A New Selection Criterion of Loop-free Alternate Interface for IP Fast Rerouting

As the technology of IP Fast Rerouting (FRR) become mature and the related methods and specifi cation such as RFC5286 accepted as standard, it is expected that IP FRR will be deployed gradually and will enhance the survivability of IP network. This paper presents a different method for computing the Loop-free Alternate Interfaces. The new algorithm can be referred as "Next-Hop Cost Decrease (NHCD)" criterion. Compared with the RFC5286 LFA method, NHCD can handle both the simultaneous link failure and node failure, including multi-link failures. It has less computational complexity and can be used uniformly in the Traffi c Engineering and Network Recovery. However, NHCD is somewhat lower than the LFA method on recovery ratio of single link failure. After a formal description of NHCD criterion and a proof of loopfree alternates, the paper presents the simulation results of NHCD.

Complementary and alternative medicine for cancer treatment:magic or fraud?

Quanjian Group,one of biggest health companies in China,is accused of making huge profits by misleading consumers.18 suspects--including Shu Yuhui,the largest shareholder of Quanjian Nature Medicine Technology Development Company--have been arrested by Tianjin prosecutors.

The emerging role of fasting-mimicking diets in cancer treatment

Cancer is one of the most common causes of morbidity and mortality worldwide.The high demand for specific nutrients and the sensitivity to nutritional deficiencies are newly recognized features of cancer cells.Dietary interventions can suppress tumor demand for particular nutrients and alter certain nutrients to target a tumor's metabolic vulnerability.Cyclic fasting or fasting-mimicking diets(FMDs)are popular approaches that can reduce nutrient intake over a specific period.Accumulating evidence suggests that FMDs attenuate tumor growth by altering the energy metabolism of cancer cells.Furthermore,FMDs potentiate the sensitivity of tumors to conventional cancer treatments and limit adverse events.Recent findings also highlight the potential value of FMDs in boosting antitumor immune surveillance.However,clinical trials regarding the impact of FMDs on cancer patients remain limited and controversial.Here,we provide the latest information on the effects of FMDs on cancer progression and treatment,focusing on future clinical applications.

基于Fast-RVM的在线软测量预测模型

生化需氧量(biochemical oxygen demand,BOD)是评价水质好坏和污水处理效果的关键指标之一。由于污水生化处理过程复杂,在线仪表维护困难,生化需氧量无法得到快速精确地测量。针对这一问题,提出了一种基于Fast-RVM的在线软测量回归模型来实时在线预测出水指标BOD。该模型采用基于贝叶斯框架的相关向量机来在线预测输出指标,并且引入快速边际似然算法来加快模型的更新速度。通过污水数据的仿真实验,结果表明该在线模型的预测精度高于离线模型,泛化能力强,模型在线更新的快速性尤为突出,能较好地实现污水处理中出水水质的实时在线预测。

关节镜下“外-内”缝合法与FasT-Fix修复半月板损伤的临床研究

目的:比较关节镜下"外-内"缝合法与FasT-Fix缝合系统修复半月板损伤的临床疗效。方法:对77例采用关节镜治疗的半月板损伤患者的病历资料进行回顾性分析,其中Ⅰ组的45例患者的半月板损伤采用"外-内"缝合法进行修复,Ⅱ组的32例患者的半月板损伤采用FasT-Fix缝合系统修复。对两组的手术时间、术中出血量、住院时间、术后体征及Lysholm膝关节评分进行比较。结果:两组患者的术中出血量、住院时间、术后体征比较,差异无统计学意义(P>0.05),但Ⅱ组手术时间比Ⅰ组短,差异有统计学意义(t=10.200,P=0.001);两组Lysholm膝关节评分比较,差异无统计学意义(χ2=0.002,P=0.961)。结论:"外-内"缝合法与FasT-Fix缝合系统修复半月板损伤,二者的短期临床疗效相近,但后者操作简便、手术时间短。

