policy since February 2018, diseases and pests, poor PELIS guideline adherence and animal damage. Benefits related to state forest access for firewood by the CFA members were negatively influenced by the moratorium policy. Diseases and pests affected benefits associated with bee keeping significantly. Comparing factors under different PFM participation status, crop production was significantly affected by policy changes, pest and diseases, animal damage and PELIS guideline adherence for CFA members than for Non-CFA members. Policy changes also affected the CFA members significantly in firewood collection and access to fodder in the state forest than the Non-CFA members. Hence, sustainable community participation in Upper Imenti Forest management requires: increasing PFM benefits, addressing factors reducing benefits and enhancing active participation of CFA members in PFM related decision-making processes.

Preserving environmental quality of ecotourism sites through community participation in Purulia District of West Bengal,India

The importance of valuing environmental resources,especially in ecotourism sites,has become increasingly important over the last two decades.Ecotourism is now considered as an important source of livelihood of local stakeholders in backward regions.Therefore,the preservation of ecotourism sites through community participation seems very important to maintain continued flow of tourists.This study aimed at recognizing the importance of community participation for the preservation of ecotourism sites.For this,this study executed a survey based on non-probability sampling in two ecotourism sites(Garpanchkot and Baranti)covering 100 respondents in Purulia District,West Bengal of India.The central issue of this study was to assess the tendency of community participation for the conservation of ecotourism sites and find the optimum condition for offering participatory labour time.This study showed that the participation of young people is high,and the majority of respondents are aware of the importance in protecting ecotourism sites.Because respondents were too poor to offer money,the contingent valuation method(CVM)was used to elicit their willingness to pay(WTP)participatory labour time for the conservation of ecotourism sites.Respondents’age,income,education level,caste,and their perceived environmental quality had significant relationship with their WTP participatory labour time by applying the ordinary least square(OLS)model.It was found that the mean WTP participatory labour time of each respondent in a month is approximately 3.64 h.The significance of this study is that community participation can improve the sense of belonging,trust,and credibility of ecotourism sites,making them more appreciative of the value and protection of these sites.

Problems and Countermeasures to Improve Clinical Trial Participants’Compensation Rights in China

Objective To discuss the problems existing in the compensation of Chinese clinical trial participants and propose some suggestions for improving their rights.Methods The literature related to the participants’right to compensation at home and abroad was searched to study the inadequacy of the compensation right for clinical trial participants in China from four aspects:insurance system,principle of attribution,legal relationship and compensation regulations.Then,some suggestions to improve the participants’right to compensation were proposed.Results and Conclusion China lacks clear legal norms for participants’right to compensation.There are problems such as unclear insurance rules and compensation rules,unclear contractual relationships between parties to clinical trials,and no laws and regulations to rely on for attribution and compensation.China should issue regulatory guidelines related to the right to compensation of participants in clinical trials,so that all parties in clinical trials can have rules to follow if there is the occurrence of injury,which can better protect the rights and interests of the participants.

The Contribution of Vocal Music Education in Colleges and Universities to Cultural Inheritance and Innovation

The importance of education and cultural inheritance is becoming increasingly prominent.Through literature review and empirical research,combining quantitative data and qualitative analysis,this paper assesses the teaching methods,curriculum,and student interest and participation in vocal music education in colleges and universities.The study found that vocal music education played a positive role in increasing students’participation in cultural activities,enhancing their identification with traditional music and improving their skills,despite problems such as inadequate teaching systems and homogenized curricula.In particular,the participation rate of students in cultural activities before and after the educational changes increased significantly from 31–54.7%to 62.4–83.6%,indicating that vocal music education can effectively stimulate students’enthusiasm for cultural participation.In addition,the strengthening of the teaching staff and innovations in teaching methods,such as the application of multimedia and virtual reality technologies,provide students with richer learning experiences and personalized learning paths.

Community Tourism in Changxi Village:Research based on Community-participated Village Tourism

On the basis of investigating community participation in tourism development of Changxi Village,Wuyuan County,the study pictures a reasonable image for the community participation in tourism village,proposes the problems and corresponding suggestions.

