This study aims to investigate on Malaysian young adults’ perceived father and mother involvement. A questionnaire survey with Father Involvement Scale, and Mother Involvement Scale was carried out on 100 male and 10...This study aims to investigate on Malaysian young adults’ perceived father and mother involvement. A questionnaire survey with Father Involvement Scale, and Mother Involvement Scale was carried out on 100 male and 100 female local university and college student aged 18 and 25 years old. The findings show that mothers engaged more in expressive and mentoring/advising involvement as compared to fathers. However, there is no difference between fathers and mothers in instrumental involvement. This study gives us a better understanding on the pattern of parental involvement in Malaysia and hence helps to promote better parent-child relationship.展开更多
Home Literacy Environment(HLE)is an important factor to influence children’s literacy abilities.The study was to look into previous studies on HLE and to propose the future direction on the relationship between fath...Home Literacy Environment(HLE)is an important factor to influence children’s literacy abilities.The study was to look into previous studies on HLE and to propose the future direction on the relationship between fathers’involvement in HLE and children’s literacy outcomes.展开更多
Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterizedby segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a mos...Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterizedby segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine is about 30%. Isolated involvement of stomach is an extremely unusual presentation of the disease accounting for less than 0.07% of all gastrointestinal CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. The diagnosis is difficult to establish in such cases with atypical presentation. In the absence of any other source of disease and in the presence of nonspecific upper gastrointestinal endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent studies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-Saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown.展开更多
Background: The parent-to-child influences can be adaptive and contribute to the optimal psychological well-being and positive perception of the athlete. Contrary to the healthy parental involvement, a family can als...Background: The parent-to-child influences can be adaptive and contribute to the optimal psychological well-being and positive perception of the athlete. Contrary to the healthy parental involvement, a family can also have negative effects on an athlete development. The purpose of this study was to determine gender, father involvement, and mother involvement differences in the psychological profiles of collegiate freshmen athletes as measured by perfectionism, physical self-concept, and psychological well-being. Methods: Eighty-two male and 73 female collegiate freshmen responded to self-reported measures of family involvement, perfectionism, physical self-concept, and psychological well-being. Three separate 2 x 2 x 2 (gender x mother involvement x father involvement) factorial multivariate analysis of variance (MANOVAs) were carried out on the respective subscales from the reported measures. Results: There were significant differences for gender as well as father involvement in perfectionism (p 〈 0.01). Freshmen females had lower concern over mistakes, and greater levels of organization as well as planfulness than males. Furthermore, freshmen athletes with high involved fathers showed greater levels of high standards for others as well as organization. Conclusion: Father involvement and mother involvement impact perfectionism, physical self-concept, and psychological well-being. perspective. extends through the freshmen year in college as shown in the athletes' Future research should develop better measures and utilize a family systems Copyright @ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved展开更多
Stevens-Johnson syndrome(SJS) or toxic epidermal necrolysis(TEN) is a severe adverse drug reaction associated with involvement of skin and mucosal membranes, and carries significant risk of mortality and morbidity. Mu...Stevens-Johnson syndrome(SJS) or toxic epidermal necrolysis(TEN) is a severe adverse drug reaction associated with involvement of skin and mucosal membranes, and carries significant risk of mortality and morbidity. Mucus membrane lesions usually involve the oral cavity, lips, bulbar conjunctiva and the anogenitalia. The oral/anal mucosa and liver are commonly involved in SJS or TEN. However, intestinal involvement is distinctly rare. We herein review the current literature regarding the gastrointestinal involvement in SJS or TEN. This review focuses mainly on the small bowel and colonic involvement in patients with SJS or TEN.展开更多
Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal cord.While the typical clinical phenotype of ALS involves ...Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal cord.While the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of ALS.Although superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized therapies.Despite numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this subpopulation.In this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during SOD1-ALS.The multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.展开更多
CASTLEMAN'S disease(CD),a rare lymphoproliferative disorder of unknown etiology, was first described in 1956 as a benign mass in the mediastinum. Although CD can present anywhere in the body, 70% of the cases are ...CASTLEMAN'S disease(CD),a rare lymphoproliferative disorder of unknown etiology, was first described in 1956 as a benign mass in the mediastinum. Although CD can present anywhere in the body, 70% of the cases are in the chest along the tracheobronchial tree or hilum of the lung in the middle mediastinum; however, they can also occur in the anterior or posterior compartments. CD is classi-fied as unicentric (UCD) or multicentric (MCD) based on the anatomical distribution, and histologically as hya-line-vascular, plasma cell, or mixed subtypes.1 Although MCD is less common than UCD, it can be rapidly pro-gressive and often fatal.展开更多