急诊床边FASTB超检查在急诊危重病中的诊治优势

目的探索急诊床边FAST B超检查在急诊危重病中的诊治优势。方法方便选取该院在2014年8月—2016年8月期间收治的60例急诊危重病患者为该次实验对象,并对此次研究患者进行动态随机化分为观察组和对照组,且分别实施常规B超检查和床边FAST B超检查,每组30例患者,对比两组患者的漏诊率、灵敏性、生存率、检查完成时间、诊断正确率。结果观察组患者检查完成时间(4.36±1.48)min、灵敏性(96.67%)、漏诊率(3.33%)、生存率(100.00%)、诊断正确率(96.67%)均优于对照组患者(P<0.05)。结论急诊床边FAST B超检查在急诊危重病中诊治效果显著。

BMMYA'平板-Fast blue RR顶层琼脂法高效筛选高酶活脂肪酶

摘建立了一种高效筛选高酶活或高产脂肪酶菌株的平板方法。该方法以华根霉(Rhizopus chinensis CCTCCM201021)脂肪酶基因proRCL在毕赤酵母中构建的基因突变文库为筛选对象,利用BMMYA'平板-FastblueRR顶层琼脂法对其中高酶活或高产的脂肪酶突变株进行筛选,将待筛菌株接种至含有2%甲醇的BMMYA'平板上,30℃生长并诱导4～5 d后,平板经脂肪酶致死温度65℃处理1 h,冰浴、室温平衡后,向平板中倾入Fast blue RR顶层琼脂。2 min内周围显示出明显的黑褐色的菌株为高酶活或高产突变株。该方法简便,快速,高效而且准确,筛选阳性率可达到90%。

Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in Apoe^(-/-)mice

Atherosclerosis is the major contributor to cardiovascular mortality worldwide.Alternate day fasting(ADF)has gained growing attention due to its metabolic benefits.However,the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal models.The present study was designed to investigate the effects of ADF on atherosclerosis in apolipoprotein E-deficient(Apoe^(-/-))mice.Eleven-week-old male Apoe^(-/-)mice fed with Western diet(WD)were randomly grouped into ad libitum(AL)group and ADF group,and ADF aggravated both the early and advanced atherosclerotic lesion formation,which might be due to the disturbed cholesterol profiles caused by ADF intervention.ADF significantly altered cholesterol metabolism pathways and down-regulated integrated stress response(ISR)in the liver.The hepatic expression of activating transcription factor 3(ATF3)was suppressed in mice treated with ADF and hepatocyte-specific overexpression of Aft3 attenuated the effects of ADF on atherosclerotic plaque formation in Apoe^(-/-)mice.Moreover,the expression of ATF3 could be regulated by Krüppel-like factor 6(KLF6)and both the expressions of ATF3 and KLF6 were regulated by hepatic cellular ISR pathway.In conclusion,ADF aggravates atherosclerosis progression in Apoe^(-/-)mice fed on WD.ADF inhibits the hepatic ISR signaling pathway and decreases the expression of KLF6,subsequently inhibiting ATF3 expression.The suppressed ATF3 expression in the liver mediates the deteriorated effects of ADF on atherosclerosis in Apoe^(-/-)mice.The findings suggest the potentially harmful effects when ADF intervention is applied to the population at high risk of atherosclerosis.

FAST和ROSIER量表对急诊脑卒中诊治敏感效率的比较研究

目的比较FAST和ROSIER量表对急诊脑卒中的诊治敏感效率。方法选取2017年3月至2019年4月广西壮族自治区江滨医院收治的202例疑似脑卒中患者,分别利用FAST评分量表及ROSIER评分量表对此202例患者进行筛查,并根据头颅CT及医院专科诊疗作为最终确诊,对比此两种量表的应用效果。结果ROSIER量表的灵敏度、特异度、阳性预测值、阴性预测值均显著高于FAST量表(P<0.05)。结论在急诊脑卒中诊治中采用ROSIER量表进行评估效果较FAST量表更佳。

Aberrant expression of alternative isoforms of transcription factors in hepatocellular carcinoma

Hepatocellular carcinoma(HCC) is one of the most prevalent malignancies worldwide and the second leading cause of death among all cancer types. Deregulation of the networks of tissue-specific transcription factors(TFs) observed in HCC leads to profound changes in the hepatic transcriptional program that facilitates tumor progression. In addition, recent reports suggest that substantial aberrations in the production of TF isoforms occur in HCC. In vitro experiments have identified distinct isoform-specific regulatory functions and related biological effects of liver-specific TFs that are implicated in carcinogenesis, which may be relevant for tumor progression and clinical outcome. This study reviews available data on the expression of isoforms of liver-specific and ubiquitous TFs in the liver and HCC and their effects, including HNF4α, C/EBPs, p73 and TCF7 L2, and indicates that assessment of the ratio of isoforms and targeting specific TF variants may be beneficial for the prognosis and treatment of HCC.

