长链脂肪酸在哺乳动物体内具有广泛的生理功能,特别是在生物膜的形成和动态特性维持中发挥着不可或缺的作用,同时,作为能量产生的重要原料,长链脂肪酸在保持心脏和骨骼肌正常功能方面也具有极其重要的作用.脂肪酸转运蛋白家族(fatty aci...长链脂肪酸在哺乳动物体内具有广泛的生理功能,特别是在生物膜的形成和动态特性维持中发挥着不可或缺的作用,同时,作为能量产生的重要原料,长链脂肪酸在保持心脏和骨骼肌正常功能方面也具有极其重要的作用.脂肪酸转运蛋白家族(fatty acid transport proteins,FATPs)是一组膜蛋白,在心脏、肝脏、肌肉和小肠等脂肪酸代谢活跃的组织器官中均有表达.已有研究表明,FATPs在长链脂肪酸的摄取和代谢调节中发挥着重要作用,现对FATPs的组织分布、结构特点、功能、作用机制及其与人类疾病的关系等方面进行综述.展开更多
为了探讨脂肪酸转运蛋白1(Fatty acid transport protein 1,FATP1)作为鸭屠体性状候选基因的可能性,试验以三穗鸭为材料,采用PCR-SSCP的方法进行单核苷酸多态性(SNPs)检测和基因型的分析。结果表明:在FATP1基因中检测到1个碱基变异,位于...为了探讨脂肪酸转运蛋白1(Fatty acid transport protein 1,FATP1)作为鸭屠体性状候选基因的可能性,试验以三穗鸭为材料,采用PCR-SSCP的方法进行单核苷酸多态性(SNPs)检测和基因型的分析。结果表明:在FATP1基因中检测到1个碱基变异,位于第5内含子65 bp处,为G→A突变,发现2种基因型(GA基因型、GG基因型),且在此位点的优势等位基因型为GA基因型,G为优势等位基因。在第1外显子、第2外显子、第4外显子、第5外显子和第8外显子上没有发现多态位点。关联分析结果表明,FATP1基因第5内含子处多态性对三穗鸭的全净膛、胸肌重、屠体重、腿肌重等性状存在显著影响(P<0.05)。展开更多
The regulation of energetic efficiency through the physiological uncoupling of oxidative phosphorylation may be a common strategy developed early in evolution.Uncoupling protein families are transporters in mitochondr...The regulation of energetic efficiency through the physiological uncoupling of oxidative phosphorylation may be a common strategy developed early in evolution.Uncoupling protein families are transporters in mitochondrial inner membrane.There are five UCP homologs in mammalian genome.UCP1-3 are closely related with each other,while UCP4 and UCP5(also called brain mitochondrial carrier protein-1,BMCP1) differ from them greatly.UCP1-4 were discovered not only in endotherms such as mammals and birds,but also in ectothermic vertebrates such as fish and amphibia.UCP5 was identified only in mammals.UCP1,which is only expressed in mammalian brown adipose tissue,mediates proton leakage of the proton gradient that is generated by the respiratory chain,and as a result,the oxidative energy is dissipated as heat.UCP2 and UCP3 function both in fever,ROS inhibition,fatty acid oxidation,the development of obesity and type 2 diabetes mellitus and so on.Their expression regulations are complex.UCP4 and UCP5 diverge from other UCP further. UCP4 is uniquely expressed in brain,whilst UCP5 transcripts are present in multiple tissues,with an especially high abundance in brain.Their functions are still unclear,but they have been implicated in processes similar to those suggested for UCP2 and UCP3.展开更多
腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一类重要的蛋白激酶,通过改变细胞代谢和调节基因转录恢复细胞ATP水平。AMPK参与了肌肉收缩介导的葡萄糖转运和脂肪酸氧化,抑制肝脏葡萄糖、胆固醇和甘油三酯产生,并具有调节...腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一类重要的蛋白激酶,通过改变细胞代谢和调节基因转录恢复细胞ATP水平。AMPK参与了肌肉收缩介导的葡萄糖转运和脂肪酸氧化,抑制肝脏葡萄糖、胆固醇和甘油三酯产生,并具有调节食物摄取和体重的作用。AMPK信号通路是目前具有吸引力的治疗肥胖、胰岛素抵抗、2型糖尿病和其它代谢病的药理靶点。展开更多
文摘长链脂肪酸在哺乳动物体内具有广泛的生理功能,特别是在生物膜的形成和动态特性维持中发挥着不可或缺的作用,同时,作为能量产生的重要原料,长链脂肪酸在保持心脏和骨骼肌正常功能方面也具有极其重要的作用.脂肪酸转运蛋白家族(fatty acid transport proteins,FATPs)是一组膜蛋白,在心脏、肝脏、肌肉和小肠等脂肪酸代谢活跃的组织器官中均有表达.已有研究表明,FATPs在长链脂肪酸的摄取和代谢调节中发挥着重要作用,现对FATPs的组织分布、结构特点、功能、作用机制及其与人类疾病的关系等方面进行综述.
文摘为了探讨脂肪酸转运蛋白1(Fatty acid transport protein 1,FATP1)作为鸭屠体性状候选基因的可能性,试验以三穗鸭为材料,采用PCR-SSCP的方法进行单核苷酸多态性(SNPs)检测和基因型的分析。结果表明:在FATP1基因中检测到1个碱基变异,位于第5内含子65 bp处,为G→A突变,发现2种基因型(GA基因型、GG基因型),且在此位点的优势等位基因型为GA基因型,G为优势等位基因。在第1外显子、第2外显子、第4外显子、第5外显子和第8外显子上没有发现多态位点。关联分析结果表明,FATP1基因第5内含子处多态性对三穗鸭的全净膛、胸肌重、屠体重、腿肌重等性状存在显著影响(P<0.05)。
文摘The regulation of energetic efficiency through the physiological uncoupling of oxidative phosphorylation may be a common strategy developed early in evolution.Uncoupling protein families are transporters in mitochondrial inner membrane.There are five UCP homologs in mammalian genome.UCP1-3 are closely related with each other,while UCP4 and UCP5(also called brain mitochondrial carrier protein-1,BMCP1) differ from them greatly.UCP1-4 were discovered not only in endotherms such as mammals and birds,but also in ectothermic vertebrates such as fish and amphibia.UCP5 was identified only in mammals.UCP1,which is only expressed in mammalian brown adipose tissue,mediates proton leakage of the proton gradient that is generated by the respiratory chain,and as a result,the oxidative energy is dissipated as heat.UCP2 and UCP3 function both in fever,ROS inhibition,fatty acid oxidation,the development of obesity and type 2 diabetes mellitus and so on.Their expression regulations are complex.UCP4 and UCP5 diverge from other UCP further. UCP4 is uniquely expressed in brain,whilst UCP5 transcripts are present in multiple tissues,with an especially high abundance in brain.Their functions are still unclear,but they have been implicated in processes similar to those suggested for UCP2 and UCP3.
文摘腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一类重要的蛋白激酶,通过改变细胞代谢和调节基因转录恢复细胞ATP水平。AMPK参与了肌肉收缩介导的葡萄糖转运和脂肪酸氧化,抑制肝脏葡萄糖、胆固醇和甘油三酯产生,并具有调节食物摄取和体重的作用。AMPK信号通路是目前具有吸引力的治疗肥胖、胰岛素抵抗、2型糖尿病和其它代谢病的药理靶点。
