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A Model for Detecting Fake News by Integrating Domain-Specific Emotional and Semantic Features
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作者 Wen Jiang Mingshu Zhang +4 位作者 Xu’an Wang Wei Bin Xiong Zhang Kelan Ren Facheng Yan 《Computers, Materials & Continua》 SCIE EI 2024年第8期2161-2179,共19页
With the rapid spread of Internet information and the spread of fake news,the detection of fake news becomes more and more important.Traditional detection methods often rely on a single emotional or semantic feature t... With the rapid spread of Internet information and the spread of fake news,the detection of fake news becomes more and more important.Traditional detection methods often rely on a single emotional or semantic feature to identify fake news,but these methods have limitations when dealing with news in specific domains.In order to solve the problem of weak feature correlation between data from different domains,a model for detecting fake news by integrating domain-specific emotional and semantic features is proposed.This method makes full use of the attention mechanism,grasps the correlation between different features,and effectively improves the effect of feature fusion.The algorithm first extracts the semantic features of news text through the Bi-LSTM(Bidirectional Long Short-Term Memory)layer to capture the contextual relevance of news text.Senta-BiLSTM is then used to extract emotional features and predict the probability of positive and negative emotions in the text.It then uses domain features as an enhancement feature and attention mechanism to fully capture more fine-grained emotional features associated with that domain.Finally,the fusion features are taken as the input of the fake news detection classifier,combined with the multi-task representation of information,and the MLP and Softmax functions are used for classification.The experimental results show that on the Chinese dataset Weibo21,the F1 value of this model is 0.958,4.9% higher than that of the sub-optimal model;on the English dataset FakeNewsNet,the F1 value of the detection result of this model is 0.845,1.8% higher than that of the sub-optimal model,which is advanced and feasible. 展开更多
关键词 Fake news detection domain-related emotional features semantic features feature fusion
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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study 被引量:2
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作者 Hengxing Zhou Yongfu Lou +32 位作者 Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1126-1132,共7页
Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic ... Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence. 展开更多
关键词 China clinical features COSTS EPIDEMIOLOGY methylprednisolone sodium succinate METHYLPREDNISOLONE retrospective study traumatic spinal cord injury TREATMENT
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Endoscopic features and treatments of gastric cystica profunda 被引量:2
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作者 Zi-Han Geng Yan Zhu +5 位作者 Pei-Yao Fu Yi-Fan Qu Wei-Feng Chen Xia Yang Ping-Hong Zhou Quan-Lin Li 《World Journal of Gastroenterology》 SCIE CAS 2024年第7期673-684,共12页
BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal layers.GCP is often linked to,or may progress into,early gast... BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal layers.GCP is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and treatment.METHODS This retrospective study involved 104 patients with GCP who underwent endoscopic resection.Alongside demographic and clinical data,regular patient followups were conducted to assess local recurrence.RESULTS Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric procedures.The primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with EGC.Univariate analysis indicated that elderly males were more susceptible to GCP associated with EGC.Conversely,multivariate analysis identified lesion morphology and endoscopic features as significant risk factors.Survival analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC. 展开更多
关键词 Gastric cystica profunda Early gastric cancer Endoscopic features Endoscopic resection ENDOSCOPY
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Directly predicting N_(2) electroreduction reaction free energy using interpretable machine learning with non-DFT calculated features
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作者 Yaqin Zhang Yuhang Wang +1 位作者 Ninggui Ma Jun Fan 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第10期139-148,I0004,共11页