Novel Fourier-based iterative reconstruction for sparse fan projection using alternating direction total variation minimization

Sparse-view x-ray computed tomography （CT） imaging is an interesting topic in CT field and can efficiently decrease radiation dose. Compared with spatial reconstruction, a Fourier-based algorithm has advantages in reconstruction speed and memory usage. A novel Fourier-based iterative reconstruction technique that utilizes non-uniform fast Fourier transform （NUFFF） is presented in this work along with advanced total variation （TV） regularization for a fan sparse-view CT. The proposition of a selective matrix contributes to improve reconstruction quality. The new method employs the NUFFT and its adjoin to iterate back and forth between the Fourier and image space. The performance of the proposed algorithm is demonstrated through a series of digital simulations and experimental phantom studies. Results of the proposed algorithm are compared with those of existing TV-regularized techniques based on compressed sensing method, as well as basic algebraic reconstruction technique. Compared with the existing TV-regularized techniques, the proposed Fourier-based technique significantly improves convergence rate and reduces memory allocation, respectively.

Diagnosis and treatment discussion of congenital factor VII deficiency in pregnancy:A case report

BACKGROUND Congenital factor VII deficiency(FVIID)is a rare autosomal recessive genetic disorder.The clinical manifestations of this deficiency vary greatly.Predicting the risk of bleeding during and after childbirth of pregnant women with congenital FVIID is difficult.Recombinant factor VIIa is the most common replacement therapy for FVIID.However,no unified diagnosis and treatment plan for pregnant women with congenital FVIID has been established.CASE SUMMARY We report the clinical history of a pregnant woman who was considered to have congenital FVIID.Recombinant factor VIIa was prophylactically administered to the pregnant woman at the time of cervical fully opening.She successfully delivered a live infant without any complications,such as postpartum hemorrhage,neonatal abnormalities,and so on.CONCLUSION Prophylaxis of recombinant factor VIIa during delivery can effectively reduce the incidence of postpartum hemorrhage among pregnant women with congenital FVIID associated with a high risk of bleeding.

The Alternative Therapeutic in Pediatric Cancer: What We Know?

Scientific research has brought about enormous national advancements in cancer management. Currently, Morocco provides several therapeutic tools for cancer, among them chemotherapy, surgery and radiotherapy. In Morocco, there is not enough published data on the use of alternative medicine in pediatric oncology. Owing to the increased interest and lack of data on this practice, we conducted this study. It aims to evaluate the uptake, the types of therapies used, the factors influencing, the reasons for this choice and the cost of AM used by patients. An investigation through a questionnaire was carried out on thirty-four children following for cancer within the pediatric hematology and oncology department (PHO) of Marrakech. The survey was conducted over a period of one month and a half between July 25 and September 5, 2022. Data were collected through a questionnaire. From the medical files, we collected data regarding type of cancer, date of admission to PHO department and the treatment received. We asked about the type of AM used: herbs, honey, spiritual AM, zamzam water (water from a “sacred” source in Mecca). Using alternative therapies is a common practice in pediatric oncology with various reasons, among them, the declining socioeconomic level, the diversity, the cultural background, the psychological and the functional status of patients and sometimes the dissatisfaction with conventional medicine.

