As an important type of emerging pollutants, ecological toxicity and risk of artificial musks are increasingly concerned. Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta...As an important type of emerging pollutants, ecological toxicity and risk of artificial musks are increasingly concerned. Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta-gamma-2-benzopyran （HHCB） as one of the most widely applied artificial musks and cadmium （Cd） as an toxic metal on zebrafish （Danio rerio） were investigated by the exposure of zebrafish to various concentrations of HHCB or/and Cd in feculent water containing bedloads. The results indicated that the joint effect of HHCB and Cd changed during different exposure times within 120 h. The index of the antioxidant enzyme system including superoxide dismutase （SOD） and perox- idase （POD）, and malondialdehyde （MDA） were sensitive and induced in the zebrafish stressed by Cd, and content of soluble protein （SP） was sensitive to HHCB and could be used as a biomarker for HHCB. Joint effects on antioxidant enzymes depended more on the effect of single Cd in the first one or two days. However, in the rest exposure days, the effect of HHCB began to dominate in the joint effect during the exposure process.展开更多
基金Acknowledgements The authors acknowledge the financial support from the National Natural Science Foundation of China （Grant Nos. 40930739 and 21037002）. The Sino-Russian Joint Research Center on Natural Resources and Eco-Environmental Sciences also gave partial aids in this work.
文摘As an important type of emerging pollutants, ecological toxicity and risk of artificial musks are increasingly concerned. Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta-gamma-2-benzopyran （HHCB） as one of the most widely applied artificial musks and cadmium （Cd） as an toxic metal on zebrafish （Danio rerio） were investigated by the exposure of zebrafish to various concentrations of HHCB or/and Cd in feculent water containing bedloads. The results indicated that the joint effect of HHCB and Cd changed during different exposure times within 120 h. The index of the antioxidant enzyme system including superoxide dismutase （SOD） and perox- idase （POD）, and malondialdehyde （MDA） were sensitive and induced in the zebrafish stressed by Cd, and content of soluble protein （SP） was sensitive to HHCB and could be used as a biomarker for HHCB. Joint effects on antioxidant enzymes depended more on the effect of single Cd in the first one or two days. However, in the rest exposure days, the effect of HHCB began to dominate in the joint effect during the exposure process.
