AIM: In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life. Since musculature is catabolized to supply amino acids for albumin synthesis in malnutritional c...AIM: In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life. Since musculature is catabolized to supply amino acids for albumin synthesis in malnutritional cirrhotic patients, muscular volume is hypothesized to play an important role in albumin production. Therefore, we investigated the correlation between serum albumin levels and the fat-free mass (FFM) in cirrhotic patients.METHODS: Fifty-seven patients (26 males and 31 females)with compensated liver cirrhosis were evaluated. Patients with edema or ascites were excluded from the study.Healthy volunteers (n = 104; 48 males and 56 females)were also evaluated as controls. FFM was measured using 5-500 kHz multifrequency bioelectric impedance analysis.To minimize the difference in FFM distribution between males and females, we introduced a new marker, relative FFM (rFFM), which represents the ratio of FFM in a patient relative to that in a volunteer of the same height. Following FFM measurement, the serum albumin levels of patients were assayed monthly.RESULTS: In patients with active cirrhosis (alanine aminotransaminase [ALT] ＞50 U/L), both albumin (the difference between maximum and minimum levels) and the standard deviation of albumin levels (SD-albumin) during the observation period showed a significant correlation with rFFM. Multiple linear regression analysis using variables such as rFFM, platelet number, and serum cholesterol levels,choline esterase, albumin, bilirubin, and ALT revealed that rFFM and ALT were significant and independent factors that influenced albumin or SD-albumin in cirrhotic patients.CONCLUSION: Our results indicate that cirrhotic patients with high rFFM showed less of a decrease in albumin levels, and that the muscle volume is one of the most important factors for maintaining serum albumins level in active cirrhosis. Exercise and protein-rich nutrition at the early stage of liver cirrhosis may be advisable for maintaining or increasing muscular volume.展开更多
目的:探究江苏省部分地区不同性别成年人脂肪质量随年龄增长的变化情况以及不同年龄段人群体质量指数(body fat index,BMI)和脂肪质量之间的关系。方法:收集2019年9月至2021年2月江苏省南京市、淮安市以及无锡市的体检人群数据,对符合...目的:探究江苏省部分地区不同性别成年人脂肪质量随年龄增长的变化情况以及不同年龄段人群体质量指数(body fat index,BMI)和脂肪质量之间的关系。方法:收集2019年9月至2021年2月江苏省南京市、淮安市以及无锡市的体检人群数据,对符合纳入标准人群进行体格检查和体成分检测,并分析其脂肪质量随年龄变化情况。结果:共收集2115名志愿者的基本信息,排除信息不全者46名,共纳入2069名进行研究分析。30岁以上成年人去脂体质量(fat free mass,FFM)随着年龄的增长呈现下降的趋势;30岁以上成年人的体脂肪量(body fat mass,BFM)、体脂百分比(percentage of body fat,PBF)、腰臀比(waist-hip ratio,WHR)和体脂指数(fat mass index,FMI)随着年龄的增长均呈现上升趋势,BFM、PBF和去脂体质量百分比(percentage of fat free mass,PFFM)在40岁出现显著上升,FFM和去脂体质量指数(fat free mass index,FFMI)在60岁开始出现显著下降。男性FMI在40岁出现显著上升,女性FMI从60岁出现显著上升。全年龄段成年人FFM随着BMI和腰围水平的升高呈上升趋势。结论:随着年龄的增长男性和女性的BFM、PBF和WHR均呈现上升趋势。各年龄段成年男性FFM显著高于女性,女性BFM、FMI、PBF和内脏脂肪面积显著高于男性。全年龄段成年人FFM随着BMI和WHR升高呈上升趋势。展开更多
文摘AIM: In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life. Since musculature is catabolized to supply amino acids for albumin synthesis in malnutritional cirrhotic patients, muscular volume is hypothesized to play an important role in albumin production. Therefore, we investigated the correlation between serum albumin levels and the fat-free mass (FFM) in cirrhotic patients.METHODS: Fifty-seven patients (26 males and 31 females)with compensated liver cirrhosis were evaluated. Patients with edema or ascites were excluded from the study.Healthy volunteers (n = 104; 48 males and 56 females)were also evaluated as controls. FFM was measured using 5-500 kHz multifrequency bioelectric impedance analysis.To minimize the difference in FFM distribution between males and females, we introduced a new marker, relative FFM (rFFM), which represents the ratio of FFM in a patient relative to that in a volunteer of the same height. Following FFM measurement, the serum albumin levels of patients were assayed monthly.RESULTS: In patients with active cirrhosis (alanine aminotransaminase [ALT] ＞50 U/L), both albumin (the difference between maximum and minimum levels) and the standard deviation of albumin levels (SD-albumin) during the observation period showed a significant correlation with rFFM. Multiple linear regression analysis using variables such as rFFM, platelet number, and serum cholesterol levels,choline esterase, albumin, bilirubin, and ALT revealed that rFFM and ALT were significant and independent factors that influenced albumin or SD-albumin in cirrhotic patients.CONCLUSION: Our results indicate that cirrhotic patients with high rFFM showed less of a decrease in albumin levels, and that the muscle volume is one of the most important factors for maintaining serum albumins level in active cirrhosis. Exercise and protein-rich nutrition at the early stage of liver cirrhosis may be advisable for maintaining or increasing muscular volume.
文摘目的:探究江苏省部分地区不同性别成年人脂肪质量随年龄增长的变化情况以及不同年龄段人群体质量指数(body fat index,BMI)和脂肪质量之间的关系。方法:收集2019年9月至2021年2月江苏省南京市、淮安市以及无锡市的体检人群数据,对符合纳入标准人群进行体格检查和体成分检测,并分析其脂肪质量随年龄变化情况。结果:共收集2115名志愿者的基本信息,排除信息不全者46名,共纳入2069名进行研究分析。30岁以上成年人去脂体质量(fat free mass,FFM)随着年龄的增长呈现下降的趋势;30岁以上成年人的体脂肪量(body fat mass,BFM)、体脂百分比(percentage of body fat,PBF)、腰臀比(waist-hip ratio,WHR)和体脂指数(fat mass index,FMI)随着年龄的增长均呈现上升趋势,BFM、PBF和去脂体质量百分比(percentage of fat free mass,PFFM)在40岁出现显著上升,FFM和去脂体质量指数(fat free mass index,FFMI)在60岁开始出现显著下降。男性FMI在40岁出现显著上升,女性FMI从60岁出现显著上升。全年龄段成年人FFM随着BMI和腰围水平的升高呈上升趋势。结论:随着年龄的增长男性和女性的BFM、PBF和WHR均呈现上升趋势。各年龄段成年男性FFM显著高于女性,女性BFM、FMI、PBF和内脏脂肪面积显著高于男性。全年龄段成年人FFM随着BMI和WHR升高呈上升趋势。