Introduction: Effective utilization of reproductive and child health (RCH) services is important to reduce morbidity and mortality among mothers as well as children under-five. After International Conference on Popula...Introduction: Effective utilization of reproductive and child health (RCH) services is important to reduce morbidity and mortality among mothers as well as children under-five. After International Conference on Population and Development (ICPD), 1994 India has increasingly integrated male participation in women’s reproductive health to improve the women’s health care during pregnancy and child birth. This study examined effect of women’s autonomy and male involvement on RCH services utilization in Uttar Pradesh State of India. Methodology: State level data of Uttar Pradesh from National Family Health Survey (NFHS-3), India for currently married women and men aged 15 - 49 years was considered. The study was restricted to couples whose youngest child was born during the three years preceding the survey (N = 2685). Pearson chi-square test was used to determine the association of background characteristics with woman’s autonomy and male involvement in RCH utilization. Logistic regression was used to understand the effects of male involvement and women’s autonomy, using both computed indices after controlling for socio-economic and background characteristics of women and their husbands. Subsequently, the exercise was extended using individual component of both the indices. All findings were reported for 95% CI and p < 0.05. Results: Findings show that except religion, other socio-economic and demographic variables such as age of women, place of residence, number of living children, caste/tribe, women’s work status, education, wealth index, household structure and exposure to mass media, husband’s age, education, and occupation were statistically significant and associated with women’s autonomy and male involvement. Multivariate analysis indicated women’s autonomous decision making and support from their husbands (male involvement) significantly influenced their utilization of RCH services after controlling for all socio-economic and demographic variables. Conclusion: To improve RCH service utilization and overall health status of women and children male involvement and women’s autonomous decision-making should be addressed in all future RCH programs in the State.展开更多
Objective:The prevalence and economic burden of Alzheimer's Disease(AD)are consistently increasing.Individuals are encouraged to engage in cognitive preventive behaviors.However,the effectiveness of information pr...Objective:The prevalence and economic burden of Alzheimer's Disease(AD)are consistently increasing.Individuals are encouraged to engage in cognitive preventive behaviors.However,the effectiveness of information provided,depends on factors including the level of personal relevance to the issue and the framing of the information.Our objective in this study was to examine the effect of involvement and message framing on an individual's intention to initiate preventive behaviors toward AD.Methods:An online quasi-experimental scenario-based study was implemented.Vignettes were prepared consisting of information on preventive behaviors to reduce the risk of AD.In the vignettes,scenarios were presented to influence the participant's involvement level(low/high).At the same time,the information was framed positively(low level of fear)or negatively(high level of fear).After exposure to the vignettes,the involvement level and framing perception(fear level)were evaluated.The effects of the two factors on perceived severity,perceived vulnerability,response-efficacy,self-efficacy,and intention to engage in recommended preventive behaviors(based on the Protection Motivation Theory)were then measured.Results:Overall,368 individuals with a mean age of 51.64(±5.48)years participated.Adjusted multiple linear regression indicated that higher involvement was associated with significantly higher perceived severity,perceived vulnerability,and intention to engage in preventive behaviors.Negative message framing was associated with significantly higher perceived severity,perceived vulnerability,and self-efficacy.Conclusion:Our findings indicated that involvement and message framing are essential factors to consider when designing communication materials for promoting health behaviors.Their effects may depend on the underlying drivers of intention toward the recommended health behaviors.展开更多
This paper contrasts Military Power of the People's Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People's Republic of China from the year 2010 to 2013 with corpus ...This paper contrasts Military Power of the People's Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People's Republic of China from the year 2010 to 2013 with corpus analysis. It distinguishes the new reports' differences from the old ones and tries to explore American's discourse colonization and discourse hegemony through corpus software WordSmith 5.0-Keywords and Concordance analysis of high frequency words. The significance of the study is that it enlightens military texts which will influence audiences' viewpoints and provides a new perspective for strategies replying American media war.展开更多
有一种思念可以很长,有一种记忆可以很久,有一双手始终舒适,有一种情永远延续……It is a peaceful night again,everything is quiet.The moonlight shines brightly,which looks like pour-ing water and the cool wind flows through...有一种思念可以很长,有一种记忆可以很久,有一双手始终舒适,有一种情永远延续……It is a peaceful night again,everything is quiet.The moonlight shines brightly,which looks like pour-ing water and the cool wind flows through the window,展开更多