Electrocatalytic nitrogen reduction to ammonia has garnered significant attention with the blooming of single-atom catalysts(SACs),showcasing their potential for sustainable and energy-efficient ammonia production.How... Electrocatalytic nitrogen reduction to ammonia has garnered significant attention with the blooming of single-atom catalysts(SACs),showcasing their potential for sustainable and energy-efficient ammonia production.However,cost-effectively designing and screening efficient electrocatalysts remains a challenge.In this study,we have successfully established interpretable machine learning(ML)models to evaluate the catalytic activity of SACs by directly and accurately predicting reaction Gibbs free energy.Our models were trained using non-density functional theory(DFT)calculated features from a dataset comprising 90 graphene-supported SACs.Our results underscore the superior prediction accuracy of the gradient boosting regression(GBR)model for bothΔg(N_(2)→NNH)andΔG(NH_(2)→NH_(3)),boasting coefficient of determination(R^(2))score of 0.972 and 0.984,along with root mean square error(RMSE)of 0.051 and 0.085 eV,respectively.Moreover,feature importance analysis elucidates that the high accuracy of GBR model stems from its adept capture of characteristics pertinent to the active center and coordination environment,unveilling the significance of elementary descriptors,with the colvalent radius playing a dominant role.Additionally,Shapley additive explanations(SHAP)analysis provides global and local interpretation of the working mechanism of the GBR model.Our analysis identifies that a pyrrole-type coordination(flag=0),d-orbitals with a moderate occupation(N_(d)=5),and a moderate difference in covalent radius(r_(TM-ave)near 140 pm)are conducive to achieving high activity.Furthermore,we extend the prediction of activity to more catalysts without additional DFT calculations,validating the reliability of our feature engineering,model training,and design strategy.These findings not only highlight new opportunity for accelerating catalyst design using non-DFT calculated features,but also shed light on the working mechanism of"black box"ML model.Moreover,the model provides valuable guidance for catalytic material design in multiple proton-electron coupling reactions,particularly in driving sustainable CO_(2),O_(2),and N_(2) conversion. 展开更多
关键词 Nitrogen reduction Single-atom catalyst Interpretable machine learning Graphene Non-DFT features
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A process-oriented approach for identifying potential landslides considering time-dependent behaviors beyond geomorphological features
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作者 Xiang Sun Guoqing Chen +4 位作者 Xing Yang Zhengxuan Xu Jingxi Yang Zhiheng Lin Yunpeng Liu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期961-978,共18页
Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential lands... Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential landslide identification that considers time-dependent behaviors.The method integrates comprehensive remote sensing and geological analysis to qualitatively assess slope stability,and employs numerical analysis to quantitatively calculate aging stability.Specifically,a time-dependent stability calculation method for anticlinal slopes is developed and implemented in discrete element software,incorporating time-dependent mechanical and strength reduction calculations.By considering the time-dependent evolution of slopes,this method highlights the importance of both geomorphological features and time-dependent behaviors in landslide identification.This method has been applied to the Jiarishan slope(JRS)on the Qinghai-Tibet Plateau as a case study.The results show that the JRS,despite having landslide geomorphology,is a stable slope,highlighting the risk of misjudgment when relying solely on geomorphological features.This work provides insights into the geomorphological characterization and evolution history of the JRS and offers valuable guidance for studying slopes with similar landslide geomorphology.Furthermore,the process-oriented method incorporating timedependent evolution provides a means to evaluate potential landslides,reducing misjudgment due to excessive reliance on geomorphological features. 展开更多
关键词 Geomorphological features Evolution history Time-dependent stability calculation Landslides identification Qinghai-Tibet Plateau
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Behaviour recognition based on the integration of multigranular motion features in the Internet of Things
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作者 Lizong Zhang Yiming Wang +3 位作者 Ke Yan Yi Su Nawaf Alharbe Shuxin Feng 《Digital Communications and Networks》 SCIE CSCD 2024年第3期666-675,共10页
With the adoption of cutting-edge communication technologies such as 5G/6G systems and the extensive development of devices,crowdsensing systems in the Internet of Things(IoT)are now conducting complicated video analy... With the adoption of cutting-edge communication technologies such as 5G/6G systems and the extensive development of devices,crowdsensing systems in the Internet of Things(IoT)are now conducting complicated video analysis tasks such as behaviour recognition.These applications have dramatically increased the diversity of IoT systems.Specifically,behaviour recognition in videos usually requires a combinatorial analysis of the spatial information about objects and information about their dynamic actions in the temporal dimension.Behaviour recognition may even rely more on the modeling of temporal information containing short-range and long-range motions,in contrast to computer vision tasks involving images that focus on understanding spatial information.However,current solutions fail to jointly and comprehensively analyse short-range motions between adjacent frames and long-range temporal aggregations at large scales in videos.In this paper,we propose a novel behaviour recognition method based on the integration of multigranular(IMG)motion features,which can provide support for deploying video analysis in multimedia IoT crowdsensing systems.In particular,we achieve reliable motion information modeling by integrating a channel attention-based short-term motion feature enhancement module(CSEM)and a cascaded long-term motion feature integration module(CLIM).We evaluate our model on several action recognition benchmarks,such as HMDB51,Something-Something and UCF101.The experimental results demonstrate that our approach outperforms the previous state-of-the-art methods,which confirms its effective-ness and efficiency. 展开更多
