BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentrax...BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.展开更多
The purpose of the study is to analyze the breeding ratio of a supercritical water cooled fast reactor (SCFR) and to increase the breeding core of SCFR. The sensitivities of assembly parameters, core arrangements and ...The purpose of the study is to analyze the breeding ratio of a supercritical water cooled fast reactor (SCFR) and to increase the breeding core of SCFR. The sensitivities of assembly parameters, core arrangements and fuel nuclide components to the breeding ratio are analyzed. In assembly parameters, the seed fuel rod diameter has higher sensitivities to the conversion ratio (CR) than the coolant tube diameter in blanket. Increasing heavy metal fraction is good to CR improvement. The CR of SCFR also increases with a reasonable core arrangement and Pu isotope mass fraction reduction in fuel, which can achieve more negative coolant void reactivity coefficient at the same time. The breeding ratio of SCFR is 1.03128 with a new core arrangement. And the coolant void reactivity coefficient is negative, which achieves a fuel breeding in initial fuel cycle.展开更多
In situ catalytic conversion of biomass fast pyrolysis vapors was carried out on HZSM-5 with varying Si/Al ratios(ranging from 20 to 300) at 450 °C. The effects of Si/Al ratios of HZSM-5 zeolites on the distribut...In situ catalytic conversion of biomass fast pyrolysis vapors was carried out on HZSM-5 with varying Si/Al ratios(ranging from 20 to 300) at 450 °C. The effects of Si/Al ratios of HZSM-5 zeolites on the distribution of biomass fast pyrolysis products and carbon deposits on catalysts were investigated. It was quite remarkable that after in situ catalytic conversion the amount of light phenols and hydrocarbons increased significantly while that of heavy phenols decreased a lot. Besides, the yield of cyclopentenones with relatively low oxygen content generally increased. It also indicated that as the Si/Al ratios of HZSM-5 increased, the amount of hydrocarbons and light phenols was found to drop greatly. The amount of carbon deposits was found to be around 8.5% with the exception of HZSM-5 with the Si/Al ratio of 300,which is much lower. Moreover, the carbon deposits yield dropped gradually with increasing Si/Al ratios of HZSM-5.Calcination of spent catalysts at 600 °C helped to restore the catalytic activity to a large extent despite a relatively lower efficiency of deoxygenation. Results indicated that HZSM-5 with relatively high acidity displayed great catalytic performance.展开更多
Due to the development of CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography), EBCT (Electron Beam Computed Tomography), SMRI (Stereotactic Magnetic Resonance Imaging), etc. ...Due to the development of CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography), EBCT (Electron Beam Computed Tomography), SMRI (Stereotactic Magnetic Resonance Imaging), etc. has enhanced the distinguishing rate and scanning rate of the imaging equipments. The diagnosis and the process of getting useful information from the image are got by processing the medical images using the wavelet technique. Wavelet transform has increased the compression rate. Increasing the compression performance by minimizing the amount of image data in the medical images is a critical task. Crucial medical information like diagnosing diseases and their treatments is obtained by modern radiology techniques. Medical Imaging (MI) process is used to acquire that information. For lossy and lossless image compression, several techniques were developed. Image edges have limitations in capturing them if we make use of the extension of 1-D wavelet transform. This is because wavelet transform cannot effectively transform straight line discontinuities, as well geographic lines in natural images cannot be reconstructed in a proper manner if 1-D transform is used. Differently oriented image textures are coded well using Curvelet Transform. The Curvelet Transform is suitable for compressing medical images, which has more curvy portions. This paper describes a method for compression of various medical images using Fast Discrete Curvelet Transform based on wrapping technique. After transformation, the coefficients are quantized using vector quantization and coded using arithmetic encoding technique. The proposed method is tested on various medical images and the result demonstrates significant improvement in performance parameters like Peak Signal to Noise Ratio (PSNR) and Compression Ratio (CR).展开更多
基金Supported by 2022 Educational Research Program for Young and Middle-aged Teachers in Fujian Province(Science and Technology),No.JAT220107.
文摘BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.
文摘The purpose of the study is to analyze the breeding ratio of a supercritical water cooled fast reactor (SCFR) and to increase the breeding core of SCFR. The sensitivities of assembly parameters, core arrangements and fuel nuclide components to the breeding ratio are analyzed. In assembly parameters, the seed fuel rod diameter has higher sensitivities to the conversion ratio (CR) than the coolant tube diameter in blanket. Increasing heavy metal fraction is good to CR improvement. The CR of SCFR also increases with a reasonable core arrangement and Pu isotope mass fraction reduction in fuel, which can achieve more negative coolant void reactivity coefficient at the same time. The breeding ratio of SCFR is 1.03128 with a new core arrangement. And the coolant void reactivity coefficient is negative, which achieves a fuel breeding in initial fuel cycle.
基金supported by the National Basic Research Program of China(2013CB228104)
文摘In situ catalytic conversion of biomass fast pyrolysis vapors was carried out on HZSM-5 with varying Si/Al ratios(ranging from 20 to 300) at 450 °C. The effects of Si/Al ratios of HZSM-5 zeolites on the distribution of biomass fast pyrolysis products and carbon deposits on catalysts were investigated. It was quite remarkable that after in situ catalytic conversion the amount of light phenols and hydrocarbons increased significantly while that of heavy phenols decreased a lot. Besides, the yield of cyclopentenones with relatively low oxygen content generally increased. It also indicated that as the Si/Al ratios of HZSM-5 increased, the amount of hydrocarbons and light phenols was found to drop greatly. The amount of carbon deposits was found to be around 8.5% with the exception of HZSM-5 with the Si/Al ratio of 300,which is much lower. Moreover, the carbon deposits yield dropped gradually with increasing Si/Al ratios of HZSM-5.Calcination of spent catalysts at 600 °C helped to restore the catalytic activity to a large extent despite a relatively lower efficiency of deoxygenation. Results indicated that HZSM-5 with relatively high acidity displayed great catalytic performance.
文摘Due to the development of CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography), EBCT (Electron Beam Computed Tomography), SMRI (Stereotactic Magnetic Resonance Imaging), etc. has enhanced the distinguishing rate and scanning rate of the imaging equipments. The diagnosis and the process of getting useful information from the image are got by processing the medical images using the wavelet technique. Wavelet transform has increased the compression rate. Increasing the compression performance by minimizing the amount of image data in the medical images is a critical task. Crucial medical information like diagnosing diseases and their treatments is obtained by modern radiology techniques. Medical Imaging (MI) process is used to acquire that information. For lossy and lossless image compression, several techniques were developed. Image edges have limitations in capturing them if we make use of the extension of 1-D wavelet transform. This is because wavelet transform cannot effectively transform straight line discontinuities, as well geographic lines in natural images cannot be reconstructed in a proper manner if 1-D transform is used. Differently oriented image textures are coded well using Curvelet Transform. The Curvelet Transform is suitable for compressing medical images, which has more curvy portions. This paper describes a method for compression of various medical images using Fast Discrete Curvelet Transform based on wrapping technique. After transformation, the coefficients are quantized using vector quantization and coded using arithmetic encoding technique. The proposed method is tested on various medical images and the result demonstrates significant improvement in performance parameters like Peak Signal to Noise Ratio (PSNR) and Compression Ratio (CR).