Land was important--in the course of spreading and seeking new converts--for both Missionaries of Africa (White Fathers) and Church Missionary Society (C.M.S.) in Buha, Western Tanzania. This paper examines the la...Land was important--in the course of spreading and seeking new converts--for both Missionaries of Africa (White Fathers) and Church Missionary Society (C.M.S.) in Buha, Western Tanzania. This paper examines the land question as one of the challenges that the White Fathers encountered in their attempt to evangelize communities in Western Tanzania. I argue that the land question remained throughout the late-colonial period one of the unresolved issues, and at some mission stations, impeded the activities of the White Fathers and C.M.S. missionaries. This paper relies on archival documents first, to examine the land question and White Fathers-C.M.S. relations in Buha from 1934 to 1959. Second, I intend to demonstrate the fact that land issues remained at the heart of the missionary enterprise in Buha. Both Catholic and Anglican missionaries were determined to have more mission plots for medical, education and religious purposes.展开更多
Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic activity.We recently have shown that fluorescently labeled Hst1(F-Hst1)targets an...Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic activity.We recently have shown that fluorescently labeled Hst1(F-Hst1)targets and activates mitochondria,presenting an important molecular mechanism.However,its regulating signaling pathways remain to be elucidated.We investigated the influence of specific inhibitors of G protein-coupled receptors(GPCR),endocytosis pathways,extracellular signal-regulated kinases1/2(ERK1/2)signaling,p38 signaling,mitochondrial respiration and Na+/K+-ATPase activity on the uptake,mitochondria-targeting and-activating properties of F-Hst1.We performed a si RNA knockdown(KD)to assess the effect of Sigma-2 receptor(S2R)/Transmembrane Protein 97(TMEM97)—a recently identified target protein of Hst1.We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1.Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1.The inhibitors of GPCR,ERK1/2,phagocytosis,and clathrin-mediated endocytosis(CME)as well as siRNA KD of S2R/TMEM97 significantly reduced the uptake,which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic activity.Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of Hst1.We further showed the intracellular trafficking and targeting process of F-Hst1,in which early endosome plays an important role.Overall,phagocytosis,CME,GPCR,ERK signaling,and S2R/TMEM97 are involved in the internalization of Hst1,while only CME and S2R/TMEM97 are critical for its subcellular targeting.The inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise its mitochondria-activating property.展开更多
Father’s Day comes on the third Sunday in June.It is not a national holiday. On that day, Americanshonour their fathers. Many people send their fathers acard or a gift. Americans are great letter-writers. Whatever ha...Father’s Day comes on the third Sunday in June.It is not a national holiday. On that day, Americanshonour their fathers. Many people send their fathers acard or a gift. Americans are great letter-writers. Whatever happensin a family, you congratulate all the members. Youcongratulate people at Easter, Christmas and Whit-展开更多
The novel, By the light of my father's smile, is the book which comprehensively embodies Alice Walker's womanist thoughts. In the novel, she describes a mixed tribe with both African and Indian ancestry. Through the...The novel, By the light of my father's smile, is the book which comprehensively embodies Alice Walker's womanist thoughts. In the novel, she describes a mixed tribe with both African and Indian ancestry. Through the mundo tribe with African features, she expresses her thoughts of Afracentrism. First of all, Alice Walker holds that African Americans should cherish the traditional African indigenous religion-animism, for it promotes equality and interrelateness among things. Furthermore, through Mundo people's cultural activities of making pots and their initiation songs, she intends to express such a womanist idea that survival and wholeness of entire race derives from that of each race, so those indigenous people who have been overrun by the powerful and wealthy western world are supposed to forgive the westerners' wrong doings, for only love can guide the entire race to achieve survival and wholeness.展开更多
文摘This study aims to investigate on Malaysian young adults’ perceived father and mother involvement. A questionnaire survey with Father Involvement Scale, and Mother Involvement Scale was carried out on 100 male and 100 female local university and college student aged 18 and 25 years old. The findings show that mothers engaged more in expressive and mentoring/advising involvement as compared to fathers. However, there is no difference between fathers and mothers in instrumental involvement. This study gives us a better understanding on the pattern of parental involvement in Malaysia and hence helps to promote better parent-child relationship.
文摘Home Literacy Environment(HLE)is an important factor to influence children’s literacy abilities.The study was to look into previous studies on HLE and to propose the future direction on the relationship between fathers’involvement in HLE and children’s literacy outcomes.
文摘Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterizedby segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine is about 30%. Isolated involvement of stomach is an extremely unusual presentation of the disease accounting for less than 0.07% of all gastrointestinal CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. The diagnosis is difficult to establish in such cases with atypical presentation. In the absence of any other source of disease and in the presence of nonspecific upper gastrointestinal endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent studies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-Saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown.