Fast Track Extubation Post Coronary Artery Bypass Graft: A Retrospective Review of Predictors of Clinical Outcomes

Introduction: Fast track (FT) cardiac surgery and early extubation (EE) are aimed at safe and effective rapid post-operative progression to discharge, and have been practiced for more than two decades. Their goal is to optimize patient care perioperatively in order to decrease costs without negatively affecting morbidity and mortality. However, the factors that predict successful EE are poorly understood, and patients with significant co-morbidities are frequently excluded from protocols. We hypothesize that independent of disease severity, early extubation leads to shorter hospital stays and can be performed safely without negatively affecting outcomes. Materials and Methods: We performed a retrospective review of 919 patients who underwent coronary artery bypass grafting (CABG) at the Southern Arizona Veteran’s Affairs Health Care System medical center over 7 years. We collected pre-operative data regarding patients’ NYHA classification, presence and severity of cerebral vascular disease, peripheral vascular disease, pulmonary disease, diabetes and hypertension. Intra-operative variables were also recorded including ASA scores, ischemic times, and time to extubation. Finally, post-operative variables such as rates of reintubation and tracheotomy, and both length of ICU and total hospital stay were also compared. Results: Prolonged periods of ischemia were found to predict a delayed extubation (HR = 0.992;CI = 0.988 - 0.997, p = 0.0015) while small body surface area (HR = 1.57;CI = 1.13, 2.17, p = 0.007) and higher pre-operative functional status of the patient, such as independent versus dependent status (HR =1.68;CI = 1.30 - 2.16, p = 1.33;CI = 1.03 - 1.70, p = 0.03) were found to be associated with earlier extubation. The early extubation (EE) group (those extubated in less than the median 7.3 hours) had an average hospital stay of 5.1 ± 4.0 days, versus 7.8 ± 8.1 days in the delayed group (>4 hours), p Conclusions: In our study population, pre-operative functional class and total body surface area predicted those patients able to tolerate early extubation after cardiac surgery. Prolonged ischemia resulted in delayed extubation. Patients that were extubated in less than 4 hours had shorter ICU and hospitalization stays, while there was no significant difference between the two groups in rate of reintubation or tracheotomy.

Complementary and Alternative Medicine: A Review on the Effects of Ginger, Cinnamon and Camellia Sinensis Leaf Tea in Diabetes

Diabetes mellitus is a chronic disease with a multitude of effects on different organ-systems. Its chronic nature makes it a challenging disease for patients to manage. Today, patients have access to many different types of conventional therapies for diabetes, each with a different mode of action and side effects. Despite the wide range of therapeutic agents available today, patients seek help from complementary and alternative medicine. The decision to use complementary and alternative medicine by patients stems from some of the harmful side effects of current conventional therapies, as well as their desire to find measures that will help them to manage their disease. Complementary and alternative medicine includes several modalities ranging from dietary components such as vitamins and herbal supplements to mind-body interventions such as yoga, meditation, and massage therapy. Here we review the use of complementary and alternative medicine including Ginger, Cinnamon, and Camellia sinensis leaf tea, and their effects on glycemic indices in diabetes.

Eriofast活性染料染锦纶织物后处理工艺优化

文中对Eriofast活性染料染深红、深紫、深黑色后处理进行试验分析,通过对固色温度、固色时间、NaOH用量、水洗温度等进行优化,并将结果应用到实际大生产中,保证锦纶织物各项色牢度合格的情况下提升织物的深度和颜色稳定性。结果表明:使用Eriofast Fix进行固色,并控制固色温度为60℃,固色时间为40 min,NaOH用量为1.75 g/L,水洗温度为60℃,染色效果较好。大生产结果表明,锦纶织物深度饱满,颜色稳定性好,各项色牢度均达到4.0~5.0级,产品质量大大满足了客户需求。