Willingness of farmers to participate in food traceability systems:improving the level of food safety

In order to solve frequently emerging food safety problems and adapt to the developing trends in the international food safety field, the Chinese government is establishing and developing food traceability systems. Whether or not food traceability sys- tems can guarantee food safety is a problem well worth discussing. Hence, we constructed a theoretical model to explore the effect of incentives in a food traceability system in order to improve food safety levels. The following results were obtained： enhancing the ef- fectiveness of a food traceability system, increasing the payment to farmers who supply safe agricultural products and strengthening the penalty for unsafe food supply actions are necessary conditions to improve the level of food safety. How to encourage farmers to use food traceability systems is another problem explored in our investigation. Based on a field survey on the willingness of vegetable growers to participate using a vegetable traceability system in Beijing, the first city in China to develop such a system, we used a de- scriptive statistics and a binary logistic regression model to investigate the factors which dominate the decision on the part of farmers to participate in a food safety system. The results indicate that i： younger farmers are more likely to get involved in a food traceability system than older farmers, ii： income from non-agricultural activities decreases the willingness of farmers to participate, iii： the high- er the cost-benefit ratio of growing vegetables, the more likely for farmers to engage in a food traceability system, iv： farmers with a great concern for food safety information have a high propensity to participate and v： increased penalties against unsafe food supply actions and high-risk expectation are adverse incentives. In contrast, high-price expectation is a positive incentive for farmers to par- ticipate, while agricultural training, government subsidies and being part of an industrial organization will significantly strengthen the confidence of farmers to participate in a food safety system.

DEVELOPING WITH FRIENDS——CIIE is expected to leverage its role as a platform foradvancing high-standard opening-up to ensure China’s bigmarket is shared by all

From November 5 to 10,the sixth China International Import Expo(CIIE),themed“New Era,Shared Future,”took place in Shanghai.It was the first fully offline edition of CIIE since the COVID-19 pandemic.This year,69 countries and three international organizations participated in the Country Exhibition,with 11 countries participating for the first time and 34 countries participating offline for the first time.Sheng Qiuping,Chinese vice minister of commerce,said at a news conference that the sixth CIIE would cover over 367,000 square meters and feature participation from a record 289 Fortune Global 500 companies and industry-leading businesses.

On the Expansion and Realization of the Right to Environmental Information in Environmental Protection Supervision

As an innovation in the environmental governance system that breaks the traditional hierarchical structure,environmental protection supervision has not only played a significant role in protecting tangible environmental rights but also expanded the basic scope of the right to environmental information—part of procedural environmental rights.In the supervision of environmental protection,the objects of the right to environmental information and the subjects of the obligation to provide environmental information have been both expanded,with the focus shifting from government information to Party information and from administrative organs to Party organs.This vividly demonstrates the Communist Party of China’s concrete efforts to protect human rights in the field of the endeavor to build an ecological civilization.At present,the realization of the right to environmental information in environmental protection supervision still faces problems such as insufficient standards and norms,disordered practice and operation,and lack of liability guarantee.In this context,based on renewing relevant subjects’cognition of the right to know in environmental protection supervision,we should further improve and specify the rule for disclosing information about environmental protection supervision,rationally distribute the obligations for information disclosure in environmental protection supervision,and clarify the accountability rules for violating relevant requirements for information disclosure,so as to promote the overall development of the environmental protection supervision system while guaranteeing the realization of the right to environmental information.

A tale of duality:Community perceptions towards the ecotourism impacts on Simien Mountains National Park,Ethiopia