文摘Background: The parent-to-child influences can be adaptive and contribute to the optimal psychological well-being and positive perception of the athlete. Contrary to the healthy parental involvement, a family can also have negative effects on an athlete development. The purpose of this study was to determine gender, father involvement, and mother involvement differences in the psychological profiles of collegiate freshmen athletes as measured by perfectionism, physical self-concept, and psychological well-being. Methods: Eighty-two male and 73 female collegiate freshmen responded to self-reported measures of family involvement, perfectionism, physical self-concept, and psychological well-being. Three separate 2 x 2 x 2 (gender x mother involvement x father involvement) factorial multivariate analysis of variance (MANOVAs) were carried out on the respective subscales from the reported measures. Results: There were significant differences for gender as well as father involvement in perfectionism (p 〈 0.01). Freshmen females had lower concern over mistakes, and greater levels of organization as well as planfulness than males. Furthermore, freshmen athletes with high involved fathers showed greater levels of high standards for others as well as organization. Conclusion: Father involvement and mother involvement impact perfectionism, physical self-concept, and psychological well-being. perspective. extends through the freshmen year in college as shown in the athletes' Future research should develop better measures and utilize a family systems Copyright @ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved
文摘Stevens-Johnson syndrome(SJS) or toxic epidermal necrolysis(TEN) is a severe adverse drug reaction associated with involvement of skin and mucosal membranes, and carries significant risk of mortality and morbidity. Mucus membrane lesions usually involve the oral cavity, lips, bulbar conjunctiva and the anogenitalia. The oral/anal mucosa and liver are commonly involved in SJS or TEN. However, intestinal involvement is distinctly rare. We herein review the current literature regarding the gastrointestinal involvement in SJS or TEN. This review focuses mainly on the small bowel and colonic involvement in patients with SJS or TEN.
文摘Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal cord.While the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of ALS.Although superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized therapies.Despite numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this subpopulation.In this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during SOD1-ALS.The multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.
文摘CASTLEMAN'S disease(CD),a rare lymphoproliferative disorder of unknown etiology, was first described in 1956 as a benign mass in the mediastinum. Although CD can present anywhere in the body, 70% of the cases are in the chest along the tracheobronchial tree or hilum of the lung in the middle mediastinum; however, they can also occur in the anterior or posterior compartments. CD is classi-fied as unicentric (UCD) or multicentric (MCD) based on the anatomical distribution, and histologically as hya-line-vascular, plasma cell, or mixed subtypes.1 Although MCD is less common than UCD, it can be rapidly pro-gressive and often fatal.
文摘Introduction: Effective utilization of reproductive and child health (RCH) services is important to reduce morbidity and mortality among mothers as well as children under-five. After International Conference on Population and Development (ICPD), 1994 India has increasingly integrated male participation in women’s reproductive health to improve the women’s health care during pregnancy and child birth. This study examined effect of women’s autonomy and male involvement on RCH services utilization in Uttar Pradesh State of India. Methodology: State level data of Uttar Pradesh from National Family Health Survey (NFHS-3), India for currently married women and men aged 15 - 49 years was considered. The study was restricted to couples whose youngest child was born during the three years preceding the survey (N = 2685). Pearson chi-square test was used to determine the association of background characteristics with woman’s autonomy and male involvement in RCH utilization. Logistic regression was used to understand the effects of male involvement and women’s autonomy, using both computed indices after controlling for socio-economic and background characteristics of women and their husbands. Subsequently, the exercise was extended using individual component of both the indices. All findings were reported for 95% CI and p < 0.05. Results: Findings show that except religion, other socio-economic and demographic variables such as age of women, place of residence, number of living children, caste/tribe, women’s work status, education, wealth index, household structure and exposure to mass media, husband’s age, education, and occupation were statistically significant and associated with women’s autonomy and male involvement. Multivariate analysis indicated women’s autonomous decision making and support from their husbands (male involvement) significantly influenced their utilization of RCH services after controlling for all socio-economic and demographic variables. Conclusion: To improve RCH service utilization and overall health status of women and children male involvement and women’s autonomous decision-making should be addressed in all future RCH programs in the State.