关键词 Behaviour recognition Motion features Attention mechanism Internet of things Crowdsensing
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Differentially private SGD with random features
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作者 WANG Yi-guang GUO Zheng-chu 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2024年第1期1-23,共23页
In the realm of large-scale machine learning,it is crucial to explore methods for reducing computational complexity and memory demands while maintaining generalization performance.Additionally,since the collected data... In the realm of large-scale machine learning,it is crucial to explore methods for reducing computational complexity and memory demands while maintaining generalization performance.Additionally,since the collected data may contain some sensitive information,it is also of great significance to study privacy-preserving machine learning algorithms.This paper focuses on the performance of the differentially private stochastic gradient descent(SGD)algorithm based on random features.To begin,the algorithm maps the original data into a lowdimensional space,thereby avoiding the traditional kernel method for large-scale data storage requirement.Subsequently,the algorithm iteratively optimizes parameters using the stochastic gradient descent approach.Lastly,the output perturbation mechanism is employed to introduce random noise,ensuring algorithmic privacy.We prove that the proposed algorithm satisfies the differential privacy while achieving fast convergence rates under some mild conditions. 展开更多
关键词 learning theory differential privacy stochastic gradient descent random features reproducing kernel Hilbert spaces
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Relationships between Terrain Features and Forecasting Errors of Surface Wind Speeds in a Mesoscale Numerical Weather Prediction Model
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作者 Wenbo XUE Hui YU +1 位作者 Shengming TANG Wei HUANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第6期1161-1170,共10页
Numerical weather prediction(NWP)models have always presented large forecasting errors of surface wind speeds over regions with complex terrain.In this study,surface wind forecasts from an operational NWP model,the SM... Numerical weather prediction(NWP)models have always presented large forecasting errors of surface wind speeds over regions with complex terrain.In this study,surface wind forecasts from an operational NWP model,the SMS-WARR(Shanghai Meteorological Service-WRF ADAS Rapid Refresh System),are analyzed to quantitatively reveal the relationships between the forecasted surface wind speed errors and terrain features,with the intent of providing clues to better apply the NWP model to complex terrain regions.The terrain features are described by three parameters:the standard deviation of the model grid-scale orography,terrain height error of the model,and slope angle.The results show that the forecast bias has a unimodal distribution with a change in the standard deviation of orography.The minimum ME(the mean value of bias)is 1.2 m s^(-1) when the standard deviation is between 60 and 70 m.A positive correlation exists between bias and terrain height error,with the ME increasing by 10%−30%for every 200 m increase in terrain height error.The ME decreases by 65.6%when slope angle increases from(0.5°−1.5°)to larger than 3.5°for uphill winds but increases by 35.4%when the absolute value of slope angle increases from(0.5°−1.5°)to(2.5°−3.5°)for downhill winds.Several sensitivity experiments are carried out with a model output statistical(MOS)calibration model for surface wind speeds and ME(RMSE)has been reduced by 90%(30%)by introducing terrain parameters,demonstrating the value of this study. 展开更多
关键词 surface wind speed terrain features error analysis MOS calibration model
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Structural features in the mid-southern section of the Kyushu–Palau Ridge based on satellite altimetry gravity anomaly
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作者 Feifei Zhang Dingding Wang +3 位作者 Xiaolin Ji Fanghui Hou Yuan Yang Wanyin Wang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第4期50-60,共11页