黑土地保护视角下黑龙江省畜禽养殖环境效应分析

为合理利用畜禽粪污资源,保护黑龙江省黑土地资源,优化农畜业生产布局,实现农牧业绿色发展,本研究基于2011—2020年统计数据及文献资料,测算了黑龙江省畜禽粪污排放情况,并据此分析黑龙江省畜禽粪污资源化利用潜力及畜禽养殖环境承载力。结果表明:从时间动态来看,2011—2020年,黑龙江省畜禽粪尿、粪尿养分、COD排放量均有小幅下降,降幅分别为3.68%、3.24%和5.82%;畜禽粪污的化肥替代潜力虽整体略有下降,但10年来均保持在35%以上,2020年化肥替代潜力已达到41.89%,具有较高的有机肥替代化肥潜力;黑龙江省畜禽粪污的能源潜力略有增长,但对煤炭的替代潜力呈下降趋势且替代作用并不显著,2020年畜禽粪污的沼气潜力为46.74亿m^(3),折合为标准煤仅占标准煤消费量的2.90%,能源潜力有待进一步开发利用;黑龙江省畜禽粪尿、粪尿氮、粪尿磷的耕地负荷均未超载,无养殖环境风险,畜禽养殖环境容量的空间剩余呈上升趋势,剩余约2/3,以氮为基准计算,余量为13006.13万头猪当量,以磷为基准计算,余量为8463.19万头猪当量,具有较大养殖潜力。从空间分布来看,黑龙江省各地区畜禽粪污排放及资源化利用潜力存在明显差异,哈尔滨市、齐齐哈尔市、绥化市、大庆市以及佳木斯市等畜禽养殖集聚区的畜禽粪尿资源丰富,畜禽粪污的替代化肥潜力、能源潜力及畜禽养殖发展潜力较大。

酸处理对生物质热解生物油影响的研究进展

随着全球能源需求的快速增长和环境与可持续发展问题的日益突出,生物质资源作为化石能源的补充受到了广泛关注。通过快速热解技术,将生物质资源转化为同时具有经济和环境效益的液体生物油备受重视。然而,通过直接热解得到的生物油存在化学组分繁多、产率低、品质差等问题。在快速热解之前对生物质进行酸处理,可以有效去除生物质中碱/碱土金属元素(AAEMs)含量,显著改变生物质的形貌结构,极大改善生物油产品的组分分布,增加如左旋葡聚糖等高附加值化合物的产率,有效提升生物油品质,更有利于生物油的分离提纯和后期的高值化利用。总结分析了国内外学者对生物质进行不同酸处理后的热解研究现状,讨论了酸处理及联合酸处理对生物质形貌结构、AAEMs含量、热解过程及热解生物油的影响,为生物质资源化利用和转化提供了思路,对生物质热解酸处理技术的研究和改进提供了参考。

中国FAST工程台址大型岩堆治理方案比较研究

FAST工程台址区存在大量的块石岩堆,对工程安全造成极大影响。以大型块石岩堆—WY15为例,通过初步勘察、详细勘察及施工勘察等不同阶段的勘察信息,进行了初步设计、施工图设计及现场设计三阶段对比分析,提出了三个可行方案进行了技术经济以及对生态环境的影响对比研究,最终得出了最优的治理方案,确保了工程安全,缩短了建设工期,降低工程投资。

肿瘤治疗电场在肿瘤治疗中的应用和机制研究进展

[背景]肿瘤治疗领域缺乏高效、安全的非侵入式治疗方法.近年来,肿瘤治疗电场(tumor treating fields,TTFields)作为一种新兴的非侵入性物理治疗技术,通过释放中频、低强度的交变电场有效抑制肿瘤生长,引发的副作用较小.[进展]目前TTFields已被广泛应用于各类肿瘤治疗的临床研究中,包括脑胶质瘤、间皮质瘤、非小细胞肺癌、胰腺癌、卵巢癌、肝癌及胃癌等.TTFields通过向生物分子施加生物物理力,扰乱肿瘤细胞的生物学功能从而抑制其生长,但具体分子机制尚不明确.为研究TTFields在肿瘤治疗中的分子机制,研究人员通过设计和搭建不同电极和交变电场发生平台,在体外研究TTFields对肿瘤细胞的作用机制.研究发现TTFields干扰细胞分裂、DNA修复、自噬、细胞迁移和细胞膜通透性等生物学过程,也影响血脑屏障、血管生成和肿瘤免疫等肿瘤微环境.[展望]本文回顾了近年来TTFields在肿瘤治疗中的应用、用于体外研究的电极设计和电场发生平台,及其潜在的抗肿瘤机制.然而,TTFields抑制肿瘤生长的分子机制仍需深入研究,评估其对能够自我更新的非肿瘤细胞和终端分化细胞的影响,以减少可能的副作用.这些研究将有助于提升TTFields的治疗潜力,为更多恶性肿瘤的治疗开辟新的可能性.