This study aims to analyze how park households perceive the economic,sociocultural,and environmental impacts of ecotourism in Simien Mountain National Park(SMNP),Ethiopia.We combined qualitative and quantitative techniques for data collection.A sequentially embedded mixed design that gives priority to quantitative data was used.We also employed a multistage sampling technique to select respondents from three districts or woredas,namely Debark,Janamora,and Beyeda woredas.Finally,397 participants were involved in the study from a random selection of three villages from each district or woreda.Data were gathered using a survey questionnaire,interviews,and focus group discussions.Data were analyzed using both descriptive and inferential statistical methods,including means,standard deviations,analysis of variance(ANOVA),and logistic regression models.The findings from a logistic regression analysis revealed that ecotourism participation had a significant relationship with gender(B=1.850,P=0.023),level of education(B=0.238,P=0.032),geographical location(B=0.420,P=0.041),and occupation(B=0.920,P=0.019).This investigation suggested that males and individuals with a higher educational background are more likely to possess optimistic perspectives concerning the impacts of ecotourism.Furthermore,individuals residing in districts relatively near ecotourism destinations,those engaged in tourism-related work,and younger participants were recognized as having optimistic viewpoints regarding the impacts of ecotourism.In conclusion,the study highlighted the need for collaborative efforts among stakeholders to maximize ecotourism’s benefits and minimize negative effects in SMNP.To achieve this,it is recommended that the Ethiopian Wildlife Conservation Agency,the Ministry of Tourism,and local government should work together to develop sustainable tourism plans that enhance local livelihoods and park conditions.Efforts should focus on increasing the participation of females and individuals with lower education levels through training and resource provision.

The Potential of Commercial Pension Insurance to Develop into One of the Pillars of Rural Pension Insurance:A Study from the Demand Perspective

The development of a multi-pillar pension insurance system is an effective solution for an aging society.Commercial pension insurance,as the third pillar of pension insurance,is an integral part of this system in China and can play a critical and complementary role in rural areas where support for the elderly is a more pressing concern and a second pillar of pension insurance remains absent.To this end,we first elaborate on the theoretical logic that commercial pension insurance can develop into one of the pillars of rural pension insurance.We then empirically test rural residents’willingness to participate in a commercial pension insurance plan(CPIP)in a probit model with household research data from rural areas in major labor-exporting provinces,such as Sichuan and Henan so as to explore whether commercial pension insurance has the potential to become one of the pillars of rural pension insurance.Our research findings can be synthesized in three points.First,rural residents out of agricultural production for five consecutive years are more willing to participate in a CPIP than other rural residents,indicating that progress in industrialization and urbanization can significantly boost such willingness.Second,the younger rural residents are more inclined to participate in a CPIP than the older generation.Third,income increases can significantly boost rural residents’willingness to participate in a CPIP.Thus,with progress in industrialization and urbanization and an increase in rural disposable income,commercial pension insurance has a promising potential in rural areas and can hopefully develop into one of the pillars of rural pension insurance.

Different people,different wild:Comparing and mapping wilderness representation in Wuyishan National Park,China

It is essential to better integrate wilderness representations of different stakeholders into wilderness conservation.The way in which local residents and other stakeholders frame the construction of wilderness of protected areas in developing countries are poorly understood.In these areas,land use policy and decision may lead to conflicts.This study aims to explore existing public wilderness representations using a questionnaire survey(n=514)administered amongst tourists and other stakeholders in the Wuyishan National Park,in southeast China.The spatial differences in public representations of wilderness across different stakeholder groups were compared against expert knowledge.We found that integrated wilderness representation maps of different stakeholder groups were consistent,namely'area where wild animals live','area with no human influence','a barren and lonely area'.However,three sub-representations of the individual stakeholders varied significantly.Moreover,expert-based wilderness mapping did not reflect public representations accurately,and an integrated wilder-ness quality map considering wilderness representations across both stakeholders and experts can better identify detailed wilderness areas.Our study provides new insights and technical support for future exploration of wilder-ness conservation and mapping in China and other countries with insufficient awareness of wilderness values and investigations in a regional scale.