The Kyushu–Palau Ridge(KPR),an anti-S-shaped submarine highland at the center of the Philippine Sea Plate(PSP),is considered the residual arc of the Izu–Bonin–Mariana Island Arc,which retains key information about ... The Kyushu–Palau Ridge(KPR),an anti-S-shaped submarine highland at the center of the Philippine Sea Plate(PSP),is considered the residual arc of the Izu–Bonin–Mariana Island Arc,which retains key information about the cessation of the Western Philippine Basin(WPB)expansion and the Parece Vela Basin(PVB)breakup.Herein,using the new generation of satellite altimetry gravity data,high-precision seafloor topography data,and newly acquired ship-borne gravity data,the topographic and gravity characteristics of the KPR mid-southern section and adjacent region are depicted.The distribution characteristics of the faults were delineated using the normalized vertical derivative–total horizontal derivative method(NVDR-THDR)and the minimum curvature potential field separation method.The Moho depth and crustal thickness were inverted using the rapid inversion method for a double-interface model with depth constraints.Based on these results,the crust structure features in the KPR mid-southern section,and the“triangular”structure geological significance where the KPR and Central Basin Rift(CBR)of the WPB intersect are interpreted.The KPR crustal thickness is approximately 6–16 km,with a distinct discontinuity that is slightly thicker than the normal oceanic crust.The KPR mid-southern section crust structure was divided into four segments(S1–S4)from north to south,formed by the CBR eastward extension joint action and clockwise rotation of the PVB expansion axis and the Mindanao fault zone blocking effect. 展开更多
关键词 structural features satellite altimetry gravity data Kyushu-Palau Ridge Central Basin Rift FAULTS Moho depth
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Machine Learning Security Defense Algorithms Based on Metadata Correlation Features
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作者 Ruchun Jia Jianwei Zhang Yi Lin 《Computers, Materials & Continua》 SCIE EI 2024年第2期2391-2418,共28页
With the popularization of the Internet and the development of technology,cyber threats are increasing day by day.Threats such as malware,hacking,and data breaches have had a serious impact on cybersecurity.The networ... With the popularization of the Internet and the development of technology,cyber threats are increasing day by day.Threats such as malware,hacking,and data breaches have had a serious impact on cybersecurity.The network security environment in the era of big data presents the characteristics of large amounts of data,high diversity,and high real-time requirements.Traditional security defense methods and tools have been unable to cope with the complex and changing network security threats.This paper proposes a machine-learning security defense algorithm based on metadata association features.Emphasize control over unauthorized users through privacy,integrity,and availability.The user model is established and the mapping between the user model and the metadata of the data source is generated.By analyzing the user model and its corresponding mapping relationship,the query of the user model can be decomposed into the query of various heterogeneous data sources,and the integration of heterogeneous data sources based on the metadata association characteristics can be realized.Define and classify customer information,automatically identify and perceive sensitive data,build a behavior audit and analysis platform,analyze user behavior trajectories,and complete the construction of a machine learning customer information security defense system.The experimental results show that when the data volume is 5×103 bit,the data storage integrity of the proposed method is 92%.The data accuracy is 98%,and the success rate of data intrusion is only 2.6%.It can be concluded that the data storage method in this paper is safe,the data accuracy is always at a high level,and the data disaster recovery performance is good.This method can effectively resist data intrusion and has high air traffic control security.It can not only detect all viruses in user data storage,but also realize integrated virus processing,and further optimize the security defense effect of user big data. 展开更多
关键词 Data-oriented architecture METADATA correlation features machine learning security defense data source integration
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Aerodynamic Features of High-Speed Maglev Trains with Different Marshaling Lengths Running on a Viaduct under Crosswinds
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作者 Zun-Di Huang Zhen-Bin Zhou +2 位作者 Ning Chang Zheng-Wei Chen Su-Mei Wang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期975-996,共22页
The safety and stability of high-speed maglev trains traveling on viaducts in crosswinds critically depend on their aerodynamic characteristics.Therefore,this paper uses an improved delayed detached eddy simulation(ID... The safety and stability of high-speed maglev trains traveling on viaducts in crosswinds critically depend on their aerodynamic characteristics.Therefore,this paper uses an improved delayed detached eddy simulation(IDDES)method to investigate the aerodynamic features of high-speed maglev trains with different marshaling lengths under crosswinds.The effects of marshaling lengths(varying from 3-car to 8-car groups)on the train’s aerodynamic performance,surface pressure,and the flow field surrounding the train were investigated using the three-dimensional unsteady compressible Navier-Stokes(N-S)equations.The results showed that the marshaling lengths had minimal influence on the aerodynamic