文摘Objective:The prevalence and economic burden of Alzheimer's Disease(AD)are consistently increasing.Individuals are encouraged to engage in cognitive preventive behaviors.However,the effectiveness of information provided,depends on factors including the level of personal relevance to the issue and the framing of the information.Our objective in this study was to examine the effect of involvement and message framing on an individual's intention to initiate preventive behaviors toward AD.Methods:An online quasi-experimental scenario-based study was implemented.Vignettes were prepared consisting of information on preventive behaviors to reduce the risk of AD.In the vignettes,scenarios were presented to influence the participant's involvement level(low/high).At the same time,the information was framed positively(low level of fear)or negatively(high level of fear).After exposure to the vignettes,the involvement level and framing perception(fear level)were evaluated.The effects of the two factors on perceived severity,perceived vulnerability,response-efficacy,self-efficacy,and intention to engage in recommended preventive behaviors(based on the Protection Motivation Theory)were then measured.Results:Overall,368 individuals with a mean age of 51.64(±5.48)years participated.Adjusted multiple linear regression indicated that higher involvement was associated with significantly higher perceived severity,perceived vulnerability,and intention to engage in preventive behaviors.Negative message framing was associated with significantly higher perceived severity,perceived vulnerability,and self-efficacy.Conclusion:Our findings indicated that involvement and message framing are essential factors to consider when designing communication materials for promoting health behaviors.Their effects may depend on the underlying drivers of intention toward the recommended health behaviors.
文摘This paper contrasts Military Power of the People's Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People's Republic of China from the year 2010 to 2013 with corpus analysis. It distinguishes the new reports' differences from the old ones and tries to explore American's discourse colonization and discourse hegemony through corpus software WordSmith 5.0-Keywords and Concordance analysis of high frequency words. The significance of the study is that it enlightens military texts which will influence audiences' viewpoints and provides a new perspective for strategies replying American media war.
文摘有一种思念可以很长,有一种记忆可以很久,有一双手始终舒适,有一种情永远延续……It is a peaceful night again,everything is quiet.The moonlight shines brightly,which looks like pour-ing water and the cool wind flows through the window,
文摘Land was important--in the course of spreading and seeking new converts--for both Missionaries of Africa (White Fathers) and Church Missionary Society (C.M.S.) in Buha, Western Tanzania. This paper examines the land question as one of the challenges that the White Fathers encountered in their attempt to evangelize communities in Western Tanzania. I argue that the land question remained throughout the late-colonial period one of the unresolved issues, and at some mission stations, impeded the activities of the White Fathers and C.M.S. missionaries. This paper relies on archival documents first, to examine the land question and White Fathers-C.M.S. relations in Buha from 1934 to 1959. Second, I intend to demonstrate the fact that land issues remained at the heart of the missionary enterprise in Buha. Both Catholic and Anglican missionaries were determined to have more mission plots for medical, education and religious purposes.
基金funded by Eurostars project,grant number E!12764。
文摘Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic activity.We recently have shown that fluorescently labeled Hst1(F-Hst1)targets and activates mitochondria,presenting an important molecular mechanism.However,its regulating signaling pathways remain to be elucidated.We investigated the influence of specific inhibitors of G protein-coupled receptors(GPCR),endocytosis pathways,extracellular signal-regulated kinases1/2(ERK1/2)signaling,p38 signaling,mitochondrial respiration and Na+/K+-ATPase activity on the uptake,mitochondria-targeting and-activating properties of F-Hst1.We performed a si RNA knockdown(KD)to assess the effect of Sigma-2 receptor(S2R)/Transmembrane Protein 97(TMEM97)—a recently identified target protein of Hst1.We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1.Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1.The inhibitors of GPCR,ERK1/2,phagocytosis,and clathrin-mediated endocytosis(CME)as well as siRNA KD of S2R/TMEM97 significantly reduced the uptake,which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic activity.Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of Hst1.We further showed the intracellular trafficking and targeting process of F-Hst1,in which early endosome plays an important role.Overall,phagocytosis,CME,GPCR,ERK signaling,and S2R/TMEM97 are involved in the internalization of Hst1,while only CME and S2R/TMEM97 are critical for its subcellular targeting.The inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise its mitochondria-activating property.
文摘Father’s Day comes on the third Sunday in June.It is not a national holiday. On that day, Americanshonour their fathers. Many people send their fathers acard or a gift. Americans are great letter-writers. Whatever happensin a family, you congratulate all the members. Youcongratulate people at Easter, Christmas and Whit-
文摘The novel, By the light of my father's smile, is the book which comprehensively embodies Alice Walker's womanist thoughts. In the novel, she describes a mixed tribe with both African and Indian ancestry. Through the mundo tribe with African features, she expresses her thoughts of Afracentrism. First of all, Alice Walker holds that African Americans should cherish the traditional African indigenous religion-animism, for it promotes equality and interrelateness among things. Furthermore, through Mundo people's cultural activities of making pots and their initiation songs, she intends to express such a womanist idea that survival and wholeness of entire race derives from that of each race, so those indigenous people who have been overrun by the powerful and wealthy western world are supposed to forgive the westerners' wrong doings, for only love can guide the entire race to achieve survival and wholeness.