A Federated Learning Framework with Blockchain-Based Auditable Participant Selection

Federated learning is an important distributed model training technique in Internet of Things(IoT),in which participant selection is a key component that plays a role in improving training efficiency and model accuracy.This module enables a central server to select a subset of participants to performmodel training based on data and device information.By doing so,selected participants are rewarded and actively perform model training,while participants that are detrimental to training efficiency and model accuracy are excluded.However,in practice,participants may suspect that the central server may have miscalculated and thus not made the selection honestly.This lack of trustworthiness problem,which can demotivate participants,has received little attention.Another problem that has received little attention is the leakage of participants’private information during the selection process.We will therefore propose a federated learning framework with auditable participant selection.It supports smart contracts in selecting a set of suitable participants based on their training loss without compromising the privacy.Considering the possibility of malicious campaigning and impersonation of participants,the framework employs commitment schemes and zero-knowledge proofs to counteract these malicious behaviors.Finally,we analyze the security of the framework and conduct a series of experiments to demonstrate that the framework can effectively improve the efficiency of federated learning.

Optimal dispatching strategy for residential demand response considering load participation

To facilitate the coordinated and large-scale participation of residential flexible loads in demand response(DR),a load aggregator(LA)can integrate these loads for scheduling.In this study,a residential DR optimization scheduling strategy was formulated considering the participation of flexible loads in DR.First,based on the operational characteristics of flexible loads such as electric vehicles,air conditioners,and dishwashers,their DR participation,the base to calculate the compensation price to users,was determined by considering these loads as virtual energy storage.It was quantified based on the state of virtual energy storage during each time slot.Second,flexible loads were clustered using the K-means algorithm,considering the typical operational and behavioral characteristics as the cluster centroid.Finally,the LA scheduling strategy was implemented by introducing a DR mechanism based on the directrix load.The simulation results demonstrate that the proposed DR approach can effectively reduce peak loads and fill valleys,thereby improving the load management performance.

Low-frequency oscillation of train-network system considering traction power supply mode

The low-frequency oscillation(LFO)has occurred in the train-network system due to the introduction of the power electronics of the trains.The modeling and analyzing method in current researches based on electrified railway unilateral power supply system are not suitable for the LFO analysis in a bilateral power supply system,where the trains are supplied by two traction substations.In this work,based on the single-input and single-output impedance model of China CRH5 trains,the node admittance matrices of the train-network system both in unilateral and bilateral power supply modes are established,including three-phase power grid,traction transformers and traction network.Then the modal analysis is used to study the oscillation modes and propagation characteristics of the unilateral and bilateral power supply systems.Moreover,the influence of the equivalent inductance of the power grid,the length of the transmission line,and the length of the traction network are analyzed on the critical oscillation mode of the bilateral power supply system.Finally,the theoretical analysis results are verified by the time-domain simulation model in MATLAB/Simulink.

Analyzing Factors Contributing to Farmers' Willingness to Participate in Rural Cooperative Finance Organizations

It has been commonly recognized that the cooperative finance organizations in China's rural areas have been playing an important role in spreading farm production risks, increasing farmers' income, as well as stimulating the overall rural economic growth. This paper attempted to identify the key factors which potentially contributed to the farmers' willingness to participate in the new-form of the rural cooperative finance organizations sponsored by the Chinese governments. In the process, a total of 442 farmer households as well as small-micro farming enterprises were sampled from the villages in Panjin municipality of Liaoning Province in China, where the new form of the rural cooperative finance organization(NFRCFO) experiment was under way. Those potential factors were classified into the four categories, including the characteristics of the famer households, the reputation of the rural finance cooperatives, transaction costs paid, as well as service quality. A discrete Logit model was used for parameter estimations. The results showed that most of the factors being considered exhibited statistically significant effects on the farmers' willingness to take part in NFRCFO, but with each presenting different levels of impacts. The causes and effects for those uncovered empirical results were fully discussed following by policy implication discussion.

Research on the Public Behaviors to Participate in the Lake Chief System-Based on the Survey of Hengshui City, China

Lake chief system is an innovative measure of ecological civilization construction in lake governance and protection in China. Due to the complexity and openness of lake resources, it is difficult for the government and the market to properly handle the arduous task of lake governance, and public participation is an effective remedy for the failure of the government and the market. In order to know the public participation in the protection lakes, this paper selected 318 citizens from Hengshui city and uses the questionnaire survey to understand the public’s participation attitude, approach and behavior of the lake chief system. The research results show that the public’s education level, length of residence and understanding of the lake chief system have a positive impact on their participation.