performance of the head and middle cars.Conversely,the marshaling lengths are negatively correlated with the time-average side force coefficient(CS)and time-average lift force coefficient(Cl)of the tail car.Compared to the tail car of the 3-car groups,the CS and Cl fell by 27.77%and 18.29%,respectively,for the tail car of the 8-car groups.It is essential to pay more attention to the operational safety of the head car,as it exhibits the highest time average CS.Additionally,the mean pressure difference between the two sides of the tail car body increased with the marshaling lengths,and the side force direction on the tail car was opposite to that of the head and middle cars.Furthermore,the turbulent kinetic energy of the wake structure on the windward side quickly decreased as marshaling lengths increased. 展开更多
关键词 High-speed maglev train marshaling lengths crosswinds aerodynamic features
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Clinical features and prognostic factors of duodenal neuroendocrine tumours:A comparative study of ampullary and nonampullary regions
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作者 Sa Fang Yu-Peng Shi +2 位作者 Lu Wang Shuang Han Yong-Quan Shi 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第3期907-918,共12页
BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare neoplasms.However,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic studies.Regrettably,there is... BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare neoplasms.However,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic studies.Regrettably,there is no consensus regarding the ideal treatment of DNETs.Even there are few studies on the clinical features and survival analysis of DNETs.AIM To analyze the clinical characteristics and prognostic factors of patients with duodenal neuroendocrine tumours.METHODS The clinical data of DNETs diagnosed in the First Affiliated Hospital of Air Force Military Medical University from June 2011 to July 2022 were collected.Neuroen-docrine tumours located in the ampulla area of the duodenum were divided into the ampullary region group;neuroendocrine tumours in any part of the duo-denum outside the ampullary area were divided into the nonampullary region group.Using a retrospective study,the clinical characteristics of the two groups and risk factors affecting the survival of DNET patients were analysed.RESULTS Twenty-nine DNET patients were screened.The male to female ratio was 1:1.9,and females comprised the majority.The ampullary region group accounted for 24.1%(7/29),while the nonampullary region group accounted for 75.9%(22/29).When diagnosed,the clinical symptoms of the ampullary region group were mainly abdominal pain(85.7%),while those of the nonampullary region groups were mainly abdominal distension(59.1%).There were differences in the composition of staging of tumours between the two groups(Fisher's exact probability method,P=0.001),with nonampullary stage II tumours(68.2%)being the main stage(P<0.05).After the diagnosis of DNETs,the survival rate of the ampullary region group was 14.3%(1/7),which was lower than that of 72.7%(16/22)in the nonampullary region group(Fisher's exact probability method,P=0.011).The survival time of the ampullary region group was shorter than that of the nonampullary region group(P<0.000).The median survival time of the ampullary region group was 10.0 months and that of the nonampullary region group was 451.0 months.Multivariate analysis showed that tumours in the ampulla region and no surgical treatment after diagnosis were independent risk factors for the survival of DNET patients(HR=0.029,95%CI 0.004-0.199,P<0.000;HR=12.609,95%CI:2.889-55.037,P=0.001).Further analysis of nonampullary DNET patients showed that the survival time of patients with a tumour diameter<2 cm was longer than that of patients with a tumour diameter≥2 cm(t=7.243,P=0.048).As of follow-up,6 patients who died of nonampullary DNETs had a tumour diameter that was≥2 cm,and 3 patients in stage IV had liver metastasis.Patients with a tumour diameter<2 cm underwent surgical treatment,and all survived after surgery.CONCLUSION Surgical treatment is a protective factor for prolonging the survival of DNET patients.Compared to DNETs in the ampullary region,patients in the nonampullary region group had a longer survival period.The liver is the organ most susceptible to distant metastasis of nonampullary DNETs. 展开更多
关键词 DUODENUM NEUROENDOCRINE TUMOUR Ampullary Nonampullary Clinical features PROGNOSTIC
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Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer
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作者 Qiu-Xiao Yu Ping-Ying Fu +2 位作者 Chi Zhang Li Li Wen-Ting Huang 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第5期1395-1406,共12页
BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality worldwide.Mesenchymal-epithelial transition factor(MET)gene participates in multiple tumor ... BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality worldwide.Mesenchymal-epithelial transition factor(MET)gene participates in multiple tumor biology and shows clinical potential for pharmacological manipulation in tumor treatment.MET amplification has been reported in CRC,but data are very limited.Investigating pathological values of MET in CRC may provide new therapeutic and genetic screening options in future clinical practice.AIM To determine the pathological significance of MET amplification in CRC and to propose a feasible screening strategy.METHODS A number of 205 newly diagnosed CRC patients undergoing surgical resection without any preoperative therapy at Shenzhen Cancer Hospital of Chinese Academy of Medical Sciences were recruited.All patients were without RAS/RAF mutation or microsatellite instability-high.MET amplification and c-MET protein expression were analyzed using fluorescence in situ hybridization(FISH)and immunohistochemistry(IHC),respectively.Correlations between MET aberration and pathological features were detected using the chi-squared test.Progression free survival(PFS)during the two-year follow-up was detected using the Kaplan-Meier method and log rank test.The results of MET FISH and IHC were com pared using one-way ANOVA.RESULTS Polysomy-induced MET amplification was observed in 14.4%of cases,and focal MET amplification was not detected.Polysomy-induced MET amplification was associated with a higher frequency of lymph node metastasis(LNM)(P<0.001)and higher tumor budding grade(P=0.02).In the survival analysis,significant difference was detected between patients with amplified-and non-amplified MET in a two-year follow-up after the first diagnosis(P=0.001).C-MET scores of 0,1+,2+,and 3+were observed in 1.4%,24.9%,54.7%,and 19.0%of tumors,respectively.C-MET overexpression correlated with higher frequency of LNM(P=0.002),but no significant difference of PFS was detected between patients with different protein levels.In terms of concordance between MET FISH and IHC results,MET copy number showed no difference in c-MET IHC 0/1+(3.35±0.18),2+(3.29±0.11)and 3+(3.58±0.22)cohorts,and the MET-to-CEP7 ratio showed no difference in three groups(1.09±0.02,1.10±0.01,and 1.09±0.03).CONCLUSION In CRC,focal MET amplification was a rare event.Polysomy-induced MET amplification correlated with adverse pathological characteristics and poor prognosis.IHC was a poor screening tool for MET amplification. 展开更多
关键词 Colorectal cancer MET AMPLIFICATION Pathological features Prognosis Fluorescence in situ hybridization
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Oncological features and prognosis of colorectal cancer in human immunodeficiency virus-positive patients: A retrospective study
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作者 Fu-Yu Yang Fan He +4 位作者 De-Fei Chen Cheng-Lin Tang Saed Woraikat Yao Li Kun Qian 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第1期29-39,共11页
BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer(CRC)among patients with human immunodeficiency virus(HIV)infection,the prognosis and pathological features of CRC in HIV-positive... BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer(CRC)among patients with human immunodeficiency virus(HIV)infection,the prognosis and pathological features of CRC in HIV-positive patients require examination.AIM To compare the differences in oncological features,surgical safety,and prognosis between patients with and without HIV infection who have CRC at the same tumor stage and site.METHODS In this retrospective study,we collected data from HIV-positive and-negative patients who underwent radical resection for CRC.Using random stratified sampling,24 HIV-positive and 363 HIV-negative patients with colorectal adenocarcinoma after radical resection were selected.Using propensity score matching,we selected 72 patients,matched 1:2(HIV-positive:negative=24:48).Differences in basic characteristics,HIV acquisition,perioperative serological indicators,surgical safety,oncological features,and long-term prognosis were compared between the two groups.RESULTS Fewer patients with HIV infection underwent chemotherapy compared to patients without.HIV-positive patients had fewer preoperative and postoperative leukocytes,fewer preoperative lymphocytes,lower carcinoembryonic antigen levels,more intraoperative blood loss,more metastatic lymph nodes,higher node stage,higher tumor node metastasis stage,shorter overall survival,and shorter progression-free survival compared to patients who were HIV-negative.CONCLUSION Compared with CRC patients who are HIV-negative,patients with HIV infection have more metastatic lymph nodes and worse long-term survival after surgery.Standard treatment options for HIV-positive patients with CRC should be explored. 展开更多
关键词 Colorectal cancer Human immunodeficiency virus Propensity score matching Oncological features Surgical safety PROGNOSIS
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Epidemiology, Clinical Features and Antifungal Resistance Profile of Candida auris in Africa: Systematic Review
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作者 Isidore Wendkièta Yerbanga Seydou Nakanabo Diallo +8 位作者 Toussaint Rouamba Delwendé Florence Ouedraogo Katrien Lagrou Rita Oladele Jean-Pierre Gangneux Olivier Denis Hector Rodriguez-Villalobos Isabel Montesinos Sanata Bamba 《Journal of Biosciences and Medicines》 2024年第1期126-149,共24页
Candida auris since it discovery in 2009 is becoming a severe threat to human health due to its very quickly spread, its worldwide high resistance to systemic antifungal drugs. In resource-constrained settings where s... Candida auris since it discovery in 2009 is becoming a severe threat to human health due to its very quickly spread, its worldwide high resistance to systemic antifungal drugs. In resource-constrained settings where several conditions are met for its emergence and spread, this worrisome fungus could cause large hospital and/or community-based outbreaks. This review aimed to summarize the available data on C. auris in Africa focusing on its epidemiology and antifungal resistance profile. Major databases were searched for articles on the epidemiology and antifungal resistance profile of C. auris in Africa. Out of 2,521 articles identified 22 met the inclusion criteria. In Africa, nearly 89% of African countries have no published data on C. auris. The prevalence of C. auris in Africa was 8.74%. The case fatality rate of C. auris infection in Africa was 39.46%. The main C. auris risk factors reported in Africa were cardiovascular disease, renal failure, diabetes, HIV, recent intake of antimicrobial drugs, ICU admissions, surgery, hemodialysis, parenteral nutrition and indwelling devices. Four phylogenetic clades were reported in Africa, namely clades I, II, III and IV. Candida auris showed a pan-African very high resistance rate to fluconazole, moderate resistance to amphotericin B, and high susceptibility to echinocandins. Finally, C. auris clade-specific mutations were observed within the ERG2, ERG3, ERG9, ERG11, FKS1, TAC1b and MRR1 genes in Africa. This systematic review showed the presence of C. auris in the African continent and a worrying unavailability of data on this resilient fungus in most African countries. 展开更多
关键词 AFRICA Antifungal Resistance Candida auris Clinical features Phylogenetic Clades
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Study on the Expression,Prognosis,and Clinical Features of HOXA6 in Liver Cancer
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作者 Huiqiong Zhu 《Proceedings of Anticancer Research》 2024年第5期159-164,共6页
Objective:To study and analyze the expression level of homeobox A6(HOXA6)in patients with liver cancer and its correlation with prognosis.Methods:From January 2020 to July 2021,43 patients with liver cancer who underw... Objective:To study and analyze the expression level of homeobox A6(HOXA6)in patients with liver cancer and its correlation with prognosis.Methods:From January 2020 to July 2021,43 patients with liver cancer who underwent surgery without prior radiotherapy or chemotherapy were selected.Liver cancer tissues and adjacent tissues were collected,and the expression levels of HOXA6 mRNA and protein were measured using RT-qPCR and Western blot.The expression level of HOXA6 in tumor tissues(without radiotherapy and chemotherapy)was compared with that in adjacent tissues.Additionally,the prognosis and clinical characteristics of patients with low HOXA6 expression were compared to those with high HOXA6 expression,and the factors influencing high HOXA6 expression in liver cancer patients were analyzed.Results:HOXA6 mRNA and protein expression levels in tumor tissues were significantly higher than in adjacent tissues(P<0.05).There was no significant difference in the 1-year and 2-year survival rates between the high HOXA6 expression group and the low HOXA6 expression group(P>0.05).However,the 3-year survival rate was lower in the high HOXA6 expression group compared to the low HOXA6 expression group(P<0.05).There were no statistically significant differences between the two groups in terms of gender,age,tumor diameter,alpha-fetoprotein levels,or hepatitis B virus DNA levels(P>0.05).However,significant differences were found in the number of tumor lesions,degree of differentiation,and the proportion of tumor metastasis between the two groups(P<0.05).Multivariate logistic regression analysis revealed that the number of tumor lesions,degree of differentiation,and tumor metastasis were influencing factors for high HOXA6 expression in liver cancer patients(P<0.05).Conclusion:HOXA6 expression levels are abnormally elevated in liver cancer patients,and higher HOXA6 expression is associated with a worse 3-year survival rate.The factors influencing HOXA6 expression include the number of tumor lesions,degree of differentiation,and tumor metastasis. 展开更多
关键词 Liver cancer HOXA6 Expression level Clinical features Influencing factors
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The Determination Method of Product Engineering Features Based on Linguistic Variables
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作者 Guo Mao 《Journal of World Architecture》 2024年第1期18-23,共6页
To overcome the problem of imprecise and unclear information in the development of quality functions,a method for determining the priority of engineering features based on mixed linguistic variables is proposed.First,... To overcome the problem of imprecise and unclear information in the development of quality functions,a method for determining the priority of engineering features based on mixed linguistic variables is proposed.First,the evaluation member uses the determined linguistic variable to give the correlation strength evaluation matrix of customer requirements and engineering features.Secondly,the relative importance of the evaluation member and customer requirements are aggregated.Finally,the priority of engineering features is obtained by calculating the deviation.The feasibility and practicability of this method are proven by taking the design of a new product of a long bag low-pressure pulse dust collector as an example. 展开更多
关键词 Quality function deployment Engineering features Linguistic variable Priority ratings
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Linguistic Features of Oral English Corpora and Their Implications for English Teaching in Colleges and Universities
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作者 Yanru Li Yu Bei 《Journal of Contemporary Educational Research》 2024年第2期208-212,共5页
The main goal of English teaching in colleges and universities is to cultivate students’ability to use the language,but many students are still unable to complete oral communication fluently after years of study.For ... The main goal of English teaching in colleges and universities is to cultivate students’ability to use the language,but many students are still unable to complete oral communication fluently after years of study.For this reason,teachers need to deeply analyze and study the linguistic features of oral English corpora and formulate reasonable teaching strategies to improve students’oral expression skills.This paper outlines the linguistic features of oral English corpora,comparatively analyzes the differences between oral English corpora and written English corpora,and explores effective teaching strategies,hoping to provide guidelines for relevant teachers. 展开更多
关键词 Oral English corpora Linguistic features Colleges and universities English teaching
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Features of Tropical Volcanic Rock and Soil of Jakarta-Bandung HSR and Engineering Countermeasures
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作者 ZHAO Dou WANG Shujie ZHENG Mingda(Translated) 《Chinese Railways》 2024年第1期30-37,共8页
The geological features of three types of tropical volcanic rock and soil distributed along Jakarta-Bandung high-speed railway(HSR),including pozzolanic clayey soil,mud shale and deep soft soil,are studied through fie... The geological features of three types of tropical volcanic rock and soil distributed along Jakarta-Bandung high-speed railway(HSR),including pozzolanic clayey soil,mud shale and deep soft soil,are studied through field and laboratory tests.The paper analyzes the mechanism and causes of engineering geological problems caused by tropical volcanic rock and soil and puts forward measures to control subgrade slope instability by rationally determining project type,making side slope stability control and strengthening waterproofing and drainage.The“zero front slope”tunneling technology at the portal,the simplified excavation method of double-side wall heading and the cross brace construction method of arch protection within the semi-open cut row pile frame in the“mountainside”eccentrically loaded soft soil stratum are adopted to control the instability of tunnel side and front slopes,foundation pits and working faces;CFG or pipe piles shall be used to reinforce soft and expansive foundation or replacement measures shall be taken,and the scheme of blind ditch+double-layer water sealing in ballastless track section shall be put forward to prevent arching deformation of foundation;the treatment measures of CFG pile,pipe pile and vacuum combined piled preloading are adopted to improve the bearing capacity of foundation in deep soft soil section and solve the problems of settlement control and uneven settlement.These engineering countermeasures have been applied during the construction of Jakarta-Bandung HSR and achieved good results. 展开更多
关键词 Jakarta-Bandung HSR tropical volcanic rock and soil engineering geological features engineering geological problems engineering countermeasures
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Analysis of the Gravity-1 Sea Launch System and Technical Features
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作者 ZHANG Tao HUANG Shuai +2 位作者 Ma Ma BU Xiangwei XU Guoguang 《Aerospace China》 2024年第1期18-27,共10页
Sea launch has the characteristics of flexible launching points, high landing area safety, and good economy. In recent years, it has become one of the important launch methods. Since 2019, China has carried out a tota... Sea launch has the characteristics of flexible launching points, high landing area safety, and good economy. In recent years, it has become one of the important launch methods. Since 2019, China has carried out a total of 11 successful sea launches. The Gravity-1(YL-1) sea launch system consists of a launch vehicle system and a sea launch platform. The sea launch program includes roll on/roll off boarding, sea mooring, sea maneuvering, anchoring and positioning, system testing, and formal launch. Through the maiden flight of YL-1, the design and manufacturing technology of large tonnage dedicated launch ship, launch vehicle vertical transfer and roll on/roll off boarding technology, anti-shake technology for sea launch, simple inflatable flexible insulation protective cover technology, and remote wireless measurement and control technology have been fully verified. 展开更多
关键词 YL-1 sea launch system technical features
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